Topics in Acute and Chronic Pancreatitis Editors L. A. Scuro and A. Dagradi Co-Editors G. P. Marzoli, P. Pederzoli, G. Cavallini, and C. Banterle With 95 Figures and 64 Tables Springer-Verlag Berlin Heidelberg New York 1981 Proceedings of the International Meeting held in Padenghe suI Garda (Italy), 14-15th September, 1979 Professor Dr. L. A. Scuro Istituto Clinica Medica dell'Universita di Padova Sede in Verona, Policlinico di Borgo Roma 1-37100 Verona (Italy) Professor Dr. A. Dagradi Istituto Clinica Chirurgica dell'Universita di Padova Sede in Verona, Policlinico di Borgo Roma 1-37100 Verona (Italy) ISBN-13: 978-3-540-I 0439-I e-ISBN-l3: 978-3-642-67879-0 DOl: 10.1007/978-3-642-67879-0 Library of Congress Cataloging in Publication Data. Main entry under title: Topics in acute and chronic pancreatitis. Proceedings of the international meeting held in Padenghe sui Garda, Italy, Sept. 14-15, 1979. 1. Pancreatitis-Congresses. I. Scuro, L.A. (Ludovico Antonio), 1924- . II. Degradi, Adamo. [DNLM: 1. Pancreatitis. WI 805 T674] RC858.P35T66 616.3'7 81-5618 AACR2 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of il lustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use a fee is payable to 'Verwertungsgesellschaft Wort', Munich. © Springer-Verlag Berlin Heidelberg 1981 The use of registered names, trademarks, etc. in the publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. 2124/3140/543210 Preface The increasing incidence of both chronic pancreatitis and pan creatic cancer was the primary impetus for the organization of this meeting, an additional factor being the widespread existence of pancreatic disease within Italy itself. It is well known that the treatment of chronic and particularly of acute pancreatitis is still a matter of controversy, and it seemed useful to compare our own experience with that of other centers working in the same field. Consequently, in addition to numerous Italian specialists in the field, doctors from the Federal Republic of Germany, Denmark, Great Britain, France, and Austria were invited to attend the meeting. The symposium lasted two days and comprised eight sessions dealing with the anatomy and physiology of the pancreas and the pathophysiology, diagnosis, and treatment of pancreatic diseases. A central feature of the discussion on the surgical treatment of chronic pancreatitis was the debate between those who favor the use of drainage and those who believe resection to be the best treatment. Finally, I would like to thank Dr. Cavallini and Dr. Pederzoli very much for their help in organizing the meeting and also the local authorities for their aid. Professor Adamo Dagradi Director of the Institute of Clinica Chirurgica, Verona Opening Address I am pleased to welcome all partlclpants and particularly the guests from abroad, to this meeting on the clinical evaluation of pancreatitis. A word about this undertaking, which has two main goals: First, to state how far we have advanced in our knowledge of pancreati tis, from both the pathologic and pathophysiologic points of view, and to debate questions of diagnosis and medical or surgical thera py. Second to compare ideas, views, and information; this also ap plies to the sessions, which hopefully will be profitable. Over the past years interest in pancreatic disease has been increas ing, and no doubt the improvement of diagnostic procedures has enhanced diagnosis, chiefly through radiologic and functional studies of the pancreas. Such interest is also justified both by the actual increase in the incidence of pancreatitis and, even more, of pancreatic cancer, which ranks fourth among neoplasms in several countries, and by the severity of clinical findings and complica tions of acute and chronic pancreatitis. Since in Italy pancreatitis is mainly related to chronic alcohol abuse, which is a problem at least as big as drug addiction, a continuons effort should be made to reduce alcohol consumption to acceptable levels. Also, all alcohol related diseases constitute a heavy social burden from the econom ic point of view. A deep knowledge of alcohol related diseases and health education programs should help in facing this problem. In summing up, this