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TOXICON An interdisciplinary journal on the toxins from animals, plants and microorganisms Editor: Alan L. Harvey Volume 36, 1998 Pergamon TOXICON An Interdisciplinary Journal on the Toxins Derived from Animals, Plants and Microorganisms. Official Journal of the International Society on Toxinology. Editor-in-Chief Professor ALAN L. HARvey, Department of Physiology and Pharmacology, University of Strathclyde, Royal College, 204 George Street, Glasgow G1 IXW, U.K. Receiving Editor, North America Professor VINCENT A. CHIAPPINELLI, George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, U.S.A. Review Editor Professor Dr GERHARD HABERMEHL, Department of Chemistry, School of Veterinary Medicine, Bischofsholer Damm 15, D-30173 Hannover 1, Germany Editorial Council B. E. C. BANKS, London E. HABERMANN, Giessen \. MENEZ, Gif-sur-Yvette A. L. BlEBER, Tempe J. B. HARRIS, Newcastle-upoTny-n e J. L. MIDDLEBROOK, Frederick J. W. BURNETT, Baltimore R. J. HUXTABLE, Tucson S. A. MINTON JR, /ndianapolis W. W. CARMICHAEL, Dayton H. IKEZAWA, Nagova R. S. Norton, Parkville F. DAJAs, Montevideo M. IsMAIL, Rivadh S. OLSNES, Oslo J. W. DALY, Bethesda C. Y. KAo, New York C. L. Ownsy, Stilhvatei J. O. Dotty, London E. KARLSSON, Uppsala T. PlEK, Amsterdam M. F. ELt-ASMAR, Cairo W.R. KEM, Gainesville L. D. POSSANI, Cuernavaca J. E. FLETCHER, Philadelphia E. Kocuva, Tel-Avis F. E. RUSSELL. Tucson L. FREIRE-MAIA, Belo Horizont F. KORNALIK, Praguc W. T. SHIER, Minneapolis P. GOPALAKRISHNAKONE, Singapors M. LAZDUNSK]I, Nicé P. N. STRONG, London E. GRISHIN, Moscon F.S. MARKLAND JR, Los Angeles R. D. G. THEAKSTON, Liverpool F. GUBENSEK, Ljubljana D. Mess, Frankfurt D. A. WARRELL, Oxford J. M. GUTIERREZ, San Jos International Society on Toxinology President: Dr France Gubensek, Department of Biochemistry, J. Stefan Institute, Box 199/1V, Ljubljana 61.000, Slovenia Secretary-Treasurer: Dr D. Mebs, Zentrum der Rechtsmedizin, Kennedyallee 104, 6000 Frankfurt am Main 70, Germany. The purpose of this society is to advance knowledge on the properties of toxins and antitoxins and to bring together scholars interested in these substances through a common society. Membership consists of those who have conducted and published meritorious original investigations in toxinology, while persons who do not qualify for membership but are interested in the field of toxinology are eligible for associate membership. Further information concerning the Society and applications for membership may be obtained from the Secretary- Treasurer. Author Service Department: For queries relating to th | submission of f articles (including electronic text and artwork) and the status of accepted manuscripts, please contact the Author Service Depart it: Tel 44 (0) 1865 843900: Fax 44 (0) 1865 843905: E-mail: authors‘a elsevier.co.uk Publishing Office: Elsevier Science Ltd, Bampfylde Street. Exeter EX] 2AH, U.K. [Tel 44 (0) 1392 251558: Fax 44 (0) 1392 425370 Advertising Office: Elsevier Science Ltd, The Boulevard, Langford Lane. Kidlington, Oxford OX5 IGB, U.K. [Tel 44 (0) 1865 843900; Fax 44 (0) 1865 843010] Frequency: Published Monthly Annual Institutional Subscription Rates 1998: Europe. The CIS and Japan NLG 2405.00. All other countries US$1382.00. Dutch Guilder prices exclude VAT. Non-VAT registered customers in the European Community will be charged the appropriate VAT in addition to the price listed. Prices include postage and insurance, and are subject to change without notice. Members of the International Society on Toxinology may order personal subscriptions at a concessional rate and details of these rates are available on request For