Table Of Content

TRENDS IN GENETICS REFERENCE EDITION Volume 14 1998 CONTENTS JANUARY COMMENT The spindle checkpoint by Kevin G. Hardwick Expressed sequence tags — ESTablishing bridges between genomes by Marco A. Marra, Ladeana Hillier and Robert H. Waterston MEETING REPORTS A bright future for the human past by Chris Tyler-Smith, Arpita Pandya and Fabricio R. Santos Tumor suppressors: from genes to function and possible therapies by Kristian Helin and Gordon Peters LETTER Visualizing the competitive recognition of TATA-boxes in vertebrate promoters by Stéphane Audic and Jean-Michel Claverie MONITOR ¢ Double advance on the Y front ¢ Smoothened boundaries ¢ Transcriptional silencers e Brassinosteroid receptor ¢ WNT signalling in development REVIEWS Molecular genetics of life span in C. elegans: how much does it teach us? by Siegfried Hekimi, Bernard Lakowski, Thomas M. Barnes and JonathanJ . Ewbank Neurexins: three genes and 1001 products by Markus Missler and Thomas C. Stidhof To be, or not to be, a flower — control of floral meristem identity by Hong Ma JNK signaling and morphogenesis in Drosophila by Stéphane Noselli GENETWORK Linking up with Entrez by Jo McEntyre | TECHNICAL Technical Tips Online mS TIPS ONLINE BOOKS Reference Manager version 8.01 (Bilany Consultants Ltd) by Graham Taylor FEBRUARY COMMENT Gene conversion in mitotically dividing cells: a view from Drosophila by Gregory B. Gloor and Dirk-Henner Lankenau Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins by Toby J. Gibson and Jtirg Spring Reply to Toby Gibson and Jiirg Spring by Jonathan Cooke MEETING REPORTS Genetics in profile by Robert L. Strausberg ‘Small genomics’ on a large scale by Mark Borodovsky MONITOR e Was Fxy eaten or decapitated? ¢ Epigenetic reprogramming ¢ Boolean yeast? e Autoimmunity: walking on AIRE PERSPECTIVE The evolution of ‘bricolage’ by Denis Duboule and Adam S. Wilkins REVIEWS The DNA revolution in population genetics by Luca L. Cavalli-Sforza The cyclin family of budding yeast: abundant use of a good idea by Brenda Andrews and Vivien Measday Controlling your losses: conditional gene silencing in mammals by Andy Porter CGENETWORK How to get the best of dbEST by Sandro Banfi, Alessandro Guffanti and Giuseppe Borsani 80 TECHNICAL Technical Tips Online gS TIPS ONLINE 8] It's a Knockout! by Anna V. Anagnostopoulos and Robert B. Scharpf 82 Books received . 83 MARCH COMMENT A gene that resuscitates a theory — somitogenesis and a molecular oscillator by Jonathan Cooke MEETING REPORTS It’s a dog’s life by Wasyl Malyj Happy Birthday Ponte by Mario Terzi MONITOR e Itinerant plant mRNAs ¢ HAPPY mapping ¢ Antiangiogenic cancer treatment ¢ Changing views about rates of change 90 REVIEWS Ataxia, arrhythmia and ion-channel gene defects by Jobannah L. Doyle‘and Lisa Stubbs The fundamental importance of human galactose metabolism: lessons from genetics and biochemistry by Klaus G. Petry and Juergen K.V. Reichardt Genetic blindness: current concepts in the pathogenesis of human outer retinal dystrophies by Kevin Gregory-Evans and Shomi S. Bhattacharya Retroelements in the human MHC class II region by Géran Andersson, Ann-Cathrin Svensson, Niclas Setterblad and Lars Rask Cholesterol metabolism and embryogenesis by Robert V. Farese, Jr and Joachim Herz CGENETWORK ICCBnet: a bioinformatics initiative for developing regions by Marvin Edelman © AL Technical Tips Online TIPS ONLINE BOOKS Primer of Genetic Analysis (2nd edn) A Problems Approach (James N. Thompson, Jr, Jenna J. Hellack, Gerald Braver and David S. Durica) by Don MacDonald Cats are not Peas: a Calico