Trace Amines: Comparative and Clinical Neurobiology PDF
Preview Trace Amines: Comparative and Clinical Neurobiology
Trace Amines Experimental and Clinical Neuroscience Trace Amines: Comparative and Clinical Neurobiology, edited by A. A. Boulton, A. V. luorio, and R. G. H. Downer, 1988 Neuropsychopharmacology of the Trace Amines, edited by A. A. Boulton, P. R. Bieck, L. Maitre, and P. Riederer, 1985 Neurobiology of the Trace Amines, edited by A. A. Boulton, G. B. Baker, W. G. Dewhurst, and M. Sandler, 1984 Neural Membranes, edited by Grace Y. Sun, Nicolas Bazan, lang-Yen Wu, Giuseppe Porcellati, and Albert Y. Sun, 1983 Trace Amines Comparative and Clinical Neurobiology Edited by A. A. Boulton and A. V. Juorio University of Saskatchewan, Saskatoon, Saskatchewan, Canada and R. G. H. Downer University of Waterloo, Waterloo, Ontario, Canada Humana Press • Clifton, New Jersey © Copyright 1988 by The Humana Press Inc. Softcover reprint of the hardcover 1st edition Crescent Manor PO Box 2148 Clifton, NJ 07015 All rights of any nature whatsoever reserved. No part of this book may be reproduced, stored in a retrieval sytem, or transmitted in any form or by any means, including electronic, mechanical, photocopying, microfilming, recording, computer database entry, or networking, or in any manner whatsoever without written permission from the publisher. Library of COngress cataloglng-In-Publlcatlon Data Trace amines: comparative and clinical neurobiology 1 edited by A.A. Boulton, A.V. Juorio, and R.G.H. Downer 760 p. cm.-(Experimental and Clinical Neuroscience) Based on the proceedings of a conference held May 28-30, 1987 in Isla Margarita, Venezuela as a satellite of the 11th International Society for Neuro chemistry Meeting. Sponsored by the International Society for Neurochemistry. Includes bibliographies and index. ISBN-13: 978-1-4612-8945-6 e-ISBN-13: 978-1-4612-4602-2 001: 10.1007/978-1-4612-4602-2 1. Biogenic amines-Physiological effect-Congresses. 2. Biogenic amines-Metabolism--Congresses. 3. Neurobiology-Congresses. I. Boulton, A. A. (Alan A.) II. Juorio, A. V. (Augusto V.) III. Downer, Roger G. H. IV. Intemational Society for Neurochemistry. Meeting. (11th: 1987: La Guaira, Distrito Federal, Venezuela) V. International Society for Neurochemistry. VI. Series. [DNLM: 1. Amines-congresses. 2. Neurobiology-congresses. QU 60 T759 1987] QP801.B66T73 1988 591'.0188-dc19 88-6847 CIP Preface This is the third Proceedings book to arise from biennial conferen ces on the Trace Amines. Since our first meeting in 1983 in Edmonton, Canada, progress has been brisk and, as will be seen from the ensuing pages, it is now possible to include major contributions from inverte brate neurobiologists as well as receptorologists. In the opening ses sion we heard about the distribution of the trace amines-now clear ly a misnomer-in insects and the pharmacological, receptor, and syn aptic characteristics of octopamine and tryptamine as well as the pos sibility of monoamines in general being targets for insecticide discov ery. In mammalian brain the distribution and characterization of the tryptamine receptor has proceeded to the point where two types have been described as well as novel agonists and antagonists, and, for the first time, a binding site for p-tyramine has been described. The com bination of lesions and pharmacological and metabolic manipulations now permits the mapping of trace aminergic pathways, and the rap idly accumulating evidence from releasing drugs, in situ microdialy sis, iontophoresis, and second messenger systems lends credence to the claim that the trace amines possess neuromodulatory functions. Although drugs with