Table Of Content

Toxicology, 73 (1992) 339-341 Elsevier Scientific Publishers Ireland Ltd. TOXICOLOGY VOLUME CONTENTS Volume 73 (1992) Review Article The carcinogenicity of ciclosporin by B. Ryffel (Zurich, Switzerland) Comparative study on the toxicity of methyl linoleate-9,10-ozonide and cumene hydroperoxide to alveolar macrophages (Using phagocytosis as a parameter of cell viability the former is more toxic and acts by a different mechanism than the latter) by R.A. Hempenius, I.M.C.M. Rietjens, H.N.A. Grooten, J. de Vries (Wageningen and Heerlen, The Netherlands) Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures (Inhibitory activity on brain or plasma cholinesterase is correlated with an index of acute toxicity) by C.N. Pope and T.K. Chakraborti (Monroe, LA) N-Methyl-N’-Nitro-N-Nitrosoguanidine: The effect on migration and cGMP level of neutrophils (The compound has two effects: increase in cGMP and enhancement of migration) by J.G.R. Elferink and B.M. de Koster (Leiden, The Netherlands) Toxicity of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats after single oral administration (2,3,7,8-TBDD seems to be less potent than 2,3,7,8-TCDD) by I.A. Ivens, E. Loser, M. Rinke, U. Schmidt and M. Neupert (Leverkusen, Germany) In vitro protein synthesis is affected by the herbicide 2,4-dichlorophenoxyacetic acid in Azospirillum brasilense (It is concluded that 2,4,-D acts through the same mechanisms in procaryotic and eucaryotic cells) by V. Rivarola, A. Fabra, G. Mori and H. Balegno (Cordoba, Argentina) Susceptible period for the teratogenicity of di-n-butyltin dichloride in rats (The teratogenic potential of di-n-butyltin is described) by M. Ema, T. Itami and H. Kawasaki (Osaka, Japan) Stimulative effects of cadmium on bone resorption in neonatal parietal bone resorption (Cadmium- stimulated bone resorption was dependent on production of prostaglandin E,) by T. Miyahara, M. Takata, S. Mori-Uchi, M. Miyata, M. Nagai, A. Sugure, M. Matsusista, H. Kozuka and S. Kuze (Toyama, Japan) On the hepatotoxicity of 1,1,2,2-tetrachloroethane (Spin trapping suggests the involvement of free radicals and lipid peroxidation as toxic mechanism) by M. Paolini, E. Sapigni, R. Mesirca, G.F. Pedulli, F.P. Corongiu, M.A. Dessi and G. Cantelli-Forti (Bologna and Cagliari, Italy; Galveston, TX) 101-115 Role of aluminium in skin reactions after diphtheria-tetanus-pertussis-poliomyelitis vaccination: An experimental study in rabbits (Aluminium seems to remain at the cuticular injection site) by A. Pineau, C. Durand, O. Guillard, B. Bureau and J.-F. Stalder (Nantes and Poitiers, France) 117-125 Review Article Lead nephrotoxicity and associated disorders: biochemical mechanisms (The hypothesis is discussed that lead nephropathy is caused by antagonism between lead and calcium) by C.V. Nolan and Z.A. Shaikh (Kingston, RI) 340 Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from 6-naphthoflavone-treated male F344 rats (Multiple rat lung cell types contain con- stitutive P-450 monooxygenase activities) by S.A. Lacy, J.B. Mangum and J.I. Everitt (Research Triangle Park, NC) Ranking toxicity of industrial dusts by bronchoalveolar lavage fluid analysis (Some biochemical parameters in bronchoalveolar lavage fluid are affected by dusts in the following order: quartz > fly ash > mica > corundum) by R. Bajpai, M. Waseem, G.S.D. Gupta and J.L. Kaw (Lucknow, India) 161-167 Blood lactate and catecholamine levels in the carbon monoxide-exposed rat: the response to elevated glucose (No relationship between CO-induced raise in blood catecholamines and a rise in blood glucose was found) by B.B. Sutariya, D.G. Penney, J.C. Dunbar and C.J. Swanson (Detriot, MI) 169-178 Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes (There is a moderate reduction of enzyme leakage after erythromycin and a strong protection against GSH loss after oxidative stress) by P. Villa, D. Cova, L. De Francesco, A. Guaitani, G. Palladini and R. Perego (Milan, Italy) .. 