History of Genetics (Laura Gould) by Steve Jones A Consumer’s Guide to DNA Testing for Genetic Disorders (Doris Teichler Zallen) by Angus Clarke Six Experimental Organisms: A Multimedia Survey (Harvey F. Lodish, ed.) by Mark Blaxter Books received APRIL COMMENT Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs by Mary C. Mullins 127 Groucho: making its Marx as a transcriptional co-repressor by Susan M. Parkhurst 130 Introns-early: slipping lately? by Clive N.A. Trotman 132 MEETING REPORTS Structural genomics taking shape by Terry Gaasterland 135 Gene therapy — the gutless approach pays off by Nigel Whittle 136 MONITOR e More is less ¢ Numbing down ¢ Organizing the organizer? e Cell death and blindness in flies 137 REVIEWS Cancer resistance genes in mice: models for the study of tumour modifiers by Allan Balmain and Hiroki Nagase 139 Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV by Patrick S. Moore and Yuan Chang 144 The riddle of MAP kinase signaling specificity by Hiten D. Madhani and Gerald R. Fink 151 LIM domains: multiple roles as adapters and functional modifiers in protein interactions by Igor B. Dawid, JosephJ .B reen and Reiko Toyama 156 GENETWORK Exploring protein homology with the Blocks server by Shmuel Pietrokovski, Jorja G. Henikoff and Steven Henikoff 162 TECHNICAL Technical Tips Online ais TIPS ONLINE 164 BOOKS In situ PCR Techniques (Omar Bagasra and John Hansen) by Trevor Jowett 105 An Electronic Companion to Beginning Microbiology (J.L. Ingraham, M. Schaechter and F.C. Neidhardt) and An Electronic Companion to Microbiology for Majors (M.L. Wheelis) by Minoru Kanebhisa 165 Molecular Genetics of Early Human Development (T. Strachan, S. Lindsay and D.I. Wilson, eds) by Sue Malcolm 106 Encyclopedia of Molecular Biology and Molecular Medicine (Vols 1-6) (Robert A. Meyers, ed.) by BernardJ . Morley and TraceyJ . Mitchell 167 Erratum 167 M Ay COMMENT Unexpected requirements for neural induction in the avian embryo by Michael Kessel and Edgar Pera 169 A new mechanism broadening the role of prion proteins in neurodegeneration by Deirdre Doyle and Mark Rogers 171 MEETING REPORTS Revolutionary stirrings in Spain by John F.Y. Brookfield 174 News we can use from bacterial chromosomes by Susan M. Rosenberg 175 MONITOR e C. elegans EPH receptor ¢ Odd SOX ¢ Unravelling Knotted gene function ¢ Hair today... 176 REVIEWS Conjunction dysfunction: CBP/p300 in human disease by Rachel H. Giles, Dorien J.M. Peters and Martijn H. Breuning Linear mitochondrial genomes: 30 years down the line by Jozef Nosek, L’'Ubomir Tomdska, Hiroshi Fukuhara, Yoshitaka Suyama and Ladislav Kovac Putting the brake on drive: meiotic drive of t haplotypes in natural populations of mice by Kristin G. Ardlie Imprinting in Prader-Willi and Angelman syndromes by Robert D. Nicholls, Shinji Saitoh and Bernhard Horsthemke PERSPECTIVE Something from nothing: the evolution and utility of satellite repeats by Amy K. Csink and Steven Henikoff 200 GENETWORK Unified access to mutation databases by Heikki Lahvdslaiho, Michael Ashburner and Thure Etzold It’s a Knockout! . x TECHNICAL Technical Tips Online WS TIPS ONLINE BOOKS Concepts in Gene Therapy (Michael Strauss and John A. Barranger, eds) by Nick Lemoine 208 The Atlas of the Chick Development (Ruth Bellairs and Mark Osmon) by Kate Storey 209 JUNE COMMENT Evolution and homology of the nervous system: cross-phylum rescues of otd/Otx genes by Anna C. Sharman and Michael Brand 211 Update: CBP/p300 transgenic mice by Rachel H. Giles 214 Wasted by an elongation factor by Majid Hafezparast and Elizabeth Fisher 