Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties, and Application

246 Pages·2022·7.08 MB·English

by  Zhentao Yu

TITANIUM ALLOYS FOR
BIOMEDICAL DEVELOPMENT
AND APPLICATIONS
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TITANIUM ALLOYS
FOR BIOMEDICAL
DEVELOPMENT AND
APPLICATIONS
DESIGN, MICROSTRUCTURE,
PROPERTIES, AND APPLICATION
Z Y
HENTAO U
JinanUniversity,Guangzhou,P.R.China
Elsevier
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Contents
List of contributors vii
Preface ix
1. Overview of the development and application of
biomedical metal materials 1
1.1 Biomedicalstainlesssteels 1
1.2 BiomedicalCoCralloys 5
1.3 Biomedicalshapememoryalloys 9
1.4 Biomedicalnoblemetals 11
1.5 Biomedicalrefractorymetals 13
1.6 Tianditsalloys 17
1.7 Degradablemetals 19
References 24
2. Design and physical metallurgy of biomedical β-Ti alloys 27
2.1 OverviewofdesignmethodsofbiomedicalTialloys 27
2.2 OverviewofcompositiondesignofbiomedicalTialloys 32
2.3 Overviewofthedesignanddevelopmentoftypicalbiomedicalβ-Tialloys 34
2.4 Smeltingandphysicalmetallurgicalpropertiesoftypicalβ-Tialloys 39
2.5 DesignandphysicalmetallurgicalpropertiesofnovelTLMalloy 45
References 51
3. Processing, heat treatment, microstructure, and property
evolution of TLM alloy 55
3.1 Overviewofprocessingandheattreatmentofβ-Tialloys 55
3.2 BilletsandsemifinishedproductsofTLMalloy 56
3.3 PlatesandstripsofTLMalloy 58
3.4 BarsandrodsofTLMalloy 65
3.5 TubesofTLMalloy 71
3.6 TLMalloyproductswithspecialspecifications 77
3.7 TLMalloyfoils 83
References 88
4. Biological and mechanical evaluation of TLM alloy 91
4.1 BiologicalevaluationofTLMalloy 91
v
vi
Contents
4.2 BiomechanicalcompatibilityofTLMalloy 109
References 123
5. Surface modification and functionalization of TLM alloy 125
5.1 SurfacemodificationofTialloys 125
5.2 SurfacefunctionalizationofTialloys 128
5.3 SurfacedealloyingofTLMalloy 134
5.4 BioactivecoatingsonTLMalloy 137
5.5 Wear-resistantcoatingsonTLMalloy 144
5.6 AnticoagulantcoatingsonTLMalloy 148
5.7 AntimicrobialcoatingsonTLMalloy 153
References 159
6. Development and application of TLM alloy for the
replacement and repair of surgical implants 163
6.1 DevelopmentandapplicationoftraditionalTiimplants 163
6.2 DesignandnovelmanufactureofTiimplants 165
6.3 Implantsfororthopedicsandtraumarepair 170
6.4 Implantsforjointrepairandreplacement 174
6.5 ImplantsfororalandmaxillofacialrepairandreplacementofTLMalloy 185
6.6 MedicaldevicesofTLMalloyforspinerepair 195
References 196
7. Development and application of TLM alloy for
treatment of soft tissue with minimally invasive surgery 199
7.1 Developmentandapplicationsurveyofminimallyinvasivedevices 199
7.2 Designandmanufacturesurveyofinterventionaldevices 201
7.3 CoronarystentsofTLMalloy 204
7.4 NonvascularstentsandrelateddevicesofTLMalloy 212
7.5 ShellofbrainandheartactivedevicesofTLMalloy 216
7.6 OtherminimallyinvasiveandinterventionaldevicesofTLMalloy 222
Reference 223
Index 227
List of contributors
LeiJing NorthwestInstituteforNon-FerrousMetalResearch,Xi’an,
P.R.China
XiqunMa NorthwestInstituteforNon-FerrousMetalResearch,Xi’an,
P.R.China
SenYu NorthwestInstituteforNon-FerrousMetalResearch,Xi’an,P.R.China
ZhentaoYu JinanUniversity,Guangzhou,P.R.China
vii
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Preface
New materials are the basis and forerunner of new technological
revolutions, and the development and application of these materials are
important milestonesof human social civilizationand material progress.
Biomedical materials are used mainly to diagnose, treat, or replace
human tissues and organs or to improve their functions. They are high-
tech materials with advanced structures or functions that are widely
applicable and have high economic value. They cannot be replaced by
drugs and have become one of the most vigorous research fields in
materials science.
Epoch-making medical devices, such as titanium hip joints, titanium
dental implants, CoCr vascular stents, and titanium artificial hearts,
have saved the lives of patients and improved their quality of life.
Among all the biomedical metal materials, such as Ti alloys, CoCr
alloys,TiNi alloys, and316Land317Lstainlesssteels,theadvanced bio-
medical titaniumand its alloys have been or are becoming themainand
key raw materials for surgical implants and minimally invasive inter-
ventional devices.
Since the beginning of the 21st century, in order to continuously
improve and enhance the functional diversity, biological safety, bio-
mechanical compatibility, and long-term application of biomedical tita-
nium alloy materials, research on the alloy design, novel material
development, processing and preparation, microstructure and property
evaluation, and product application of these materials has been deepen-
ing and becoming a research hotspot in the field of new biomaterials in
the world. This book consists of seven chapters, focusing primarily on
alloy design, physical metallurgy, materials processing, microstructure
and mechanical properties, surface modification, advanced manufactur-
ing, and clinical research of novel biomedical beta-type TLM titanium
alloy. The book also offers a comprehensive and systematic introduction
into the research and development achievements of the author’s
research group inthe past 18 years.
The first chapter describes the latest research progress of alloy
design, typical microstructure, mechanical properties, and clinical appli-
cations of commonly used medical metals (stainless steels, cobalt(cid:1)chro-
mium alloys, titanium alloys, shape memory alloys, etc.) and
degradable metals (magnesium alloys, zinc alloys, etc.).
ix