Trends in Human Hair Growth and Alopecia Research PDF
Preview Trends in Human Hair Growth and Alopecia Research
Trends in Human Hair Growth and Alopecia Research Trends in Human Hair Growth and Alopecia Research Edited by D. Van Neste, J.M. Lachapelle and J.L. Antoine Occupational Dermatology Unit, Catholic University of Louvaln, Bruxelles, Belgium ..& KLUWER ACADEMIC PUBLISHERS .,~ DORDRECHT / BOSTON / LONDON Distributors for the United States and Canada: Kluwer Academic Publishers, PO Box 358, Accord Station, Hingham, MA 02018-0358, USA for all other countries: Kluwer Academic Publishers Group, Distribution Center, PO Box 322, 3300 AH Dordrecht, The Netherlands British Library Cataloguing in Publication Data Trends in human hair growth and alopecia research I. Man. Hair. Growth I. Neste, D. Van, (Dominique) I. Lachapelle, J.M. III. Antoine, J-L (Jean-Luc) 612'.799 ISBN-13: 978-94-011-7875-4 e-ISBN-13: 978-94-011-7873-0 DOl: 10.1007/978-94-011-7873-0 Copyright © 1989 by Kluwer Academic Publishers Softcover reprint of the hardcover 1s t edition 1989 All rights reserved. No part of this pUblication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers, Kluwer Academic Publishers BV, PO Box 17, 3300 AA Dordrecht, The Netherlands. Published in the United Kingdom by Kluwer Academic Publishers, PO Box 55, Lancaster, UK. Kluwer Academic Publishers BV incorporates the publishing programmes of D. Reidel, Martinus Nijhoff, Dr W. Junk and MTP Press. Lasertypeset by Martin Lister Publishing Services, Carnforth, Lanes. England Contents Foreword: AlM Vermorken ix List of Contributors xi Part I: Biology and Experimental Models 1 Embryogenesis of the hair follicle and hair cycle L De Weert 3 2 Keratin expression in the hum~n hair follicle JSchweizer 11 3 The mammalian tongue filiform 'papillae: a theoretical model for primitive hairs D Dhouail/y and T-T Sun 29 4 Comparative electrophoretic analysis of sulfur containing proteins of hair bulb keratogenous zone and hair sh~ft C Nappe, M Kermici and P Bore 35 5 Four murine monoclonal antibodies specific for the inner root sheath in the human hair follicle G Serre, V Mils, C Vincent, A Conter, S Michel, J Kadouche and J-P 43 Soleilhavoup 6 The dermo-epithelial interaction and the hair follicle Ch M Lapiere 53 7 Isolation, culture and in vitro behavior of cells isolated from papillae of human hair follicles AG Messenger 57 8 A new in vitro culture system to produce a fully differentiated epidermis from human hair follicle outer root sheath cells M-C Lenoir, BA Bernard, G Pautrat, M Darmon and B Shroot 67 9 Non-keratinocyte cells in the hair follicle (with special emphasis to the human hair follicles) J-POrtonne 75 10 The human hair follicle: a target for androgens C Sultan, K Bakkar and AlM Vermorken 89 11 Effects of testosterone, dihydrotestosterone and estradiol on the growth behavior of cultured hair bulb papilla cells and root sheath fibroblasts A Arai, K Katsuoka, F Kiesewetter, H Schell and OP Hornstein 99 12 Pharmacological aspects of hair follicle growth HUno 105 v TRENDS IN HUMAN HAIR GROWTH AND ALOPECIA RESEARCH 13 Human hair follicle grafts onto nude mice: morphological study D Van Neste, G Warnier, M Thulliez and F Van Hoof 117 14 On the behavior of dye ions in an isotachophoresis boundary: application to the mitosis mechanism K Uyttendae/e 133 Part II: Diagnostic Methods 15 Dynamic exploration of hair growth: critical review of methods available and of their usefulness in the clinical trial protocol D Van Neste 143 16 Phototrichogram analysis: technical aspects and problems in relation with automated quantitative evaluation of hair growth by computer-assisted image analysis D Van Neste, M Dumortier and W De Coster 155 17 PIXE-microanalysis in green hair KH Kurz, HF Merk, GK Steig/eder, M Hijfert and B Gonsior 167 18 Office diagnosis of pathological changes in hair cuticular cell pattern D Van Neste and Y Houbion 173 Part III: Hair and Scalp Diseases and Therapy: Trichothiodystrophy, Pattern Baldness, Alopecia Areata 19 Clinical symptoms associated with trichothiodystrophy: a review of the literature with special emphasis on light sensitivity and the association with xeroderma pigmentosum (complementation