Toxicology Letters 1992: Vol 64-65 Table of Contents

5 Pages·1992·1.2 MB·English

CONTENTS
Preface vii
Cholesterol and mevalonic acid modulation in cell metabolism and multiplication
M.R. Soma, A. Corsini and R. Paoletti (Italy) 1
Assessment of accumulated body burden of metals
S. Skerfving and U. Nilsson (Sweden) 17
Molecular biology approaches to biological monitoring of genotoxic substances
E. Nieboer, F.E. Rossetto and J.D. Turnbull (Canada) 25
Monitoring of early nephrotoxic effects of industrial chemicals
R. Lauwerys, A. Bernard, A. Cardenas (Belgium) 33
Individual susceptibility to toxicity
P. Grandjean (Denmark) 43
Evaluation of adverse effects in the standard-setting process
D. Henschler (Germany) 53
The Toxic Oil Syndrome (TOS, 1981): from the disease towards a toxicological
understanding of its chemical aetiology and mechanism
W.N. Aldridge (UK) 59
Qualitative and quantitative experimental models to aid in risk assessment for
immunotoxicology
M.I. Luster, D.G. Pait, C. Portier, G.J. Rosenthal, D.R. Germolec, C.E. Comment,
A.E. Munson, K. White and P. Pollock (USA) 71
The mechanisms and evaluation of chemically induced allergy
I. Kimber and R.J. Dearman (UK) 79
Athymic experimental animals in pharmaco-immunological research
P. Juult, H.B. Christensen, H.P. Hougen, O. Svendsen, P. Thygesen and
J. Rygaard (Denmark) 85
Cellular and humoral mechanisms of immunotoxicological tissue manifestations
induced by immunotoxic drugs
K. Udaka (Japan) 93
The popliteal lymph node assay: a tool for studying the mechanisms of drug-induced
autoimmune disorders
J. Descotes (France) 101
Molecular basis for differences in susceptibility to toxicants: introduction
A.R. Boobis (UK) 109
Genetically determined differences in drug metabolism as a risk factor in drug toxicity
M. Eichelbaum, H.K. Kroemer, and G. Mikus (Germany) 115
Acetyltransferases and susceptibility to chemicals
D.W. Hein, T.D. Rustan, M.A. Doll, K.D. Bucher, R.J. Ferguson, Y. Feng,
E.J. Furman and K. Gray (USA) 123
The molecular mechanism of peroxisome proliferator action: a model for species
differences and mechanistic risk assessment
S. Green, J.D. Tugwood and I. Issemann (UK) 131
Inherited defects in DNA repair and susceptibility to DNA-damaging agents
J. Hansson (Sweden) 141
Are newer scientific concepts in regulatory toxicology used timely and appropriately?
C. Hodel (France) and R. Bass (Germany) 149
x
New approaches to the assessment of eye and skin irritation
G. Calvin (Belgium)
Classification of chemicals as sensitisers based on new test methods
P.A. Botham (UK)
Classification of chemicals for carcinogenic and mutagenic properties
P.G.N. Kramers and H. Roelfzema (The Netherlands)
The European Community classification of chemicals for reproductive toxicity
F.M. Sullivan (UK)
Public health problems of organic solvents
M. Ikeda (Japan)
Methodology in neurotoxicology — activities within the World Health Organization
and International Programme on Chemical Safety
G.C. Becking (USA)
Principles of identifying and characterizing neurotoxicity
R.C. MacPhail (USA)
International validation of a neurobehavioral screening battery: the IPCS/WHO
collaborative study
V.C. Moser and R.C. MacPhail (USA)
Integration of behavioral and neurophysiologica! approaches in neurotoxicology
E. Frantik and M. Horvath (Czechoslovakia)
Developmental aspects of neurobehavioural toxicity
G. Bignami, G. Laviola, E. Alleva, R. Cagiano, C. Lacomba and V. Cuomo (Italy)
Extrapolation from animals to humans: scientific and regulatory aspects
G. Winneke and H. Lilienthal (Germany)
The evolution of toxic effluents in fires and the assessment of toxic hazard
D.A. Purser (UK)
The development of a new small-scale smoke toxicity test method and its comparison
with real-scale fire tests
B.C. Levin (USA)
Modeling of toxicological effects of fire effluents: prediction of toxicity and evaluation
of animal model
J. Pauluhn (Germany)
Pre-hospital strategy for therapeutic intervention of fire victims
F.J. Baud, F. Richter, H. Julien and C. Bismuth (France)
Hospital treatment of victims exposed to combustion products
