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t.buck · a.franke · m.j. monaghan Editors Three-dimensional Echocardiography Lehrprogramm gemäß (cid:2)(cid:3)§1(cid:4)4 JuSchG (cid:5)(cid:2)(cid:3)(cid:4) R O M Thomas Buck, Andreas Franke, Mark J. Monaghan (Editors) Three-dimensional Echocardiography Thomas Buck, Andreas Franke, Mark J. Monaghan (Editors) Three-dimensional Echocardiography With 248 figures including 825 single illustrations and 5 tables 1 23 Thomas Buck, MD, FACC, FESC Mark J. Monaghan, PhD, FRCP(Hon), FACC, FESC Associate Professor of Medicine Professor of Echocardiography Assistant Director, Department of Cardiology Director, Noninvasive Cardiology Director, Echocardiography King’s College Hospital West German Heart Center Essen London, UK University Hospital Essen Essen, Germany Andreas Franke, MD, FESC Associate Professor of Medicine Head, Department of Cardiology, Angiology and Intensive Care Medicine Klinikum Region Hannover – Klinikum Siloah Hannover, Germany ISBN-13 978-3-642-11178-5 Springer-Verlag Berlin Heidelberg New York Bibliographic information Deutsche Bibliothek The Deutsche Bibliothek lists this publication in Deutsche Nationalbibliographie; detailed bibliographic data is available in the internet at <http://dnb.ddb.de>. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable to prosecution under the German Copyright Law. SpringerMedizin Springer-Verlag GmbH ein Unternehmen von Springer Science+Business springer.de © Springer-Verlag Berlin Heidelberg 2011 The use of general descriptive names, registered names, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Planning: Hinrich Kuester, Heidelberg Project management: Barbara Karg, Heidelberg Copy-Editing: Dr. Mary Gossen, Dietzenbach Cover design: deblik Berlin Typesetting: TypoStudio Tobias Schaedla, Heidelberg, Germany SPIN 12824397 2126 – 5 4 3 2 1 0 About the editors Thomas Buck, MD, FACC, FESC Thomas Buck is an Associate Professor of Medicine and Cardiology at the Uni- versity Hospital of Essen, Germany. There he holds the position of Director of Echocardiography Laboratories as well as the appointments of Chief Consultant and Assistant Medical Director of the Department of Cardiology at the West German Heart Center. Since the beginning of his academic career in 1992, three-dimensional echocardiography has been a major field of his scientific interest. One of his primary clinical areas of expertise is the management of heart valve disease patients, where his early scientific work was stimulated while working as a Research Fellow at Mas- sachusetts General Hospital. As one of his official assignments, he is currently acting as the Chair of the German Working Group of Echocardiography. In addition to a considerable number of scientific articles, his work includes several teaching book contributions and international patents in the field of echocardiography. Since the introduction of real-time 3D echocardiography into clinical practice, he has regu- larly organized national and international training courses as an expert trainer. Andreas Franke, MD, FESC Andreas Franke is Associate Professor of Medicine and Cardiology and Director of the Department of Cardiology, Angiology and Intensive Care Medicine of the Klinikum Siloah in Hannover, Germany. During his clinical and academic career starting in 1988 at the RWTH Technical University Aachen, echocardiography and congenital heart disease in adults have been his main fields of scientific interest and work. His primary clinical areas of expertise besides non-invasive cardiac imag- ing are the interventional therapy of coronary artery disease and the management of valvular disease. Since the early 90’s he was involved in further development of three-dimensional echocardiography and published numerous clinical studies on 3D echo. Between 1998 and 2001 he was nucleus member of the Working Group on Echocardiography of the ESC as organizer of the subgroup 3D echocardiogra- phy. Over the last ten years he also contributed to several textbooks and atlases on echocardiography. Moreover, since 2003 he regularly organizes national real-time 3D echocardiographic training courses as an expert trainer. Mark J. Monaghan PhD, FRCP(Hon), FACC, FESC Mark J. Monaghan is a Professor of Echocardiography and Director of Non- Invasive Cardiology at King’s