Toxicology in the Middle Ages and Renaissance This pageintentionallyleftblank Toxicology in the Middle Ages and Renaissance Edited by Philip Wexler AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1800,SanDiego,CA92101-4495,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom Copyrightr2017ElsevierInc.Allrightsreserved. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicor mechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem,without permissioninwritingfromthepublisher.Detailsonhowtoseekpermission,furtherinformationaboutthe Publisher’spermissionspoliciesandourarrangementswithorganizationssuchastheCopyrightClearance CenterandtheCopyrightLicensingAgency,canbefoundatourwebsite:www.elsevier.com/permissions. 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WellcomeLibrary,London TypesetbyMPSLimited,Chennai,India “For Nancy, Yetty, Will, Jake, Lola, and Gigi, with Love” This page intentionallyleftblank CONTENTS List of Contributors.............................................................................xi Preface..............................................................................................xiii Acknowledgments................................................................................xv About the Editor................................................................................xvii Chapter 1 Poison and Its Dose: Paracelsus on Toxicology....................1 UrsLeo Gantenbein 1.1 The Four Pillars of Medicine........................................................1 1.2 Poison and the Alchemist in the Stomach....................................3 1.3 Noxious Mineral Vapors and the Miner’s Disease.......................6 1.4 The Dose Makes the Poison.........................................................8 References...........................................................................................10 Chapter 2 The Golden Age of Medieval Islamic Toxicology...............11 Mozhgan M. Ardestani,Roja Rahimi,Mohammad M.Esfahani, Omar Habbal andMohammad Abdollahi 2.1 Introduction................................................................................11 2.2 Prominent Toxicologists in Medieval Islamic Era......................12 2.3 Toxicologists after 1500 AD.......................................................23 2.4 Discussion...................................................................................28 Acknowledgment................................................................................29 References...........................................................................................29 Chapter 3 Maimonides’ Book on Poisons and the Protection Against Lethal Drugs.........................................................31 Gabriele Ferrario 3.1 Maimonides................................................................................31 3.2 Maimonides Medical Works and Medical Practice....................32 3.3 The Treatise on Poisons and the Protection Against Lethal Drugs...............................................................................34 3.4 Structure and Contents of On Poisons........................................37 3.5 The Hebrew Translations and Their Circulation........................39 3.6 The Latin Translations and Their Circulation............................40 References...........................................................................................41 viii Contents Chapter 4 Pietro d’Abano, De venenis: Reintroducing Greek Toxicology into Late Medieval Medicine.................43 Alain Touwaide Further Readings................................................................................52 Chapter 5 The Case Against the Borgias: Motive, Opportunity, and Means....................................................53 CathyCobb 5.1 Introduction................................................................................53 5.2 Accusations.................................................................................54 5.3 Motive........................................................................................54 5.4 Opportunity................................................................................55 5.5 Means.........................................................................................55 References...........................................................................................59 Chapter 6 Aqua Tofana......................................................................63 Mike Dash 6.1 History........................................................................................63 6.2 Symptoms...................................................................................65 6.3 Poisons and the Criminal Magical Underworld.........................65 6.4 The Slow Poisons........................................................................67 References...........................................................................................69 Chapter 7 Poisons and the Prince: Toxicology and Statecraft at the Medici Grand Ducal Court......................................71 Sheila Barker 7.1 Poisons in 16th-Century Society.................................................71 7.2 Knowledge of Poisons at the Medici Court................................74 7.3 Medici Antidotes........................................................................75 7.4 Testing Poisons...........................................................................78 7.5 Resources....................................................................................81 References...........................................................................................81 Chapter 8 Georgius Agricola, a Pioneer in the Toxic Hazards of Mining, and His Influence..............................................83 SverreLangård 8.1 Education and Early Life...........................................................83 8.2 De re Metallica...........................................................................85 Contents ix 8.3 Diseases in Miners and Their Prevention...................................86 8.4 Bergsucht and Its Causes............................................................87 8.5 A Third Wave of Mining in the 20th Century............................88 Conflict of Interest..............................................................................90 References...........................................................................................90 Chapter 9 Jan Baptist Van Helmont and the Medical(cid:1)Alchemical Perspectives of Poison........................................................91 Georgiana D. Hedesan 9.1 Van Helmont’s Paracelsian Legacy on Poisons..........................91 9.2 Universal Poison in a Christian Perspective...............................93 9.3 Van Helmont’s Criticism of Galenic Purgatives.........................95 9.4 The Alchemical Solution............................................................98 9.5 Conclusions................................................................................99 References.........................................................................................100 Chapter 10 Origin of Myths Related to Curative, Antidotal and Other Medicinal Properties of Animal “Horns” in the Middle Ages.........................................................101 Chris Lavers 10.1 A Brief History of Alicorn......................................................101 10.2 Origins....................................................................................102 10.3 Unicorns of the Arab World...................................................103 10.4 Khutu.....................................................................................105 10.5 The Walrus and the Narwhal.................................................107 10.6 The Woolly Rhinoceros and Mammoth.................................109 10.7 Bone from the Forehead of a Bull..........................................110 10.8 Conclusion..............................................................................112 Disclaimer.........................................................................................113 References.........................................................................................113 Chapter 11 Animal Stones and the Dark Age of Bezoars..................115 Maria doSameiro Barroso 11.1 Introduction............................................................................115 11.2 Bezoars: Philological, Conceptual, and Symbolic Framework..............................................................115 11.3 Bezoars and Their Glory........................................................117 11.4 Bezoars in the Mist of History................................................118 11.5 Conclusion..............................................................................122