Toxicology in Vitro 1993: Vol 7 Index

13 Pages·1993·3.4 MB·English

Toxicology
in Vitro
An international journal published in association with BIBRA
Author and Subject Indexes
to Volume 7 (1993)
TOXICOLOGY IN VITRO
An international journal published in association with BIBRA
Editors
DANIEL ACOSTA Bas J. BLAAUBOER
Department of Pharmacology and Toxicology, Research Institute of Toxicology,
College of Pharmacy, University of Texas, Utrecht University, Yalelaan 2,
Austin, TX 78712, USA PO Box 80.176, NL-3508
TD Utrecht, The Netherlands
Associate Editor Review Editor
STUART E. JAGGERS PHILIP A. BOTHAM
BIBRA International, Zeneca Central Toxicology Laboratory,
Woodmansterne Road, Carshalton, Alderley Park, Macclesfield,
Surrey SMS 4DS, UK Cheshire SK10 4TJ, UK
Editor Emeritus
IAIN F. H. PURCHASE
Zeneca Central Toxicology Laboratory, Alderley Park,
Macclesfield, Cheshire SK10 4TJ, UK
Managing Editor Editorial Assistant
TuAN A. H6 STELLA HILL
BIBRA International, Woodmansterne Road,
Carshalton, Surrey SMS 4DS, UK
International Editorial Board
J. C. Barrett H. R. Glatt W. E. Parish
NIEHS, Research Triangle Park University of Mainz Unilever Research
NC, USA Mainz, Germany Bedford, UK
E. Borenfreund T. J. B. Gray J. A. Popp
Rockefeller University Sterling—Winthrop Research Centre Sterling Winthrop Inc.,
New York, NY, USA Alnwick, UK Collegeville, PA, USA
J. Bradlaw A. Guillouzo N. Stacey
FDA Hopital de Pontchaillou National Institute of Occupational
Washington, DC, USA INSERM, Rennes, France Health and Safety
N. Brown G. C. Hard Sydney, Australia
St George’s Hospital and Medical American Health Foundation
K. A. Stitzel
School Valhalla, NY, USA
The Procter & Gamble Company
London, UK C. A. McQueen Cincinnati, OH, USA
B. Ekwall University of Arizona
H. Tahti
University of Uppsala Tucson, AZ, USA
University of Tampere
Uppsala, Sweden P. Maier
Tampere, Finland
R. Fahrig Swiss Federal Institute of Technology
Fraunhofer-Institut fiir Toxikologie and University of Zurich P. J. van Bladeren
und Aerosol-Forschung Schwerzenbach, Switzerland TNO-CIVO Institute
Hannover, Germany M. Nagao Zeist, The Netherlands
J. L. Farber National Cancer Center E. Walum
Thomas Jefferson University Research Institute University of Stockholm
Philadelphia, PA, USA Tokyo, Japan Stockholm, Sweden
S. D. Gangolli K. Onozaki F. Zucco
MRC Toxicology Unit Nagoya City University Consiglio Nazionale Delle Ricerche
Leicester, UK Nagoya, Japan Rome, Italy
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Index of Authors
Abdallah M., 55 Cubria J. C., 669 Hagino §S., 35
Abdulla E. M., 341 Curroé D., 581 Hahne S. J. M., 769
Abir R., 817 Czuppon A. B., 531 Hall L. L., 221
Aerts L. A. G. J. M. van, 743, 769 Hansen D. K., 735
Akrawi M., 477 Dauphin J.-F., 499 Happel A., 365
Alvarez-Bujidos M. L., 669 Davenport-Jones J., 569 Haring R., 345
Andersson M., |, 205 Dazy A. C., 373 Harvey A. L., 275
Andrews J. E., 757 De Angelis I., 403 Hasmall R. L., 587
Arjun §., I11 Debetto P., 511 Herrero E., 481
Atterwill C. K., 69, 229, 569 Degwert J., 389 Herrmann K., 41
Deknudt Gh., 471 Heuer J., 551
Babich H., 105 Delhaise F., 719 Hewitt P., 141
Bai C. L., 197 Desager J. P., 809 Hildebrand H., 421
Barber C. V., 695 Descotes J., 317 Hoet P. H. M., 359
Barile F. A., 111 Despontin K., 809 Honegger P., 335, 785
Basketter D. A., 265, 269 Dickson F. M., 381 Hopkinson D., I11
Baur X., 531 Dickson F. M., 385 Hoppe U., 389
Beamand J. A., 605 Dierickx P. J., 527 Hotchkiss S. A. M., 141
Bechter R., v, 247, 281, 685, 827 Donato M. T., 481 Hubert N., 55
Beckman M., 321 Dossou K. G., 299, 465 Hughes M. F., 221
Begue J.-M., 493 Dunnage J. E., 69 Hur H. B., 817
Beisker W., 447 Husoey T., 149
Bellairs R., 701 Easty D. L., 461
Benford D. J., 293, 381, 385 Ebron-McCoy M., 757 Itagaki H., 35
Bergquist J., 205 Elcombe B. M., 587 Izumi J., 517
Berry M., 461 Endo-Capron S., 7
