Table Of Content

Toxicology Letters Toxicology Letters 149 (2004) I-III www.elsevier.com/locate/toxlet Author index Volume 149 (2004) Adams, T.B., R.L. Smith, Issues and challenges in the safety Cain, K., see Roberts, R.A. 149, 37 evaluation of food flavors 149, 209 Cantelli Forti, G., see Hrelia, P. 149, 261 Adams, T.B., see Smith, R.L. 149, 197 Caporaso, N.E., see Baccarelli, A. 149, 287 Airo, P., see Cimaz, R. 149, 155 Ceccatelli, S., C. Tamm, E. Sleeper, S. Orrenius, Neural stem cells Angelini, S., see Hrelia, P. 149, 261 and cell death 149, 59 Autrup, H., see Georgiadis, P. 149, 269 Chabicovsky, M., see Bursch, W. 149, 25 Cimaz, R., E. Meregalli, M. Biggioggero, O. Borghi, A. Tincani, Baccarelli, A., A.C. Pesatori, S.A. Masten, D.G. Patterson Jr., L.L. M. Motta, P. Aird, P.L. Meroni, Alterations in the immune system Needham, P. Mocarelli, N.E. Caporaso, D. Consonni, J.A. Grass- of children from mothers treated with immunosuppressive agents man, P.A. Bertazzi, M.T. Landi, Aryl-hydrocarbon receptor- during pregnancy 149, 155 dependent pathway and toxic effects of TCDD in humans: a Cohen, S.M., see Smith, R.L. 149, 197 population-based study in Seveso, Italy 149, 287 Consonni, D., see Baccarelli, A. 149, 287 Baeyens, A., see Vral, A. 149, 345 Corsini, E., see Viviani, B. 149, 85 Baltrons, M.A., see Sard6n, T. 149, 75 Costa, L.G., A. Vitalone, M. Guizzetti, Signal transduction mechan- Barriot, P., see Bismuth, C. 149, 11 isms involved in the antiproliferative effects of ethanol in glial Bartesaghi, S., see Viviani, B. 149, 85 cells 149, 67 Baud, F.J., see Bismuth, C. 149, 11 Court, M., see Roman, D. 149, 133 Bekyrou, M., see Georgiadis, P. 149, 269 Coyle, B., see Roberts, R.A. 149, 37 Bertazzi, P.A., see Baccarelli, A. 149, 287 Beskid, O., see Sram, R.J. 149, 335 De Ridder, L., see Vral, A. 149, 345 Biggioggero, M., see Cimaz, R. 149, 155 Demopoulos, N.A., see Georgiadis, P. 149, 269 Binkova, B., see Sram, R.J. 149, 335 Descotes, J., Importance of immunotoxicity in safety assessment: a Bismuth, C., S.W. Borron, F.J. Baud, P. Barriot, Chemical weapons: medical toxicologist’s perspective 149, 103 documented use and compounds on the horizon 149, 11 Donaldson, K., see Stone, V. 149, 255 Blyszczuk, P., see Rolletschek, A. 149, 361 Doull, J., see Smith, R.L. 149, 197 Bohnenberger, S., see Schrenk, D. 149, 43 Duffin, R., see Stone, V. 149, 255 Boitier, E., see Roberts, R.A. 149, 37 Bombail, V., J.G. Moggs, G. Orphanides, Perturbation of epigenetic Englert, N., Fine particles and human health—a review of epide- status by toxicants 149, 51 miological studies 149, 235 Borghi, O., see Cimaz, R. 149, 155 Borron, S.W., see Bismuth, C. 149, 11 Botham, P.A., The validation of in vitro methods for skin irrita- Farmer, P.B., DNA and protein adducts as markers of genotoxi- tion 149, 387 city 149, 3 Brown, D.M., see Stone, V. 149, 255 Feron, V.J., see Smith, R.L. 149, 197 Bursch, W., B. Grasl-Kraupp, U. Wastl, K. Hufnagl, M. Chabicov- Flynn, D.J., J.R. Lundehn, ECCO peer review—development since sky, H. Taper, R. Schulte-Hermann, Role of apoptosis for mouse 1996 and future prospects 149, 421 liver growth regulation and tumor promotion: comparative