specific actions on trace aminergic systems are still required, it is interesting to note that prodrugs of phenylethyla mine have now been synthesized and that intriguing new condensa tion adducts have been identified following interaction between trace and other amines and cigaret smoke constituents and alcohol metabo lites. Some of these latter substances are capable of interacting with some receptors and enzymes. As biological markers of stress, migraine, depression, schizophre nia, and tardive dyskinesia, the trace amines or their acidic metabo lites or their associated enzymes seem particularly good candidates. Alan A. Boulton Augusto V. Juorio Roger G. H. Downer v Acknowledgments This book is based on the Proceedings of the Trace Amines: Their Comparative and Clinical Neurobiology conference which was held May 28th to 30th, 1987 at the Hotel Bella Vista, Isla Margarita, Venez uela. The meeting was also arranged as a Satellite of the 11 th Interna tional Society for Neurochemistry Meeting and we are grateful to the ISN for their sponsorship and also for a financial contribution. In addi tion we are grateful to the following pharmaceutical companies for their financial support: American Cyanamid Company, Princeton, New Jersey, USA Boehringer Ingelheim (Canada) Ltd., Burlington, Ontario, Canada Ciba-Geigy AG, Basel, Switzerland Ciba-Geigy Canada Ltd., Mississauga, Ontario, Canada Ciba-Geigy Ltd., Summit, New Jersey, USA Hoechst Roussel Pharmaceuticals Inc., Somerville, New Jersey, USA Lilly Research Laboratories, Indianapolis,lndiana, USA Pfizer Canada Inc., Pointe Claire, Dorval, Quebec, Canada Rhone-Poulenc Pharma Inc., Montreal, Quebec Stauffer Chemical Company, Richmond, California, USA Upjohn Company of Canada, Don Mills, Ontario, Canada Warner-Lambert Company (Parke-Davis Canada Inc.), Scarborough, Ontario, Canada Contributors BAKER, GLEN B. • Department of Psychiatry, University of Al berta, 1st Floor, Clinical Sciences Building, Edmonton, Alberta, Can ada T6G2G3 BlECK, PETERR. • Humanpharmakologisches Institut Ciba-Geigy GMBH, Ob dem Himmelreich 9, D-7400 Tiibingen, Germany BOULTON, ALAN A.. Neuropsychiatric Research Division,A114 CMR Building, University of Saskatchewan, Saskatoon, Saskatchew an, Canada S7N OWO CELUCH, STELLA M. • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO CIPRIAN-OLUVIER, JORGE • Francisco de Vittoria 2322/24, Buenos Aires, Argentina 1425 COLLINS, MICHAEL A. • Department of Biochemistry, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA COOPER, THOMAS B. • Analytical Psychopharmacology Lab, Nathan S. Kline Institute, Orangeburg, NY 10962, USA DIAMOND, BRUCE I. • Department of Psychiatry, Medical Col lege of Georgia, 1515 Pope Avenue, Augusta, GA 30912, USA DOWNER, ROGER G. H. • Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1 DURDEN, DAVID A. • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO DYCK, ULUAN E. • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO EVANS, PETER D. • Department of Zoology, University of Cambridge, Downing Street, Cambridge, England CB13EJ, UK FARAJ, BAHJAT • Department of Radiology, 467 Woodruff Memorial Building, Emory University School of Medicine, Atlanta, GA 30322, USA vii viii Contributors FLETCHER, PAUL J. • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO GREENSHAW,ANDREW J. • Department of Psychiatry, Univers ity of Alberta, 1st Floor, Clinical Sciences Building, Edmonton, Al berta, Canada T6G 2G3 HARRIS, JOSEPH • Department of Chemistry, Arizona State Uni versity, Tempe, AZ 85287, USA HENRY, DAVID P. • Lilly Laboratory for Clinical Research, Uni versity of Indiana, School of Medicine, Indianapolis, IN 46202 USA 46202 JENNINGS, KENT R. • Insecticide Discovery Department, Ameri can Cyanamid Co., PO Box 400, Princeton, NJ 08540, USA JUORIO, AUGUSTO V. • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatche wan, Canada S7N OWO KIENZL, EUZABET • LBI for Clinical Neurobiology, Lainz Hospi tal, Vienna, Austria LANGE, ANGELA B. • Department of Zoology, University of Toronto, Toronto, Ontario, Canada M5S lA8 LANGER, SALOMON Z .