Traditional Chinese Medicine: Scientific Basis for Its Use PDF
Preview Traditional Chinese Medicine: Scientific Basis for Its Use
Traditional Chinese Medicine Scientific Basis for Its Use 1 0 0 P F 2- 5 8 7 3 7 9 4 8 1 8 7 9 9/ 3 0 1 0. 1 oi: d g | or 3c. 1s h 20ubs.r Marcp://p nloaded on 06 pril 2013 on htt wA Do30 n o d e h s bli u P View Online RSC Drug Discovery Series Editor-in-Chief Professor David Thurston, Kings College, London, UK Series Editors: Dr David Fox, Vulpine Science ad Learning, UK 1 0 Professor Salvatore Guccione, University of Catania, Italy 0 P Professor Ana Martinez, Instituto de Quimica Medica-CSIC, Spain F 2- Professor David Rotella, Northeastern University, USA 5 8 7 3 Advisor to the Board: 7 49 Professor Robin Ganellin, University College London, UK 8 1 8 Titles in the Series: 7 9/9 1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups 03 2: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 1 1 0. 3: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 2 1 oi: 4: Accounts in Drug Discovery g | d 5: New Frontiers in Chemical Biology or 6: Animal Models for Neurodegenerative Disease 3c. 7: Neurodegeneration 1s March 20p://pubs.r 891::0:GPEhaPxrtrrmoataceecinlelu-uCtlaiocraulapnPledrdoIcRnetserscaecDpetelolvurelslaorpSmigennatling nloaded on 06 pril 2013 on htt 1111112345::::: NNDNBieereouwwgmgleSHecDdytoeinecdrstaiihzglDoenItnimiscsSeataiTrgnsaeientcPseghrganeindeodsilc:otDQgivirueeusagTninotDixtMiaisctceoiovdlveoicegAirynypaplrCohaecmheisstry wA Don 30 1167:: PPhoalyrammaicneeutDicraulgSDaltisscaonvderyCocrystals d o 18: Proteinases as Drug Targets e h 19: Kinase Drug Discovery s bli 20: Drug Design Strategies: Computational Techniques and Applications u P 21: Designing Multi-Target Drugs 22: Nanostructured Biomaterials for Overcoming Biological Barriers 23: Physico-Chemical and Computational Approaches to Drug Discovery 24: Biomarkers for Traumatic Brain Injury 25: Drug Discovery from Natural Products 26: Anti-Inflammatory Drug Discovery 27: New Therapeutic Strategies for Type 2 Diabetes: Small Molecules 28: Drug Discovery for Psychiatric Disorders 29: Organic Chemistry of Drug Degradation 30: Computational Approaches to Nuclear Receptors 31: Traditional Chinese Medicine How to obtain future titles on publication: A standing order plan is available for this series. A standing order will bring delivery of each new volume immediately on publication. For further information please contact: BookSalesDepartment,RoyalSocietyofChemistry,ThomasGrahamHouse, Science Park, Milton Road, Cambridge, CB4 0WF, UK Telephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247, Email: [email protected] Visit our website at www.rsc.org/books View Online Traditional Chinese Medicine ScientificBasisforItsUse 1 0 0 P F Edited by 2- 5 8 7 James David Adams Jr 3 97 School ofPharmacy,UniversityofSouthern California,Los Angeles, CA, USA 4 18 Email: [email protected] 8 7 9 9/ Eric J. Lien 3 0 1 School ofPharmacy,UniversityofSouthern California,Los Angeles, CA, USA 0. 