orders, claims, product enquiries (no manuscript enquiries) please contact the Customer Support Department at the Regional Sales Office nearest to you Ihe Americas: Elsevier Science, Customer Support Department, P.O. Box 945, New York, NY 10010. U.S.A. [Tel: (+ 1) 212-633-3730 1-888 4ES-INFO Fax: (+ 1) 212-633-3680. E-mail: usinfo-fa elsevier.com]. Japan: Elsevier Science Customer Support Department, 9-15 Higashi-Azabu |-chome, Minato- ku, Tokyo 106, Japan [Tel: (+ 81) 3-5561-5033. Fax: (+81) 3-5561-5047. E-mail: infovu elsevier.co.jp]. Asia Pacific (excluding Japan): Elsevier Science (Singapore) Pte Ltd. No. | Temasek Avenue, 17-01 Millenia Tower, Singapore 039192 [Tel: (+65) 434-3727. Fax: (+65) 337-2230. E-mail asiainfo.a elsevier.com.sg]. Rest of the World: Elsevier Science Customer Service Department, P.O. Box 211, 1001 AE Amsterdam, The Netherlands [Tel (+ 31) 20-485-3757. Fax: (+ 31) 20-485-3432. E-mail: nlinfo-fic elsevier.nl] Back issues: Back issues of all previously published volumes are available direct from Elsevier Science offices (Oxford, New York) Complete volumes and single issues can be purchased for 1993-1997. Earlier issues are available in high quality photo-duplicated copies as complete volumes only PERIODICALS POSTAGE PAID AT RAHWAY, NJ. Toxicon (ISSN 0041-0101) is published monthly by Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB. U.K. The annual subscription in the U.S.A. is $1382.00. Toxicon is distributed in the U.S.A. by Mercury Airfreight International Ltd, 365 Blair Road, Avenel. NJ 07001, U.S.A. POSTMASTER: please send address changes to Toxicon, ¢ o Elsevier Science RSO, Customer Support Department. 655 Avenue of the Americas. New York, NY 10010, U.S.A © 1998 Elsevier Science Ltd. All rights reserved LIST OF CONTENTS 1998 Vol. 36, No. 1 Instructions for Contributors to Toxicon Obituary Dr Tomoyi Suzuki J. Vetter Review Article— Toxins of Amanita phalloides D. J. West. E. B. Andrews. A. R. MeVean, Presence of a toxin in the salivary glands of the marine snail Cymatiwn M. C. Thorndykaend J. D. Taylor intermedius that targets nicotinic acetylcholine receptors L. A. F. Ferreira, S. M. Lucas, E. W. Alves, Isolation, characterization and biological properties of two kinin-like V. V. Hermann, A. P. Reichl. G. Habermehl peptides (peptide-S and peptide-R) from Scaptocosa raptoria venom and R. B. Zingali G. J. Kelso and K. M. Blumenthal Identification and characterization of novel sodium channel toxins from the sea anemone Anthopleura xanthogrammica Y. Tokeshi, M. Nakamura. K. Kinjoh Inhibition of habutobin activities by habu antivenom M. Sunagawa, K. Hanashiro and T. Kosugi K. L. Bell. S. K. Sutherland and Some pharmacological studies of venom from the inland taipan W. ¢ Hodgson (Oxyuranus microlepidotus) E. Carredano, B. Westerlund, B. Persson. [he three-dimensional structures of two toxins from snake venom M. Saarinen, S. Ramaswamy, D. Eaker and throw light on the anticoagulant and neurotoxic sites of phospholipase H. Eklund \ M. Ismail, M. A. Abd-Elsalam and Pharmacokinetics of | I-labelled Wal/terinnesia aegvptia venom and its M. S. Al-Ahaidib specific antivenins: flash absorption and distribution of the venom a t M. Fatehi, A. L. Harvey and E. G. Rowan Characterisation of the effects of depolarising toxins on nerve terminal action potentials: apparent block of presynaptic potassium currents Y. Zhang, R. Gao, W.-H. Lee, S.-W. Zhu. Characterization of a fibrinogen-clotting enzyme from Trimeresurus Y.-Liang Xiong and W.