Trends and advances in veterinary genetics

235 Pages·2019·38.116 MB·English

by  Cheryl Natividad

TRENDS AND ADVANCES IN
VETERINARY GENETICS

TRENDS AND ADVANCES IN
VETERINARY GENETICS
Cheryl Natividad
www.delvepublishing.com
Trends and Advances in Veterinary Genetics
Cheryl Natividad
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e-book Edition 2019
ISBN: 978-1-77361-849-4 (e-book)
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ABOUT THE AUTHOR
Cheryl Agdaca-Natividad graduated with a BS Biology degree (magna cum laude)
at the Saint Louis University, Baguio City in the Philippines. She took the licensure
examination for secondary teachers in 2003 where she ranked number 10 among the
examinees. She earned her master’s degree in Genetics at the premier state university,
University of the Philippines Los Baños. She taught in the same university from 2006 to
2017, handling lecture and laboratory classes in general biology, cell biology, genetics,
and molecular genetics. Apart from teaching, her work involved proposing and revising
laboratory manuals and mentoring students in their research work.

TABLE OF CONTENTS
List of Figures ........................................................................................................ix
List of Tables .......................................................................................................xxi
Preface........................................................................ .....................................xxiii
Chapter 1 Introduction ..............................................................................................1
Chapter 2 Review of Genetics and Its
Significance to Veterinary Medicine .........................................................5
2.1 Deoxyribonucleic Acid (DNA): The Genetic Material ...........................6
2.2 Central Dogma of Molecular Biology .................................................10
2.3 Mutations in the Genetic Message .....................................................14
2.4 Chromosomes as Genetic Elements ...................................................15
2.5 Cell Division and its Genetic Implications .........................................17
2.6 Significance of Genetics in Veterinary Medicine ................................21
Reference ................................................................................................23
Chapter 3 Genetics and Disease ..............................................................................25
3.1 The Genetic Basis of Disease In Animals ............................................26
3.2 Genetic Tools to Diagnose Genetic Disorders ....................................40
3.3 Genetic Tools to Treat Genetic Disorders ............................................52
References ...............................................................................................64
Chapter 4 Genetics and Immunity ...........................................................................69
4.1 Major Defense Barriers ......................................................................71
4.2 Understanding the Immunogenetics of Leprosy Using
Animal Models ...............................................................................95
4.3 Animal Models for HIV Infection or AIDS ........................................102
References .............................................................................................110
Chapter 5 Sequencing The Genome of Domestic Animals .....................................115
5.1 Sequencing Technologies .................................................................116
5.2 Analyzing Genomic Data.................................................................124
5.3 Significance of Sequencing Domestic Animal Genomes ..................127
5.4 Sequencing the Genome of Domestic Animals ................................129
References .............................................................................................146
Chapter 6 Veterinary Pharmacogenetics and Pharmacogenomics .........................147
6.1 Significance of Pharmacogenomics ..................................................148
6.2 Data Generation and Analysis in Pharmacogenomics ......................150
6.3 Animal Models of Pharmacogenomics .............................................157
6.4 Limitations of Animal Models ..........................................................165
References .............................................................................................167
Chapter 7 Veterinary Nutrigenomics .....................................................................169
7.1 Diet and Gene Expression ................................................................170
References .............................................................................................178
Chapter 8 Veterinary Epigenetics ...........................................................................179
8.1 Epigenetic Mechanisms ...................................................................180
8.2 Animal Models in Epigenetics ..........................................................189
8.3 Epigenetics in Cloned Animals .........................................................191
8.4 Epigenome and The Environment .....................................................194
8.5 Epigenetics and Animal Behavior .....................................................197
8.6 Epigenetics and Immunity ................................................................200
8.7 Epigenetics and Cancer ....................................................................200
References .............................................................................................203
Index .....................................................................................................205
viii