Tissue Engineering I PDF
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102 Advances in Biochemical Engineering/Biotechnology SeriesEditor:T.Scheper EditorialBoard: W.Babel·I.Endo·S.-O.Enfors·A.Fiechter·M.Hoare·W.-S.Hu B.Mattiasson·J.Nielsen·H.Sahm·K.Schügerl·G.Stephanopoulos U.vonStockar·G.T.Tsao·C.Wandrey·J.-J.Zhong AdvancesinBiochemicalEngineering/Biotechnology SeriesEditor:T.Scheper RecentlyPublishedandForthcoming Volumes TissueEngineeringII RegenerativeMedicineI BasicsofTissueEngineeringandTissue Theories,ModelsandMethods Applications VolumeEditor:Yannas,I.V. VolumeEditors:Lee,K.,Kaplan,D. Vol.93,2005 Vol.103,2006 TechnologyTransferinBiotechnology TissueEngineeringI VolumeEditor:Kragl,U. ScaffoldSystemsforTissueEngineering Vol.92,2005 VolumeEditors:Lee,K.,Kaplan,D. Vol.102,2006 RecentProgressofBiochemicalandBiomedical EngineeringinJapanII CellCultureEngineering VolumeEditor:Kobayashi,T. VolumeEditor:Hu,W.-S. Vol.91,2004 Vol.101,2006 RecentProgressofBiochemicalandBiomedical BiotechnologyfortheFuture EngineeringinJapanI VolumeEditor:Nielsen,J. VolumeEditor:Kobayashi,T. Vol.100,2005 Vol.90,2004 GeneTherapyandGeneDeliverySystems PhysiologicalStressResponsesinBioprocesses VolumeEditors:Schaffer,D.V.,Zhou,W. VolumeEditor:Enfors,S.-O. Vol.99,2005 Vol.89,2004 SterileFiltration MolecularBiotechnologyofFungalβ-Lactam VolumeEditor:Jornitz,M.W. AntibioticsandRelatedPeptideSynthetases Vol.98,2006 VolumeEditor:Brakhage,A. Vol.88,2004 MarineBiotechnologyII VolumeEditors:LeGal,Y.,Ulber,R. Biomanufacturing Vol.97,2005 VolumeEditor:Zhong,J.-J. Vol.87,2004 MarineBiotechnologyI VolumeEditors:LeGal,Y.,Ulber,R. NewTrendsandDevelopmentsinBiochemical Vol.96,2005 Engineering Vol.86,2004 MicroscopyTechniques VolumeEditor:Rietdorf,J. BiotechnologyinIndiaII Vol.95,2005 VolumeEditors:Ghose,T.K.,Ghosh,P. Vol.85,2003 RegenerativeMedicineII ClinicalandPreclinicalApplications BiotechnologyinIndiaI VolumeEditor:Yannas,I.V. VolumeEditors:Ghose,T.K.,Ghosh,P. Vol.94,2005 Vol.84,2003 Tissue Engineering I ScaffoldSystemsforTissueEngineering Volume Editors: Kyongbum Lee · David Kaplan Withcontributionsby C.Chan·T.A.Holland·J.Jiang·D.Kaplan C.T.Laurencin·Z.Li·H.H.Lu·T.Matsumoto A.G.Mikos·D.J.Mooney·P.V.Moghe·L.S.Nair S.Patil·C.S.Ranucci·E.J.Semler·J.Velema 123 AdvancesinBiochemicalEngineering/Biotechnologyreviewsactualtrendsinmodernbiotechnology. Itsaim isto coverallaspects ofthisinterdisciplinary technologywhereknowledge, methodsand expertisearerequiredforchemistry,biochemistry,micro-biology,genetics,chemicalengineeringand computerscience.Specialvolumesarededicatedtoselectedtopicswhichfocusonnewbiotechnological productsandnew processes for their synthesis and purification.They give the state-of-the-art of atopicinacomprehensivewaythusbeingavaluablesourceforthenext3–5years.Italsodiscusses newdiscoveriesandapplications.Specialvolumesareeditedbywellknownguesteditorswhoinvite reputedauthorsforthereviewarticlesintheirvolumes. In references Advances in Biochemical Engineering/Biotechnologyis abbeviated Adv Biochem En- gin/Biotechnolandiscitedasajournal. SpringerWWWhomepage:springer.com VisittheABEcontentatspringerlink.com LibraryofCongressControlNumber:2006929796 ISSN0724-6145 ISBN-103-540-31944-1SpringerBerlinHeidelbergNewYork ISBN-13978-3-540-31944-3SpringerBerlinHeidelbergNewYork DOI10.1007/11579328 Thisworkissubjecttocopyright.Allrightsarereserved,whetherthewholeorpartofthematerial isconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broad- casting,reproductiononmicrofilmorinanyotherway,andstorageindatabanks.Duplicationof thispublicationorpartsthereofispermittedonlyundertheprovisionsoftheGermanCopyrightLaw ofSeptember9,1965,initscurrentversion,andpermissionforusemustalwaysbeobtainedfrom Springer.ViolationsareliableforprosecutionundertheGermanCopyrightLaw. 