Transplant International Official Journal of the European Society for Organ Transplantation: Proceedings of the 5th Congress of the European Society for Organ Transplantation, Maastricht, October 7–10, 1991

733 Pages·1992·29.58 MB·English

by  E. David-Neto

TRANSPLANT
International
Supplement 1 to Volume 5, 1992
Proceedings of the
5th Congress of the European Society
for Organ Transplantation
Maastricht, October 7-10, 1991
Editor-in-Chief: Gauke Kootstra
Guest Editors: G. Opelz, W. A. Buurman,
J.P. van Hooff, P. MacMaster, J. Wallwork
Springer-Verlag Berlin Heidelberg GmbH
TRANSPLANT
International
Official Journal of the European Society for Organ Transplantation
Editor-in-Chief Editorial Board
G. Kootstra H. Brynger, Goteborg
Department of Surgery, University Hospital, P. 0. Box 5800, W. A. Buurman, Maastricht
6202 AZ Maastricht, The Netherlands P. Hayry, Helsinki
R. A. P. Koene, Nijmegen
W. Land, Munich
Guest Editors P. McMaster, Birmingham
M.J.Mihatsch, Basel
Professor Dr. Gerhard Opelz G. Opelz, Heidelberg
Institute of Immunology, University of Heidelberg, B. Ringe, Hannover
lm Neuenheimer Feld 305, R. van Schilfgaarde, Groningen
W-6900 Heidelberg, FRG G. Sirchia, Milan
J.P. Soulillou, Nantes
Dr. W. A. Buurman
J.P. Squifflet, Brussels
Department of Surgery, University of Limburg,
J. Wallwork, Cambridge
(B. M. C.) Beeldsnijderdreef 101,
NL-6216 EA Maastricht
Professor Dr. J.P. van Hooff International Advisory Board
Department of Nephrology, University Hospital Maastricht,
P. Debyelaan 25, R. Y. Caine, Cambridge
NL - 6202 AZ Maastricht J. M. Dubernard, Lyon
J. Fabre, East Grinstead, Sussex
Mr. P. MacMaster
L. Fernandez-Cruz, Barcelona
The Liver Unit, Queen Elizabeth Hospital, Edgbaston,
A. Flatmark, Oslo
UK-Birmingham B152TH
F. Frey, Bern
Dr. J. Wallwork D. Fries, Paris
Papworth Hospital, Papworth Everard, C. G. Groth, Stockholm
UK-Cambridgeshire CB3 SRE R. Margreiter, lnnsbruck
C. Mawas, Marseille
P. Michielsen, Leuven
E. Moiler, Stockholm
P. Morris, Oxford
J. A. Myburgh, Johannesburg
W. L. Olszewski, Warsaw
K. Ota, Tokyo
R. H. Rubin, Boston, Mass.
A. G. R. Sheil, Sydney
S. Slavin, Jerusalem
H. W. Sollinger, Madison, Wis.
T. E. Starzl, Pittsburgh, Pa.
C. R. Stiller, London, Ont.
F. Valderrabano, Madrid
Assistant to the Editor
Pamela Falger
Preface
This supplement to Transplant International contains the Proceedings of the
successful 5th Congress of the European Society for Organ Transplantation
held in Maastricht from 7-10 October 1991.
Of 827 abstracts submitted to the congress, 548 were selected by the Scien
tific Committee for either oral or poster presentation. Of these 548 presenta
tions, the guest editors selected 212 full papers for publication in this book.
Two aspects are important where proceedings are concerned-the quality of
the papers and the speed of publication. I thank our authors and guest editors,
whose combined expertise has given us a guarantee of quality. I also thank our
editorial and production teams for their tremendous efforts to hasten editing,
proofreading, printing, and publication. In particular, I would like to express my
gratitude to Maurits Booster, M.D., and Sylvia van Roosmalen for their assist
ance and support in seeing this supplement through to completion.
As a concession to time, we have waived some of our stringent rules of style
and limited our correspondence with authors by, for example, page proofs being
reviewed and corrected in house only. This enables us to publish two months
earlier but has the disadvantage that, given the allotted time, we have not been
able to ensure that each and every article has an abstract, nor that every "i" has
been dotted in the reference lists or in the addresses/institute affiliations of all
the authors.
Although contributions to the congress came from every corner ofthe globe,
the core of publications is of European origin, so that this book provides the rea
derwith an update of the state of transplantation in Europe.
May the reader enjoy this book as much as I enjoyed the final editing of it.