College Hospital, London UK. He has worked in the field of Echocardiography for over 25 years and has published extensively on the subject, especially on the use of 3D. In addition he holds two International patents on Echo technology and lectures widely at International meetings and Cardiology Conferences throughout the world. He runs several teaching Courses and Work- shops on 3D Echocardiography every year and has contributed to and co-edited several textbooks. Professor Monaghan has been a Board member of the European Association of Echocardiography and is a past President of the British Society of Echocardiography. Table of contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 Left ventricular function . . . . . . . . . . . . . . . 55 Thomas Buck, Andreas Franke, Harald P. Kühl and Mark J. Monaghan 4.1 Assessment of left ventricular volumes and ejection fraction . . . . . . . . . . . . . . . . . . . . . . .56 2 Three-dimensional echocardio- 4.2 Evaluation of left ventricular mass . . . . . . . . . .59 graphy: lessons in overcoming time 4.3 Assessment of regional left ventricular and space . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .62 Jos R.T.C. Roelandt and Joseph Kisslo 4.4 Determination of left ventricular 2.1 Reconstruction techniques . . . . . . . . . . . . . . . . . .3 dyssynchrony . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .65 2.1.1 The linear scanning approach . . . . . . . . . . . . . . .4 4.5 Parametric imaging . . . . . . . . . . . . . . . . . . . . . . . .65 2.1.2 The fan-like scanning approach . . . . . . . . . . . . .6 4.6 Transesophageal real-time 3D echo- 2.1.3 The rotational scanning approach . . . . . . . . . . .6 cardiography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .67 2.2 Volumetric real-time (high-speed) 4.7 Three-dimensional assessment of left scanning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10 atrial volume and function . . . . . . . . . . . . . . . . .68 2.3 The future is based on the past . . . . . . . . . . . . .17 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .70 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18 5 Three-dimensional stress 3 Basic principles and practical echocardiography . . . . . . . . . . . . . . . . . . . . . 73 application . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Andreas Franke Thomas Buck (with contribution by 5.1 Method . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .73 Karl E. Thiele, Philips Medical Systems, 5.2 Clinical studies on 3D stress echo- Andover, MA, USA) cardiography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .79 3.1 How real-time 3D ultrasound works . . . . . . . .21 5.3 Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .80 3.1.1 It’s all about the transmit beams . . . . . . . . . . . .21 5.4 New approaches and future perspectives . . .80 3.1.2 The need for bigger, better, faster . . . . . . . . . .24 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .80 3.1.3 Fully sampled matrix array transducers . . . . .24 3.1.4 Parallel receive beam processing . . . . . . . . . . .26 6 Cardiac dyssynchrony . . . . . . . . . . . . . . . . . 83 3.1.5 Three-dimensional color flow . . . . . . . . . . . . . .27 Mark J. Monaghan and Shaumik Adhya 3.2 The probes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27 6.1 Technique . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .83 3.3 Live 3D echocardiographic 6.1.1 Acquisition of 3D volumes . . . . . . . . . . . . . . . . .83 examination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .29 6.1.2 Measures of intraventricular 3.3.1 First steps and learning curve . . . . . . . . . . . . . .29 dyssynchrony . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .83 3.3.2 Three-dimensional acquisition 6.1.3 Performing 3D analyses . . . . . . . . . . . . . . . . . . . .86 (modes and image settings) . . . . . . . . . . . . . . . .29 6.1.4 Measurement variability . . . . . . . . . . . . . . . . . . .91 3.3.3 Standard 3D views . . . . . . . . . . . . . . . . . . . . . . . . .34 6.2 Normal values . . . . . . . . . . . . . . . . . . . . . . . . . . . . .92 3.4 Basic 3D analysis: cropping and 6.3 Dyssynchrony in heart failure and left slicing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40 bundle branch block . . . . . . . . . . . . . . . . . . . . . . .93 3.4.1 First steps