symposium is meant to make some contribu tion to the advancement of the study of acute and chronic pan creatitis. Professor Ludovico A. Scuro Director of the Institute of Clinica Medica, Verona Table of Contents Radiographic Study of the Anatomy ofthe Pancreas (Ho An- acker) 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Elements of Surgical Anatomy of the Pancreas (Go Po Mar- zoli, So Vesentini, and Go Mangiante) 11 0 0 0 0 0 0 0 0 0 0 0 0 Physiologic Control of the External Pancreatic Secretion in Man (Ho W orning) 23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pancreatic Malfunction - When, How, Why? (Ko Go Wormsley) 37 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pancreatic Extracts in Chronic Pancreatitis: Which, How, and When? (Go Dobrilla, Mo Felder, and Go de Pretis) 55 Radiological Approach to Acute and Chronic Pancreatitis (Go Fo Pistolesi, C. Fugazzola, C. Procacci, Fo Frasson, and L. Mazzi) 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Diagnostic Algorithm for Pancreatic Disease (Go Fontana, Po L. Costa, A. Vandelli, Go Silvani, Po Maiolo, Mo Melan- dri, and C. Camporesi) 85 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Morphogenesis of Acute Pancreatitis (Mo Wanke) 93 0 0 0 0 0 The Role of Total Parenteral Nutrition in the Treatment of Pancreatic Diseases (Ro Dionigi, Uo Prati, C. Tibaldeschi, and L. Dominioni) 115 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conservative Surgical Treatment of Acute Necrotic-Haem- orrhagic Pancreatitis (Po Pederzoli) 125 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pancreatic Abscess (Po Pederzoli, To Pilon, Co Bassi, and Go Po Marzoli) 133 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 One-Year Follow-Up to Acute Necrotic-Haemorrhagic Pancreatitis (Go Angelini) 137 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Surgical Treatment of Acute Pancreatitis (A. Fritsch) 143 0 0 0 Surgical Treatment of Acute Pancreatitis (Yo Staudacher, Ro Chiesa, and Vo Di Carlo) 153 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 VIII Table of Contents Morphology of Chronic Pancreatitis (Y. Becker) . . . . .. 161 Indications for Surgical Treatment of Chronic Pancreatitis (I. Vantini and C. Cavallini) ................. 173 Intraoperative Cytodiagnosis in Pancreas Disease (E. Bod- ner) ............................ 183 General Remarks to Chapters 19-21 (F. Gschnitzer) 189 The Pancreas-jejunal shunts (G. P. Marzoli) ..... 191 The Use of Resection in the Treatment of Chronic Pancrea- titis (R. Pichimayr and K. D. Rumpf) . . . . . . . . . . .. 205 Chronic Pancreatitis: Surgical Indications, Procedures and Limitations (A. Dagradi) ................... 223 Long Term Results of Pancreaticoduodenalresection (PDR) in Chronic Pancreatitis (G. Serio) .............. 241 The Endocrine Function of the Pancreatic Residue Mter Partial Duodenopancreatectomy (K. D. Rumpf) ...... 245 Follow-up of Chronic Pancreatitis. Methodological Consid- erations. (G. Bianchi Porro, A. Prada and M. Petrillo) 253 Longterm Evolution of Chronic Pancreatitis: The Italian Experience (L. A. Scuro) .................. . List of Contributors Prof. H. Anacker, Direktor des Instituts fUr Rontgendiagnostik am Klinikum rechts der Isar der TU Miinchen, Ismaningerstr. 22, D- 8000 Miinchen 80 Dr. G. P. Angelini, Istituto Clinica Medica, Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Dr. J. Antonschmidt, Klinik fUr Abdominal- und Trans plantationschirurgie, Karl-Wiechert-Allee 9, D-3000 Hannover 61 Prof. C. Banterle, Primario Divisione Medicina Intema, Ospedale Zonale, I-Besenzano (Brescia) Dr. C. Bassi, Istituto Clinica Chirurgica, Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Prof. V. Becker, Direktor des Pathologischen Instituts der Univer sitat Erlangen-Niimberg, Krankenhausstr. 8-10, D-8520 Erlan gen Prof. E. Bodner, Vorstand der II. Universitatsklinik fUr Chirurgie, Anichstr. 