ana- Foa, V., see Fustinoni, S. 149, 353 lysis of mice with high (C3H/He) and low (C57BI/6J) cancer Freathy, C., see Roberts, R.A. 149, 37 susceptibility 149, 25 Frewer, L., The public and effective risk communication 149, 391 Fustinoni, S., L. Perbellini, L. Soleo, M. Manno, V. Foa, Biological Cadby, P., Novel estimates of the exposure to flavouring sub- monitoring in occupational exposure to low levels of 1,3-buta- stances 149, 215 diene 149, 353 doi: 10.1016/S0378-4274(04)00141-9 II Author index of volume 149 Galli, C.L., see Viviani, B. 149, 85 Mulder, P.G.H., see Weisglas-Kuperus, N. 149, 281 Garcia, A., see Sardén, T. 149, 75 Georgiadis, P., N.A. Demopoulos, J. Topinka, G. Stephanou, Needham, L.L., see Baccarelli, A. 149, 287 M. Stoikidou, M. Bekyrou, K. Katsouyianni, R. Sram, H. Autrup, Nemery, B., see Nemmar, A. 149, 243 S.A. Kyrtopoulos, Impact of phase I or phase II enzyme poly- Nemmar, A., M.F. Hoylaerts, P.H.M. Hoet, B. Nemery, Possible morphisms on lymphocyte DNA adducts in subjects exposed to mechanisms of the cardiovascular effects of inhaled particles: urban air pollution and environmental tobacco smoke 149, 269 systemic translocation and prothrombotic effects 149, 243 Germolec, D.R., Sensitivity and predictivity in immunotoxicity Norppa, H., Cytogenetic biomarkers and genetic polymorph- testing: immune endpoints and disease resistance 149, 109 isms 149, 309 Goodman, J.I., see Smith, R.L. 149, 197 Gore, E.R., see Herzyk, DJ. 149, 115 Orphanides, G., see Bombail, V. 149, 51 Grasl-Kraupp, B., see Bursch, W. 149, 25 Orrenius, S., Mitochondrial regulation of apoptotic cell death 149, Grassman, J.A., see Baccarelli, A. 149, 287 19 Guizzetti, M., see Costa, L.G. 149, 67 Orrenius, S., see Ceccatelli, S. 149, 59 Hall, R.L., see Smith, R.L. 149, 197 Patterson Jr., D.G., see Baccarelli, A. 149, 287 Herzyk, D.J., E.R. Gore, Adequate immunotoxicity testing in drug Paul, G., see Roman, D. 149, 133 development 149, 115 Paul, G., see Ulrich, P. 149, 123 Hoet, P.H.M., see Nemmar, A. 149, 243 Perbellini, L., see Fustinoni, S. 149, 353 Hoylaerts, M.F., see Nemmar, A. 149, 243 Perentes, E., see Ulrich, P. 149, 123 Hrelia, P., F. Maffei, S. Angelini, G. Cantelli Forti, A molecular Pesatori, A.C., see Baccarelli, A. 149, 287 epidemiological approach to health risk assessment of urban air Piersma, A., see Van Loveren, H. 149, 141 pollution 149, 261 Piersma, A.H., Validation of alternative methods for developmental Hufnagl, K., see Bursch, W. 149, 25 toxicity testing 149, 147 Portoghese, P.S., see Smith, R.L. 149, 197 Jones, R., see Stone, V. 149, 255 Renn, O., Perception of risks 149, 405 Katsouyianni, K., see Georgiadis, P. 149, 269 Renwick, A.G., Risk characterisation of chemicals in food 149, Kehren, J., see Roman, D. 149, 133 163 Kyrtopoulos, S.A., see Georgiadis, P. 149, 269 Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of Landi, M.T., see Baccarelli, A. 149, 287 flavouring agents 149, 223 Leiss, W., Effective risk communication practice 149, 399 Rigoni, M., see Rossetto, O. 149, 91 Lord, P.G., Progress in applying genomics in drug develop- Roberts, R.A., C. Michel, B. Coyle, C. Freathy, K. Cain, E. Boitier, ment 149, 371 