P. Kulling (Sweden)
Progress and challenges in the preclinical assessment of cytokines
T.J. Hayes and J.A. Cavagnaro (USA)
Preclinical evaluation of recombinant human interleukin-4
J.B. Cornacoff, K.A. Gossett, T.A. Barbolt and J.H. Dean (USA)
Pathology induced by Interleukin-6
B. Ryffel, M. Kammiiller (Switzerland), R. Robison and L. Myers (USA)
Utilization of homologous proteins to evaluate the safety of recombinant human
proteins — case study: recombinant human interferon-gamma (rhIFN-y)
J.D. Green and T.G. Terrell (USA)
Experience with the preclinical assessment of basic fibroblast growth factor (bFGF)
G. Mazué, F. Bertolero, L. Garofano, M. Brughera and P. Carminati (Italy)
Current guidelines for the preclinical safety assessment of therapeutic proteins
R. Bass, U. Kleeberg, H. Schréder and E. Scheibner (Germany)
Difficulties in conceiving and applying guidelines for the safety evaluation of
biotechnologically-produced drugs: some examples
J.-R. Claude (France)
xi
Ca”*-dependent mechanisms of cytotoxicity and programmed cell death
S. Orrenius, M.J. McCabe Jr. and P. Nicotera (Sweden) 357
Structural and functional aspects of the thyroid follicular epithelium
L.E. Ericson and M. Nilsson (Sweden) 365
Cell proliferation and thyroid neoplasia
E.D. Williams (UK) 375
Pathophysiology of chemical injury of the thyroid gland
C.C. Capen (USA) 381
Chemical carcinogenesis in the thyroid gland
Y. Hiasa, Y. Kitahori, N. Konishi and M. Ohshima (Japan) 389
Thyroid gland neoplasia: non-genotoxic mechanisms
R.M. McClain (USA) 397
Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design
P. Krogsgaard-Larsen and J.J. Hansen (Denmark) 409
Role of GABA in the genesis of chemoconvulsant seizures
K. Gale (USA) 417
Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes
T. Narahashi, J.M. Frey, K.S. Ginsburg and M.L. Roy (USA) 429
Second messengers in cholinergic-induced convulsions and neuronal injury
K.M. Savolainen and M.-R. Hirvonen (Finland) 437
Glutamate transmission is involved in the mechanisms of neuronal degeneration
produced by intrahippocampal tetanus toxin in rats
G. Bagetta and G. Nisticé (Italy) 447
Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in
relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand
C.P. Wild (France), S.M. Shrestha (Nepal), W.A. Anwar (Egypt) and R. Montesano
(France) 455
The use of biomarkers in epidemiology: the example of bladder cancer
P. Vineis (Italy) 463
Advantages and limitations of laboratory methods for measurement of
carcinogen-DNA adducts for epidemiological studies
R.K. Kaderlik, D.-X. Lin, N.P. Lang and F.F. Kadlubar (USA) 469
Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation
in high risk subjects for tobacco-related lung cancer
H. Bartsch, M. Castegnaro, M. Rojas, A.-M. Camus, K. Alexandrov and M. Lang
(France) 477
Use of biomarkers in epidemiology: quantitative aspects
L. Ehrenberg and M. Térnqvist (Sweden) 485
Use of white rot fungi in the degradation of environmental chemicals
M.M. Shah, D.P. Barr, N. Chung and S.D. Aust (USA) 493
Hazard assessment of chemical contaminants in soil
C.L.M. Poels and W. Veerkamp (The Netherlands) 503
Hazard assessment in freshwater ecosystems
N.O. Crossland (USA) 511
Advances in prediction of exposure for organic chemicals
D. Calamari (Italy) 519
Biochemical responses as indicators of toxic effects of chemicals in ecosystems
C.H. Walker (UK) 527
Environmental hazard classification of chemicals
A. Lundgren (Sweden) 535
Role of reactive oxygen species in cell toxicity
H. Sies and H. de Groot (Germany) 547
xii
Mechanisms of cytotoxicity caused by antitumour drugs
J.A. Hickman, H.M. Beere, A.C. Wood, C.M. Waters, and R. Parmar (UK)
Thiol modification and cell signalling in chemical toxicity
P. Nicotera, J.M. Dypbukt, A.D. Rossi (Sweden), L. Manzo (Italy) and S. Orrenius
(Sweden)
Programmed cell death and its protective role with particular reference to apoptosis
R. Schulte-Hermann, W. Bursch, B. Kraupp-Grasl, F. Oberhammer and A. Wagner
(Austria)
Paracetamol toxicity and its prevention by cytoprotection with iloprost
D.S. Davies, D.J. Fawthrop, P. Nasseri-Sina, J.W. Wilson, S.J. Hardwick and
