Toxicology Letters Toxicology Letters 148 (2004) V—VI www.elsevier.com/locate/toxlet Volume contents Volume 148 (2004) Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B, in newborn and partially hepatectomized mice ee UE OR: ED ak occa ie Se PEs SR AR Che ee 0 Cais oe bea ek ee SCE ee eee «,-Microglobulin as a promising marker of cadmium-induced tubular dysfunction, possibly better than B-microglobulin J. Moriguchi, T. Ezaki, T. Tsukahara, K. Furuki, Y. Fukui, S. Okamoto, H. Ukai, H. Sakurai and M. Ikeda (Japan) ....... Effects of acute lindane intoxication and thyroid hormone administration in relation to nuclear factor-KB activation, tumor necrosis factor-% expression, and Kupffer cell function in the rat C. Valencia, P. Cornejo, P. Romanque, G. Tapia, P. Varela, L.A. Videla and V. Fernandez (Chile) ................... 21 Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels as nn ge da arse he eee wat yw a ea SalB aa a i ee i ee 29 The role of mdr2 in manganese-bilirubin induced cholestasis in mice a. 7, Pen, Se, 42.1, Fee Bes BE.. WOE Toon ik i oe ea he Wee ee wie be eee eee eeas 41 Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes ne a ce Gg a yg gk kee a a Aa OT A eh OE ek ka ee ee 53 Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase es 0 UO a Sos ks 0 Galn ak wa id WS MUR Ge Ck be et a ee ba ke ee ee 65 Fatty acid alterations in liver and milk of cadmium exposed rats and in brain of their suckling offspring K.. Petersson Girawé, 1. Pickova. PC. Dutta and A. Oskarsson (Sweden)... ni ccc ewe eee en neenee 73 Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay N.H. Kleinsasser, U.A. Harréus, E.R. Kastenbauer, B.C. Wallner, A.W. Sassen, R. Staudenmaier and A.W. Rettenmeier Desa e iN grey ony Sac at Auta baa gta wera gal bare ox WIG Ans LO Gwe Ache aU Ns eS tel ES PE RW Se Seeks 83 Primary cultures of microglial cells for testing toxicity of anticancer drugs M. Vairano, G. Graziani, L. Tentori, G. Tringali, P. Navarra and C.D. Russo (Italy) .....0..... 2e .ee .eee. ee.e e ee 9] The role of nitric oxide in the particulate matter (PM2.5)-induced NF«B activation in lung epithelial cells H.Y. Nam, B.H. Choi, J.Y. Lee, S.G. Lee, Y.H. Kim, K.H. Lee, H.K. Yoon, J.S. Song, H.J. Kim and Y. Lim IR ass er Re ia br UCR ey awe te fe rete ee gaa e wear ns ae Riyal key tee cd oa Nk yg Oa ig i RES The mechanism of indole acetic acid cytotoxicity Dir Ge eee, he, Oe Ra EA; Pe aes ae BR rk Ca) wok ion nk ee re ee ee et we ew ee rine Distribution and disposition of benzalkonium chloride following various routes of administration in rats Y. Xue, Y. Hieda, Y. Saito, T. Nomura, J. Fujihara, K. Takayama, K. Kimura and H. Takeshita (Japan) ............... Changes in the spontaneous and_ stimulus-evoked activity in the somatosensory cortex of rats on acute manganese administration cae, <a, a a, NED es aide ag aia nase egw av eae ee eRe OP ARR PSS ENE SES RS Induction of hepatic metallothionein synthesis by endoplasmic reticulum stress in mice M. Kondoh, M. Tsukada, M. Kuronaga, M. Higashimoto, M. Takiguchi, S. Himeno, Y. Watanabe and M. Sato (Japan) Identification of principal cytochrome P-450 in triphenyltin metabolism in rats a as ea hig wg Win SN ca’a ble ¥ atghecbR wood FR a pe ky a le es 141 PARE CORAIC HT et MaaT NOSIS eI ON cs ant cae Pm oy lee An ST I ae OR Ne Sak peau gingegs Gein Gut aati Shine Las kei etelag Soe Oe 149 doi: 10.1016/S0378-4274(04)00108-0 VI Volume contents Special Issue on Health Effects of Environmental Heavy Metals A commentary on the impacts of metals and metalloids in the environment upon the metabolism of drugs and chemicals M.R. Moore (Australia) Cadmium in oysters and scallops: the BC experience G.M. Kruzynski (Canada) Cadmium and nutritional intake in pregnant Japanese women M. Nishijo, K. Tawara, R. Honda, J.-i. Kuriwaki, H. Nakagawa, K. Tanebe and S. Saito (Japan) Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men S. Satarug, P. Ujjin, Y. Vanavanitkun, J.R. Baker and M.R. Moore (Australia, Thailand) Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects S. Satarug, M. Nishijo, P. Ujjin, Y. Vanavanitkun, J.R. Baker and M.R. Moore (Australia, Japan, Thailand) Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2 A. Abu-Bakar, S. Satarug, G.C. Marks, M.A. Lang and M.R. Moore (Australia, Sweden) Instructions to authors Author index Subject index Volume contents