Berthet P., 809 Eskes T. K. A. B., 743 Jacobs M. C., 809
Bertram-Neis E., 505 Eto K., 707 Jaffe P., 817
Bianchi V., 511 James C. A., 159
Bieri F., 427 Fahn S., 595 Janson X., 7
Bjerregaard H. F., 411 Falkenberg F. W., 421 Jaurand M. C., 7
Bilaauboer B. J., 293 Fantel A. G., 695 Jenssen J., 149
Bocchio F., | Fautz R., 305 Jégo P., 55
Boge G., 623 Fijneman P. H. S., 769 Johnston H. B., 229
Bomhard E., 421 Finley R. B., 177 Johnston H., 569
Borella S., 511 Fisher H. L., 221 Jones C., 685
Borenfreund E., 105 Fissler B., 185 Jones H. B., 69
Bos R. P., 769 Forsby A., |
Botham P. A., 155, 393 Fortunati E., 511 Kalweit S., 505
Bouis P., 427 Fouce R. B., 669 Kato S., 35
Bouzard D., 499 Fournex R., 453 Kavlock R. J., 757
Bowden H. C., 799 Fujii K., 673 Kawashima K., 259
Brady A. M., 587 Furuya K.., 61 Kefalas V., 235
Braxatorisova E., 803 Kenna J. G., 311
Bremer S., 551 Galli C. L., 559 Kennedy S. W., 159
Brissot P., 55 Gerner I., 505 Kheuang L., 7
Broccia M. L., 777 Ghosh A., 137 Kiell A., 365
Brook F. A., 679 Giavini E., 777 Kikuchi T., 61
Brown K. M., 285 Gibassier J., 87 Kimber I., 295, 393
Burin G. J., 285 Giladi N., 595 Kishida K., 707
Girard J.-P., 205 Klaasboer H. H., 743
Cadet J. L., 595 Goffinet G., 433 van Kleef R. G. D. M., 327
Cain K., 117 Gofflot F., 719, 751 Klug S., 727
Caldwell J., 141 Gofflot G., 809 Kniepen J., 541
Cambar J., 417 Goonetilleke S., 569 Knight T. L., 311
Campbell I. C., 341 Gomez-Lechon M. J., 481, 523 Kobayashi T., 35
Cano E., 785 Graviere C., 499 Koch P., 493
Cao J., 447 Gray T. J. B., 605 Koéter H. B. W. M., 81
Carda M. B., 695 Greiner B., 685 Kondo T., 61
Castell J. V., 481, 523 Gueniche A., 15 Krafft N., 827
Catroux P., 465 Guennou C., 373 Krauser K., 505
Chapman D. E., 213 Guery C., 453 Kreiling R., 505
Charlton J. A., 129 Guillouzo A., 493, 499 Kremers P., 433
Chesne C., 499 Gurney J. A., 117 Kucera P., 785, 803
Ciabattoni G., 581 Gurwitz D., 345
Coecke S., 487 Gilden M., 25 L’Azou B., 417
Condevaux F., 317 Lachapelle J. M., 809
Copp A. J., 679 Haakmat A. S., 615 Lake B. G., 605
Cottin M., 465 Hadnagy W., 365 Lang B., 427
Coussement W., 471 Hagenaars A. M., 615 Lauwerys R., 751
iil
iV Index of Authors
Lawrence J. N., 381, 385 Perez M. J., 299 Steiling W., 505
Pertijs J. C. L. M., 743, 769
Le Tellier C., 87 Stepniewski J. P., 453
Lecart C., 809 Pesando D., 205 Stern A., 105
Leclech G., 87 Phillips I. R., 477 Sterner O., 1, 205
Leibold E., 447 Picard J. J., 719, 751, 809 Stewart J., 177
Lenoir E., 809 Piersma A. H., 615, 763 Stouvenakers N., 433
Lenz D., 537 Pillar A. M., 69 Strandberg C., 205
Leppens H., 547 Pineau N., 299 Strohbusch A., 185
Lescoat G., 55 Pinus H., 817 Sutton M., 595
Lewan L., | Plaetse F. V., 547 Sysmans M., 471
Lewis D. F. V., 605 Pohl I., 551 Syversen T., 149
Lewis R. W., 155, 393 Ponec M., 15
Liebsch M., 505 Postma N. S., 743 Tabata H., 259
Lison D., 751 Powis G., 213 Takahashi S., 61
Lo B., 595 Prati M., 777 Takanaka A., 259
Lorenzen A., 159 Preziosi P., 581 Talukder G., 137
Lorenzon G., 453 Prince A. K., 69 Tanaka N., 517
Louvet M., 433 Przedborski S., 595 Tedone R., 317
Lovell W. W., 95 Purcell W., 569 Terlouw G. D. C., 247, 281, 685,
827
Madle S., 185 Reinhardt C. A., 293 Tesh J. M., 799
Marano F., 373 Renier A., 7 Teuns G., 471
Marczynski B., 531 Repetto G., 353 Therasse P., 809
Marek W., 531 Repetto M., 353 Thomas H., 427
Marinovich M., 559 Rivedal E., 631, 637 Thomas S. M., 229, 569
Martinez L. A., 523 Roche H., 623 Thome J. P., 433
Massart C., 87 Roelandt L., 433 Tirmenstein M. A., 645
Maurer G., 493 Rogers J. M., 757 Todaro A., 433
Martensson U., 241 Rogiers V., 439, 477, 487 Toussaint M. J. M., 443
McCall J. C., 155, 393 Rohou S., 499 Tsurumi K., 707
McGlynn H., 407 Romet-Haddad S., 373
Menegola E., 777 Rosenbruch M., 541 Ujhazy E., 803
Mertens K., 439 Roseng L. E., 631, 637 Usami M., 259
Michener S. R., 213 Ross F. W., 799
Mihalikova K., 803 Rougier A., 299, 465