-Y. Wang iejnegeri venom, and comparative study with other venom proteases Yun Zhang, Wen-Hui Lee, Rong Gao, Effects of Pallas’ viper gkistrodon halys pallas) venom on blood Yu-Liang Xiong, Wan-Yu Wang and coagulation and characterization of a prothrombin activator Shao-Wen Zhu R. Q. Monteiro, N. Yamanouye Variability of bothrojaracin isoforms and other venom principles in C. R. Carlini, J. A. Guimaraes, C. Bon and individual jararaca (Bothrops jararaca) snakes maintained under R. B. Zingali seasonally invarian C. Alvarez, M. E. Lanio, M. Tejuca. rhe role of ionic strength on the enhancement of the hemolytic activity D. Martinez, F. Pazos, A. M. Campos, of sticholysin I, a cytolysin from Stichodactyvla helianthus M. V. Encinas. T. Pertinhez., S. Schreier and E. A. Lissi Susumu Kumagai, Yoshiko Sugita-Konishi, he fate and acute toxicity of aflatoxin B,; in the mastomys and rat Yukiko Hara-Kudo, Yoshinori Ito, Youko Noguchi, Yoshie Yamamoto and Atsuo Ogura M. R. de Oliveira and M. S. Palma Polybitoxins: a group of phospholipases A> from the venom of the neotropical social wasp paulistinha (Polyhia paulista) S. L. Morton, P. D. R. Moeller, K. A. Young Okadaic acid production from the marine dinoflagellate Prorocentrum and B. Lanoue belizeanum Faust isolated from the Belizean coral reef ecosystem II] IV List of Contents M. I. Alam and A. Gomes 207 Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantam Short Communications C.-L. Ho, Y.-L. Lin, W.-C. Chen, R Rocchi Comparison of the immunogenicity of wasp venom peptides with or and T. Piek without carbohydrate moieties G. Picolo, R. Giorgi, M. M. Bernardi and The antinociceptive effect of Crotalus durissus terrificus snake venom Is Y. Cury mainly due to a supraspinally integrated response Bibliography of Toxinology International Society on Toxinology Membership Application Announcement Vol. 36, No. 2 Tomoaki Tsutsumi, Satoshi Nagata. Anti-idiotype monoclonal antibodies against anti-microcystin anti- Fuyuko Yoshida and Yoshio Ueno body and their use in enzyme immunoassay l.-H. Lee, Y.-M. Chen and H.-N. Chou First report of microcystins in Taiwan R. A. Cavinato, H. Remold and T. L. Kipnis Purification and variability in thrombin-like activity of Bothrops atrox venom from different geographic regions C. J. Cao, M. E. Eldefrawi, A. T. Eldefrawi, Toxicity of sea nettle toxin to human hepatocytes and the protective J. W. Burnett, R. J. Mioduszewski., effects of phosphorylating and alkylating agents D. E. Menking and J. J. Valdes A. Negri and L. Llewellyn Comparative analyses by HPLC and the sodium channel and saxiphilin “H-saxitoxin receptor assays for paralytic shellfish toxins in crustaceans and molluscs from tropical North West Australia W. Wiister, P. Golay and D. A. Warrell Synopsis of recent developments in venomous snake systematics, No. 2 S. Bagchi and S. B. Deshpande Indian red scorpion (Buthus tamulus) venom-induced augmentation of cardiac reflexes is mediated through the mechanisms involving kinins in urethane anaethetized rats G. Leon, R. Estrada, F. Chaves, G. Rojas, Inhibition by CaNa,EDTA of local tissue damage induced by Bothrops M. Ovadia and J. M. Gutiérrez asper (terciopelo) venom: application in horse immunization for antivenom production A. M. B. Moreira-Ferreira, In vivo protection against Titvus serrulatus scorpion toxins by E. Kalapothakis, C. R. Diniz and immunization of mice with a non-toxic protein C. Chavez-Olortegui .. Debont, A. Swerts, J. J. Van der Walt. Comparison and characterization of the venoms of three Parabuthus G. J. Miiller, F . Verdonck, P. Daenens scorpion species occurring in Southern Africa and J. Tytgat E. Cohen and G. B. Quistad Cytotoxic effects of arthropod venoms on various cultured cells P. Saborio, M. Gonzalez and M. Cambronero Accidente ofidico en ninos en Costa Rica: epidemiologia y deteccion de factores de riesgo en el desarrollo de absceso y necrosis L. D. Rash, R. G. King and W. € Hodgson Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffrovi) W. W. Decker, G. M. Bogdan, R. A. Garcia, Heat and motion stability of polyvalent Crotalidae antivenin, ovine P. Wollen and R. C. Dart Fab Y. F. Pouchus, S. Dauvergne, D. Morel, Combined use of analytical high-performance liquid chromatography F. Mondeguer, C. Marcaillou-Lebaut, and cell morphology transformation assay to detect new protein Z. Amzil and J.