1 Email: [email protected] oi: d g | or 3c. 1s h 20ubs.r Marcp://p nloaded on 06 pril 2013 on htt wA Do30 n o d e h s bli u P View Online 1 0 0 P F 2- 5 8 7 3 7 9 4 8 1 8 7 9 9/ 3 0 1 0. RSC Drug Discovery Series No. 31 1 oi: org | d IISSBSNN::2907481-1-3-82409373-661-9 3c. 1s h 20ubs.r A catalogue record for this book is available from the British Library nloaded on 06 Marcpril 2013 on http://p #AAlplaTrrihtgefhrtRosmoryefsaaelirrSvdeoedcaielitnygofforCthheempuisrtproys2es01o3fresearchfornon-commercialpurposes wA Do30 or for private study, criticism or review, as permitted under the Copyright, n DesignsandPatentsAct1988andtheCopyrightandRelatedRightsRegulations o d 2003,thispublicationmaynotbereproduced,storedortransmitted,inanyform e sh orbyanymeans,withoutthepriorpermissioninwritingofTheRoyalSocietyof ubli Chemistry or the copyright owner, or in the case of reproduction in accordance P withthetermsoflicencesissuedbytheCopyrightLicensingAgencyintheUK,or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page. The RSC is not responsible for individual opinions expressed in this work. Published by The Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge CB4 0WF, UK Registered Charity Number 207890 For further information see our web site at www.rsc.org PrintedintheUnitedKingdombyHenryLingLimited,Dorchester,DT11HD,UK 5 0 0 P Preface F 2- 5 8 7 3 7 9 4 8 1 8 7 9 9/ 3 0 0.1 ‘‘I believe in the goodness of the American and Chinese people who remain 1 oi: good friends.’’ d g | Dr Hua Chuen Mei or from ‘‘Dr Hua Chuen Mei – May 30, 1925’’ available at 3c. h 201ubs.rs www.abeduspress.com. Marcp://p LindaMeiAdams,mywife,isthegrand-daughterofDrHuaChuenMei,who nloaded on 06 pril 2013 on htt wa3inc0acMsuCsahaeniydnA1ao9.fm2rM5eio.ryitHcinaewgnwiiflnoeanwthatyenhedIerncithnaeesreSrnhainmatinJoougnthnhaaeelriS1,we9t2Eht5lvoe,amwdeheLnfiuectnhmadtleetMddhetesoLie,vtohetureaazuMalgCPhaotyhli3imnc0eeesMSettooastvtuieosdmpneeenoantnkst wA Do30 Cantonese. My wife’s grand-mother, Polly Lum, used Traditional Chinese n Medicine even though her son, son-in-law and grand-son were all Western- o ed trainedMDs.IamgratefultotheMeiandLumfamiliesforhelpingmelearnthe h blis utilityofTraditionalChineseMedicine,evenwhenAmericanMedicinemaynot Pu recognize the utility. I was able to learn the philosophy for using Traditional Chinese Medicine, which differs greatly from the medicine I learned as a Graduate Student of Pharmacology at the University of California San Francisco.Thisphilosophydependsonlivinginbalanceinordertobehealthy. Iwasalsotaughttheimportanceofspiritualityinhealth,sincehealthrequiresa healthybody,mindandspirit.Mypoembelowis‘‘bekindtoyourself,bekindto others, allow God to love you.’’ My Chinese name, below, is Ha Cheen Sing, SummerThousand Honest,andwasgiventomebymymother-in-law. 跟自己做慈善 跟第二的人做慈善 讓上帝愛你 夏千诚 RSCDrugDiscoverySeriesNo.31 TraditionalChineseMedicine:ScientificBasisforItsUse EditedbyJamesDavidAdams,Jr.andEricJ.Lien #TheRoyalSocietyofChemistry2013 PublishedbytheRoyalSocietyofChemistry,www.rsc.org v View Online vi Preface I am grateful to Professor Eric Lien for encouraging me to think about the Science involved in Traditional Chinese Medicine. This has been a great challenge for me and resulted in this book. I am grateful to all the authors of the chapters who have applied their great expertise in this book. 05 James David Adams Jr, PhD 0 FP Associate Professor of Pharmacology and Pharmaceutical Sciences 52- School of Pharmacy, University of Southern California 8 37 Los Angeles, CA, USA 7 9 4 8 1 8 97 Knowledge and Health 9/ 3 0 1 Knowledge and learning have no limits. 