Van Cauteren H., 471
Miltenburger H. G., 305, 505 Rutten A. A. J. J. L., 81
Van Den Heuvel R., 547
Miranda M. A., 523 Ryan M. P., 407
Van Maele-Fabry G., 719, 751, 809
Moirand R., 55
Vannier B., 453
Monnet-Tschudi F., 335 Safran N., 345
Vanparys Ph., 471
Montuschi P., 581 Sakemi K., 259
Vercruysse A., 439, 477, 487
Moody R. P., 167 van de Sandt J. J. M., 81
Verdier F., 317
Morel I., 55 Sanner T., 637
Vijverberg H. P. M., 327
Sanz P., 353
Vincentini O., 403
Nadeau B., 167 Sasaki K., 517
Virat M., 317
Nassberger L., 241 Sato H., 61
Viviani B., 559
Nemery B., 359 Sato N., 673
Neubert D., 727 Sawyer T. W., 653
Wachter F., 685
Nicol M., 87 Schilter B., 785
Waechter F., 427
Niewold Th. A., 443 Schliter G., 421
Wakuri S., 517
Ninomiya H., 707 Schmid B., 785
Walum E., 321
Noordhoek J., 743, 769 Schoeters G. E. R., 547
Nordin M., 321 Schranner T., 447 Wachter F., 685
Weishaupt C., 541
Niisse M., 447 Schreiber G. H., 531
Weiss M. T., 653
Nzeribe R., 177 Schwarz L. R., 447
West M., 569
Schwengberg S., 421
Whittle E., 265, 269
Ocaktan A., 55 Seelbach A., 185
Williams S., 569
Odland L., 321 Seemayer N. H., 365
Wirnsberger T., 505
Ohno Y., 707 Segaert A., 487
de Wit M. M. L., 443
Ono H., 517 Segner H., 537
Wright B. G., 177
Oortgiesen M., 327 Shahar A., 345
Oostendorp A. G. M., 769 Shainberg A., 345
Ordofiez D., 669 Sharma A., 137 Xie K., 275
Ornoy A., 817 Shephard E. A., 477
Ortiz Al., 669 Shrivastava S. P., 221 Yamada M., 61
Shum A. S. W., 679 Yuge O., 673
Pape W. J. W., 389 de Silva O., 299
Pape W., 505 Simmons N. L., 129 Zhao J., 827
Parker C. L., 177 Spielmann H., 505, 551 Zijlstra J. A., 785
Pasdeloup N., 55 Stacey N. H., 197, 235 Zucco F., 397, 403
Peereboom J. H. J. C., 743, 769 Stammati A., 403 Zurich M.-G., 335
van Pelt F. N. A. M., 311 Steckel F., 389 Zwart R., 327
Pergamon
Index of Subjects
Abortions recurrent, immunoglobulin G exchange Brain development, metal compound toxicity and
and 817 335
Adenosine triphosphate (ATP) assays, In cytotox- Brain cell cultures aggregating embryonic, vali-
icity study of 32 MEIC chemicals 517 .. . leakage dation with twelve coded compounds 785...
induction in ELD cells | dissociated, lasalocid-induced neurotoxicity 345
Adrenaline cardiovascular effects on chick . reaggregate, ethylcholine mustard aziridinium
embryo 541 effects 69
Alkoxyacids glycol ethers and, comparative
embryotoxicity 777
Aluminium metabolic changes and 229 Caesium chloride clastogenic effects on human
Aneugens detection by micronucleus assay 185 peripheral blood lymphocytes 137
Anticholinergic drugs toxicity in human neuro- Calcium cytosolic, changes in chemically induced
blastoma cell lines 595 cytotoxicity 511
Antidepressants mitogen stimulation effects of Carbon tetrachloride bile acid transport effects in
human lymphocytes 241 rat hepatocytes 197 . . . lipid peroxidation inducing,
Antimuscarinic agents toxicity in human neuro- in guinea pig liver microsomes 673...
blastoma cell lines 595 trichloroethylene interactive toxicity 235
Antioxidant enzyme metal salt effects on, in fish Carcinogens micronucleus induction in hepato-
erythrocytes 623 cytes by flow cytometric analysis 447
Apoptosis after toluene diisocyanate exposure 531 Cardiovascular effects adrenaline and nicotine on
Aroclor 1254 cyclophosphamide embryotoxicity chick embryo 541
and mutagenicity effects 769 Cell communication, TPA inhibition in hamster
2-Arylpropionic acids photoperoxidation by 523 embryo cells 631 ... cultures, toxicity mechanism
Auranofin plasminogen activator effects in post- study in 559 ... growth inhibition, in chemically
implantation embryos 751 induced cytotoxicity 511... lines, human renal 129
Centrifugal elutriation proximal kidney cell iso-
lation and purification 117
Bacterial endotoxin effects on rat and hamster Cerebral cultures see Brain cell cultures
hepatocyte cultures 443 Chemicals acute toxicity, prediction study I11...