-F. Verbist phosphatase inhibitors of okadaic acid type List of Contents D. V. Tambourgi, V. I Petricevich, 39] Endotoxemic-like shock induced by Loxosceles spider venoms F. C. Magnoli, S. L. M R. Assaf, S. Jancat pathological changes and putative cytokine mediators and W. Dias Da Silva Short Communications M. Lopes-Ferreira, K. C Barbaro, Thalassophryne nattereri fish venom: biological and biochemical D. F. Cardoso, characterization and serum neutralization of its toxic activities A. M. Moura-Da-Silva and I. Mota Michael Gochfeld and Joanna Burger Apparent paralytic shellfish poisoning in captive herring gulls fed commercial scallops J. McElhiney, L. A. Lawton, C. Edwards and Development of a bioassay employing the desert locust (Schistocerca S. Gallacher gregaria) for the detection of saxitoxin and related compounds in cyanobacteria and shellfish lr. Omori-Satoh, M. Takahashi, Y. Nagaoka Comparison of antihemorrhagic activities in skeletal muscle extracts and D. Mebs from various animals against Bothrops jararaca snake venom Bibliography of Toxinology International Society on Toxinology Membership Application Vol. 36, No. 3 B. J. Hawgooc Historical Review—Hugh Alistair Reid OBI MD: Investigation and treatment of snake bite K. Mizuno, N. Nakahata and Y. Ohizumi Characterization of mastoparan-induced histamine release from RBL-2H3 cells Rong Gao, Yun Zhang, Qing-Xiong Meng. Characterization of three fibrinogenolytic enzymes from Chinese green Wen-Hui Lee, Dong-Sheng Li, tree viper ( Trimeresurus stejnegeri) venom Yu-Liang Xiong and Wan-Yu Wang H. E. Khoo, D. Chen and R. Yuen Role of free thiol groups in the biological activities of stonustoxin, a lethal factor from stonefish (Synanceja horrida) venom M. V. Ramos, D. M. Mota, C. R Teixeira, Isolation and partial characterisation of highly toxic lectins from Abrus B. S. Cavada and R. A. Moreira pul hellus seeds M.S. Palma, Y Itagaki, 7 Fujita, Structural characterization of a new acylpolyaminetoxin from the H. Naoki and 7 Nakajima venom of Brazilian garden spider Nephilengys cruentata Win-Aung, Sein-Sein-May, Effects of Russell’s viper venom on renal lysosomal functions in Aung-Myat-Kyaw. Baby-Hla and Aye-Kyaw experimental mice A. M. Soares, V. M. Rodrigues, A rapid procedure for the isolation of the Lys-49 myotoxin II from M. I. Homsi-Brandeburgo, M. H. Toyama, Bothrops moojeni (caissaca) venom: biochemical characterization, F. R. Lonibardi, R. K. Arni and J. R. Giglio crystallization, myotoxic and edematogenic activity C.-Y. Chen and H.-N. Chou Transmission of the paralytic shellfish poisoning tOXINS, from dinoflagellate to gastropod A. J. Fatani, B. L. Furman and I. J Zeitlin The involvement of plasma kinins in the cardiovascular effects of Leiurus quinquestriatus scorpion venom in anaesthetised rabbits M. L. Merchant, J F. Hinton Sphingomyelinase D activity of brown recluse spider (Loxosceles and C. R. Geren reclusa) venom as studied by “'P-NMR: effects on the time-course of sphingomyelin hydrolysis Short Communication F. Canduri, L. C. Mancuso, Crystallization of piratoxin I, a myotoxic Lys49-phospholipase A> A. M. Soares, J. R. Giglio, homologue isolated from the venom of Bothrops pirajai R. J. Ward and R. K. Arni Reviews Bibliography of Toxinology VI List of Contents Announcement International Society on Toxinology Membership Application Vo3l6, .No. 4 C. Chavez-Olortegui, V. C. Zanetti ELISA for the detection of venom antigens in experimental and A. P. Ferreira, J. C. Minozzo, clinical envenoming by Lovxosceles intermedia spiders O. C. Mangili and I. C. Gubert B. J. Benton, S. A. Keller, D. | Spriggs, Recovery from the lethal effects of saxitoxin: a therapeutic window for B. R. Capacianod F.