Table Of Content

ER Toxicology 114 (1996) 259-260 Volume contents Volume 114 (1996) Doxorubicin- and daunorubicin-induced energy deprivation and nucleotide degradation in isolated cardiomyocytes Increased ATP hydrolysis initiates the drug-related cell damage R.F. Vidal, S. Eksborg, M. Sundberg, M. Carlberg, B. Elfsson, B.S. Andersson (Sweden) Renal insufficiency induced by cisplatin in rats is ameliorated by cyclosporin A Renal failure may be caused by mitochondrial dysfunction which can be alleviated by cyclosporine A P.I. Campbell, I.A. Al-Nasser (Saudi Arabia) Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver Monooxigenases and transferases are differentially induced by flavonoids M.-C. Canivenc-Lavier, M.-F. Vernevaut, M. Totis, M.-H. Siess, J. Magdalou, M. Suschetet (France) ... . The cyanobacterial toxin microcystin-LR induced DNA damage in mouse liver in vivo The microbiol toxin causes tissue damage as measured by a number of biochemical parameters P.V. Lakshmana Rao, R. Bhattacharya (India) Differential effect of interleukin-1% on rat hepatic cytochrome P450 monoxygenases An investigation on the down regulations of the hepatic P450 system R.K. Sindhu, H. Sakai, T. Okamoto, Y. Kikkawa (USA) Immunotoxicology Improved ex vivo/in vitro lymph node cell proliferation assay in guinea pigs for a screening test of contact hypersensitivity of chemical compounds The predictive value of ex-vivo/in vitro lymph node cell proliferation assay is further documented R. Kashima, Y. Oyake, J. Okada, Y. Ikeda (Japan) Influence of mercuric chloride on resistance to generalized infection with herpes simplex virus type 2 in mice Mercuric chloride impairs the resistance of mice to herpes simplex virus type-2 infection M.M. Christensen, S. Ellermann-Eriksen, J. Rungby, S.C. Mogensen (Denmark) Increased IL-1, IL-6 and TNFz secretion and mRNA levels in WEHI-3 cells exposed to cyclopiazonic acid The mycotoxin cyclopiazonic acid can superinduce the secretion and mRNA levels of cytokines associated with macrophage activation M.L. Marin, S.-5. Wong, J.J. Pestka (USA) Toxicology Information and Resources A database designed to support dose-response analysis and risk assessment D.J. Guth, T. S. Raymond (USA) Bronchial responsiveness and inflammation in guinea-pigs exposed to toluene diisocyanate: a study on single and repeated exposure Bronchioalveolar hyperresponsiveness is not causally connected with neutrophil activation F. Gagnaire, M. Ban, J.C. Micillino, M. Lemonnier, P. Bonnet (France) Cadmium suppresses A9 desaturase activity in rat hepatocytes A study with primary rat hepatocyte cultures N. Kudo, K. Waku (Japan) 260 Volume contents | Toxicology 114 (1996) 259-260 Dose-response relationship for rat liver DNA damage caused by i,2-dimethylhydrazine A critical analysis of an extensive dose-response study K.T. Kitchin, J.L. Brown (USA) 113-124 Mechanism of cadmium-induced cytotoxicity in rat hepatocytes: cadmium-induced active oxygen-related permeabil- ity changes of the plasma membrane Cd stimulates production of intracellular hydrogen peroxide T. Koizumi, H. Shirakura, H. Kumagai, H. Tatsumoto, K.T. Suzuki (Japan) Relationship between mitochondrial dysfunction and toxicity of propyl gallate in isolated rat hepatocytes Fructose protects against and azide enhances hepatocyte death caused by propyl gallate Y. Nakagawa, P. Moldéus, G.A. Moore (Japan, Sweden) Stimulatory effect of anesthetics on dechlorination of carbon tetrachloride in guinea-pig liver microsomes Anesthetics studied were isoflurane, enflurane, halothane and sevoflurane K. Fujii (Japan) Immunotoxicology Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat Cats treated with propylthiouracil develop the lupus-like syndrome and anti-myeloperoxidase antibodies L. Waldhauser, J. Uetrecht (Canada) 155-162 Immunomodulating effects after perinatal exposure to methylmercury in mice Perinatal exposure to methylmercury affects thymocyte development and stimulates lymphatic proliferative responses in mice A. Thuvander, J. Sundberg, A. Oskarsson (Sweden) Accumulation of ochratoxin A in rat kidney in vivo and in cultivated renal epithelial cells in vitro The mycotoxin accumulates in the rena! papilla and inner medulla G. Schwerdt, K. Bauer, M. Gekle, S. Silbernagl (Germany) Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone Alveolar macrophages are involved in leukotriene generation M.J. Coffey, C.S. Wheeler, K.B. Gross, W.L. Eschenbacher, P.S. Sporn, M. Peters-Golden (USA) Decreased liver type I 5’-deiodinase and increased brown adipose tissue type II 5’-deiodinase activity in 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-treated Long-Evans rats TCDD has differential effects on enzymes regulating thyroid hormone levels A. Raasmaja, M. Viluksela, K.K. Rozman (Finland) 199-205 The carcinogenicity of dichloroacetic acid in the male fischer 344 rat F344 male rats appear to be more sensitive to the carcinogenic action of dichloroacetic acid than are B6C3F1 male mice A.B. DeAngelo, F.B. Daniel, B-M. Most, G.R. Olson (USA) 207-221 The effect of carbon monoxide on oxygen metabolism in the brains of awake sheep Central effects are postulated that are not related to hypoxia P. Langston, D. Gorman, W. Runciman, R. Upton (Australia) Characterisation of the toxic metabolite(s) of naphthalene Quinones of |-naphthol rather than naphthalene-1,2 epoxide are the toxic metabolites A.S. Wilson, C.D. Davis, D.P. Williams (UK), A.R. Buckpitt, M. Pirmohamed, B.K. Park (USA) 233-242 Immunotoxicology Effects of ozone upon macrophage-interferon interactions In vitro exposure of macrophages to ozone reduces the binding of, and responsivity to interferon-y M.D. Cohen, J.T. Zelikoff, Q. Qu, R.B. Schlesinger (USA) 243-252 ag Oe, Toe Pete aR ae eer ohn ee fe: Oe ee eee Poe a ee ere nee See on 253 255-258 AR gC AUER ates bon. nea IR eT oe ie OR ac yn i, eh ee ee LN * 259-260