0. oi:1 Teaching and learning reinforce each other. g | d Education should not discriminate against anyone. or Doing good deeds brings the most happiness. 3c. 1s Newknowledgecanpromotegoodhealth,enhanceproductivityandcontribute h 20ubs.r tolongevity. Marcp://p Sustain vitality and youthfulness as long as possible. nloaded on 06 pril 2013 on htt Good memories will laSscthofoorlevoefrP.harmacy, University of SPoEruortfhiecesrJsno.rLCEiaemlnif,eoPrrihntuDias wA Los Angeles, CA, USA Do30 n o d e h s bli u P 7 0 0 P F Contents 2- 5 8 7 3 7 9 4 8 1 8 7 9 9/ Chapter 1 The Traditional and Scientific Bases for Traditional Chinese 3 10 Medicine: Communication Between Traditional Practitioners, 0. 1 Physicians and Scientists 1 doi: James D. Adams Jr and Eric J. Lien g | or 3c. 1.1 Introduction 1 1s h 20ubs.r 1.2 The Basis of Traditional Chinese Medicine 2 Marcp://p 1.3 Disease Causation 4 wnloaded on 06 April 2013 on htt 11111.....45678 DTRTChhoaiseennerdcaTalosupremasyidPoiMzirnteeidouv,nsetnaPtlAliaAolclnopebwporo-tChaecohnBttoroodtlylhetedoTCHrleieanatilmcaIetlsnTetlrfoiaflDs isease 87769 Do30 References 10 n o d e h blis Chapter 2 Structure–Activity Relationship Analysis of Plant-Derived Pu Compounds 11 Eric J. Lien, Linda L. Lien and James D. Adams 2.1 Introduction 11 2.2 Structure–Activity Relationship Analysis 12 2.2.1 FromNaturalSourcestoSyntheticCompounds 12 2.2.2 From Estradiol, Phytoestrogens to Synthetic Diethylstilbestrol 13 2.3 Medicinal Diet (Yao San) 14 2.4 Immunostimulating (Fu-zhen) Herbs 15 References 16 RSCDrugDiscoverySeriesNo.31 TraditionalChineseMedicine:ScientificBasisforItsUse EditedbyJamesDavidAdams,Jr.andEricJ.Lien #TheRoyalSocietyofChemistry2013 PublishedbytheRoyalSocietyofChemistry,www.rsc.org vii View Online viii Contents Chapter 3 Huang Di Nei Jing and the Treatment of Low Back Pain 17 Minchen Wang (Vince) 3.1 Significance of Low Back Pain (LBP) 17 3.1.1 Prevalence of LBP 17 07 3.1.2 Human Cost 17 0 FP 3.1.3 Medical Cost and Societal Cost 18 52- 3.2 Scope of the Problem – What Is Involved in LBP? 18 8 37 3.2.1 Diversity of Causes and Diagnosis 18 7 49 3.2.2 Practical Considerations of LBP 18 8 81 3.3 Introduction to Huang Di Nei Jing 19 7 9/9 3.3.1 Overview 19 3 0 3.3.2 Historical Perspectives 20 1 10. 3.3.3 The Significance of the Nei Jing 20 doi: 3.4 Treatment of LBP According to the Nei Jing 25 g | 3.4.1 Overview of Pain in the Nei Jing 25 or 3c. 3.4.2 Pain and Qi Stagnation in the Nei Jing 25 1s h 20ubs.r 3.4.3 Key Features of the Nei Jing’s LBP Treatment 27 wnloaded on 06 MarcApril 2013 on http://p 33..56 MS333c...556oie...d121netrifnTFSSicutDrereBamaaatatmuytesmrgiaLesierseBnoysoPtfoffoLfTMrBLrLePoBaBdPtTemPrrTeneTarnreAttemacateumtmnpetuennntctCtuormepfoarriLsoBnPs 3232318091 Do30 3.6.2 The Nature of the Pain 31 on 3.6.3 Summary of Scientific Principles for LBP d e Treatment 41 h s bli 3.7 A Rational Approach to LBP Treatment Based on the u P Nei Jing 41 3.7.1 Mapping the Low Back for Point Selection 42 3.7.2 Treatment Guide for LBP 43 3.8 Conclusion 45 References 46 Chapter 4 Understanding Ch’i: The Life-Force Energy that Determines Vitality, Health and Wellbeing 48 Marcia R. Babcock 4.1 TheOriginoftheUniverse:theCosmologyofCh’iand Its Manifest Forms as Yin and Yang 48 4.2 Ch’i as Life Force Is