Thyroid Hormone

396 Pages·2012·10.613 MB·English

by  N. K. Agrawal (editor)

THYROID HORMONE

Edited by Neeraj Kumar Agrawal
Thyroid Hormone
http://dx.doi.org/10.5772/2964
Edited by Neeraj Kumar Agrawal

Contributors
Pradip K. Sarkar, Asano Ishikawa, Jun Kitano, José María Fernández-Santos, Jesús Morillo-
Bernal, Rocío García-Marín, José Carmelo Utrilla, Inés Martín-Lacave, Irmgard D. Dietzel,
Sivaraj Mohanasundaram, Vanessa Niederkinkhaus, Gerd Hoffmann, Jens W. Meyer,
Christoph Reiners, Christiana Blasl, Katharina Bohr, R.G. Ahmed, N.K. Agrawal, Ved Prakash,
Manuj Sharma, Giuseppe Pasqualetti, Angela Dardano, Sara Tognini, Antonio Polini, Fabio
Monzani, Renata de Azevedo Melo Luvizotto, Sandro José Conde, Miriane de Oliveira,
Maria Teresa De Sibio, Keize Nagamati Jr, Célia Regina Nogueira, Eva Feigerlova, Marc Klein,
Anna Angelousi, Lelia Groza, Bruno Leheup, Georges Weryha, Einav Yehuda-Shnaidman,
Bella Kalderon, Jacob Bar-Tana, Emina Kasumagic-Halilovic, Begler Begovic, Francesco
Torino, Agnese Barnabei, Roberto Baldelli, Marialuisa Appetecchia, Clara Spinel, Magnolia
Herrera

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First published July, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Thyroid Hormone, Edited by Neeraj Kumar Agrawal
p. cm.
ISBN 978-953-51-0678-4

Contents

Preface IX
Section 1 Thyroid Hormone Physiology 1
Chapter 1 “Quo Vadis?” Deciphering the Code
of Nongenomic Action of Thyroid Hormones
in Mature Mammalian Brain 3
Pradip K. Sarkar
Chapter 2 Ecological Genetics of Thyroid Hormone Physiology
in Humans and Wild Animals 37
Asano Ishikawa and Jun Kitano
Chapter 3 Paracrine Regulation of Thyroid-Hormone
Synthesis by C Cells 51
José María Fernández-Santos, Jesús Morillo-Bernal,
Rocío García-Marín, José Carmelo Utrilla
and Inés Martín-Lacave
Chapter 4 Thyroid Hormone Effects on Sensory Perception,
Mental Speed, Neuronal Excitability
and Ion Channel Regulation 85
Irmgard D. Dietzel, Sivaraj Mohanasundaram,
Vanessa Niederkinkhaus, Gerd Hoffmann, Jens W. Meyer,
Christoph Reiners, Christiana Blasl and Katharina Bohr
Section 2 Developmental Physiology 123
Chapter 5 Maternal-Fetal Thyroid Interactions 125
R.G. Ahmed
Section 3 Thyroid Hormone Excess 157
Chapter 6 Thyroid Hormone Excess:
Graves’ Disease 159
N.K. Agrawal, Ved Prakash and Manuj Sharma
VI Contents

Section 4 Thyroid Hormone Deficiency 181
Chapter 7 Mild Thyroid Deficiency in the Elderly 183
Giuseppe Pasqualetti, Angela Dardano, Sara Tognini,
Antonio Polini and Fabio Monzani
Section 5 Thyroid Hormone in Special Situations 211
Chapter 8 Obesity and Weight Loss:
The Influence of Thyroid Hormone on Adipokines 213
Renata de Azevedo Melo Luvizotto, Sandro José Conde,
Miriane de Oliveira, Maria Teresa De Sibio, Keize Nagamati Jr
and Célia Regina Nogueira
Chapter 9 Thyroid Disorders and Bone Mineral Homeostasis 251
Eva Feigerlova, Marc Klein, Anna Angelousi, Lelia Groza,
Bruno Leheup and Georges Weryha
Chapter 10 Thyroid Hormone and Energy Expenditure 277
Einav Yehuda-Shnaidman, Bella Kalderon and Jacob Bar-Tana
Chapter 11 Thyroid Autoimmunity in Patients with Skin Disorders 297
Emina Kasumagic-Halilovic and Begler Begovic
Chapter 12 Thyroid Function Abnormalities
in Patients Receiving Anticancer Agents 311
Francesco Torino, Agnese Barnabei,
Roberto Baldelli and Marialuisa Appetecchia
Section 6 Experimental Advances 343
Chapter 13 Thyroid Culture from Monolayer to Closed Follicles 345
Clara Spinel and Magnolia Herrera

Preface

Thyroid hormone is important for controlling metabolism and many other body
functions. Changes in thyroid hormone physiology, its regulation and diseases thereof
have been a concern for the mankind.
Understanding of thyroid hormone(s) has been continuously updated and revised.
The contributions from different authors have been incorporated in this book for this
purpose. The original work of these contributors will be especially useful in furthering
the knowledge on thyroid and help in creating new vistas of research.
The book incorporates physiology of thyroid hormone in maternal-fetal axis, and
regulation of thyroid hormone synthesis in health and disease. The controversy in the
cut-off for delineating normal from abnormal thyroid function has also been dealt
with. Thyroid hormone deficiency and excess states have been highlighted through
elaborate review to encompass the present understanding and management of such
problems. A separate section on thyroid hormone changes in special situation has been
incorporated.

Dr Neeraj Kumar Agrawal
Associate Professor and Head of Department of Endocrinology and Metabolism
Institute of Medical Sciences, Banaras Hindu University,
Varanasi, India