Balb/c mice monoclonal antibody development cell growth inhibition and cytosolic calcium
against rat papillary antigen 421 ... proliferative changes causing 511 ... eye irritancy using cho-
response study 299 rioallantoic membrane test 35 MEIC test,
B-N-methyl-L-amino-alanine (L-BMAA) cytotoxicity in primary neurone cultures 653 ...
neuro-
filament concentration modulation and 341 screening, in whole chick and rat embryo cultures,
Bile acid serum, elevated, uptake relationship 197 aggregating brain cell cultures 785
... transport, carbon tetrachloride and chloroform Chemiluminescence phagocytosis assessment 317
effects in rat hepatocytes 197 Chick embryo cardiovascular effects of adrenaline
Biochemical effects pentamidine in human liver and nicotine 541 ... development, endpoints 701
cells 177 2-Chlorodibenzofuran developmental toxicity in
Biotoxins aquatic, diamine oxidase inhibition by cultured rat embryos 259
669 Chloroform on bile acid transport effects in rat
Biotransformation capacity maintenance by hu- hepatocytes 197
man hepatocyte cultures 493 Chorioallantoic membrane (CAM) test quantita-
Bis(2-methoxyethyl) ether human/rat microsomal tive, using trypan blue in eye irritancy prediction 35
metabolism comparison 645 Chromatid exchanges genotoxicity assay in rat
BMY 43748 comparative metabolism in cultured pleural mesothelial cells 7
hepatocytes 499 Cis -diamminedichloroplatinum II see Cisplatin
Bone marrow cultures, x-irradiation in vitro/in Cisplatin toxicity modulation by dimethyl
vivo 547 sulphoxide in cultured thyrocytes 87
Bovine corneal opacity-permeability assay evalua- Clastogenicity caesium chloride on human
tion as Draize test alternative 471 peripheral blood lymphocytes 137
vi Index of Subjects
Coal fly ash cytotoxicity in macrophage culture N,N-Diethyl-m-toluamide (DEET) dermal ab-
61 sorption test comparison 167
Cocaine microfilament effects in chick embryo Diethylstilboestrol in whole embryo culture 799
cultures 285 Diffusion system static/flow-through comparison,
Colony formation in cytotoxicity study of 32 percutaneous absorption of p-substituted phenols
MEIC chemicals 517 221
Conceptal tissue rat, cytochrome P-450 isozymes Dihydropyridines porphyria induction in rodent
in 685 hepatocyte cultures 587
Conceptus cultured, cytochrome P-450-depen- Dimethyl sulphoxide (DMSO) protective effects
dent metabolism 247 in cultured thyrocytes 87
Contact hypersensitivity epidermal cytokines and 2,4-Dinitrochlorobenzene (DNCB) proliferative
295 response study 299
Corneal toxicity isolated human and rabbit eyes 2,6-Dinitrotoluene (2,6-DNT) metabolism, hu-
461 man/rat liver 213
Corrosivity test human skin, comparison with in DNA denaturation after toluene diisocyanate ex-
vivo data 269 ... human skin, method development posure 531 ... synthesis, genotoxicity assay in rat
265 pleural mesothelial cells 7
Cri:CD (Charles River) rats glycol ethers and Draize eye irritation test bovine corneal opacity-
alkoxyacids, comparative embryotoxicity 777 permeability assay as alternative 471 ... chorio-
Culturing technique rat embryos, gestation days allantoic membrane test as alternative 35
14-15 695 cytotoxicity assays validation as alternative 505...