Gauke Kootstra, M.D., Ph. D. Maastricht,
Editor-in-chief, Transplant International January 1992
ISBN 978-3-540-55342-7 ISBN 978-3-642-77423-2 (eBook)
DOI 10.1007/978-3-642-77423-2
Published also as Supplement 1 to Volume 5, 1992 ISSN 0934-087 4
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©Springer-Verlag Berlin Heidelberg 1992
Originally published by Springer-Verlag Berlin Heidelberg in 1992
The use of registered names, trademarks, etc. in this publication does not imply, even in the
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TRANSPLANT
International
Official Journal of the European Society for Organ Transplantation
Kidney
E. David-Neto, W. Nahas, E. C. Sampaio, L. E.lanhez, E. Sabbaga,
and S. A rap C8A/A ZA, in the absence of prednisone, improves
linear growth in renal transplanted children 83
H.lsoniemi, E. v. Willebrand, J. Ahonen, B. Eklund,
K. Hockerstedt, L. Krogerus, L. Kyllonen, K. Salmela,
and P. Hayry Late histopathological findings in renal allografts
with four immunosuppressive regimens 86
A. Nanni-Costa, S.lannelli, A. Vangelista, A. Buscaroli,
G. Liviano, C. Raimondi, P. Todeschini, G. Lamanna, S. Stefani,
and V. Bonomini Flow cytometry evaluation of urinary sediment
in renal transplantation 88
M. Kyo, F. Gudat, P. Dalquen, B. Huser, G. Thiel, N. Fujimoto,
Y.lchikawa, T. Fukunishi, S. Nagano, and M. J. Mihatsch
Early diagnosis of kidney transplant rejection and cyclosporin
nephrotoxicity by urine cytology 813
J. W. S. Merkus, L. B. Hi I brands, A. J. Hoitsma, W. N.J. C. van
Asten, R. A. P. Koene, and S. H. Skotnicki Haemodynamic
changes in human kidney allografts following administration of
nifedipine: assessment with doppler spectrum analysis 817
F. Quarto Di Palo, D. Castagnone, R. Rivolta, F. Ceccherelli,
A. Elli, M. Parenti, P. Palazzi, and C. Zanussi Cyclosporine renal
cortical vasoconstriction measured by colour doppler imaging in
kidney transplantation 821
C. Chakalarovski, Ph. Lang, Cl. Buisson, B. Bourgeon, L.lntrator,
L. Deforge, A. Benmaadi, G. Fruchaud, G. Rostoker, Ph. Remy,
D. Belghiti, and B. Wei I Monoclonal immunoglobulins in patients
with renal transplants: characterization, evolution and risk factors 823
C. Pouteii-Noble, R. Ecochard, S. Bosshard, B. Lacavalerie,
A. Donia, G. Landrivon, J. C. Tardy, J. M. Dubernard, M. Aymard,
and J. L. Touraine Cytomegalovirus (CMV) excretion as a factor in
the severity of CMV disease in kidney and simultaneous kidney and
pancreas transplantation 826
E. Rondeau, B. Bourgeon, M. N. Peraldi, Ph. Lang, C. Buisson,
K. M. Schulte, B. Weill, and J.D. Sraer Prophylaxis of CMV
disease by ganciclovir (DH PG) in seronegative recipients of renal
allograft from seropositive donors 830
L. Mjornstedt, J. Konar, G. Nyberg, M. Olausson, L. Sandberg,
and I. Karl berg Renal retransplantation in patients with
HLA-antibodies 832
VI
Y. Vanrenterghem, M. Waer, M. R. Christiaens,
and P. Michielsen (for the Leuven Collaborative Group for
Transplantation) Bilateral nephrectomy of the native kidneys
reduces the incidence of arterial hypertension and erythrocytosis in
kidney graft recipients treated with cyclosporin S35
P. K. Donnelly, G. Mobb, A. R. Simpson, P. S. Veitch, P.R. F. Bell
A logical basis for age matching in organ transplantation:
studies of recipient renal function in relation to donor age S38
K.Ota, K. Takahashi, T.Agishi, T.Sonda, T.Oka, S. Ueda,
H. Amemiya, T. Shiramizu, H. Okazaki, N. Akiyama, A. Hasegawa,
T. Kawamura, H. Takagi, and A. Ueno Multicentre trial of
ABO-incompatible kidney transplantation S40
C. Pouteii-Noble, J. C. Tardy, P. Chossegros, C. Trepo, M. Aymard,
and J. L. Touraine Should hepatitits-C virus antibody-positive