35, A-6020 Innsbruck Dr. C. Camporesi, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Dr. G. Cavallini, Istituto Clinica Medica, Universita di Padova, Sede in Verona, Policlinico B. Rom, 1-37100 Verona Dr. R. Chiesa, Clinica Chirurgica, Universita di Milano, Policlini co, 1-20100 Milano Dr. P. L. Costa, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Prof. A. Dagradi, Direttore di Istituto di Clinica Chirurgica Uni versita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Dr. Ch. Datan, Klinik fUr Abdominal- und Transplantationschir urgie, Karl-Wiechert-Allee 9, D-3000 Hannover 61 x List of Contributors Dr. G. de Pretis, Ospedale Generale Regionale di Bolzano, Divi sione di Gastroenterologia, Via Sernesi 1, 1-39100 Bolzano Dr. V. Di Carlo, Clinica Chirurgica, Universita di Milano, Policli nico, 1-20100 Milano Prof. R. Dionigi, Istituto di Patologia Chirurgica, Policlinico San Matteo, 1-27100 Pavia Prof. G. Dobrilla, Ospedale Generale Regionale di Bolzano, Divi sione di Gastroenterologia, Via Sernesi 1, 1-39100 Bolzano Dr. L. Oominioni, Istituto di Patologia Chirurgica, Polic1inico San Matteo, 1-27100 Pavia Dr. M. Felder, Ospedale Generale Regionale di Bolzano, Divisio ne di Gastroenterologia, Via Sernesi 1, 1-39100 Bolzano Prof. G. Fontana, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Dr. F. Frasson, Istituto Radiologia, Universita di Padova, Sede in Verona, Polic1inico B. Roma, 1-37100 Verona Prof. A. Fritsch, Vorstand der I. Chirurgischen Universitatsklinik, Allgemeines Krankenhaus der Stadt Wien, Aiserstr. 4, A-1090 Wien IX Dr. C. Fugazzola, Istituto Radiologia, Universita di Padova, Sede in Verona, Polic1inico B. Roma, 1-37100 Verona Prof. F. Gschnitzer, Vorstand der I. Universitatsklinik fUr Chirur gie, Allgemeines Krankenhaus, A-6020 Innsbruck Dr. P. Maiolo, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Dr. G. Mangiante, Istituto di Clinica Chirurgica, Universita di Pa dova, Sede in Verona, Polic1inico B. Roma, 1-37100 Verona Dr. L. Mazzi, Istituto Radiologia, Universita di Padova, Sede in Verona, Polic1inico B. Roma, 1-37100 Verona Prof. G. P. Marzoli, Istituto di Clinica Chirurgica, Universita di Padova, Sede in Verona, Polic1inico B. Roma, 1-37100 Verona Prof. H.-J. Mitzkat, Arbeitsgruppe Oiabetologie, Medizinische Po liklinik der Medizinischen Hochschule Hannover, 0-3000 Hanno ver 61 Dr. M. Melandri, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Dr. P. Pederzoli, Istituto Clinica Chirurgica, Universita di Padova, Sede in Verona Polic1inico B. Roma, 1-37100 Verona List of Contributors XI Dr. M. Petrillo, Servizio di Gastroenterologia, Ospedale L. Sacco, Via G. B. Grassi 74,1-20157 Milano Prof. R. Pichlmayr, Klinik fur Abdominal- und Transplantations chirurgie, Karl-Wiechert-Allee 9, D-3000 Hannover 61 Dr. T. Pilon, Istituto Clinica Chirurgica. Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Prof. G. F. Pistolesi, Direttore Istituto Radiologia, Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Dr. G. Bianchi Porro, Servizio di Gastroenterologia, Ospedale L. Sacco, Via G. B. Grassi 74, 1-20157 Milano Dr. A. Prada, Servizio di Gastroenterologia, Ospedale L. Sacco, Via G. B. Grassi 74, 1-20157 Milano Dr. U. Prati, Istituto di Patologia Chirurgica, Policlinico San Mat teo, 1-27100 Pavia. Dr. C. Procacci Istituto Radiologia, Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona PD Dr. K.-D. Rumpf, Klinik fUr Abdominal- und Transplantationschirurgie, Karl-Wiechert-Allee 9, D-30oo Han nover 61 Prof. L. A. Scuro, Direttore Istituto Clinica Medica, Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Prof. G. Serio, Istituto Clinica Chirurgica, Universita di Padova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Dr. G. Silvani, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Prof. V. Staudacher, Direttore Clinica Chirurgica, Universita di Milano, Policlinico, 1-20100 Milano Dr. C. Tibaldeschi, Istituto di Patologia Chirurgica, Policlinico San Matteo, 1-27100 Pavia Dr. A. Vandelli, Divisione di Medicina Generale, Ospedale G. B. Morgagni, 1-47100 Forli Dr. I. Vantini, Clinica Medica, Universita di Padova, Sede in Ve rona, Policlinico B. Roma, 1-37100 Verona Dr. S. Vesentini, Istituto di Clinica Chirurgica, Universita di Pa dova, Sede in Verona, Policlinico B. Roma, 1-37100 Verona Prof. M. Wanke, Chefarzt des Pathologischen Instituts, Stadtkran kenhaus Rendsburg, Akademisches Lehrkrankenhaus der Univer siHit Kiel, Lilienstrasse, D-2370 Rendsburg
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