Cutaneous toxicity (see also Skin) ... potential, silicon microphysiometer for ocular testing com-
corrosivity test development 265 ... potential, in parison 465
vivo/in vitro data comparison 269 Drugs metabolism, biotransformation capacity
Cyclophosphamide embryotoxicity and muta- maintenance by human hepatocyte cultures 493
genicity in rat hepatocytes 769
Cyclosporin vasoconstriction and prevention in
glomeruli 417 Electrophysiological measurements cytotoxicity in
Cytochrome P-450 dependent conceptal metab- toad renal epithelial cells (A6) 411
olism 247 ... expression, phenobarbital and val- Embryo cultures chick, cocaine effects on microfi-
proate effects in co-cultured hepatocytes 477 ... laments 285 ... developmental toxicity of xeno-
isozymes, in rat conceptal tissue 685 biotic compounds 615 ... post-implantation see
Cytokines contact hypersensitivity and 295 ... Post-implantation embryo culture ... post-implan-
effects on rat and hamster hepatocyte cultures tation, 2-chlorodibenzofuran developmental tox-
443 icity 259 ... pre-implantation see Pre-implantation
Cytotoxicity biological/statistical significance of embryo culture ... rat see Rat embryo cultures
in vitro testing 111 ... chemically induced, cell Embryonic stem cell cultures in embryotoxicity
growth inhibition and cytosolic calcium changes in test development 551
511 ... chemicals, topical application 81 ... coal Embryotoxicity cyclophosphamide, sex difference
fly ash in macrophage culture 61 ... comparison of and Aroclor 1254 treatment effects 769 ... glycol
four tests 149 ... electrophysiological measure- ethers and alkoxyacids 777 ... L-homocysteine in
ments in toad renal epithelial cells (A6) 411 ... rodents 743 ... isotretinoin in human serum 809
eugenol to replicating cells 105... MEIC chemicals . testing, development using mouse embryonic
by colony formulation and ATP assays 517 ... stem cell cultures 551 ... testing of twelve coded
MEIC test chemicals in primary neurone cultures compounds 785 valproate-induced, folate
653 ... ocular irritancy test comparison 155 ... effects 735
surfactant-induced human keratinocytes 381 Endotoxin effects on rat and hamster hepatocyte
surfactants in skin cell cultures 15 cultures 443
Cytotoxicity assays fish cell line 537 ... vali- Endpoints in chick embryo development 701
dation as alternative to Draize test 505 Epidermal cytokines contact hypersensitivity and
295
Epithelial cells (A6), cytotoxicity using electro-
Dermal absorption procedure automated 167 physiological measurements 41 1
Developmental toxicity 2-chlorodibenzofuran in Epithelium permeability to pollutants in tracheal
cultured rat embryos 259 xenobiotic com- cell cultures 373
pounds 615 Erythrocytes lysis test, comparison with K562
Dialdehydes unsaturated, structure—activity re- cytotoxicity test 155 ... sea bass, metal salt effects
lationship 1, 205 on antioxidant enzyme activities 623
Diamine oxidase inhibition by aquatic biotoxins Ethoxyresorufin-O-deethylase (EROD) induc-
669 tion UV irradiation effects in hepatocytes 159
Index of Subjects Vii
Ethylcholine mustard aziridinium (ECMA) effects Halothane hepatocyte exposure to, TFA-proteins
in rat brain reaggregate cultures 69 and 311
17x-Ethynyloestradiol in whole embryo culture Hen’s egg test—chorioallantoic membrane
799 (HET-—CAM) validation § as alternative to
Eugenol (4-hydroxy-3-methoxy-allybenzene) cyto- Draize test 505
toxicity to replicating cells 105 Hepatic microsomes bis(2-methoxyethyl) ether
Eye irritancy (see also Draize eye irritation test) metabolism in human/rat 645
bovine corneal opacity-permeability assay, Hepatocyte cultures bacterial endotoxin and hy-
evaluation as Draize test alternative 471 ... cho- drocortisone effects in rat and hamster 443 ...
rioallantoic membrane test evaluation 35 ... sur- biotransformation capacity maintenance 493 ...
factants, predictive ability of tests comparison 155 flavin-containing monooxygenase expression in
Eyes isolated human and rabbit, corneal toxicity 487 ... malondialdehyde measurement in 439 ...
models 461 toxicity testing using silicon PCB effects 433 ... porphyria induction by griseo-
microphysiometer 465 fulvin and dihydropyridines 587 . . . propaquizafop
effects on lauric acid hydroxylation and peroxiso-
mal f-oxidation 427 ... pyoverdin Pa A, iron
toxicity inhibition 55 ... quinolone metabolism in
FAC Scan analysis proliferative response specifi-
499 ... rat carbon tetrachloride/trichloroethylene
city 299
interactive toxicity study 235 ... rat long-term, on
Fatty acid changes carbon tetrachloride-induced
porous membranes 453 ... sequential, cyclophos-
lipid peroxidation and 673
phamide embryotoxicity and mutagenicity 769 ...