215 MEETING REPORTS Studies of populations and genetic diseases: mixing it up by Anna Di Rienzo 218 Variations on the theme of genomics by Tod M. Woolf and Margaret Taylor 219 LETTER LCMV cDNA formation: which reverse transcriptase is responsible? by Abram Gabriel and Shu-Chun Teng 220 MONITOR e Argonaute catapults new gene family to prominence ¢ New introns ¢ Cancer checkpoint 221 REVIEWS The retinoblastoma gene family: cousins with overlapping interests by George Mulligan and Tyler Jacks 223 Limbs are moving: where are they going? by John W.R. Schwabe, Concepcion Rodriguez-Esteban and Juan Carlos Izpisua Belmonte 229 Combinatorial control in ubiquitin-dependent proteolysis: don’t Skp the F-box hypothesis by E. Elizabeth Patton, Andrew R. Willems and Mike Tyers 236 PERSPECTIVE ; A simple mechanism for the avoidance of entanglement during chromosome replication by John E. Hearst, Louis Kauffman and W. Martin McClain 244 GENETWORK New public database of expressed human genome by Janine Sieja Hagerman 247 Protein annotation: detective work for function prediction by Tobias Doerks, Amos Bairoch and Peer Bork 248 | TECHNICAL ‘Technical Tips Online BS TIPS ONLINE 250 BOOKS Intelligence, Genes and Success: Scientists Respond to The Bell Curve (B. Devlin, S.E. Fienberg, D.P. Resnick and K. Roeder, eds) by Nicholas J. Mackintosh 251 JULY COMMENT Frog genetics: Xenopus tropicalis jumps into the future by Enrique Amaya, Martin F. Offield and Robert M. Grainger 253 Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression by Mary K. Montgomery and Andrew Fire 255 MEETING REPORTS Politicogenomics takes centre stage by Mark Patterson 259 Giving genomics a heart by Edward M. Rubin and Steve Mockrin 260 Lily or Billy — Y the difference? by Deborah Charlesworth and Philip M. Gilmartin 261 LETTER Transposons, DNA methylation and gene control by Rob A. Martienssen 263 MONITOR e It’s a mitochondrial knockout ¢ Engineering resistance to cold — is it a snap? ¢ SMAD2 205 PERSPECTIVE The future of genetic epidemiology by Nicholas J. Schork, Lon R. Cardon and Xiping Xu 206 REVIEWS Laser-capture microdissection: opening the microscopic frontier to molecular analysis by Nicole L. Simone, Robert F. Bonner, John W. Gillespie, Michael R. Emmert-Buck and Lance A. Liotta Anterior patterning in mouse by Rosa S.P. Beddington and ElizabethJ .R obertson How many homeobox genes does it take to make a pituitary gland? by Dawn E. Watkins-Chow and SallyA .C amper GENETWORK - HSS ICAL Technical Tips Online TIPS ONLINE Functional genomics — bioinformatics is ready for the challenge by Temple F. Smith BOOKS Cells: A Laboratory Manual (D.L. Spector, R.D. Goldman and L.A. Leinwand, eds) by Caroline M. Alexander i)\ O hr AUGUST COMMENT Ribozymes to the rescue: repairing genetically defective mRNAs by John_ J. Rossi 295 Propagating epigenetic states through meiosis: where Mendel’s gene is more than a DNA moiety by Amar J.S. Klar 299 MEETING REPORT Pathways to enlightenment by Rachel Wood 302 LETTERS Population genetics and human origins — haplotypes are key! by Jody Hey 304 Reply by Luca Cavalli-Sforza 305 MONITOR e Engulfing death ¢ Mitochondrial recombination: naturally ¢ Waspish sexuality e Chimeric eukaryotes 305 PERSPECTIVES You are what you eat: a gene transfer ratchet could account for bacterial genes in eukaryotic nuclear genomes by W. Ford Doolittle 307 Splitting the ATM: distinct repair and checkpoint defects in ataxia—telangiectasia by Penny A. Jeggo, Antony M. Carr and Alan R. Lehmann 312 REVIEWS A locus control region regulates yeast recombination by James E. Haber