-C. T. Chang 4-aminopyridine (4-AP) K. Shiomi, A. Kazama, K. Shimakura and Purification and properties of phospholipases A, from the crown-of- Y. Nagashima thorns starfish (Acanthaster planci) venom M. Alzahaby, A. | Harvey. L. ¢ Young 60 | Purification of a 5-HT uptake inhibitor from the venom of Cerastes G. Faure and E. G Rowan vipera Chewn-Lang Ho, Wan-Chen Chen and 609 Structures and biological activities of new wasp venom peptides Yah-Luen Lin isolated from the black-bellied hornet (Vespa basalis) venom H. Heatwole and J. Powell Resistance of eels (Gvmmothorax) to the venom of sea kraits (Laticauda colubrina): a test of coevolution L. Zaman, O Arakawa, A. Shimosu. Occurrence of a methyl derivative of saxitoxin§ in Bangladeshi Y. Shida and Y Onoue freshwater puffers S. A. Seyedroudbari and M. M. Khan In vitro effects of smokeless tobacco extract on tumor necrosis factor-x (TNF-x) and interleukin-1/ (IL-1) production, and on lymphocyte proliferation L. M.S. Rudrammayji and T. V Gowda Isolation and = characterization of an endogenous inhibitor of phospholipase A, from Indian cobra (Naja naja naja) venom P. Breton, J.-C. Bizot, J Buee and Brain neurotoxicity of Penitrem A electrophysiological, behavioral 1. De La Manche and histopathological study A. K. Mukherjee, S. K. Ghosal and C. Maity Effect of oral supplementation of vitamin I on the hemolysis and erythrocyte phospholipid-splitting action of cobra and viper venoms M. R. Popoff Interactions between bacterial toxins and intestinal cells Short Communication M. Nakamura. K. Kinjoh, K. Hanashiro Inhibitory effect of habu antivenom on fibrinopeptide A_ release M. Sunagawa, Y. Tokeshi, 1 Ueda and induced by 7rimeresurus flavoviridis crude venom I. Kosugi Bibliography of Toxinology International Society on Toxinology Membership Application Vo3l6, .No. 5 E. Beer and F. Putorti 697 Dysphonia, an uncommon symptom of systemic neurotoxic enveno- mation by Vipera aspis bite. Report of two cases R. E. Sheridan Gating and permeability of ion channels produced by botulinum toxin types A and E in PC12 cell membranes L. Anderson, B. Bussler, H. Martins and Enkephalin-processing oligopeptidases in cobra venom: inhibition by M. Dufton thiorphan and bestatin reveals co-operative actions E. Beer and R. Musiani \ case of intestinal infarction following Vipera aspis bite List of Contents Vil Xiu-Hai Ren, Jian Zhao, Lu Pu, Differential neurotoxicity of etorphine-like opiates: lack of correlation Kun Ling, De-Ling Yin and Gang Pei with their ability to activate opiate receptors A. Lobo de Araujo, J. L. Donato and C. Bon Purification from Bothrops lanceolatus (fer de lance) venom of a fibrino(geno)lyuc enzyme with esterolytic activity I. Olamendi-Portugal, F. Gomez-Lagunas, [wo similar peptides from the venom of the scorpion Pandinus G. B. Gurrola and L. D. Possani imperator, one highly effective blocker and the other inactive on K channels R. S. de Moura, A. S. Aguiar, Pharmacological aspects of mouse hind-paw oedema induced by A.R. Melgarejo and L. C. R. M. de Carvalho Lachesis muta rhombeata venom Hitoshi Miyagi, Ko-Ichi Kato and Purification of haemorrhagic proteinase from the venom of Hidenobu Takahashi {ekistrodon