Regulation of apoptosis by peroxisome proliferators 149, 37 Lundehn, J.R., see Flynn, D.J. 149, 421 Rogers, J.V., see McDougal, J.N. 149, 301 Rolletschek, A., P. Blyszczuk, A.M. Wobus, Embryonic stem cell- Machera, K., K. Markakis, Mediterranean countries impact on the derived cardiac, neuronal and pancreatic cells as model systems to implementation of Council Directive 91/414/EEC 149, 433 study toxicological effects 149, 361 Maffei, F., see Hrelia, P. 149, 261 Rollo, K., see Stone, V. 149, 255 Mahl, A., see Roman, D. 149, 133 Roman, D., P. Ulrich, G. Paul, M. Court, P. Vit, J. Kehren, A. Mahl, Mahl, A., see Ulrich, P. 149, 123 Determination of the effect of calcineurin inhibitors on the rat’s Manno, M., see Fustinoni, S. 149, 353 immune system after KLH immunisation 149, 133 Marinovich, M., see Viviani, B. 149, 85 Roman, D., see Ulrich, P. 149, 123 Marinovich, M., Preface 149, 1 Rossetto, O., M. Rigoni, C. Montecucco, Different mechanism of Markakis, K., see Machera, K. 149, 433 blockade of neuroexocytosis by presynaptic neurotoxins 149, Marnett, L.J., see Smith, R.L. 149, 197 91 Masten, S.A., see Baccarelli, A. 149, 287 Rossner, P., see Sram, R.J. 149, 335 McDougal, J.N., J.V. Rogers, Local and systemic toxicity of JP-8 from cutaneous exposures 149, 301 Sardon, T., M.A. Baltrons, A. Garcia, Nitric oxide-dependent and Meregalli, E., see Cimaz, R. 149, 155 independent down-regulation of NO-sensitive guanylyl cyclase in Meroni, P.L., see Cimaz, R. 149, 155 neural cells 149, 75 Michel, C., see Roberts, R.A. 149, 37 Schmitz, H.-J., see Schrenk, D. 149, 43 Mocarelli, P., see Baccarelli, A. 149, 287 Schrenk, D., H.-J. Schmitz, S. Bohnenberger, B. Wagner, Moggs, J.G., see Bombail, V. 149, 51 W. Worner, Tumor promoters as inhibitors of apoptosis in rat Montecucco, C., see Rossetto, O. 149, 91 hepatocytes 149, 43 Motta, M., see Cimaz, R. 149, 155 Schulte-Hermann, R., see Bursch, W. 149, 25 Author index of volume 149 Il Sleeper, E., see Ceccatelli, S. 149, 59 Ulrich, P., G. Paul, E. Perentes, A. Mahl, D. Roman, Validation of Smerhovsky, Z., see Sram, R.J. 149, 335 immune function testing during a 4-week oral toxicity study with Smith, R.L., see Adams, T.B. 149, 209 FKS506 149, 123 Smith, R.L., T.B. Adams, S.M. Cohen, J. Doull, V.J. Feron, Ulrich, P., see Roman, D. 149, 133 J... Goodman, R.L. Hall, L.J. Marnett, P.S. Portoghese, W.J. Waddell, B.M. Wagner, Safety evaluation of natural flavour Van Loveren, H., A. Piersma, Immunotoxicological consequences of complexes 149, 197 perinatal chemical exposures 149, 141 Soleo, L., see Fustinoni, S. 149, 353 Vit, P., see Roman, D. 149, 133 Sram, R., see Georgiadis, P. 149, 269 Vitalone, A., see Costa, L.G. 149, 67 Sram, R.J., O. Beskid, B. Binkova, P. Rossner, Z. Smerhovsky, Viviani, B., S. Bartesaghi, E. Corsini, C.L. Galli, M. Marinovich, Cytogenetic analysis using fluorescence in situ hybridization Cytokines role in neurodegenerative events 149, 85 (FISH) to evaluate occupational exposure to carcinogens 149, Vral, A., H. Thierens, A. Baeyens, L. De Ridder, Chromosomal 335 aberrations and in vitro radiosensitivity: intra-individual versus Stanek, A., The accession countries benefit in the field of plant