Female sex hormones in whole embryo culture
structure—activity relationships for peroxisomal
799
enzyme induction 605
Fertilization sesquiterpenoids and, sea urchin
Hepatocytes carbon tetrachloride and chloro-
gametes 205
form effects on bile .. . acid transport 197 . . . chick
Fischer 344 rats percutaneous absorption of 4,4’-
embryo, UV irradiation effects 159 . . . co-cultured,
methylene-bis (2-chloroaniline) and 4,4’-methyl-
phenobarbital and valproate effects on cytochrome
enedianiline 141 ... percutaneous absorption of
P-450 expression 477 ... halothane exposure and
p-substituted phenols 221
TFA-protein generation 311 ... human liver cells,
Fish cultured fathead minnow cells, protein con-
pentamidine effects 177 ... micronucleus induc-
tent and fish lethality data correlation 527 ... sea
tion, flow cytometric analyses 447 ... monooxy-
bass, metal salt effects on antioxidant enzyme
genase inhibition by interferons 481
activities in erythrocytes 623
L-Homocysteine stereospecific embryotoxicity in
Fish cell line cytotoxicity assays 537
rodents 743
Flavin-containing monooxygenase expression in
Hormones female sex, in whole embryo culture
rat hepatocyte culture 487
799
Flow cytometry micronucleus induction in hep-
Hydrocortisone effects on rat and hamster hep-
atocytes 447
atocyte cultures 443
Folate derivatives valproate-induced neural tube
N-Hydroxy-N-methyl-7-propoxy-2-naphthalenethan-
defects and 735
amine (QA 208-199, QAB) see QA 208-199,
Formate embryonic sensitivity and pH in whole
QAB
embryo culture 757
Furazolidone toxic effects on intestinal cells, food
contamination studies 403
Immunocompetent cells in cells irritation screen-
ing 389
Gap junctional intercellular communication Immunofluorescence cocaine effects on microfila-
(GJIC) protein kinase C inhibitor effects 637 ments in chick embryos 285
Genotoxicity talc in mesothelial cells 7 . . . toluene Immunoglobulin G exchange and recurrent abor-
diisocyanate 531 tions 817
Gentamicin nephrotoxicity mechanisms and Immunotoxicity screening multiple endpoint test
models 407 battery 305
Gestation days 14—15, culturing technique for rat Inflammatory mediators release in keratinocytes
embryos 695 following irritation 385
Glomerulus rat, prevention of cyclosporin- Insect repellent DEET, dermal absorption test
induced vasoconstriction in 417 comparison 167
Glycol ethers alkoxyacids and, comparative em- Interactive toxicity carbon tetrachloride and
bryotoxicity 777 trichloroethylene in rat hepatocyte cultures 235
Griseofulvin porphyria induction in rodent hep- Interferons monooxygenase inhibition in human
atocyte cultures 587 hepatocytes 481
vill Index of Subjects
Intestinal cells furazolidone effects 403 . . . in toxi- Metabolic changes aluminium/iron induced in
cological studies 397 neuroblastoma cells and primary neural cultures
INVITOX 92 Seventh International Workshop 229
on in vitro Toxicology 293 Metal compounds toxicity during brain develop-
Iron metabolic changes and 229 ... toxicity inhi- ment 335
bition in hepatocytes by pyoverdin Pa A 55 Metal salts antioxidant enzyme effects on fish
a-Irradiation bone marrow cultures, in vitro/in erythrocytes 623
vivo 547 Methoctramine toxicity in human neuroblastoma
Isotretinoin embryotoxicity in human serum 809 cell lines 595
2-Methoxyethanol microsomal formation 645
4,4’-Methylene-dis (2-chloroaniline) (MbOCA) per-
cutaneous absorption 141
Japanese White rabbit embryos, culturing tech-
4,4’-Methylenedianiline (MDA) percutaneous
nique 707
absorption 141
Methylmercury chloride neurotoxicity in neuro-
blastoma cells 353
K562 cytotoxicity test, comparison with red
Methylmercury chloride neurotoxicity in neuro-
blood cell lysis test 155
blastoma cells 353
Kainate neurofilament concentration modulation
B-N-Methyl-L-amino-alanine (L-BMAA)
neuro-
and 341
filament concentration modulation and 341
Keratinocyte cultures inflammatory mediator re-
Microfilament cocaine effects in chick embryo
lease following irritation 385 ... surfactant-in-
cultures 285
duced cytotoxicity in 381
Micronucleus assay aneugenic effect detection 185
Kidney cells proximal, isolation and purification
Micronucleus induction in hepatocytes, flow cyto-
117
metric analysis 447
Microsomes guinea pig liver, lipid peroxidation in
673
Lasalocid induced neurotoxicity in dissociated
Mitochondrial poisons effects on muscle cell cul-
cerebral cultures 345
tures 25
Lauric acid hydroxylation propaquizafop effects
Mitogen stimulation antidepressant effects 241
in hepatocytes, comparison with benzafibrate 427
Monoclonal antibody development against rat
Lethality data fish, protein content in cultured
papillary antigen 421
fathead minnow cells correlation 527
Monooxygenase flavin-containing, expression in
Liver human S-9 fraction and whole embryo cul-
rat hepatocyte cultures 487 ... inhibition by inter-
ture in teratogenic prediction 827
ferons in human hepatocytes 481
Liver cells see Hepatocytes
Mouse embryo post-implantation, developmental
Liver slice tissue culture human/rat, 2,6-dinitro-
table 719
toluene metabolism 213
MTT assay comparison with other cytotoxicity
Local lymph node assay (LLNA) contact allergens
tests 149
screening procedure 299
Multicentre Evaluation of in vitro Cytotoxicity