Described in Many Cultures 50 4.3 Perceiving and Measuring Ch’i 50 4.4 Historical Measurement of Vital Energy Using Scientific Methods 51 View Online Contents ix 4.5 Modern Western Doctors Interested in the Energy Field Surrounding Human Beings 51 4.6 Comparison of TCM and Ayurveda 52 4.7 Cultivation of Ch’i: Improving the Quality and Strength of Ch’i Flows 52 07 4.8 Energy Healing Practices Across the World 53 0 FP 4.9 Chinese Practices to Balance and Facilitate Ch’i Flow 53 52- 4.9.1 Traditional Chinese Medicine 53 8 37 4.9.2 What Can Happen to the Ch’i? 54 7 49 4.9.3 TCM: Acupuncture and Moxibustion 54 8 81 4.9.4 TCM: Herbal Medicine 54 7 9/9 4.9.5 TCM: Massage (Tui Na) 55 3 0 4.10 Movement/Exercise 55 1 10. 4.10.1 T’ai Chi Ch’uan 55 doi: 4.10.2 Pa Kua Chang 56 g | 4.10.3 Hsing I 56 or 3c. 4.11 Ch’i Kung 57 1s h 20ubs.r 4.12 Geomancy 57 nloaded on 06 Marcpril 2013 on http://p Refere44n..11c22e..s12 dGGiveeooinmmaaatinnoccnyy:: TFhenegapShpuliciation of ch’i to 555878 wA Do30 Chapter 5 When Modern Computational Systems Biology Meets n Traditional Chinese Medicine 61 o d Calvin Yu-Chian Chen e h s bli u 5.1 Introduction 61 P 5.2 Modernizing Traditional Chinese Medicine for a Global Stage 62 5.3 TCM in Drug Discovery: Application from the Molecular Level 63 5.4 Futuristic Drug Discovery: the Top-Down and Bottom-Up Systematic View 63 5.5 Unleashing the Potential of TCM Through Systems Biology 66 5.6 An Example of a Systems Approach to TCM Drug Development 70 5.7 Integration of TCM with Systems Biology: A Long Way to Go 73 5.7.1 Science Should Be Open Access 73 5.7.2 Pharmacological Data Have Limited Applicability in Investigating Novel Leads 75 5.7.3 Bigger Is Not Better in Terms of TCM Drug Compound Screening 75 View Online x Contents 5.7.4 Traceback Information Is Critical 75 5.7.5 Modernization of TCM Formulas 76 References 77 7 Chapter 6 Modern Drug Discovery from Chinese Materia Medica Used 0 P0 in Traditional Chinese Medicine 81 F 2- Kuo-Hsiung Lee, SusanL. Morris-Natschke,Joshua Brattlie, 5 78 Jingxi Xie and Eileen Belding 3 7 9 4 18 6.1 Introduction to Drug Discovery Based on Traditional 8 97 Chinese Medicine (TCM) 81 9/ 3 6.2 Ephedra sinica/Ephedrine – Pseudoephedrine 82 0 1 0. 6.2.1 Introduction 82 1 oi: 6.2.2 Source Plant and Traditional Uses 83 d g | 6.2.3 Chemistry 83 or 6.2.4 Pharmacology 84 3c. h 201ubs.rs 6.3 P6.o2d.o5phyMlloumderenmHodiis/tPoorydophyllotoxin, Etoposide and 84 Marcp://p Teniposide 85 nloaded on 06 pril 2013 on htt 6666....3333....1234 IDMNnreteuwrcoghdDaDunrciiusstgcimoonDvoeefrsyAigcntion 88885678 wA Do30 6.4 Salvia miltiorrhiza/Tanshinone IIA 90 n 6.4.1 Introduction 90 o d 6.4.2 Source Plant and Traditional Uses 90 e h s 6.4.3 Chemistry 90 bli u 6.4.4 Pharmacology 91 P 6.4.5 Use as a Lead for New Drug Design 92 6.4.6 Use as a Chemical Probe 93 6.5 Anisodus tanguticus/Anisodamine and Anisodine 93 6.5.1 Introduction 93 6.5.2 Source Plant and Traditional Uses 94 6.5.3 Chemistry 94 6.5.4 Pharmacology 95 6.5.5 Drug Development 96 6.6 Camptotheca acuminata/Camptothecin 98 6.6.1 Introduction 98 6.6.2 Drug Discovery 98 6.6.3 Lead for New Drug Design 100 6.7 Schisandra chinensis/DDB 100 6.7.1 Introduction 100 6.7.2 Source Plant and Traditional Uses 100 6.7.3 Chemistry 101 6.7.4 Pharmacology 102
The list of books you might like
