topics on cervical cancer with an advocacy for prevention

294 Pages·2012·9.96 MB·English

by  Intech Prepress 1

TOPICS ON CERVICAL
CANCER WITH AN
ADVOCACY FOR
PREVENTION

Edited by Rajamanickam Rajkumar
Topics on Cervical Cancer with an Advocacy for Prevention
Edited by Rajamanickam Rajkumar

Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2012 InTech
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Technical Editor Teodora Smiljanic
Cover Designer InTech Design Team

First published February, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Topics on Cervical Cancer with an Advocacy for Prevention,
Edited by Rajamanickam Rajkumar
p. cm.
ISBN 978-953-51-0183-3

Contents

Preface IX
Chapter 1 Predictors of Cervical Cancer Screening:
An Application of Health Belief Model 1
Sedigheh Sadat Tavafian
Chapter 2 Community Based Cancer
Screening – The 12 “ I ”s Strategy for Success 25
Rajamanickam Rajkumar
Chapter 3 Challenges to Cervical Cancer in the
Developing Countries: South African Context 39
Nokuthula Sibiya
Chapter 4 Cervical Cancer in Sub Sahara Africa 51
Atara Ntekim
Chapter 5 The Indicators of Predicting
Disease Outcome in HPV Carcinogenesis 75
Coralia Bleotu and Gabriela Anton
Chapter 6 Cervical Cancer Treatment in Aging Women 103
Kenji Yoshida, Ryohei Sasaki, Hideki Nishimura,
Daisuke Miyawaki and Kazuro Sugimura
Chapter 7 Cervical Cancer Prevention by
Liquid-Based Cytology in a Low-Resource Setting 115
Mongkol Benjapibal and Somsak Laiwejpithaya
Chapter 8 Microinvasive Carcinoma of the Cervix 131
Fernando Anschau, Chrystiane da Silva Marc,
Maria Carolina Torrens and Manoel Afonso Guimarães Gonçalves
Chapter 9 The Clinical Outcome of Patients
with Microinvasive Cervical Carcinoma 139
Špela Smrkolj
VI Contents

Chapter 10 New Therapeutic Targets 147
Magali Provansal, Maria Cappiello,
Frederique Rousseau, Anthony Goncalves and Patrice Viens
Chapter 11 A Transcriptome- and Marker-Based
Systemic Analysis of Cervical Cancer 155
Carlos G. Acevedo-Rocha, José A. Munguía-Moreno,
Rodolfo Ocádiz-Delgado and Patricio Gariglio
Chapter 12 Evaluation of p53, p16INK4a and E-Cadherin
Status as Biomarkers for Cervical Cancer Diagnosis 195
M. El Mzibri, M. Attaleb, R. Ameziane El Hassani,
M. Khyatti, L. Benbacer, M. M. Ennaji and M. Amrani
Chapter 13 New Biomarkers for Cervical Cancer –
Perspectives from the IGF System 215
Martha-Lucía Serrano, Adriana Umaña-Pérez,
Diana J. Garay-Baquero and Myriam Sánchez-Gómez
Chapter 14 HPV Bioinformatics: In Silico Detection,
Drug Design and Prevention Agent Development 237
Usman Sumo Friend Tambunan and Arli Aditya Parikesit
Chapter 15 Therapeutic Exploitation of Targeting
Programmed Cell Death for Cervical Cancer 253
Yang Sun and Jia-hua Liu
Chapter 16 Antiproliferative Effect
and Induction of Apoptosis by
Inula viscosa L. and Retama monosperma L.
Extracts in Human Cervical Cancer Cells 267
L. Benbacer, N. Merghoub, H. El Btaouri, S. Gmouh,
M. Attaleb, H. Morjani, S. Amzazi and M. El Mzibri

Preface

Cervical cancer is one of the leading cancers in women, especially among those living
in the poor socioeconomic conditions in the developing world. Much research has
been done into possible treatments and preventative measures to hep combat the
disease, and while there is a wealth of information and statistical evidence in terms of
incidence, survival and mortality rates the challenge is to communicate what this
means to the average person on the street.
If we can ensure that cervical cancer can be screened for at an early stage, effective
precancer treatment can be given and an evidence-based cure can be developed by
meticulous follow up, then, we are justified. Women empowerment, education and
screening/treatment of cervical cancer preceded by affordable, acceptable and
accessible strategies, will play a critical role.
This book by InTech – Open Access Publisher is a commendable project. If the
chapters could inspire a worldwide crusade to prevent cerrvical cancer, especially
among the most underprivileged women in the developing countries, the mission is
fulfilled.

Dr Rajamanickam Rajkumar
Professor, Community Medicine
Meenakshi Medical College Hospital & Research Institute,
Kanchipuram Tamil Nadu
India