Toxicology in Transition: Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21–24, 1994 PDF
Preview Toxicology in Transition: Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21–24, 1994
Archives of Toxicology, Supplement 17 Toxicology in Transition Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21-24, 1994 Edited by the Publication Committee G. H. Degen, J. P. Seiler and P. Bentley With 104 Figures and 59 Tables , Springer Gisela H. Degen Institut fUr Arbeitsphysiologie an der Universitat Dortmund Ardeystr.67 0-44139 Dortmund Jurg P. Seiler Interkantonale Kontrollstelle fUr Heilmittel Erlachstr. 8 CH-3000 Bern 9 Philip Bentley Ciba-Geigy Ltd. K-136.3.23 CH-4002 Basel ISBN-l3: 978-3-642-79453-7 e-ISBN-13:978-3-642-79451-3 DOl: 10 .1 007/978-3-642-79451-3 CIP data applied for This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, speci fically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must al ways be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1995 Softcover reprint of the hardcover I st edition 1995 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and the refore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application con tained in this book. In every individual case the user must check such information by consulting the relevant literature 1Ypesetting: Camera ready by authors SPIN 10487327 27/3\30 - 5 4 3 2 I 0-Printed on acid-free paper Contents Genetically Modified Cells and Animals in Toxicological Research Concepts, potentials, methods for constructing transgenic cells and animals -Introduction K. Biirki ................................................................................................................. 3 Use of recombinant cells in metabolic and mechanistic studies (analysis of pathways) W. A. Schmalix and f. D6hmer... ......................................................................... 8 Applications for transgenic animals in toxicology D. Brusick ............................................................................................................ 23 The Benchmark Dose Concept Principles, benefits and limitations of the NOEL approach D.l. Esdaile .......................................................................................................... 37 Comparison of benchmark doses (BMD) with no-observed-adverse effect-levels (NOAEL) and low-observed-adverse-effect-levels (LOAEL) for subchronic studies R. S. Nair. M. W. Stevens. M. A. Martens. and f. Ekuta..................................... 44 Bioindicators in Ecotoxicology Bioindicators in ecotoxicology: an overview f. Lopez-Barea........ ... ................ ................................................................. ........ 57 Use of cytochrome P450 lA in fish as a biomarker of aquatic pollution A. Goksf/Jyr ..... ....... ..... ....... ..... ..... .............. ..... ..... ....... ....... ... ......... ..... ....... ..... ..... 80 Receptor-mediated toxicity Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression S. Safe and V. Krishnan......... ........................ ..................................................... 99 Inhibitors of the sodium pump: toxins, then drugs, and now hormones f.-D. Horisberger .............................................................................................. 116 Rodent responses to peroxisome proliferators - a receptor-mediated phenomenon? f. D. Tugwood .................................................................................................... 125 VI Role of second messengers in mineral particle-induced production of reactive oxygens species by phagocytes K. Savolainen and M. Ruotsalainen .................................................................... 134 Estrogenic effects of some xenobiotics M. Vargova, M. Gajdova, J. Jakubovsky, and L. Ws6lova ............................... 148 In Vitro tests in regulatory toxicology In Vitro methods in regulatory toxicology: the crucial significance of validation M. Balls ............................................................................................................. 155 Scientific, ethical and legal aspects of the acceptance of in vitro methods in regulatory toxicology E. Walunl ............................................................................................................ 163 The validation and use of in vitro teratogenicity tests R. Bechter ........................................................................................................... 170 In Vitro methods in regulatory toxicology R. Bass ............................................................................................................ 192 In Vitro tests in regulatory toxicology: symposium chairman's summing-up M. Balls .............................................................................................................. 205 Ex Vivo and in Vitro Models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism S. Ellouk-Achard, V. Levesse, C. Martin, C. Pham-Huy, H. Dutertre- Catella, M. Thevenin, 1.-M. Warnet, and 1. R. Claude .................................... 209 Rabbit renal proximal tubule suspensions as a model for nephrotoxicity evaluation of native or in situ metabolized B-Iactam antibiotics H. Dutertre-Catella, C. Martin, M. Debray, C. Pham-Huy, M. Thevenin, 1.M. Warnet, R. A. Podevin, and 1. R. Claude ................................................ 215 Neurobehavioral abnormalities induced by substance abuse Neurobehavioral abnormalities induced by prenatal exposure to substances of abuse -stating the problem J. Elsner .............................. .............................................................................. 221 Prenatal exposure to marihuana and tobacco during infancy, early and middle childhood: effects and an attempt at synthesis. P. A. Fried.. ....... ..... ..... ................... ....... ....... ... ....... .......... ......... ..... ............ ....... 233 Delayed developmental neuro-and immunotoxicity of benzodiazepines M. SchlumpJ, R. Parmer, E. E. Butikofer, S.lnderbitzin, A. R. Salili, A . .A. Schreiber, H. R. Ramseier, H. van Loveren, and W. Lichtensteiger .................. 261 VII Changes of EEG of freely-moving rats caused by three generation organophosphate treatment L. NagynUlijtbzyi ................................................................................................ 