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Results may vary. OPDIVO® + YERVOY® is not approved for patients younger than 18 years of age. Indication & Important Safety Information for OPDIVO (nivolumab) • H ormone gland problems: headaches that will not go away or + YERVOY (ipilimumab) unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or Only your healthcare professional knows the specifics of your weight loss; feeling more hungry or thirsty than usual; urinating condition and how OPDIVO in combination with YERVOY may fit into more often than usual; hair loss; feeling cold; constipation; your your overall therapy. The information below does not take the place voice gets deeper; dizziness or fainting; changes in mood or behavior, of talking with your healthcare professional, so talk to them if you such as decreased sex drive, irritability, or forgetfulness have any questions. • K idney problems: decrease in the amount of urine; blood in your What are OPDIVO and YERVOY? urine; swelling in your ankles; loss of appetite OPDIVO and YERVOY are prescription medicines used to treat people • S kin problems: rash; itching; skin blistering or peeling; painful sores with a type of advanced stage lung cancer called non-small cell lung or ulcers in mouth or nose, throat, or genital area cancer (NSCLC). OPDIVO may be used in combination with YERVOY as your first treatment for NSCLC when your lung cancer has spread to • E ye problems: blurry vision, double vision, or other vision problems; other parts of your body (metastatic) and your tumors are positive for eye pain or redness PD-L1, but do not have an abnormal EGFR or ALK gene. Problems can also happen in other organs and tissues. These are It is not known if OPDIVO and YERVOY are safe and effective when not all of the signs and symptoms of immune system problems that used in children younger than 18 years of age. can happen with OPDIVO and YERVOY. Call or see your healthcare provider right away for any new or worsening signs or symptoms, What is the most important information I should know about which may include: OPDIVO and YERVOY? • C hest pain; irregular heartbeat; shortness of breath; swelling of OPDIVO and YERVOY are medicines that may treat certain cancers by ankles working with your immune system. OPDIVO and YERVOY can cause • C onfusion; sleepiness; memory problems; changes in mood or your immune system to attack normal organs and tissues in any behavior; stiff neck; balance problems; tingling or numbness of the area of your body and can affect the way they work. These problems arms or legs can sometimes become serious or life-threatening and can lead • D ouble vision; blurry vision; sensitivity to light; eye pain; changes in to death and may happen anytime during treatment or even after eye sight your treatment has ended. You may have more than one of these • P ersistent or severe muscle pain or weakness; muscle cramps problems at the same time. Some of these problems may happen • L ow red blood cells; bruising more often when OPDIVO is used in combination with YERVOY. Getting medical help right away may help keep these problems Call or see your healthcare provider right away if you develop any from becoming more serious. Your healthcare team will check new or worse signs or symptoms, including you for these problems during treatment and may treat you with • L ung problems: new or worsening cough; shortness of breath; chest corticosteroid or hormone replacement medicines. Your healthcare pain team may also need to delay or completely stop your treatment if you • I ntestinal problems: diarrhea (loose stools) or more frequent have severe side effects. bowel movements than usual; stools that are black, tarry, sticky, What should I tell my healthcare provider before receiving OPDIVO or have blood or mucus; severe stomach-area (abdominal) pain or and YERVOY? Before you receive OPDIVO and YERVOY, tell your tenderness healthcare provider about all of your medical conditions, including • L iver problems: yellowing of your skin or the whites of your eyes; if you: severe nausea or vomiting; pain on the right side of your stomach • h ave immune system problems such as Crohn’s disease, ulcerative area (abdomen); dark urine (tea colored); bleeding or bruising more colitis, or lupus easily than normal • h ave received an organ transplant Talk to your doctor about OPDIVO + YERVOY www.OPDIVOYERVOY.com 1-855-OPDIVOYERVOY • h ave received or plan to receive a stem cell transplant that uses • C omplications, including graft-versus-host disease (GVHD), donor stem cells (allogeneic) of bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be severe and can • h ave received radiation treatment to your chest area in the past lead to death. These complications may happen if you underwent and have received other medicines that are like OPDIVO transplantation either before or after being treated with OPDIVO • h ave a condition that affects your nervous system, such as or YERVOY. Your healthcare provider will monitor you for these myasthenia gravis or Guillain-Barré syndrome complications. • a re pregnant or plan to become pregnant. OPDIVO and YERVOY The most common side effects of OPDIVO when used in combination can harm your unborn baby with YERVOY include: feeling tired; diarrhea; rash; itching; nausea; • a re breastfeeding or plan to breastfeed. It is not known if OPDIVO pain in muscles, bones, and joints; fever; cough; decreased appetite; or YERVOY passes into your breast milk. Do not breastfeed during vomiting; stomach-area (abdominal) pain; shortness of breath; upper treatment with OPDIVO or YERVOY and for 5 months after the last respiratory tract infection; headache; low thyroid hormone levels dose of OPDIVO or YERVOY (hypothyroidism); decreased weight; and dizziness. Females who are able to become pregnant: Your healthcare These are not all the possible side effects of OPDIVO and YERVOY. provider should do a pregnancy test before you start receiving Call your doctor for medical advice about side effects. OPDIVO or YERVOY. You are encouraged to report side effects of prescription drugs to • Y ou should use an effective method of birth control during your the FDA. Call 1-800-FDA-1088. treatment and for at least 5 months after your last dose of OPDIVO (10 mg/mL) and YERVOY (5 mg/mL) are injections for OPDIVO or YERVOY. Talk to your healthcare provider about birth intravenous (IV) use. control methods that you can use during this time. • T ell your healthcare provider right away if you become pregnant or This is a brief summary of the most important information about think you are pregnant during treatment with OPDIVO or YERVOY. OPDIVO and YERVOY. For more information, talk with your healthcare You or your healthcare provider should contact Bristol Myers Squibb providers, call 1-855-673-4861, or go to www.OPDIVO.com. at 1-844-593-7869 as soon as you become aware of the pregnancy. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare providers and pharmacist when you get a new medicine. What are the possible side effects of OPDIVO and YERVOY? OPDIVO and YERVOY can cause serious side effects, including: • S ee “What is the most important information I should know about OPDIVO + YERVOY?” • S evere infusion reactions. Tell your healthcare team or nurse right away if you get these symptoms during an infusion of OPDIVO or YERVOY: chills or shaking; itching or rash; flushing; shortness of © 2020 Bristol-Myers Squibb Company. All rights reserved. OPDIVO®, YERVOY®, breath or wheezing; dizziness; feel like passing out; fever; back or and the related logos are trademarks of Bristol-Myers Squibb Company. neck pain 7356US2002303-03-01 12/20 VOL. 197, NOS. 1–2 | 2021 4 | Conversation 6 | For the Record The Brief News from the U.S. and around the world 7 | Trump’s assault on institutions made visible 18 | The extreme climate of 2020 19 | Milestones: Pierre Cardin and Brian Urquhart The View Ideas, opinion, innovations 21 | Ian Bremmer on the risks of 2021 The Olympic logo at Tokyo’s National 23 | Nayomi Stadium on Dec. 16 Munaweera on Photograph by Kenji reconnecting Chiga for TIME Time Off Features What to watch, read, see and do The Year Ahead The Antisocial ON THE 91 | After a national COVERS: Network THE MOLECULE: Behind the vaccines trauma, people By Walter Isaacson 26 A heavily armed white- crave escapism PLUS: Why it’s safe By Heidi J. 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