of 3D dataset cropping . . . . . . . . . .40 6.3.1 Relationship between left ventricular 3.5 Basic 3D measurements . . . . . . . . . . . . . . . . . . . .48 function and dyssynchrony . . . . . . . . . . . . . . . .93 3.6 Artifacts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .48 6.3.2 Patterns of dyssynchrony . . . . . . . . . . . . . . . . . . .95 3.6.1 Stitching artifacts . . . . . . . . . . . . . . . . . . . . . . . . . .48 6.3.3 SDI as a predictor of outcome of cardiac 3.6.2 Dropout artifacts . . . . . . . . . . . . . . . . . . . . . . . . . .49 resynchronisation therapy . . . . . . . . . . . . . . . . .95 3.6.3 Blurring and blooming artifacts . . . . . . . . . . . .50 6.4 Dyssynchrony due to right ventricular 3.6.4 Gain artifacts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .51 pacing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .96 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .53 6.5 Dyssynchrony in other situations . . . . . . . . . . .97 VIII Table of contents 6.5.1 In children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .97 9.4 Evaluation of prosthetic and 6.5.2 In congenital right heart disease . . . . . . . . . . .97 reconstructed valves . . . . . . . . . . . . . . . . . . . . . . . 171 6.5.3 After acute myocardial infarction . . . . . . . . . . .97 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172 6.5.4 In amyloidosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . .98 6.6 Assessment of dyssynchrony after CRT . . . . .98 10 Three-dimensional echocardiography 6.7 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .98 in adult congenital heart disease . . . . . . 175 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .99 Folkert J. Meijboom, Heleen van der Zwaan, and Jackie McGhie 7 The right ventricle . . . . . . . . . . . . . . . . . . .101 10.1 Patent foramen ovale . . . . . . . . . . . . . . . . . . . . . . 177 Stephan von Bardeleben, Thomas Buck, 10.2 Atrial septal defect . . . . . . . . . . . . . . . . . . . . . . . . . 177 and Andreas Franke 10.3 Ventricular septal defect . . . . . . . . . . . . . . . . . . . 182 7.1 Assessment of right ventricular volumes 10.4 Atrioventricular septal defects . . . . . . . . . . . . . 184 and function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104 10.5 Ebstein’s anomaly . . . . . . . . . . . . . . . . . . . . . . . . . . 187 7.2 New aspects of 3D right ventricular 10.6 Transposition of the great arteries . . . . . . . . . 189 analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 10.7 Congenitally corrected transposition References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 of the great arteries . . . . . . . . . . . . . . . . . . . . . . . . 191 10.8 Tetralogy of Fallot . . . . . . . . . . . . . . . . . . . . . . . . . . 193 8 Valvular heart disease – 10.9 RT3DE in other congenital cardiac insufficiencies . . . . . . . . . . . . . . . . . . . . . . .109 malformations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 Thomas Buck 10.10 The role of RT3DE in the analysis of 8.1 Mitral regurgitation . . . . . . . . . . . . . . . . . . . . . . 109 right ventricular function . . . . . . . . . . . . . . . . . . 193 8.1.1 Evaluation of mitral valve insufficiency . . . 109 10.10.1 Acquisition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 8.1.2 Classification of mitral valve 10.10.2 Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196 insufficiency . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 10.11 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196 8.1.3 Mitral valve prolapse, flail and Barlow’s References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198 disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112 8.1.4 Mitral valve quantification . . . . . . . . . . . . . . . . 116 11 Congenital heart disease in 8.1.5 Papillary muscle rupture . . . . . . . . . . . . . . . . . 121 children . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 8.1.6 Functional mitral regurgitation . . . . . . . . . . . 122 John M. Simpson 8.1.7 Endocarditis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 11.1 Technical and patient-specific factors . . . . . . 201 8.1.8 Mitral valve prosthesis . . . . . . . . . . . . . . . . . . . 126 11.2 Selection of imaging probes in children . . . . 202 8.1.9 Mitral valve repair . . . . . . . . . . . . . . . . . . . . . . . . 