donors be excluded from kidney donation? S44
Th. Sautner, M. Gnant, P. Gotzinger, P. Wamser, R. Steininger, and
F. MOhlbacher Cadaveric kidney donation beyond the age of
60 years-a comparative analysis of 1180 grafts from different donor
agegroups S47
J. Boletis, Ch. Stathakis, H. Papastathi, I. Vafiadi, D. Goumenos,
B. Miriagou, A. Hatzakis, A. Kostakis, and Gr. Vosnides
Antibodies against hepatitis C virus among renal transplant patients
in Greece S51
A. Buscaroli, A. Nanni Costa, S.lannelli, G. Cianciolo,
L. DeSantis, G. La Manna, S. Stefani, A. Vangelista, and
V. Bonomini Value of panel reactive antibodies (PRA) as a guide to
the treatment of hyperimmunized patients in renal transplantation S54
A.M. Castelao, J. M. Grifio, I. Sa bate, D. Seron, E. Andres,
S. Gilvernet, J. Bover, C. Gonzalez, and J. Alsina CyclosporinA
(CsA) and azathioprine (AZA) combination in renal allografts with
CsA nephrotoxicity S58
I. Dawidson, C. Lu, B. Palmer, P. Peters, P. Rooth, R. Risser,
A. Sagalowsky, and Z. Sandor Verapamil (VP) improves the
outcome after renal transplantation (CRT) S60
D. Dickerson, B. Adams, G. Engelbrecht, G. Boltman,
R. Hickman, and D. Kahn DTPA renal scan assessment of renal
allograft dysfunction in rats S63
T. Etienne, C. Goumaz, P. Rued in, and M. Jean net Renal
retransplantation in Switzerland: poor HLA matching of first and
subsequent allografts does not appear to affect overal graft survival S65
R. M. Fagugli, A. Selvi, L. Fedeli, R. Brugnano, M. Cozzari, and
U. Buoncristiani Renal funtional reserve in kidney transplant
recipients S67
S. J. Harper, J. Moorhouse, P. S. Veitch, T. Horsburgh, J. Walls,
P.R. F. Bell, P. K. Donnelly, and J. Feehally Nifedipine improves
immediate, and 6-and 12-month graft function in cyclosporin A (CyA)
treated renal allograft recipients S69
L. B. Hi Ib rands, A. J. Hoitsma, and R. A. P. Koene Post-transplant
haemoglobin levels and host kidney status S73
J. Kaden, G. May, C. Schonemann, P. Muller, J. Groth, W. Seeger,
F. Seibt, M. Henkert, J. Lippert Effect of ATG prophylaxis in
sensitized and non-sensitized kidney graft recipients S75
VII
D. Koutsikos, B. Agroyannis, G. Tserkezis, M. Zentelis,
P. Neamonitis, I. Ladas, A. Kapetanaki, H. Tzanatos-Exarchou,
P. Founda, and A. Katsani Ocular findings in patients with
successful renal transplantation 879
R. Marcen, N. Gallego, L. Orofino, J. Sabater, J. Pascual,
J. L. Teruel, F. Liafio, and J. Ortufio Influence of cyclosporin A
(CyA) on renal handling of urate 881
D. Chevet, F. Michel, Ch. Mousson, Y. Tanter, J. M. Rebibou,
N. Casadeval, and G. Rifle Erythrocytosis in renal allograft
recipients.Benefit of staggered venous erythropoietin measurements 884
A. Moutabarrik, M.lshibashi, H. Kameoka, N. Kawaguchi,
Y. Takano, Y. Kokado, S. Onishi, T. Sonoda, S. Takahara, and
A. Okuyama In vitro FK506 kidney tubular cell toxicity 887
A. Moutabarrik, M.lshibashi, M. Fukunaga, H. Kameoka,
Y. Takano, Y. Kokado, T. Sonoda, S. Takahara, and A. Okuyama
FK506 mechanism of nephrotoxicity: stimulatory effect on endothelin
secretion by cultured kidney cells 893
K. P. Nordal, E. Dahl, J. Halse, and A. Flatmark Early kidney
transplantation may prevent aluminium-related bone disease 898
S. Ohsaki, S. Teraoka, T. Tojimbara, K. Takahasi, H. Toma,
T. Agishi, and K. Ota Effect of prostaglandin E1 on graft function of
kidneys from living related donors S 100
A. 0. Seeberger, A. Tibell, and G. Tyden Renal transplantation in
r-HuEPO-treated patients 8104
J. Pascual, R. Marcen, L. Orofino, C. Quereda, J. L. Teruel,
F. Mampaso, F. Liafio, J. J. Villafruela, and J. Ortufio
Long-term beneficial effects of azathioprine addition to ongoing