179-189 Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures (Hepatocyte cultures were more sensitive than keratinocyte cultures) by L. Garza-Ocafias, G.C. Hsieh, D. Acosta, O. Torres-Alanis and A. Pifieyro-Lopez (Nuevo Leon, México; Austin, TX) 191-201 Fluoranthene induces programmed cell death and alters growth of immature B cell populations in bone marrow cultures (Fluoranthrene compromises B lymphopoiesis at several levels) by F. Hinoshita, J.A. Hardin and D.H. Sherr (Boston, MA) 203-218 Inhibitory effect of lead on the release of tissue plasminogen activator from human vascular endothelial cells in culture (Lead decreases the release of tissue plasminogen activator without concomitant nonspecific inhibition of protein synthesis) by T. Kaji, C. Yamamoto, M. Sakamoto and H. Kozuka (Kanazawa and Toyama, Japan) 219-227 Depletion of essential elements by calcium disodium EDTA treatment in the dog (EDTA treatment results in increased urinary excretion of Zn, Cu and Mn, decrease of Zn levels in duodenum, skin and hair and increase in renal Cu) by S.E.M. Ibim, J. Trotman, P.I. Musey and W.E.B. Semafuko (Tuskegee, AL) 229-237 The hepatotoxicity of chloroform in precision-cut rat liver slices (Glutathione depletion was an early sign of toxicity, seen as early as after 3 h) by S. Azri-Meehan, H.P. Mata, A.J. Gandolfi and K. Brendel (Tucson, AZ) 239-250 Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase (Overproductoin of formaldehyde in vascular tissue may be a pathogenetic mechanism) by P.J. Boor, M.B. Trent, G.A. Lyles, M. Tao and G.A.S. Ansari (Galveston, TX; Dundee, UK). 251-258 Toxicity assessment of toxins T-514 and T-544 of Buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures (Liver cells were highly sensitive to the two toxins, whereas skin toxicity was less severe and delayed) by L. Garza-Ocanas, G.C. Hsieh, D. Acosta, O. Torres-Alanis and A. Pineyro-Lopez (Nuevo Leon, México; Austin, TX) 259-267 Actin filament alteration as a potential marker for cholestasis: a study in isolated rat hepatocyte couplets (Pericanalicular F-actin abnormalities may be indicative of hepatocellular cholestasis) by N. Thibault, J.R. Claude and F. Ballet (Vitry sur Seine Cedex and Paris, France) 269-279 Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane (Cytosolic proteins are trifluoroacetylated and adduct formation was selective for glutathione- S-transferase) by A.P. Brown, K.L. Hastings, A.J. Gandolfi, D.C. Liebler and K. Brendel (Tucson, AZ) 281-295 inhibition of protein synthesis in liver and kidney of mice by bolesatine: mechanistic approaches to the mode of action at the molecular level (The fungal mycotoxin does not seem to belong to the ribosome- inactivating proteins) by O. Kretz, L. Barbieri, E.E. Creppy and G. Dirheimer (Strasbourg and Bordeaux, France; Bologna, Host resistance to Trichinella spiralis infection in rats and mice: species-dependent effects of cyclophosphamide exposure (Rats appear to be inherently more sensitive to cyclophosphamide than are mice) by R.W. Luebke, C.B. Copeland, D.L. Andrews, M.M. Riddle and R.J. Smialowicz (Research Triangle Park, NC) 305-321 Announcements 323-324 Contents of journals relating to Toxicology 325-332 Subject Index Volume 73 333-336 Author Index Volume 73 337 Contents Volume 73 339-341