group D). D Van Neste, X Miller and E Bohnert 183 20 High-sulfur protein deficient human hair: clinical aspects and biochemical study of two unreported cases of a variant type of trichothiodystrophy D Van Neste, H Degreef, N Van Haute, J Van Hee, J Vandermaesen , A 195 Taieb, A Mafeville, D Fontan, N Bakry, JM Gillespie and RC Marshall 21 The effect of cyproterone acetate on hair roots and hair shaft diameter in androgenetic alopecia in females JDR Peereboom-Wynia, AH Van der Willigen, E Stolz and Th Van Joost 207 22 Androgenetic alopecia: some thoughts and views about its topical treatment R Venafra 215 23 Effects of a topical preparation on some hair growth parameters evaluated utilizing morphometric computerized analysis. C Pelfini 219 24 A placebo controlled clinical trial with a topical preparation containing HUCP and thioglycoran in male pattern baldness Y Privat 231 25 Topical minoxidil used before and after hair transplantation surgery P Bouhanna 247 26 Clinical and macrophotographic study of the percutaneous implantation of synthetic hair P Bouhanna 257 vi CONTENTS 27 Patch testing procedures in patients suffering from suspected allergic contact dermatitis to minoxidil JM Lachapelle, D Tennstedt, B Leroy, V Van Den Haute and F Naert 267 28 Histological study of alopecia areata H Uno and G Orecchia 273 29 In situ immunophenotyping of follicular keratinocytes in alopecia areata H Niedecken, G Lutz, R Bauer and HW Kreysel 283 30 Expression of Langerhans cell antigens in the hair follicles in alopecia areata. Histological changes in alopecia areata. H Niedecken, G Lutz, R Bauer and HW Kreysel 291 31 Analysis of T cell, activated T cell and NK cell subsets in peripheral blood lymphocytes from patients with alopecia areata R Imai, J Miura, K Numata, Y Aikawa, K Takamori and H Ogawa 299 32 Mutagenic evaluation of SADBE in human lymphocytes E Capel/i and G Orecchia 305 33 Treatment of severe alopecia areata by topical application of cyclosporine. Comparative trial versus placebo in 43 patients Y de Prost, D Teil/ac, F Paquez, C Carrugi, H Bachelez and R Touraine 313 34 Anatomo-clinical illustration of a hair-follicle naevus D Tennstedt and JM Lachapelle 317 35 Head gear induced traumatic alopecia during orthodontic treatment DVanNeste 321 Index 325 vii Acknowledgements The contents of this book are based on the original contributions and presentations made at the international research symposium The Human Hair Follicle in Biomedical Research held at the Louvain University, Brussels, February 5-6, 1988. Organized under the auspices of the SRD - SOClETE DE RECHERCHE DERMATOLOGIQUE Local program committee: Professor A. Kint, Rijks-Universiteit Gent, Gent, Belgium Professor 1.M. Lachapelle and Dr D. Van Neste Universite Catholique de Louvain, Brussels, Belgium Concept and organization: Skinterface sprl, Tournai, Belgium ' This International Research Symposium acknowledges financial support from the following institutions COMMISSION FRAN<;AIS DE LA CULTURE DE L'AGGLOMERATION DE BRUXELLES FONDS NATIONAL DE LA RECHERCHE SCIENTIFIQUE MINISTERE DE L'EDUCATION NATIONALE Foreword It is now thirty years since William Montagna and Richard Ellis edited 'The Biology of Hair Growth". In his introduction, Stephen Rothman, of the University of Chicago, USA and one of the driving forces behind research on skin at the time, wrote: 'The pilary system is a perfect micr9cosmic structure. In this microcos mos we find birth, development, ageing and death, activity and rest, color for mation and decolorification, greasiness and dryness, infection and sterilization, hypertrophy and atrophy, Qenign tumours and malignant ones." He foresaw the human pilary system as a model for the study of a multitude of human diseases including ageing and cancer. It was not, how ever, until the seventies that the development of micro-biochemical tech niques indeed allowed the use of the human hair follicle as a convenient biopsy tissue for Biomedical Research in general. Measurement of enzyme activities, and important co-factors, and culturing of cells from single follicles all became possible. In the eighties dermal papilla cells were grown in cul ture and this opened the way to study hair