cyclosporine-prednisone protocol in renal transplantation 8107
A. R. Pontin, A. Ovnat, J. E. Jacobson, C. R. Swanepoel, D. Kahn
Protective effect of vasodilators in donors requiring pressor support 8110
B. Rosenkranz, W. Niebel, K. Albrecht, K. Wagner, T. Philipp,
and F. W. Eigler The use of OKT3 in steroid-resistant rejections
following cadaveric kidney transplantation 8112
M. Salvadori, L. Comparini, E. Bertoni, S. Bandini, G. Mancini,
F. Martinelli, P. Tosi, G. Nicita, and R. Lenzi Aging on the waiting
list: should it be a further criterion for cadaver kidney allocation? 8114
Th. Sautner, M. Gnant, C. Banhegyi, P. Wamser, P. Gotzinger,
R. Steininger, and F. Mi.ihlbacher Risk factors for development of
panel reactive antibodies and their impact on kidney transplantation
outcome 8116
P. Wienand, T. Schroder, and C. Baldamus Early or delayed
onset of cyclosporine by sequential immunosuppression? 8121
S. Stefani, A. Nanni-Costa, S.lannelli, A. Buscaroli,
L. C. Borg nino, M. P.Scolari, G. Mosconi, G. Cianciolo,
L. B. DeSanctis, and V. Bonomini Application of flow cytometry in
clinical renal transplantation 8123
V. Delaney, N. Sumrani, J. Hong, R. Davis, B. Sommer
The course of H IV disease in renal allograft recipients S 129
K. Takahashi, S. Teraoka, K. Ota, M. Kosaki, H. Okazaki and the
JISG The Japanese Interferon Study Group (JISG) has
established the efficacy of human interferon-~ for serious CMV
pneumonitis in kidney recipients 8133
VIII
J. Thorogood, J. C. van Houwelingen, J. J. van Rood,
F. A. Zantvoort, G. M. Th. Schreuder, and G. G. Persijn
Factors affecting the long-term outcome following non-living kidney
transplantation 8138
G. Tufveson, M. Bengtsson, C. Bergstrom, L. Fredin, G. Lewen,
0. Sjoberg, I. Skarp, T. Totterman, J. Wahlberg, and B. Wikstrom
Is repeated mismatching at reg rafting deleterious? 8140
P. Vereerstraeten, M. Andrien, E. Dupont, D. Abramowicz,
L. dePauw, M. Goldman, and P. Kinnaert Detrimental role of
donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney
graftsurvival 8143
D. Stippel, P. Wienand, N. WeiBenberg, C. Baldamus, and
U. Kruppenbacher CMV prophylaxis after renal transplantation
with immunoglobulin or CMV-hyperimmunoglobulin-a prospective
clinical trial 8146
J. C. West, J. E. Bisordi, E. C.Squiers, R. Latsha, J. Miller, and
S. E. Kelley Length of time on dialysis prior to renal transplantation
is a critical factor affecting patient survival after allografting 8148
P. Wienand, T. Schroder, D. Stippel, and C. Baldamus
Donor conditions and graft survival-a retrospective study 8151
T. Yasumura, T. Oka, Y. Ohmori, Y. Nakane, N. Yoshimura, I. Nakai,
T. Hamashima Clinical factors which influence the long-term
survival of kidney allografts donated from haploidentical donors 8153
H. A. Bock, M. Bachofen, J. Land mann, and G. Thiel Glomerular
hyperfiltration after unilateral nephrectomy in living kidney donors 8156
Liver
S. Friman, H. Persson, I. Karl berg, J. Svanvik The bile acid
independent flow is reduced in the transplanted liver 8163
R. Raakow, R. Steffen, M. Knoop, G. Blumhardt, P. Lemmens,
M. Wiens, H. Keck, and P. Neuhaus Quadruple
immunosuppression including a new IL-2-receptor antibody and the
incidence of infections after liver transplantation 8168
S. Agnes, A. W. Avolio, S.C. Magalini, M. Foco, and
M. Castagneto Should retransplantation still be considered for
primary non-function after liver transplantation? 8170
C. M. Bakker, H. J. Metselaar, Th. N. Groen land, 0. T. Terpstra,
and J. Stibbe Increased fibrinolysis in orthotopic but not in
heterotopic liver transplantation: the role of the an hepatic phase S 173