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Coverdesign:WMXDesignGmbH,Heidelberg TypesettingandProduction:LE-TEXJelonek,Schmidt&VöcklerGbR,Leipzig Printedonacid-freepaper 02/3141YL–543210 SeriesEditor Prof.Dr.T.Scheper InstituteofTechnicalChemistry UniversityofHannover Callinstraße3 30167Hannover,Germany [email protected] VolumeEditors Prof.Dr.KyongbumLee Prof.Dr.DavidKaplan AssistantProfesssor ProfessorandChair ChemicalandBiologicalEngineering DepartmentofBiomedicalEngineering TuftsUniversity ScienceandTechnologyCenter 4ColbyStreet,Room142 Medford,MA02155,USA Medford,MA02155,USA [email protected] [email protected] EditorialBoard Prof.Dr.W.Babel Prof.Dr.M.Hoare SectionofEnvironmentalMicrobiology DepartmentofBiochemicalEngineering Leipzig-HalleGmbH UniversityCollegeLondon Permoserstraße15 TorringtonPlace 04318Leipzig,Germany London,WC1E7JE,UK [email protected] [email protected] Prof.Dr.S.-O.Enfors Prof.Dr.I.Endo DepartmentofBiochemistryand ExecutiveDirector Biotechnology SaitamaIndustrialTechnologyCenter RoyalInstituteofTechnology 3-12-18,KamiaokiKawaguchi-shi Teknikringen34, Saitama,333-0844,Japan 10044Stockholm,Sweden [email protected] [email protected] VI EditorialBoard Prof.Dr.A.Fiechter Prof.Dr.J.-J.Zhong InstituteofBiotechnology CollegeofLifeScience&Biotechnology EidgenössischeTechnischeHochschule ShanghaiJiaoTongUniversity ETH-Hönggerberg 800Dong-ChuanRoad 8093Zürich,Switzerland Minhang,Shanghai200240,China ae.fi[email protected] [email protected] Prof.Dr.W.-S.Hu Prof.Dr.J.Nielsen ChemicalEngineering CenterforProcessBiotechnology andMaterialsScience TechnicalUniversityofDenmark UniversityofMinnesota Building223 421WashingtonAvenueSE 2800Lyngby,Denmark Minneapolis,MN55455-0132,USA [email protected] [email protected] Prof.Dr.K.Schügerl Prof.Dr.B.Mattiasson InstituteofTechnicalChemistry DepartmentofBiotechnology UniversityofHannover,Callinstraße3 ChemicalCenter,LundUniversity 30167Hannover,Germany P.O.Box124,22100Lund,Sweden [email protected] [email protected] Prof.Dr.U.vonStockar Prof.Dr.H.Sahm LaboratoiredeGénieChimiqueet InstituteofBiotechnolgy Biologique(LGCB),DépartmentdeChimie ForschungszentrumJülichGmbH SwissFederalInstitute 52425Jülich,Germany ofTechnologyLausanne [email protected] 1015Lausanne,Switzerland urs.vonstockar@epfl.ch Prof.Dr.G.Stephanopoulos DepartmentofChemicalEngineering Prof.Dr.C.Wandrey MassachusettsInstituteofTechnology InstituteofBiotechnology Cambridge,MA02139-4307,USA ForschungszentrumJülichGmbH [email protected] 52425Jülich,Germany [email protected] Prof.Dr.G.T.Tsao ProfessorEmeritus PurdueUniversity WestLafayette,IN47907,USA [email protected] AdvancesinBiochemicalEngineering/Biotechnology AlsoAvailableElectronically For all customers who have a standing order to Advances in Biochemical Engineering/Biotechnology, we offerthe electronic version via SpringerLink freeofcharge.Pleasecontactyourlibrarianwhocanreceiveapasswordorfree accesstothefullarticlesbyregisteringat: springerlink.com Ifyoudonothaveasubscription,youcanstillviewthetablesofcontentsofthe volumesandtheabstractofeacharticlebygoingtotheSpringerLinkHome- page,clickingon“BrowsebyOnlineLibraries”,then“ChemicalSciences”,and finallychooseAdvancesinBiochemicalEngineering/Biotechnology. Youwillfindinformationaboutthe – EditorialBoard – AimsandScope – InstructionsforAuthors – SampleContribution atspringer.comusingthesearchfunction. AttentionallUsers ofthe“SpringerHandbookofEnzymes” Informationonthishandbookcanbefoundontheinternetat springeronline.com AcompletelistofallenzymeentrieseitherasanalphabeticalNameIndexor as the EC-Number Index is available at the above mentioned URL. You can