inter-individual variability 149, 345 protection products 149, 429 Vreugdenhil, H.J.I., see Weisglas-Kuperus, N. 149, 281 Stephanou, G., see Georgiadis, P. 149, 269 Stoikidou, M., see Georgiadis, P. 149, 269 Waddell, W.J., Analysis of thresholds for carcinogenicity 149, 415 Stone, V., R. Jones, K. Rollo, R. Duffin, K. Donaldson, D.M. Brown, Waddell, W.J., see Smith, R.L. 149, 197 Effect of coal mine dust and clay extracts on the biological Wagner, B., see Schrenk, D. 149, 43 activity of the quartz surface 149, 255 Wagner, B.M., see Smith, R.L. 149, 197 Walgren, J.L., D.C. Thompson, Application of proteomic technol- Tamm, C., see Ceccatelli, S. 149, 59 ogies in the drug development process 149, 377 Taper, H., see Bursch, W. 149, 25 Walker, R., Criteria for risk assessment of botanical food supple- Tesseraux, I., Risk factors of jet fuel combustion products 149,295 ments 149, 187 Thierens, H., see Vral, A. 149, 345 Wastl, U., see Bursch, W. 149, 25 Thompson, D.C., see Walgren, J.L. 149, 377 Weisglas-Kuperus, N., H.J.I. Vreugdenhil, P.G.H. Mulder, Immu- Tincani, A., see Cimaz, R. 149, 155 nological effects of environmental exposure to polychlorinated Topinka, J., see Georgiadis, P. 149, 269 biphenyls and dioxins in Dutch school children 149, 281 Tritscher, A.M., Human health risk assessment of processing-related Wobus, A.M., see Rolletschek, A. 149, 361 compounds in food 149, 177 Worner, W., see Schrenk, D. 149, 43 Toxicology Letters Toxicology Letters 149 (2004) V-VII www.elsevier.com/locate/toxlet Subject index Volume 149 (2004) Aberrant cells 149, 269 Cytotoxicity 149, 361 Acrylamide 149, 177 Acrylonitrile 149, 335 Decision tree 149, 187 Air pollution 149, 243, 261, 269, 295 Developmental neurotoxicity 149, 67 Alternatives 149, 147 Developmental toxicity 149, 141, 147 Aluminium 149, 255 Differentiation 149, 361 Apoptosis 149, 19, 25, 37, 43, 59 Dioxins 149, 281, 287 Aryl-hydrocarbon receptor 149, 287 Disease resistance 149, 109 Astroglia 149, 75 DNA adduct 149, 3, 269 Authorisation 149, 421 DNA methylation 149, 51 Dopaminergic neurons 149, 361 Beta-cells 149, 361 Dose-response modelling 149, 163 Biomarkers 149, 261, 353, 377 Drug development 149, 377 Botanical supplements 149, 187 1,3-Butadiene 149, 335, 353 Embryo culture 149, 147 Embryonic stem cells 149, 147, 361 C3H/He 149, 25 Embryotoxicity 149, 147, 361 CS7BL/6J 149, 25 Endogenous damage 149, 3 Cancer risk 149, 261 Epigenetic 149, 51 Cancer susceptibility 149, 345 ERK 149, 59 Carcinogenic polycyclic aromatic hydrocarbons 149, 335 Estrogen 149, 51 Carcinogenicity 149, 415 Ethanol 149, 67 Cardiac cells 149, 361 Ethyl benzene 149, 335 Cardiolipin 149, 19 ETS 149, 269 Caspase 149, 19 Extrapolation from animals to humans 149, 415 Cell proliferation 149, 25 Chemical weapons 149, 11 Chloropropanols 149, 177 Fas 149, 59 Chromatin 149, 51 FEMA 149, 415 Chromosomal aberrations 149, 309, 335 FK506 = 149, 123 Clay 149, 255 Flavors 149, 209, 415 Clinical immunotoxicology 149, 103 Flavouring agent 149, 223 Clostridial neurotoxins 149, 91 Flavouring substances 149, 215 Coal mine dust 149, 255 Flow cytometry 149, 123, 133 Combustion products 149, 295 Fluorescence in situ hybridization 149, 335 