Understanding cell migration guidance: lessons from sex myoblast migratidn in C. elegans by Estella B. Chen and MichaelJ . Stern Of genes and genomes and the origin of maize by Shawn White and John Doebley GENETWORK Using metabolic pathway databases for functional annotation by Michael Y. Galperin and Steven E. Brenner It’s a Knockout! by Anna V. Anagnostopoulos , ; : N TECHNICAL Technical Tips Online Lis TIPS ONLINE BOOKS! Genetics of Common Diseases: Future Therapeutic and Diagnostic Possibilities (lan N.M. Day and Steven E. Humphries, eds) by Leigh Field SEPTEMBER COMMENT Who pulls the string to pattern cell division in Drosophila? by Helen Skaer The Drosophila genome project: a progress report by Gerald M. Rubin Survival with HIV infection: good luck or good breeding? by Sarah L. Rowland-Jones MEETING REPORTS Stem-cell gene therapy: problems and solutions by David M. Bodine 340 The most complex trait of all by Thalia Eley and Robert Plomin 347 LETTER Innexins: a family of invertebrate gap-junction proteins by Pauline Phelan, Jonathan P. Bacon, Jane A. Davies, Lucy A. Stebbings, Martin G. Todman, Leon Avery, Richard A. Baines, Thomas M. Barnes, Chris Ford, Siegfried Hekimi, Raymond Lee, Jocelyn E. Shaw, Todd A. Starich, Kathryn D. Curtin, Yi-an Sun and Robert J.W yman 348 MONITOR e Organizer reveals embryonic CNS patterning ¢ Ku — that’s an interesting protein ¢ Comb quietly ¢ I hear you Noggin 350 REVIEWS Changing styles in C. elegans genetics by Jonathan Hodgkin and C. elegans l 4 Robert K. Herman review series Chimeras and mosaics in mouse mutant analysis by Janet Rossant and Andrew Spence PERSPECTIVES Traps to catch unwary oncogenes by Anne-Odile Hueber and Gerard I. Evan 304 Selfishness and death: raison d’étre of restriction, recombination and mitochondria by Ichizo Kobayashi 368 GENETWORK SY TECHNICAL Technical Tips Online aS TIPS ONLINE 374 Detection of potential target genes in silico? by Giovanni Lavorgna, Edoardo Boncinelli, Andreas Wagner and Thomas Werner 372 BOOKS Genetics Society and Clinical Practice (Peter S. Harper and Angus J. Clarke) by Sara L. Tobin 377 Tissue in situ Hybridization: Methods in Animal Development (Trevor Jowett) by Chris Healy and Paul Sharpe 377 Chromosomal Variation in Man: A Catalog of Chromosomal Variants and Anomalies (8th edn) (D.S. Borgaonkar) by John C.K. Barber 378 OCTOBER COMMENT Do EST patents matter? by Rebecca S. Eisenberg 379 Coordination of human genome sequencing via a consensus framework map by David R. Bentley, Kim D. Pruitt, Panigiotis Deloukas, Greg D. Schuler and Jim Ostell 381 MEETING REPORT Developmental biology gets high by Olivier Pourquié and Patrick Lemaire 384 LETTERS Late-replicating satellites: something for all centromeres? by Ingo Schubert 385 Reply by Steven Henikoff and Amy K. Csink 386 Does a common mitochondrial DNA polymorphism underlie susceptibility to diabetes and the thrifty genotype? by Joanna Poulton 387 MONITOR e Methylating silence ¢ Sox — food for thought ¢ Snuff movies in Drosophila 390 REVIEWS Use of isolated inbred human populations for identification of disease genes by Val C. Sheffield, Edwin M. Stone and Rivka Carmi 391 Protein precipitation: a common etiology in neurodegenerative disorders? by Akira Kakizuka 396 Putting the genome on the map by Joanna M. Bridger and WendyA . Bickmore 403 Genetics of programmed cell death in C. elegans: past, present and future © depen lL: by Mark M. Metzstein, Gillian M. Stanfield and H. Robert Horvitz review series v 410 Genomic disorders: structural features of the genome can lead to DNA sail rearrangements