Treatment of Acute Hepatitis C - PHC

288 Pages·2006·1.58 MB·English

Management of
Patients with Viral
Hepatitis
This book contains the manuscripts of the presentations from the
2nd International Conference on the Management of Patients with Viral
Hepatitis, January 2007, Paris, France.

Printed in January 2007
by the Nouvelle Imprimerie Laballery, 58500 Clamecy
Print number : 611205, copyright : January 2007, printed in France

Articles in this book can be cited as: In: Marcellin P, editor. Management of
Patients with Viral Hepatitis. Paris: APHC; 2007.

This book is supported by an unrestricted educational grant from
F. Hoffmann-La Roche Ltd.

© 2007 APHC, Paris, France
Management of
Patients with Viral
Hepatitis
Editor

Patrick Marcellin
Service d’Hépatologie
Hôpital Beaujon
University of Paris VII
France

CONTRIBUTING AUTHORS
Alfredo Alberti
Department of Clinical and Experimental Medicine and Venetian
Institute of Molecular Medicine, University of Padova, Padova, Italy
Bruce Bacon
Division of Hepatology, St Louis University School of Medicine,
St Louis, Missouri, USA
Jason Bratcher
Lenox Hill Hospital, New York, USA
Michel Beaugrand
Service d’Hépatologie, Hôpital Jean Verdier, Bondy, France
Yves Benhamou
Service d’Hépato-Gastroentérologie, Hôpital Pitié-Salpétrière, Paris,
France
Maria Buti
Liver Unit, Hospital General Universitario Valle Hebron, Barcelona,
Spain
Stéphane Chevaliez
French National Reference Center for Viral Hepatitis B, C and delta,
Department of Virology & INSERM U635, Henri Mondor Hospital,
University of Paris XII, Créteil, France
Gary L. Davis
Division of Hepatology, Baylor University Medical Center, Dallas,
Texas, USA
Yves Deugnier
Clinique des Maladies du Foie, Hôpital Pontchaillou, University of
Rennes, Rennes, France
Douglas Dieterich
Department of Medicine, Mount Sinai Medical Center, New York,
USA
Geoffrey Dusheiko
Centre for Hepatology, Royal Free and University College School of
Medicine, London, UK

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Management of Patients with Viral Hepatitis, Paris, 2007
Rafael Esteban
Liver Unit, Hospital General Universitario Valle Hebron, Barcelona,
Spain
Patrizia Farci
Department of Medical Sciences, University of Cagliari, Cagliari,
Italy
Giovanna Fattovich
Department of Gastroenterology, University of Verona, Verona, Italy
Dominique Guyader
Service des Maladies du Foie, Inserm U 522 and CIC Inserm 0203
Hôpital Pontchaillou, 35033 Rennes, France
Chee-Kin Hui
Department of Medicine, Queen Mary Hospital, The University of
Hong Kong, Hong Kong SAR, China
Stephanos J. Hadziyannis
Department of Medicine and Hepatology, Henry Dunant Hospital and
Hepatitis Research Laboratory of Athens University, Evgenidion
Hospital, Athens, Greece
Jenny Heathcote
Toronto Western Hospital, University Health Network, University of
Toronto, Toronto, Canada
George L. K. Lau
Division of Hepatology, Queen Mary Hospital, University of Hong
Kong, Pokfulam, Hong Kong, China
Anna S.F. Lok
Division of Gastroenterology, University of Michigan Medical Center,
Ann Arbor, Michigan, USA
Patrick Marcellin
Service d’Hépatologie and Inserm U 773, Hôpital Beaujon, University
of Paris VII, Clichy, France
Francesco Negro
Division of Gastroenterology, University Hospital, Geneva,
Switzerland
Nicola Olivari
Department of Surgical and Gastroenterological Science, Section of
Gastroenterology, University of Verona, Italy
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Contributing Authors
Michela Pasino
Department of Surgical and Gastroenterological Science, Section of
Gastroenterology, University of Verona, Italy
Jean-Michel Pawlotsky
Department of Virology and INSERM U635, Henri Mondor Hospital,
University of Paris XII, Créteil, France
Robert P. Perrillo
Division of Hepatology, Baylor University Medical Center, Dallas,
Texas, USA
Bruno Roche
Centre Hépatobiliaire, Hôpital Paul Brousse, 14 Avenue Paul Vaillant
Couturier, 94800 Villejuif, France
Patrick Saitta
The Mount Sinai Medical Center, New York, USA
Didier Samuel
Centre Hépatobiliaire, Hôpital Paul Brousse, Medical School of
University of Paris XI, Villejuif, France
Christoph Sarrazin
Saarland University Hospital, Department of Internal Medicine II,
Homburg, Germany
Silvia Zanni
Department of Surgical and Gastroenterological Science, Section of
Gastroenterology, University of Verona, Italy
Stefan Zeuzem
Department of Internal Medicine II, Saarland University Hospital,
Homburg, Germany
Fabien Zoulim
Service d’Hépato-Gastroentérologie and INSERM U271, Hôpital
Hôtel Dieu, University of Lyon, Lyon, France