caliginosus (Kankoku-Mamushi) Short Communications B. J. Hopkins and W. C. Hodgson Enzyme and biochemical studies of stonefish (Syvnanceja trachynis) and soldierfish (Gyvmnapistes marmoratus) venoms K. Shiomi. M. Ishii, K. Shimakura ligloylcholine: a new choline ester toxin from the hypobranchial gland Y. Nagashima and M. Chino of two species of muricid gastropods (Thais clavigera and Thais bronni) Shin-Jung Lin. Yung-Hsiang Tsai. Paralytic toxins in Taiwanese starfish As/ropecten scoparius Hsi-Pin Lin and Deng-Fwu Hwang C. F. S. Amaral, D. Campolina, M. B. Dias. Tourniquet ineffectiveness to reduce the severity of envenoming after C. M. Bueno and N. A. Rezende Crotalus durissus snake bite in Belo Horizonte, Minas Gerais, Brazil N. Pakmanee, O. Khow, W. Kumsap. Envenomation of mice by Thai cobra ( Naja kaouthia) venom: tolerable I. Omori-Satoh, L. Chanhome, S. Sriprapat venom concentration and exposure time and V. Sitprija I. K. Monsees, U. Winterstein, W.-B. Schill Influence of r gossypol on the secretory function of cultured rat sertoli and W. Miska cells Bibliography of Toxinology International Society on Toxinology Membership Application Vol. 36, No. 6 J.-P. Chippaux and M. Goyffon {rticle—Venoms, antivenoms and immunotherapy G. M. de Plater, R. L. Martin and The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus P. J. Milburn anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release Thomson, J. M. Al-Hassan, S. Fayad, Purification of a toxic factor from Arabian Gulf catfish epidermal Al-Saleh and M. Ali secretions I. Y. Shemesh, C. Kristal, L. Langerman and Preliminary evaluation of Vipera palaestinae snake bite treatment in \. Bourvin accordance to the severity of the clinical syndrome Haiyan Zhao, Liang Tang, Xiaoqiang Wang, Structure of a snake venom phospholipase A, modified by p-bromo- Yuancong Zhou and Zhengjiong Lin phenacyl-bromide M.N. Krifi. H. Kharrat, K. Zghal, Development of an ELISA for the detection of scorpion venoms in M. Abdouli, F. Abroug, S. Bouchoucha, sera of humans envenomed by Androctonus australis garzonii (Aag) K. Dellagi and M. El Ayeb and Buthus occitanus tunetanus (Bot): correlation with clinical severity of envenoming in Tunisia R. H. Valente, J. C. Novello, S. Marangoni, Mitochondrial swelling and oxygen consumption during respiratory B. Oliveira, L. Pereira-da-Silva and state 4 induced by phospholipase A, isoforms isolated from the South D. V. Macedo American rattlesnake (Crotalus durissus terrificus) venom Vill List of Contents I. Nobuhisa, T. Ogawa. M. Deshimaru, Retrotransposable CR1-like elements in crotalinae snake genomes I. Chijiwa, K.-l. Nakashima, Y. Chuman, Y. Shimohigashi, Y. Fukumaki, S. Hattori and M. Ohno L. M. S. Rudrammayji and T. V. Gowda 9? 1 Purification and characterization of three acidic, CYLOLOXIC phospholipases A from Indian cobra (Naja naja naja) venom A. Allavena, G. L. Mariottini, A. M. Carli. In vitro evaluation of the cytotoxic, hemolytic and clastogenic activities S. Contini and A. Martelli of Rhizostoma pulmo toxin(s) Short Communications K. Sepcic., T. Turk and P. Macek Anticholinesterase activity of the fluorescent zoanthid pigment, parazoanthoxanthin A M. Gallacci, E. C. Nunes, I G. Moreira. Reduction of crotoxin-induced neuromuscular blockade by gamma N. Nascimento, J. R Rogero and radiation V.S. Vassiliefl Bibliography of Toxinology International Society on Toxinology Membership Application Erratum Vol. 36, No. 7 R. M. Dawson 953 Review Article— The toxicology of microcystins A. Tarasiuk, S. Khvatskin and S. Sofet 963 Effects of antivenom serotherapy on hemodynamic pathophysiology in dogs injected with L. quinguestriatus scorpion venom B. J. Hopkins and