Table Of Content

Toxicology Letters Toxicology Letters 149 (2004) IX—XI www.elsevier.com/locate/toxlet Volume contents Volume 149 (2004) Proceedings of EUROTOX 2003 Preface The Gerhard Zbinden memorial lecture DNA and protein adducts as markers of genotoxicity P.B. Farmer (UK) Key note lecture Chemical weapons: documented use and compounds on the horizon C. Bismuth, S.W. Borron, F.J. Baud and P. Barriot (France, USA) Mechanisms of Toxicity Mitochondrial regulation of apoptotic cell death S. Orrenius (Sweden) Role of apoptosis for mouse liver growth regulation and tumor promotion: comparative analysis of mice with high (C3H/He) and low (C57B1/6J) cancer susceptibility W. Bursch, B. Grasl-Kraupp, U. Wastl, K. Hufnagl, M. Chabicovsky, H. Taper and R. Schulte-Hermann (Austria) Regulation of apoptosis by peroxisome proliferators R.A. Roberts, C. Michel, B. Coyle, C. Freathy, K. Cain and E. Boitier (France, UK) Tumor promoters as inhibitors of apoptosis in rat hepatocytes D. Schrenk, H.-J. Schmitz, S. Bohnenberger, B. Wagner and W. Worner (Germany) Perturbation of epigenetic status by toxicants V. Bombail, J.G. Moggs and G. Orphanides (UK) Neural stem cells and cell death S. Ceccatelli, C. Tamm, E. Sleeper and S. Orrenius (Sweden) Signal transduction mechanisms involved in the antiproliferative effects of ethanol in glial cells L.G. Costa, A. Vitalone and M. Guizzetti (USA, Italy) Nitric oxide-dependent and independent down-regulation of NO-sensitive guanylyl cyclase in neural cells T. Sardon, M.A. Baltrons and A. Garcia (Spain) Cytokines role in neurodegenerative events B. Viviani, S. Bartesaghi, E. Corsini, C.L. Galli and M. Marinovich (Italy) Different mechanism of blockade of neuroexocytosis by presynaptic neurotoxins O. Rossetto, M. Rigoni and C. Montecucco (Italy) Immunotoxicology Importance of immunotoxicity in safety assessment: a medical toxicologist’s perspective J. Descotes (France) Sensitivity and predictivity in immunotoxicity testing: immune endpoints and disease resistance D.R. Germolec (USA) Adequate immunotoxicity testing in drug development D.J. Herzyk and E.R. Gore (USA) Validation of immune function testing during a 4-week oral toxicity study with FK506 P. Ulrich, G. Paul, E. Perentes, A. Mahi and D. Roman (Switzerland) doi: 10.1016/S0378-4274(04)00143-2 xX Volume contents Determination of the effect of calcineurin inhibitors on the rat’s immune system after KLH immunisation D. Roman, P. Ulrich, G. Paul, M. Court, P. Vit, J. Kehren and A. Mahl (Switzerland) Immunotoxicological consequences of perinatal chemical exposures H. Van Loveren and A. Piersma (The Netherlands) Validation of alternative methods for developmental toxicity testing A.H. Piersma (The Netherlands) Alterations in the immune system of children from mothers treated with immunosuppressive agents during pregnancy R. Cimaz, E. Meregalli, M. Biggioggero, O. Borghi, A. Tincani, M. Motta, P. Aird and P.L. Meroni (Italy) Food Toxicology Risk characterisation of chemicals in food A.G. Renwick (UK) Human health risk assessment of processing-related compounds in food A.M. Tritscher (Switzerland) Criteria for risk assessment of botanical food supplements R. Walker (UK) Safety evaluation of natural flavour complexes R.L. Smith, T.B. Adams, S.M. Cohen, J. Doull, V.J. Feron, J.1. Goodman, R.L. Hall, L.J. Marnett, P.S. Portoghese, W.J. Waddell and B.M. Wagner (UK, USA, The Netherlands) Issues and challenges in the safety evaluation of food flavors T.B. Adams and R.L. Smith (USA, UK) Novel estimates of the exposure to flavouring substances P. Cadby (Switzerland) Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents A.G. Renwick (UK) Environmental Toxicology Fine particles and human health—a review of epidemiological studies N. Englert (Germany) Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects A. Nemmar, M.F. Hoylaerts, P.H.M. Hoet and B. Nemery (Belgium) Effect of coal mine dust and clay extracts on the biological activity of the quartz surface V. Stone, R. Jones, K. Rollo, R. Duffin, K. Donaldson and D.M. Brown (UK, Germany) A molecular epidemiological approach to health risk assessment of urban air pollution P. Hrelia, F. Maffei, S. Angelini and G. Cantelli Forti (Italy) Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke P. Georgiadis, N.A. Demopoulos, J. Topinka, G. Stephanou, M. Stoikidou, M. Bekyrou, K. Katsouyianni, R. Sram, H. Autrup and S.A. Kyrtopoulos (Greece, Czech Republic, Denmark) Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children N. Weisglas-Kuperus, H.J.I. Vreugdenhil and P.G.H. Mulder (The Netherlands) Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy A. Baccarelli, A.C. Pesatori, S.A. Masten, D.G. Patterson Jr., L.L. Needham, P. Mocarelli, N.E. Caporaso, D. Consonni, J.A. Grassman, P.A. Bertazzi and M.T. Landi (USA, Italy) Risk factors of jet fuel combustion products I. Tesseraux (Germany) Local and systemic toxicity of JP-8 from cutaneous exposures J.N. McDougal and J.V. Rogers (USA) New Methadological approaches in the evaluation of toxicity and human exposure to chemicals Cytogenetic biomarkers and genetic polymorphisms H. Norppa (Finland) Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens R.J. Sram, O. Beskid, B. Binkova, P. Rossner and Z. Smerhovsky (Czech Republic) Chromosomal aberrations and in vitro radiosensitivity: intra-individual versus inter-individual variability A. Vral, H. Thierens, A. Baeyens and L. De Ridder (Belgium) Volume contents Biological monitoring in occupational exposure to low levels of 1,3-butadiene S. Fustinoni, L. Perbellini, L. Soleo, M. Manno and V. Foa (Italy) Embryonic stem cell-derived cardiac, neuronal and pancreatic cells as model systems to study toxicological effects A. Rolletschek, P. Blyszczuk and A.M. Wobus (Germany) Progress in applying genomics in drug development P.G. Lord (USA) Application of proteomic technologies in the drug development process J.L. Walgren and D.C. Thompson (USA) The validation of in vitro methods for skin irritation P.A. Botham (UK) Risk assessment: Principles and applications The public and effective risk communication L. Frewer (The Netherlands) Effective risk communication practice W. Leiss (Canada) Perception of risks O. Renn (Germany) Analysis of thresholds for carcinogenicity W.J. Waddell (USA) ECCO peer review—development since 1996 and future prospects D.J. Flynn and J.R. Lundehn (UK, Germany) The accession countries benefit in the field of plant protection products A. Stanek (Czech Republic) Mediterranean countries impact on the implementation of Council Directive 91/414/EEC K. Machera and K. Markakis (Greece) Instructions to authors Author index Subject index Volume contents