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CONTENTS
Hepatitis C and Hepatitis B in 2007............................................................7
P. Marcellin
How to Use Virological Tools for the Optimal Management of
Chronic Hepatitis C....................................................................................25
S. Chevaliez, J-M. Pawlotsky
How to Predict the Outcome of Chronic Hepatitis C...............................37
A. Alberti
Fibroscan® in Patients with Chronic Viral Hepatitis...............................43
M. Beaugrand
What is the Optimal Treatment for Naïve Patients with
Chronic Hepatitis C?..................................................................................49
S. Zeuzem, C. Sarrazin
Clinical Case: Chronic Hepatitis C – Non-Responder to Pegylated
Interferon and Ribavirin............................................................................65
J. Heathcote
How to Manage Patients with HIV/HCV Co-Infection............................73
J. Bratcher, P. Saitta, D. Dieterich
Pre- and Post-Treatment of Liver Transplant Patients
with Hepatitis C..........................................................................................95
D. Samuel, B. Roche
Steatosis and HCV: Dangerous Liaisons?...............................................111
F. Negro
Alcohol in Chronic Hepatitis C: Legal or Prohibited?..........................119
G. L. Davis
Iron and HCV: The Middle Age?............................................................131
Y. Deugnier, D. Guyader
Clinical Case: Management of Patients with Chronic Hepatitis C......143
B. Bacon
How to Use Virological Tools for the Optimal Management of Chronic
Hepatitis B.................................................................................................149
F. Zoulim
How to Predict the Outcome of Chronic Hepatitis B.............................163
G. Fattovich, N. Olivari, M. Pasino, S. Zanni
New Drugs for Chronic Hepatitis B.........................................................179
M. Buti, R. Esteban

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Management of Patients with Viral Hepatitis, Paris, 2007
Treatment of HBeAg-Positive Chronic Hepatitis B with Interferon or
Nucleos(t)ide Analogs...............................................................................189
G. Dusheiko
Why Treat Patients with HBeAg-Positive Chronic Hepatitis B with
Pegylated Interferon?...............................................................................221
C-K. Hui, G. K. Lau
Why Treat Patients with HBeAg-Negative Chronic Hepatitis B with
Nucleos(t)ide Analogs?.............................................................................233
S. J. Hadziyannis
Why Treat Patients with HBeAg-Negative Chronic Hepatitis B with
Pegylated Interferon?...............................................................................245
R. P. Perrillo
Management of HBV/HIV Co-Infection.................................................255
Y. Benhamou
Treatment of Patients with Chronic Hepatitis Delta..............................263
P. Farci
Clinical Case: Management of Antiviral-Resistant Hepatitis B...........273
A. S. F. Lok

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