• Departement de Recherche Biologique, Laboratoires d'Etudes et de Recherches Synthelabo, 58 rue de la Glaciere, 75013 Paris, France LARSON, ALICE A. • Department of Vet Biology, University of Minnesota, College of Veterinary Medicine, 295 AnSci/Vet Med. Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA MIDGLEY, JOHN • Nuclear Medicine Center, Veterans Admini stration Medical Center, 1601 Archer Road, Gainesville, FL 32602, USA NATHANSON, JAMES A. • Department of Neurology, Massachu setts General Hospital, Boston, MA 02114, USA NGUYEN, TUONG VAN. Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchew an, Canada S7N OWO ORIKASA, SHUZO • Neuropsychiatric Research Division, CMR Building University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO OSBORNE, NEVILLE N. • Nuffield Laboratory of Ophthalmol ogy, University of Oxford, Walton Street, Oxford, 0X2 6AW, UK Contributors ix PATERSON, I. ALICK • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO PERRY, DAVID C. • Department of Pharmacology, George Wash ington University School of Medicine, 2300 Eye Street, NW, Washing ton, DC 20037, USA READER, TOMAS A. • Centre de Recherche en Sciences Neuro logiques, Universite de Montreal, Case Postale 6128, succursale A, Montreal, Quebec, Canada H3C 3J7 RICHARDSON, MARY ANN • Clinical Research Division, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA SANDLER, MERTON • Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London W6 OXG, UK SARPER, RAUF • Nuclear Medicine, VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA SATOH, NOBUNORI • Department of Pharmacology, Tohoku College of Pharmacy, 4-4-1, Komatsushima, Sendai 983, Japan SLOLEY, B. DUFF • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO TIPTON, KEITH F. • Biochemistry Department, Trinity College, University of Dublin, Dublin 2, Ireland, UK VA CCARI, ANDREA • Instituto di Farmacologia, via Porcell, 90100 Cagliari, Italy WHIM, MATTHEW • Department of Zoology, University of Cam bridge, Downing Street, Cambridge, CB2 3EJ, UK WILSON, JOHN X. • Department of Physiology, Health Sciences Center, University ofW estern Ontario, London, Ontario, CanadaN6A 5Cl WOOD, PAUL L. • Department of Neuropharmacology, Neuro science Research, Ciba-Geigy Ltd., 556 Morris Avenue, Summit, NJ 07901, USA YU, PETER • Neuropsychiatric Research Division, CMR Building, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N OWO Contents v Preface vi Acknowledgments vii Contributors xi Contents xvii Abbreviations Neurobiology: Invertebrates Invited Contributions 3 Pharmacological Characteristics of Octopamine-Sensitive Adenylate Cyclase and N-Acetyl Octopamine Transferase in Insects, R. G. H. Downer, J. W. D. Gole, R. J. Martin, and G. L. Orr 17 Octopamine Receptors on Locust Skeletal Muscle, P. D. Evans 33 The Firefly Light Organ: A Model for a Trace Amine Synapse, J. A. Nathanson 41 The Regulation of Insect Visceral Muscle by Octopamine, I. Orchard and A. B. Lange 53 Monoamines as Targets for Insecticide Discovery, K. R. Jennings, D. G. Kuhn, S. Trotta, and W. K. Whitney Submitted Contributions 65 N-AcetyI5-Hydroxytryptamine and N-Acetyl Dopamine in the Cockroach (Periplaneta americana), B. D. Sioley and R. G. H. Downer xi
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