downloadandprintthemfreeofcharge. Acompletelistofallsynonyms(morethan25,000entries)usedfortheenzymes isavailableinprintform(ISBN3-540-41830-X). Save 15% We recommend a standing order for the series to ensure you automatically receiveallvolumesandallsupplementsandsave15%onthelistprice. Preface It is our pleasure to present thisspecial volume ontissue engineering in the series Advances in Biochemical Engineering and Biotechnology. This volume reflects the emergence of tissue engineering as a core discipline of modern biomedical engineering, and recognizes the growing synergies between the technological developments in biotechnology and biomedicine. Along this vein,thefocusofthisvolumeistoprovideabiotechnologydrivenperspective oncellengineeringfundamentalswhilehighlightingtheirsignificanceinpro- ducingfunctionaltissues.Ouraimistopresentanoverviewofthestateofthe artofaselectionofthesetechnologies,punctuatedwithcurrentapplications intheresearchanddevelopmentofcell-basedtherapiesforhumandisease. To prepare this volume, we have solicited contributions fromleaders and experts in their respective fields, ranging from biomaterials and bioreactors to gene delivery and metabolic engineering. Particular emphasis was placed on including reviews that discuss various aspects of the biochemical pro- cessesunderlyingcellfunction,suchassignaling,growth,differentiation,and communication. The reviews of research topics cover two main areas: cellu- larand non-cellularcomponents andassembly; evaluation andoptimization oftissuefunction;andintegratedreactororimplantsystemdevelopment for researchandclinicalapplications.Manyofthereviewsillustratehowbiochemi- calengineeringmethodsareusedtoproduceandcharacterizenovelmaterials (e.g. genetically engineered natural polymers, synthetic scaffolds with cell- typespecific attachment sitesorinductive factors),whose unique properties enable increased levels of control over tissue development and architecture. Otherreviewsdiscusstheroleofdynamicandsteady-statemodelsandother informatics tools in designing, evaluating, and optimizing the biochemical functionsofengineeredtissues.Reviewsthatillustratetheintegrationofthese methodsandmodelsinconstructingmodel,implant(e.g.skin,cartilage),or ex-vivosystems(e.g.bio-artificialliver)arealsoincluded. It is our expectation that the mutual relevance of tissue engineering and biotechnologywillonlyincreaseinthecomingyears,asourneedsforadvanced healthcareproductscontinuetogrow.Already,tissuederived cellsconstitute important production systems for therapeutically and otherwise useful bio- moleculesthatrequirespecializedpost-translationalprocessingfortheirsafety andefficacy.Biochemicalengineeringproducts,rangingfromgrowthfactorsto X Contents polymerscaffolds,areusedasbuildingblocksorsignalmoleculesatvirtually every stage of engineered tissue formation. Importantly, the realization of engineered tissuesas clinicallyuseful andcommercially viableproductswill at least in part depend on overcoming the same efficiency challenges that thebiotechnologyindustryhasbeenfacing.Inthislight,weseetheinterface betweentissueengineeringandvariousotherfieldsofbiochemicalengineering asaveryexcitingareaforresearchanddevelopmentwithenormouspotential for cross-disciplinary education. In this regard, we anticipate that this and othersimilarvolumeswillalsobeusefulassupplementarytextforstudents. We extend our special thanks to all of the contributing authors as well as Springer for embarking on this project. We are especially grateful to Dr. Thomas Scheper and Ulrike Kreusel for their incredible patience and hard workasourproductioneditors. Medford,August2006 KyongbumLee DavidKaplan
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