M. Adler, N. Bourgeois, J. van de Stadt, and M. Gel in
A Pugh score of 8 adequately selects patients with parenchymal
cirrhosis for liver transplantation 8175
L. M. Barkholt, M. von Sydow, L. Magnius, B.-G. Ericzon,
B. Veress, and J.P. Andersson Seroprevalence and outcome of
hepatitis C in liver transplantation 8179
A. Corti, A. De Gas peri, G. Oppizzi, E. Pannacciulli, A. Cristalli,
G. Fantini, E. Mazza, M. Prosperi, A. Rocchini, D. Sabbadini,
C. Savi, A. Scaiola, S. Vai, F. Romani, L. DeCarlis, G. F. Rondinara
Somatomedin C (IGF I) plasma levels after orthotopic liver
transplantation (O LT ) in end-stage cirrhotic patients S 185
S. Friman, H. Persson, T. ScherstEm, J. Svanvik,
I. Karl berg Adjuvant treatment with ursodeoxycholic acid
reduces acute rejection after liver transplantation 8187
IX
A. Totterman, M. Lalla, K. Salmela, and K. Hockerstedt
Cholestasis and kidney dysfunction in liver transplant patients
reduces cyclosporine metabolite excretion 8190
F. V. Fernandes, J. Coutinho, M.P. Henriques, B. da Silva,
A. Baptista, A. I. Santos, and F. Godinho
Choledochoenterostomywith an anti-reflux mechanism 8193
E. Jaurrieta, J. Fabregat, J. Figueras, R. Bella,
P. Mareno-Llorente, A. Rafecas, J. Torras, T. Casanovas,
and L. Casais Liver transplantation in hepatocellular carcinoma 8196
H. P. Lemmens, G. Blumhardt, P. Neuhaus, H. Keck, N. Tsiblakis,
R. Rossaint, R. Langer, and R. Steffen Technique of arterial
anastomosis in liver transplantation, surgical management in routine
situations and anatomical variations 8198
R. Margreiter, C. Aichberger, A. Konigsrainer, G. Reibnegger,
G. Weiss, and H. Wachter Biliary neopterin for differentiation
between liver allograft rejection and viral graft infection S 199
I. R. Marino, V. P. Scantlebury, 0. Bronsther, S.lwatsuki,
and T. E. Starzl Total hepatectomy and liver transplant for
hepatocellular adenomatosis and focal nodular hyperplasia S201
R. Mondragon, G. Mieli-Vergani, N.D. Heaton, A. P. Mowat,
V. Vougas, R. Williams, and K. C. Tan Liver transplantation for
fulminant liver failure in children S206
N. P. Mora, B.S. Husberg, T. A. Gonwa, R. Goldstein,
and G. B. Klintmalm The impact of the different severe infections
on the outcome of liver transplantation. A study of 150 patients S209
M. Nozawa, H.lkebukuro, I. Otsu, M.lnagaki, H. Ebata, and M. Mito
Hepatic support by hepatocyte transplantation in congenitally
metabolic diseased rats S211
S. K. Donica, L C. Roberts, P. K. Duke, S. T. Black, T. H. Swygert,
T. C. Gunning, M.A. E. Ramsay, and A. W. Paulsen Blood
transfusion in orthotopic liver transplantation: six-year experience S214
F. Romani, C. V. Sansalone, P. Rimoldi, G. Rondinara, L de Carlis,
L. S. Belli, F. Riolo, V. Pitotta and L Belli Liver transplantation for
small HCC in cirrhosis S215
Heart, Lung, Heart-Lung
J. de Boer, B. Cohen, J. Thorogood, J. D' Amaro, and G. G. Persijn
Results of acute heart retransplantation in Eurotransplant 8219
C. Campana, A. Gavazzi, R. Marioni, A. D' Armini, N. Pederzolli,
C. Larizza, C. Berzuini, L Martinelli, M. Vigano,
and C. Montemartini Right ventricular failure after heart
transplantation: relationship with preoperative haemodynamic
parameters S221
A. Wasler, F.lberer, K. H. Tscheliessnigg, H. Metzler, H. Gombotz,
J. Berger, T. Auer, and B. Petutschnigg Preoperative
prostaglandin E1 treatment to prevent right ventricular failure after
orthotopic heart transplantation 8224
K. Groeneveld, A. H. M. M. Balk, A. J. Ouwehand, E. H. M. Loonen,
M. vd Linden, S. Strikwerda, B. Mochtar, N.H. P.M. Jutte,
and W. Weimar Phenotype of endomyocardial biopsy-derived
T-lymphocyte cultures and chronic rejection after heart
transplantation 8228