A.R. Boobis (UK)
Protection from oxidative damage in mouse liver cells
A.W. Harman, G.M. Adamson and S.G. Shaw (Australia)
The clinical toxicology of Chlordecone as an example of toxicological risk assessment
for man
P.S. Guzelian (USA)
Interaction and distinction of genotoxic and non-genotoxic events in carcinogenesis
H. Yamasaki, M. Mesnil and H. Nakazawa (France)
Prediction of non-genotoxic carcinogenesis
J. Ashby (UK)
Pathological markers for non-genotoxic agent-associated carcinogenesis
N. Ito, R. Hasegawa, K. Imaida, T. Masui, S. Takahashi and T. Shirai (Japan)
Non-genotoxic factors in the carcinogenetic process: problems of detection and hazard
evaluation
S. Parodi, D. Malacarne and M. Taningher (Italy)
Risk assessment of non-genotoxic carcinogens
S.H. Moolgavkar and E.G. Luebeck (USA)
Chemicals classified by IARC: an investigation of some of their toxicological
characteristics
D.B. McGregor (France)
Molecular and cellular basis for adequate metabolic design of genotoxicity studies
F. Oesch, B. Oesch-Bartlomowicz, H.J. Arens, T. Friedberg, D. Utesch, H.R. Glatt
and K.L. Platt (Germany)
Problems and opportunities in toxicity testing arising from species differences in
xenobiotic metabolism
J. Caldwell (UK)
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug
toxicity
R. Kato and Y. Yamazoe (Japan)
Dose-dependent metabolism and dose setting in chronic studies
J.S. Bus and R.H. Reitz (USA)
Metabolic studies as a basis for the interpretation of metal toxicity
L. Manzo (Italy), L.G. Costa (USA), M. Tonini, C. Minoia and E. Sabbioni (Italy)
Characterization of the effects of aluminum on luciferase biosensors for the detection
of ecotoxicity
J. Guzzo, A. Guzzo and M.S. DuBow (Canada)
Cell injury and death caused by bacterial protein toxins
G. Donelli and C. Fiorentini (Italy)
Induction of apoptosis in cultured hepatocytes and in the regressing liver by
transforming growth factor-f1 occurs without activation of an endonuclease
F. Oberhammer, G. Fritsch, M. Pavelka, G. Froschl, R. Tiefenbacher (Austria),
T. Purchio (USA) and R. Schulte-Hermann (Austria)
xiii
Toxicity in animals and safety in humans: the predictive value of animal studies
G. Rosati, A. Morisetti and P. Tirone (Italy) 705
Epidemiology of adverse reactions to intravascular iodinated contrast media
G. Ansell (UK) 717
The profile evolution of acute severe poisoning in Spain
S. Nogué, L. Marruecos, J. Nolla, J. Monteis, A. Ferrer and E. Civeira (Spain) 725
Rapidly developing cocaine-induced peripheral portal liver damage
S.J. Charles and C.J. Powell (UK) 729
Mechanism of pain induced by radiocontrast media
A.P. Corrado, G. Ballejo, E.A ntunes and G. de Nucci (Brazil) 739
A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the
pigeon
P. Navarra, M. Martire, R. del Carmine, G. Pozzoli and P. Preziosi (Italy) 745
Production of lipid hydroperoxides and depletion of reduced glutathione in liver
mitochondria after acute ethanol administration to rats
T. Trenti, E. Sternieri, D. Ceccarelli, D. Gallesi and A. Masini (Italy) 751
Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma
cysteine and thiol groups after reduced glutathione administration
T. Trenti, M. Bertolotti, C.N. Castellana, A. Ferrari, L.A. Pini and E. Sternieri
(Italy) 757
Properties of bolesatine, a translational inhibitor from Boletus satanas Lenz.
Amino-terminal sequence determination and inhibition of rat mitochondrial
protein synthesis
O. Kretz, J. Reinbolt, E.-E. Creppy and G. Dirheimer (France) 763
Molecular basis for differences in susceptibility to coal workers’ pneumoconiosis
P.J.A. Borm, R. Schins, Y.M.W. Janssen and L. Lenaerts (The Netherlands) 767
Behavioral toxicity of guanidinosuccinic acid in adult and young mice
R. D’Hooge, Y.-Q. Pei, B. Marescau and P.P. De Deyn (Belgium) 773
Three-generation reproductive studies of a synthetic pyrethroid — cyhalothrin
P.B. Deshmukh (India) 779
Safety/risk assessment of pesticides: principles, procedures and examples
F.C. Lu and M.L. Dourson (USA) 783
Author Index Vol. 64/65 (1992) 789
Subject Index Vol. 64/65 (1992) 795