Translational Research in Pain and Itch PDF
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Advances in Experimental Medicine and Biology 904 Chao Ma Yuguang Huang Editors Translational Research in Pain and Itch Advances in Experimental Medicine and Biology Volume 904 Editorial Board Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel N.S. Abel Lajtha, Kline Institute for Psychiatric Research, Orangeburg, NY, USA John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Rodolfo Paoletti, University of Milan, Milan, Italy More information about this series at h ttp://www.springer.com/series/5584 Chao Ma (cid:129) Yuguang Huang Editors Translational Research in Pain and Itch Editors Chao Ma Yuguang Huang Department of Anatomy, Histology and Department of Anesthesiology, Peking Embryology, Institute of Basic Medical Union Medical College Hospital, Peking Sciences, Neuroscience Center, School Union Medical College of Basic Medicine, Peking Union Chinese Academy of Medical Sciences Medical College Beijing , China Chinese Academy of Medical Sciences Beijing , China ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-94-017-7535-9 ISBN 978-94-017-7537-3 (eBook) DOI 10.1007/978-94-017-7537-3 Library of Congress Control Number: 2016932496 © Springer Science+Business Media Dordrecht 2016 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by SpringerNature The registered company is Springer Science+Business Media B.V. Dordrecht. Pref ace The past decade has witnessed exciting advances in the basic research of pain and itch – both are our most basic yet still mysterious sensations. Clinically, the treat- ment of prolonged and intractable pain (chronic pain) and itch (pruritus) cost bil- lions of dollars every year worldwide while the results are often unsatisfying or accompanied with serious side effects. Despite the slow progress in drug discovery, scientists all over the world have recently acquired more insights into the mecha- nisms underlying pain and itch in both physiological and pathological conditions. The gaps between basic research and clinical application are eagerly waiting to be fi lled by translational research. T his book provides a comprehensive review of recent advances in the transla- tional research on pain and itch. The contributing authors are world-renowned sci- entists and have made important discoveries in the relevant fi eld of research. Their fi ndings not only shed light on the mechanisms but also pave the way for develop- ing novel strategies for the effective and safe treatment of chronic pain and pruritus. Hopefully not long from now, medical practitioners can be more confi dent and patients can be more optimistic when facing these annoying (and often terrible) conditions. W e sincerely appreciate all the contributing authors, our editorial team from the Joint Laboratory of Anesthesiology and Pain in Peking Union Medical College, and the Springer publisher. This book would not be possible without their time and effort. Beijing, China Chao Ma Yuguang Huang v Contents 1 Assessment of Itch and Pain in Animal Models and Human Subjects ............................................................................... 1 Tangmi Yuan , Juan Li , Le Shen , Wanying Zhang , Tao Wang , Yinyan Xu , Jie Zhu , Yuguang Huang , and Chao Ma 2 Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse ............................................................. 23 Robert H. LaMotte 3 Modulation of C-nociceptive Activities by Inputs from Myelinated Fibers .......................................................................... 33 Duan Wan-Ru and Xie Yi-Kuan 4 New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation .................................................................... 41 You Wan 5 Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury? .......................................................................... 59 Xian-Guo Liu , Rui-Ping Pang , Li-Jun Zhou , Xu-Hong Wei , and Ying Zang 6 Peripheral Nociceptors as Immune Sensors in the Development of Pain and Itch ..................................................... 77 Tao Wang and Chao Ma 7 Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy ............................................................... 87 Vineeta Tiwari , Vinod Tiwari , Shaoqiu He , Tong Zhang , Srinivasa N. Raja , Xinzhong Dong , and Yun Guan vii viii Contents 8 Pain Modulation and the Transition from Acute to Chronic Pain ........................................................................................ 105 Mary M. Heinricher 9 Advances in the Treatment of Neuropathic Pain ................................. 117 Li Xu , Yuguan Zhang , and Yuguang Huang 10 Integrated, Team-Based Chronic Pain Management: Bridges from Theory and Research to High Quality Patient Care .................. 131 Mary A. Driscoll and Robert D. Kerns Contributors Xinzhong Dong D ivision of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, J ohns Hopkins University, B altimore, MD , USA Mary A. Driscoll VA Connecticut Healthcare System , West Haven , CT , USA Yale University School of Medicine , New Haven , CT , USA Yun Guan Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine , Johns Hopkins University , Baltimore , MD , USA Shaoqiu He D ivision of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, J ohns Hopkins University, B altimore, MD , USA Mary M. Heinricher D ept. Neurological Surgery, O regon Health & Science University , Portland , USA Yuguang Huang Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College , Chinese Academy of Medical Sciences , Beijing , China Robert D. Kerns VA Connecticut Healthcare System , West Haven , CT , USA Yale University School of Medicine , New Haven , CT , USA Robert H. LaMotte Department of Anesthesiology , Yale University School of Medicine , New Haven , CT , USA Juan Li Department of Anesthesiology , Peking Union Medical College Hospital , Beijing , China Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine , Peking Union Medical College , Beijing , China ix
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