Council Directive 91/414/EEC 149, 421, 433 Food processing 149, 177 Cyclic GMP 149, 75 Cyclosporin A 149, 133 G2 assay 149, 345 CYPIAI 149, 269 Genomics 149, 37 CYPIBI 149, 269 Genotoxicity 149, 3 Cytochrome c_ 149, 19 Genotype 149, 309 Cytogenetic biomarker 149, 309 Glial cell proliferation 149, 67 Cytokines 149, 85 GRAS 149, 209, 415 doi: 10.1016/S0378-4274(04)00142-0 VI Subject index of volume 149 GSTMI1 149, 269 Particulate matter 149, 235 GSTP1 149, 269 PCBs _ 149, 281 Guidelines 149, 187 Peer review programme 149, 421 Peroxisome proliferators 149, 37 Health effects 149, 235 Pesticide 149, 429 Hepatocytes 149, 43 Phospholipase A, 149, 91 Hepatocarcinogenesis 149, 25 Phospholipase D 149, 67 Pimecrolimus 149, 133 Plant protection products 149, 421, 429, 433 Immune changes 149, 281 Platelet activation 149, 243 Immune function 149, 155 Polychlorinated biphenyls 149, 43 Immune response 149, 123, 133 Polymorphism 149, 269, 309 Immunoglobulins 149, 123 PPARa 149, 37 Immunosuppressants 149, 155 Pre-school children 149, 281 Immunotoxicity 149, 103, 109, 115, 141 Predictive toxicology 149, 371 In vitro alternatives 149, 387 Pregnancy 149, 155 In vitro radiosensitivity 149, 345 Protein adduct 149, 3 Infection 149, 109 Protein kinase C ¢ 149, 67 Inflammation 149, 255 Proteomics 149, 377 Interleukin-1B 149, 85 Intra- and inter-individual variances 149, 345 Quartz 149, 255 Jet fuel 149, 295, 301 Registration 149, 429 Regulation 149, 39] KLH antibodies 149, 115 Risk assessment 149, 163, 177, 187 KLH 149, 123, 133 Risk communication 149, 391, 399, 405 Risk factors 149, 295 Laser capture microscopy 149, 37 Risk management 149, 391, 399 Liver 149, 43 Risk perception 149, 391, 405 Lung inflammation 149, 243 Rodents 149, 109 Lymphocytes 149, 345 2 i Safety assessment 149, 209 Mechanism-based risk assessment 149, 371 Safety evaluation 149, 197 Mediterranean worker/consumer exposure 149, 433 Safety 149, 223 Metabolism 149, 223 Science translation 149, 399 Micronucleus assay 149, 345 Science/policy interface 149, 399 Micronucleus 149, 309 Sister chromatid exchange 149, 309 Mitochondria 149, 19 Skin irritation 149, 301, 387 Mixtures 149, 197 Skin sensitization 149, 301 Molecular epidemiology 149, 287 Snake presynaptic neurotoxins 149, 91 SNARE proteins 149, 91 Natural flavour complexes 149, 197 Social theories of risk 149, 405 Neoplasia 149, 109 Soluble guanylyl cyclase 149, 75 Neurodegeneration 149, 85 Stochastic modelling 149, 215 Neuroexocytosis 149, 91 Synaptic vesicles 149, 91 Newborn 149, 155 Systemic toxicity 149, 301 Nitric oxide 149, 75 Non-genotoxic carcinogen 149, 51 T-cell-dependent antibody test 149, 115 Non-threshold toxicity 149, 163 Tacrolimus 149, 123, 133 Nutrition 149, 51 Terrorism 149, 11 Testing guidelines 149, 141 Occupational exposure 149, 353 TGFB1 149, 37 Oxidative damage 149, 3 Threshold toxicity 149, 163 Oxidative stress 149, 59 Thresholds 149, 415 Thrombosis 149, 243 Particles 149, 243 Time-series analyses 149, 235 Subject index of volume 149 Toxicity 149, 223 Tumour necrosis factor-x 149, 85 Toxicogenomics 149, 371 Toxins 149, 11 Validation 149, 147, 387 Tumor promotion 149, 43 Tumor susceptibility 149, 25 Warfare 149, 11