differentiation in vitro. Studying hair differentiation is, in fact, studying growth regulation and it is this aspect that by far transcends the importance of studying hair growth itself. Let us not forget that metastatic prostate cancer is treated with the same drug -cyproterone acetate -that is used for the treatment of alopecia and hirsutism in women. A breakthrough in the treatment of alopecia has recently been achieved, not so much in the sense that an effective treatment for most cases of alope cia is now available but in the sense that the approach has dramatically changed. Since Aristotle, himself balding, discovered that eunuchs did not develop baldness, treatment and research have been aimed at inhibiting an drogen action in order to prevent hair loss. Minoxidil is the first drug in use for a new approach, namely the induction of local hypertrichosis without in terfering in the mechanisms of androgen action. In the coming years a series of drugs with a strong hypertrichotic effect promises to increase the effectiveness of alopecia treatment. These chemi cals are potent, however, and unacceptable side-effects are to be feared in longer term use with large numbers of patients. We are therefore confronted with a major challenge both for academia and for pharmaceutical and cos metic industries. While the regrowth of hair may require potent drugs, their lifelong use for prevention of alopecia and for the maintenance of hair regrowth should ix TRENDS IN HUMAN HAIR GROWTH AND ALOPECIA RESEARCH not be necessary. There is an important task ahead in the development of ef fective but simple and safe treatments for the above-mentioned goal; as al ways in research, once that the basic understanding of a problem has been achieved, simplification is always possible. The Commission of the European Communities has recently decided to accept research into skin diseases as one of the major opportunities in the field of "Age-Related Health Problems" research. Moreover, it was agreed that the possibility of collaboration with industry in European coordinated research actions should be investigated. This brings together a challenging scientific situation with a challenging political one. My own personal hope is that the achievement of the above-mentioned goal to control the growth of normally differentiating hair cells will bring us closer to the understanding and control of the growth of cancer cells. May the human hair follicle continue to be a valuable model for the study of both cellular differentiation and transformation! Fons VERMORKEN Medical Reseach Division Commission of the European Communities, Brussels x List of Contributors A.Arai J. M. Lachapelle Derm. Universitiisklinik Dermatologie UCL 3033 Hartmansstrasse 14 30 Clos Chapelle-aux-Champs D-8520 Erlangen B-1200 Bruxelles West Germany Belgium P.Bouhanna Ch. M. Lapiere Dermatologie Service de Dermatologie 89 avenue de Villiers Hopital de Baviere-CHU Sart-Tilman F-75017 Paris B-4000 Liege France Belgium H. Degreef M.-C. Lenoir Department de Dermatologie AZ St Pieter CIRD Brusselsestraat 69 Centre Internationale de Reserche B-3000 Leuven Dermatologiques Belgium Sophia Antipolis F-06565 Val bonne Cedex Y. de Prost France Department of Dermatology Hopital Necker Enfants Malades A.G. Messenger 149 rue de Sevres Department of Dermatology F-75743 Paris Cedex 15 Royal Hallamshire Hospital France University of Sheffield Sheffield S10 2JF J. De Weert United Kingdom Dermatologie Akademisch Ziekenhuis Vrijheidslaan 20 ' X. Miller B-9000 Gent Dermatologist Belgium Cite Bourschterbach 27 L-9029 Warken D.Dhouailly Luxembourg Laboratoire de Zoologie et Biolologie Animale J. Miura Universite Scientifique et Medicale de Department of Dermatology Grenoble BP 68 Juntendo University School of Medicine F-38402 Saint Martin d'Heres Cedex 2-1-1 Hongo France Bunkyo-ku Tokyo 113 R.lmai Japan Department of Dermatology Juntendo University School of Medicine C.Nappe 2-1-1 Hongo L'Oreal-Laboratoires de Recherche Bunkyo-Ku Fondamentale Tokyo 113 1 Avenue Eugene Schueller Japan BP22 F-93601 Aulnay sous Bois Cedex K.H. Kurz France Universitats-Hautklinik J. Stelzmann-Strasse 9 D-5000 K61n 41 West Germany xi
The list of books you might like