W. C. Hodgson Cardiovascular studies on venom from the soldierfish (Gymnapistes marmoraus) P. G. Sells, P. loannou and A humane alternative to the measurement of the lethal effects (LDs_) of R. D. G. Theakston non-neurotoxic venoms using hens’ eggs M. Sugiki, E. Yoshida, K. Anai and Activation of single-chain urokinase-type plasminogen activator by a M. Maruyama hemorrhagic metalloproteinase, jararafibrase I, in Bothrops jararaca venom A. Naka. T. lida, 1 Ohara, K. Yamamoto, Nicking sites in a subunit of cholera toxin and Escherichia coli heat- T. Miwatani and T Honda labile enterotoxin for Vibrio cholerae hemagglutinin, protease C. C. Morini, E. C. L. Pereira, Injury and recovery of fast and slow skeletal muscle fibers affected by H. S. Selistre de Araujo, C. I Ownby and ACL myotoxin isolated from {ekistrodon contortrix laticinctus lr. F. Salvini (Broad-Banded Copperhead) venom A. R. de Roodt, J. A. Dolab. 7 Fernandez. Cross-reactivity and heterologous neutralization of crotaline anti- L. Segre and S. E. Hajos venoms used in Argentina L. Feitosa, W. Gremski, S. S. Veiga, Detection and characterization of metalloproteinases with gelatinoly- M. C. Q. B. Elias, E. Graner, tic. fibronectinolytic and fibrinogenolytic activities in Brown spider O. C. Mangili and R. R. Brentani (Loxosceles intermedia) venom Short Communications F. M. Y. Fung and J. L. Ding 1053 \ novel antitumour compound from the mucus of a coral, Galaxea fascicularis, inhibits topoisomerase | and II M. B. Smolka, S. Marangoni, B. Oliveira 1059 Purification and partial characterization of a thrombin-like enzyme. J. C. Novello balterobin, from the venom of Bothrops alternatus Bibliography of Toxinology 1065 Announcement 1071 International Society on Toxinology I Membership Application List of Contents Vo3l6, .No. 8 Ee. Russell In memory of Robert Endean D.A Bloom, J. W. Burnett and P. Alderslade Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside H.-H. Chang and S. J. Lo Full-spreading platelets induced by the recombinant rhodostomin are via binding to integrins and correlated with FAK phosphorylation Fladmark, M. H Serres, N. L. Larsen, Sensitive detection of apoptogenic toxins in suspension cultures of rat Yasumoto, T. Aune and S. O Doskeland and salmon hepatocytes Hisada, T. Fujita, H. Naoki, Y. Itagaki, Structures of spider toxins: hydroxyindole-3-acetylpolyamines and a Irie, M. Miyashita and T. Nakajima new generalized structure of type-I compounds obtained from the venom of the Joro spider, Nephila clavata K. Ana, M. Sugiki, [ Yoshida and Inhibition of a snake venom hemorrhagic metalloproteinase by human M. Maruyama and rat z-macroglobulins P. Sautiere, S. Cestele, C. Kopeyan, New toxins acting on sodium channels from the scorpion Leiurius \. Martinage, H. Drobeeq, Y. Doljansky quinguestriatus hebraeus suggest a clue to mammalian vs_ insect and D. Gordon selectivity fH. Pan, AL: Liv, L-] Ou-Yang. Diversity of cDNAs encoding phospholipase A, from tekistrodon G.-Z. Yang. Y.-C Zhou, Z.-P. Li and halvs Pallas venom, and its expression in / coli X.-F. Wu O. C. A. de Perez, P. Koscinezuk,. P. Teibler. Actividades hemorragica y edematizante y alteraciones histologicas en M. S. Negrette, R. Ruiz, S. Marunak y almohadilla plantar del raton inducidas por venenos de serpientes de G. Bogarin los generos Bothrops y Crotalus de Argentina I Nucaro, M. Jodra, | Russell, Conversion of tyrosine to phenolic derivatives by Taiwan cobra venom L. Anderson, P. Dennison ind M. Dufton Short Communications J. R. Moura, M. A. M. Prado, M. V. Gomez. Investigation of the effect of PhTx2, from the venom of the spider E. Kalapothakis, C. R. Diniz, M. N. Cordeiro Phoneutria nigriventer, on the