and human disease traits by James R. Lupski 417 The VHL tumour-suppressor gene paradigm by William G. Kaelin, Jr and Eamonn R. Maher 423 GENETICS & SOCIETY Genetics and human reproduction by Anne McLaren BOOKS Principles of Development (Lewis Wolpert, Rosa Beddington, Jeremy Brockes, Thomas Jessel, Peter Lawrence and Elliot Meyerowitz, eds) by Richard Harland Genetics Manual. Current Theory, Concepts, Terms (George P. Rédei) by Gabby Dover DNA Damage and Repair: Vol. I, DNA Repair in Prokaryotes and Lower Eukaryotes; and Vol. Il, DNA Repair in Higher Eukaryotes (Jac. A. Nickoloff and Merl F. Hoekstra, eds) by Richard D. Wood Guide to Human Genome Computing (2nd edn) (MJ. Bishop, eds) by Fran Lewitter Authors’ correction INOVEMBER COMMENT Monoallelic expression: ‘there can be only one’ by Rolf Ohlsson, Benjamin Tycko and Carmen Sapienza Mouse alleles: if you’ve seen one, you haven't seen them all by Allan Peter Davis and Monica J. Justice 438 MEETING REPORT Chromosomes in the Rocky Mountains by Robert A. Sclafani 44] LETTER Evidence for massive gene exchange between archaeal and bacterial hyperthermophiles by L. Aravind, Roman L. Tatusov, Yuri I. Wolf, D. Roland Walker and Eugene V. Koonin 442 MONITOR ¢ Boating for beginners ¢ phabulosa and leafbladeless — new roles for the adaxial domain REVIEWS Sex biases in the mutation rate by Laurence D. Hurst and Hans Ellegren Frizzled signaling and the developmental control of cell polarity by Joshua M. Shulman, Norbert Perrimon and Jeffrey D. Axelrod Molecular mechanisms of vertebrate left-right development by Ann F. Ramsdell and H. Joseph Yost | Genetics of RAS signaling in C. elegans by Paul W. Sternberg and Min Han C. elegans , l ‘ review series Yn CGENETWORK A brief guide to phylogenetic software by DouglasJ . Eernisse BOOKS Retroviruses (J.M. Coffin, S.-H. Hughes and H.E. Varmus, eds) by John A.T. Young DECEMBER COMMENT Immunological analysis of chromatin: FIS and CHIPS by Colyn Crane-Robinson and Alan P. Wolffe LIM protein interactions: Drosophila enters the stage by Igor B. Dawid MEETING REPORTS We are devo-evo by Axel Meyer Turning over the pieces of the post-genomic jigsaw puzzle by Stephen Anderson LETTER Genomics, Chi sites and codons: ‘islands of preferred DNA pairing’ are oceans of ORFs by Trent Colbert, Andrew F. Taylor and Gerald R. Smith MONITOR e The organelle of death ¢ Bubbles, loops and globins ¢ Prion nonsense e bicoid outside the Dipterans? 488 REVIEWS 490 A tale of dwarfs and drugs: brassinosteroids to the rescue by Thomas Altmann 495 Counting on comparative maps by Joseph H. Nadeau and David Sankoff Fragile sites still breaking by Grant R. Sutherland, Elizabeth Baker and Robert I. Richards 501 C. elegans neuroscience: genetics to genome by Martin Chalfie and em, C. elegans l . Erik M. Jorgensen review series 506 ~~ PERSPECTIVE Ageing and mammalian mitochondrial genetics by Phillip Nagley and Yau-Huei Wei 513 GENET WORK SRY TECHNICAL Technical Tips Online aS TIPS ONLINE In Situ Blast: a WWW resource for tissue-specific EST database searches by Alessandro Guffanti and Guiseppe Borsani The MITOP database — a one-stop shop for mitochondrial information by Curt Scharfe HGBASE: a database of human gene polymorphism by Anthony J. Brookes and Chandra M. Sarkar RHScoresFormat: a tool for formatting radiation hybrid data by Patricia Rodriguez-Tomé, Rune Madsen, Hege Andersen and Carsten Helgesen BOOKS ICRF Handbook of Genome Analysis (two volumes) (by N.K. Spurr, B.D. Young and S.P. Bryant) by Duncan Shaw Books received Erratum AUTHOR INDEX SUBJECT INDEX 527 INDEX OF BOOKS REVIEWED