Towards personalized p immunotherapy of cancer PDF
Preview Towards personalized p immunotherapy of cancer
NCT Conference 2013 New Cancer Targets Towards personalized immunotherapy of cancer Hans-Georg Rammensee Interfakultäres Institut für Zellbiologie Abteilung Immunologie Prof. Dr. Hans‐Georg Rammensee Towards patient-specific tumor antigen selection for vaccination. Rammensee HG, Weinschenk T, Gouttefangeas C, Stevanović S. Immunol Rev 188:164-76, 2002 1. MHC, peptides, and cancer 2. Our strategy to identify cancer associated peptides 3. Clinical studies 4. Why mutated antigens should be the better targets 5. Problems this can be recognized by T cells protein fragment This is true for all proteins inside a = peptid cell, also for tumor Antigen presentation associated changes, by HLA molecule including mutations Antigen processing Cancer cells differ from normal cells eg., in gene expression This can be sensed by T cells - no matter which cellular compartment is affected by the change 3 classes of tumor antigens Limited to few cancer We know plenty of such antigens; This is our vision entities immune responses tend to be weak but stronger immune responses may lead to autoimmunity Isolation of Naturally Presented HLA-Ligands Lab Meeting Daniel Kowalewski 07.07.2011
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