Lung cells isolated, in pulmonary toxicology 359
(MEIC) 32 chemicals by colony formulation
Lung toxicity testing see Pulmonary toxicity test-
and ATP assays 517 ... cell growth inhibition and
ing
cytosolic calcium changes, chemically induced 511
Lymphocytes caesium chloride clastogenic effects
... Chemical assay in primary neurone cultures 653
137 ... mitogen stimulation, antidepressant effects
Muscle cell cultures toxicity screening 25
241
Mutagenicity cyclophosphamide, sex difference
and Aroclor 1254 treatment effects 769
Mutants mouse, neural tube defects analysis in
Macrophage alveolar, coal fly fish cytotoxicity 61 whole embryo culture 679
... human cultures, in pulmonary toxicity testing
365
Malondialdehyde measurement in rat hepatocyte Nephrotoxicity gentamicin, mechanisms and
cultures 439 models 407
MEIC see Miulticentre Evaluation of in vitro Nerve cell toxicity see Neurotoxicity
Cytotoxicity (MEIC) Neural cell cultures primary, aluminium/iron in-
Membrane toxicity sesquiterpenoids | duced metabolic changes 229
Mercuric chloride neurotoxicity in neuroblas- Neural tube defects analysis in mouse mutant,
toma cells 353 ... plasminogen activator effects in using whole embryo culture 679 ... valproate-
post-implantation embryos 751 induced in rat and mouse embryos, folate effects
Mesothelial cells —_ talc genotoxicity assays 7 735
Index of Subjects ix
Neurite outgrowth fB-N-methyl-L-amino-alanine Phenols p-substituted, percutaneous absorption,
and kainate effects 341 comparative study 221
Neuroblastoma _ cells aluminium/iron induced Photoallergens in vitro screening 95
metabolic changes 229 ... antimuscarinic agents Photoperoxidation 2-arylpropionic acids, as pho-
and anticholinergic drug toxicity 595 ... mercuric totoxicity indicator 523
chloride and methylmercury chloride effects 353 Phototoxicity photoperoxidation by 2-arylpropi-
Neuroepithelium microfilament integrity disrup- onic acid 523
tion, cocaine causing, in chick embryos 285 Plasminogen activator activity retinoic acid, aura-
Neurofilaments fB-N-methyl-L-amino-alanine and nofin and mercuric chloride effects in cultured
kainate effects 341 mouse embryos 751
Neurone cultures MEIC test chemicals cytotox- Pollutants epithelium permeability in tracheal
icity 653 cell cultures 373 ... inhaled, pulmonary toxicity
Neurotoxicity assessment, new models and investigation using human macrophages 365
*tiered-test’ model validation 569 ... ethylcholine Polychlorinated biphenyls (PCBs) effects on hep-
mustard aziridinium in rat brain cultures 69 ... atocyte cultures as alternative to in vivo systems 433
evaluation, electrophysiological/biochemical Porous membranes rat hepatocytes, long-term
methods 275 ... in vitro test implications 341 ... culture on 453
lasalocid-induced in dissociated cerebral cultures Porphyria induction by griseofulvin and dihy-
345 ... mercuric chloride and methylmercury dropyridines in rodent hepatocyte cultures 587
chloride 353 ... risk estimation 321 Porphyrin accumulation TCB-mediated, UV ir-
Neurotoxins effect on nicotinic acetylcholine radiation effects in hepatocytes 159
receptors in cell cultures 327 ... identification, Post-implantation embryo culture mouse, devel-
cellular methods 321 opmental table 719... mouse, plasminogen activa-
Neutral red assay, comparison with other cyto- tor activity in 75] rodent, L-homocysteine
toxicity tests 149 ... assay, eugenol cytotoxicity embryotoxicity 743
105 ... uptake in skin toxicity testing 81 Progesterone in whole embryo culture 799
Nicotine cardiovascular effects on chick embryo Proliferative response sodium lauryl sulphate/2,4-
541 dinitrochlorobenzene 299
Nicotinic acetylcholine receptors neurotoxicants Propaquizafop effects, benzafibrate comparison
in cell cultures 327 427 ... lauric acid hydroxylation and peroxisomal
B-oxidation effects in hepatocyte cultures 427
Protein kinase C inhibitors, effect on cell com-
Ocular irritancy see Eye irritancy munication and transformation 637
Ocular toxicity testing using silicon microphys- Protein content in cultured fish cells, lethality
iometer 465 data correlation 527 ... measurement, comparison
17/ -Oestradiol in whole embryo culture 799 with other cytotoxicity test 149
Pseudomonas aeruginosa peptidic fluorescent
siderophore 55
Papillary antigen monoclonal antibody develop- Pulmonary toxicity testing 581... human macro-
ment against 421 phage cultures in 365
Partial least square (PLS) method struc- Pulmonary toxicology isolated lung cells in 359
ture—activity correlation, unsaturated dialdehydes Pyoverdin Pa A iron toxicity inhibition in rat
l hepatocyte cultures 55
Pentamidine biochemical effects in human liver
cells 177
Pentane formation carbon tetrachloride-induced QA 208-199, QAB cytochrome P-450-dependent
lipid peroxidation and 673 biotransformation in cultured rat conceptuses 247
Percutaneous absorption 4,4’-methylene-bi(s2 - Quinolones comparative metabolism in culture
chloroaniline) and 4,4’-methylenedianiline 141 ... hepatocytes 499
p-substituted phenols, static/flow-through diffu-
sion system comparison 221
Peroxisomal f -oxidation propaquizafop effects in Rabbit embryo culture trypan blue effects 707
hepatocytes, comparison with benzafibrate 427 Rat embryo cultures culturing technique for ges-