release of [°H]-acetylcholine from rat and M. A. Romano-Silva al Lawrence, A. D. Cembella, N. W. Ross 1193 Cross-reactivity of an anti-okadaie acid antibody to dinophysistoxin-4 and J. i. € Wright (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid diol ester Conference Report 1197 Bibliography of Toxinology 1203 International Society on Toxinology Membership Application Vo3l6, .No. 9 1209 Announcement Redi Award presented to Dr Evert Karlsson 12th World Congress on Animal, Plant and Microbial Toxins B.D Possani 1211 Introduction 1215 Abstracts of Plenary Lectures Abstracts from Symposia Abstracts of Oral Communications Abstracts of Poster Presentations Biblioggrraappnhyy) of Toxinologyg\ International Society on Toxinology Membership Application List of Contents Vol. 36, No. 10 J. C. Cogo, J. Prado-Franceschi, J. R. Giglio, An unusual presynaptic action of Bothrops insularis snake venom A. P. Corrado, M. A. Cruz-H6fling. mediated by phospholipase A> fraction J. L. Donato, G. B. Leite and L. Rodrigues-Simion! D. Mebs, K. Holada, F. Kornalik, J. Simak, Severe coagulopathy after a bite of a green bush viper (Atheris H. Vankova, D. Miller, H. Schoenemann, squamiger): case report and biochemical analysis of the venom H. Lange and H.-W. Herrmann C. J. Gordon, Ying Yang and J. S. Ramsdell Behavioral thermoregulatory response to maitotoxin in mice A.C. Mattiello-Sverzut, M. D. Fontana, Pathological changes induced by PhTx1! from Phoneutria nigriventer C. R. Diniz and M. A. da Cruz-H6fling spider venom in mouse skeletal muscle i vitro L. G. D. Heneine, A. D. de Carvalho Jr.. Development of an ELISA to assess the potency of horse therapeutic C. F. Barbosa and M. R. Aravjo dos Santos polyvalent antibothropic antivenom B. S. Cheun, M. Loughran, T. Hayashi, Use of a channel biosensor for the assay of paralytic shellfish toxins Y. Nagashima and E. Watanabe I. F. Pazos, C. Alvarez, M. E. Lanio, Modification of sticholysin I] hemolytic activity by free radicals D. Martinez. V. Morera, E. A. Lissi and A. M. Campos W. F. De Azevedo Jr... R. J. Ward, Crystal structure of piratoxin-l: a calcium-independent, myotoxic F. Canduri, A. Soares, J. R. Giglio and phospholipase Aj-homologue from Bothrops pirajai venom R. K. Arni J. Prado-Franceschi, S. Hyslop. J. C. Cogo. Characterization of a myotoxin from the Duvernoy’s gland secretion A. L. Andrade. M. T. Assakura,. A. P. Reichl. of the xenodontine colubrid Philodryvas olfersii (green snake): effects on M. A. Cruz-H6fling and striated muscle and the neuromuscular junction L. Rodrigues-Simioni M. 1. Alam and A. Gomes Adjuvant effects and antiserum action potentiation by a (herbal) compound 2-hydroxy-4-methoxy benzoic acid isolated from the root extract of the Indian medicinal plant ‘sarsaparilla’ (/7emidesmus indicus R. Br.) W.S. Maria, M. O. Cambuy, J. O. Costa, Neutralizing potency of horse antibothropic antivenom. Correlation D. T. Velarde and C. Chavez-Olortegui between in vivo and in vitro methods A.M. C. Martins, H. S. A. Monteiro. Effects of Crotalus durissus cascavella venom in the isolated rat kidney E. O. G. Junior, D. B. Menezes and M. C. Fonteles E. E. Sanchez, C. Garcia, J. C. Pérez and The detection of hemorrhagic proteins in snake venoms using S. J: De La Zerda monoclonal antibodies against Virginia opossum (Didelphis virginiana) serum Review Bibliography of Toxinology International Society on Toxinology Membership Application Vol. 36, No. 11 Special Issue: Highlights in Toxin Research Based on presentations at the /2th World Congress on Animal, Plant and Microbial Toxins (held in Cuernavaca, Mexico, September 1997) \. Harvey Introduction

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