288 Developmental neurotoxicity of carbon monoxide M. R. Carratu. R. Cagiano. M. A. De Salvia. L. Trabace. and V. Cuomo .......... 295 Safety assessment of over the counter (OTC) products The safety assessment of over the counter (OTC) products B. Schnlid ........................................................................................................... 305 OTC pharmaceuticals and genotoxicity testing: the paracetamol, anthraquinone, and griseofulvin cases L. Miiller ........................................................................................................... 312 Safety assessment of OTC products: doxylamine succinate 1. A. Skare.......................................................... ............................... ................ 326 Safety assessment of OTC products: a regulatory view P. Sjoberg ........................................................................................................... 341 Drug toxicity findings and no action taken F. W. Wolff. ...................................................................................................... 346 Species specificity of organ toxicity Species specificity of organ toxicity W. Butler .............. ........................................................................... ............ ...... 351 Species specificity at the molecular level: the case of nitric oxide synthase E. Felley-Bosco . ................................................................................................ 357 Mechanisms underlying species-specificity in target organ specificity E. A. Lock. . ....................................................................................................... 367 Species specificity of organ toxicity: behavioral differences G. Bignami. G. Dell 'Onw. and E. Alleva .......................................................... 375 Terrestrial ecotoxicity of chemical substances Development of OECD test guidelines and hazard assessment procedures for terrestrial effects N. Grandy....... ............ ............... ..................... .................... .............. ................. 397 Development of guidance for terrestrial effects assessment L. Sams¢e-Petersen and F. Pedersen ............................................................... 406 VIII Application of quick and simple plant bioassays to assess the genotoxicity of environmental pollutants -Detection of potential health hazards of air, water and soil contaminants T.-H. Ma ......................................................................................................... 420 Comparison of susceptibility to chemicals (pesticides) of species used for human and environmental effect assessment W. Pfluger ........................................................................................................ 434 Toxicological evaluation of pollutants in soil -concept of the AGU and assessment of tolerable concentrations for metals B. Liebl. U. Schwegler. E. Roscher. and G. Kerscher ..................................... 446 Immunodeficient mouse systems scm The (severe combined immnodeficiency) mouse -its biology and use in immunotoxicological research M. Lf/Jvik ............................................................................................................. 455 scm The mouse as a tool to bridge the gap between animal and human responses H. Van Loveren and C. De Heer ........................................................................ 468 scm The mouse and its use in immunopharmacological and immunotoxicological investigations C. H. Ladel. H. Puschner. and U. Bamberger .................................................. 472 Stereochemical effects Chirality -from molecules to organisms J. P. Seiler ......................................................................................................... 491 Interactions between the in vitro metabolism of xenobiotics and fatty acids. The case of ibuprofen and other chiral profens. J.M. Mayer. B. Testa. M. Roy-deVos. C. Audergon. and J.C. Etter ................ 499 Side effects and toxic reactions of chiral drugs: a clinical perspective M. Eichelbaum ................................................................................................ 514 Analysis of (S)-and (R)-propanolol in human plasma and urine by a specific immunoenzymtic assay versus HPLC C. Pham-Huy. A. Sahui-Gnassi. F. Massicot. H. Galons. H. Dutertre- Catella. B. Radenen. J.M. Warnet. H. T. Duc. and J. R. Claude .................. 522 Biological behavior of prestages of cancer cells Biological behavior of prestages of cancer cells: an introduction R. Schulte-Hermann ........................................................................................ 531 IX Preneoplastic lesions in kidney and carcinogenesis by non-genotoxic compounds D. R. Dietrich and T. Rasollyi ...................................................................... 536 Early cellular alterations in chemical liver carcinogenesis as assessed by immunohistochemical and molecular biological techniques H. S. Huitfeldt .................................................................................................. 547 Late Manuscripts The UK approach to the regulation and evaluation of novel foods produced by biotechnology D. A. Jonas ...................................................................................................... 557 Young Scientists Poster Award Molecular mimikry of CF3CO-Iysine by lipoic acid I: the dehydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase as autoantigen in halothane hepatitis U. Christen and J. Gut ...................................................................................... 565 Molecular mimikry of CF3CO-Iysine by lipoic acid II: lipoic acid bearing proteins as autoantigen in halothane hepatitis N. Frey, V. Koch, and J. Gut ............................................................................. 566 Subject Index .............................................................................................. 567 Genetically Modified Cells and Animals in Toxicological Research (Chair: Dr. K. Biirla, Switzerland)
The list of books you might like