Peroxisomal enzyme induction, structure—activity tation days 14—15 695... . strain differences and 281
relationships and, in rat hepatocytes 605 ... trypan blue effects 707
pH formate sensitivity effects in whole embryo Red blood cells see Erythrocytes
culture 757 Renal cell lines human, for toxicological model
Phagocytosis chemiluninescence assessment 317 systems 129
Phenobarbital cytochrome P-450 _ expression Retinoic acid plasminogen activator effects in
effects in co-cultured hepatocytes 477 post-implantation embryos 751
Index of Subjects
Saxitoxin diamine oxidase inhibition by 669 12-O-Tetradecanoylphorbol-13-acetate (TPA) cell
Sea bass (Dicentrarchus labrax) metal salt effects communication and, in hamster embryo cells 631
on antioxidant enzymes in erythrocytes 623 Tetrazolium salt (MTT) assay in skin toxicity
Sea urchin fertilization, sesquiterpenoids and 205 testing 81
Sesquiterpenoids fertilization and, sea urchin Tetrodotoxin diamine oxidase inhibition by 669
gametes 205 ... membrane toxicity | Thiobarbituric acid assay malondialdehyde
Sex difference cyclophosphamide embryotoxicity measurement in rat hepatocyte cultures 439
and mutagenicity effects 769 Thromboxane B, (TXB,) release in lung toxicity
Sex hormones in whole embryo culture 799 testing 581
Silicon microphysiometer ocular toxicity testing Thyrocytes dimethyl sulphoxide as antidote to
using, correlation with Draize test 465 cisplatin-induced damage in 87
Skin cell cultures, toxicity screening 15... corro- *Tiered-test’ model preliminary validation of 569
sivity test, in vivo/in vitro data comparison 269 ... Tin derivatives, toxicity in cell cultures 559
corrosivity test, method development 265 ... tox- Toluene diisocyanate DNA denaturation and
icity testing 81 apoptosis after exposure to 531
Skin irritation estimation using human skin ce!l Tosufloxacin comparative metabolism in culture
cultures 15 ... immunocompetent cells in 389 ... hepatocytes 499
inflammatory mediator release in keratinocytes Toxicity mechanisms, tin derivatives in cell cul-
and 385 ... in vitro/in vivo data correlation 15... tures 559 ... screening in human skin cell cultures
TNF-a release and 393 15 ... screening in rat skeletal muscle cell cultures
Sodium lauryl sulphate proliferative response 25 ... testing, whole embryo culture and 763
study 299 Toxicity Profiles (BIBRA) 557
Sodium valproate (see also Valproic acid) . . . cyto- Toxicological studies intestinal cells in 397 ...
chrome P-450 expression effects in co-cultured model systems, human renal cell lines for 129
hepatocytes 477 Tracheal cell cultures epithelium permeability to
Sprague-Dawley rats flavin-containing mono- pollutants 373
oxygenase expression in hepatocyte cultures 487 Transformation protein kinase C inhibitor effects
. malondialdehyde measurement in hepatocyte 637
cultures 439 phenobarbital and valproate Trichloroethylene carbon tetrachloride interactive
effects on cytochrome P-450 expression 477 ... toxicity 235
prevention of cyclosporin-induced vasoconstric- Trifluoroacetylated proteins (TF A-proteins) halo-
tion in glomeruli 417 ... structure—activity re- thane exposure and antigen generation in rat
lationships for peroxisomal enzyme induction 605 hepatocyte culture 311
Stobadin in vivo/in vitro teratological study 803 Trypan blue effects on rat/rabbit embryo cultures
Strain differences rats, whole embryo culture sys- 707 ... in eye irritancy prediction 35
tem effects 281 Tumour necrosis factor-x (TNF-«) release skin
Structure—activity relationships peroxisomal en- irritancy and 393
zyme induction and, in rat hepatocytes 605 ...
unsaturated dialdehydes 1, 205
Surfactants cytotoxicity causing, in keratinocytes
Uridine incorporation comparison with other
381... effects on muscle cell cultures 25 ... ocular
cytotoxicity tests 149
irritancy test comparison 155
UV irradiation cell culture medium, porphyrin
Symposium, Third vertebrate whole embryos cul-
accumulation and EROD induction effects 159
ture 679-834
Syrian hamster bacterial endotoxin and hydro-
cortisone effects on hepatocyte cultures 443 ...
embryo cells, protein kinase C inhibitor effects 637 Validation 505-510 ... Draize eye irritation test
... embryo cells, TPA and cell communication in alternatives in Germany, cytotoxicity assay,
631 HET—CAM test 505 ... ‘tiered-test’ model in neu-
rotoxicity testing 569 ... whole chick and rat
embryo cultures, aggregating brain cell cultures
3T3 cells surfactant-induced cytotoxicity in 381 785
Tale genotoxicity in mesothelial cells 7 Valproate cytochrome P-450 expression effects in
Teratogenicity chick embryo studies in 701 ... co-cultured hepatocytes 477
immunoglobulin G and recurrent abortions 817... Valproic acid neural tube defects and, folate
stobadin, in vivo /in vitro comparison 803 . . . trypan effects 735 ... zebrafish developmental effects 41
blue on rat/rabbit embryo cultures 707 . . . valproic Vasoactive agents prevention of cyclosporin-
acid in zebrafish 41 ... whole embryo culture and induced vasoconstriction in glomeruli 417
human liver S-9 fraction model 827 ... whole Vasoconstriction cyclosporin-induced, prevention
embryo culture in mechanism elucidation 727 in glomeruli using vasoactive agents 417