128 11.3 Presentation of 3D echocardiographic 8.1.10 Rare etiologies . . . . . . . . . . . . . . . . . . . . . . . . . . . 132 images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202 8.1.11 Assessment of severity of mitral 11.4 Types of cardiac lesions which can be regurgitation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 assessed using 3D echocardiography . . . . . . 203 8.2 Aortic regurgitation . . . . . . . . . . . . . . . . . . . . . . 143 11.4.1 Abnormalities of venous drainage . . . . . . . . . 203 8.3 Right-sided heart valves . . . . . . . . . . . . . . . . . . 149 11.4.2 Atrial septal defects . . . . . . . . . . . . . . . . . . . . . . . . 203 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 11.4.3 Ventricular septal defects . . . . . . . . . . . . . . . . . . 204 11.4.4 Atrioventricular valves . . . . . . . . . . . . . . . . . . . . . 208 9 Valvular heart disease – stenoses . . . . .155 11.4.5 Atrioventricular septal defects . . . . . . . . . . . . . 208 Jose L. Zamorano and Jose Alberto de Agustín 11.4.6 Mitral valve abnormalities . . . . . . . . . . . . . . . . . 208 9.1 Evaluation of mitral valve stenosis . . . . . . . . 155 11.4.7 Ebstein’s anomaly of the tricuspid valve . . . . 208 9.1.1 Morphological assessment of the mitral 11.4.8 Atrioventricular junction . . . . . . . . . . . . . . . . . . . 208 valve . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 11.4.9 Complex anatomy . . . . . . . . . . . . . . . . . . . . . . . . . 212 9.1.2 Functional assessment of mitral stenosis . . 155 11.5 Three-dimensional echocardiography 9.2 Evaluation of aortic valve stenosis . . . . . . . . 162 during catheter intervention and 9.2.1 Morphological assessment of aortic surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 162 11.5.1 Imaging during catheter intervention . . . . . . 214 9.2.2 Functional assessment of aortic 11.5.2 Three-dimensional imaging during stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 9.3 Evaluation of tricuspid and pulmonary 11.6 Role of RT3DE in the assessment of valve stenosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 cardiac function in children . . . . . . . . . . . . . . . . 217 Table of contents IX 11.6.1 The left ventricle . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 11.6.2 The right ventricle . . . . . . . . . . . . . . . . . . . . . . . 217 11.7 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 12 Cardiac tumors and sources of embolism . . . . . . . . . . . . . . . . . . . . . . . . . . . .223 Björn Plicht 12.1 Sources of embolism . . . . . . . . . . . . . . . . . . . . . 223 12.1.1 Cardiac and vascular thrombi, spontaneous echo contrast . . . . . . . . . . . . . . 223 12.1.2 Patent foramen ovale . . . . . . . . . . . . . . . . . . . . 226 12.1.3 Infective endocarditis . . . . . . . . . . . . . . . . . . . . 231 12.2 Primary cardiac tumors . . . . . . . . . . . . . . . . . . 233 12.2.1 Primary benign cardiac tumors . . . . . . . . . . . 233 12.2.2 Primary malignant tumors . . . . . . . . . . . . . . . 236 12.3 Secondary cardiac tumors and metastases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 236 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239 13 Monitoring and guiding cardiac interventions and surgery . . . . . . . . . . . .241 Harald P. Kühl, Andreas Franke, and Thomas Buck 13.1 Method . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241 13.2 Intraoperative monitoring and guiding . . . 241 13.3 Periinterventional monitoring and guiding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 244 13.3.1 Transcatheter closure of PFO and ASD . . . . 244 13.3.2 Transcatheter closure of VSD . . . . . . . . . . . . . 248 13.3.3 Percutaneous aortic valve implantation . . . 248 13.3.4 Percutaneous mitral repair . . . . . . . . . . . . . . . 249 13.3.5 Left atrial appendage occluder implantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 256 13.3.6 Percutaneous occluder implantation for paravalvular leaks . . . . . . . . . . . . . . . . . . . . 258 13.3.7 Percutaneous mitral valvuloplasty . . . . . . . . 259 13.3.8 Electrophysiological procedures . . . . . . . . . . 263 13.4 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 Subject index . . . . . . . . . . . . . . . . . . . . . . . .267 List of authors Adhya, Shaumik, BSc MBBS MRCP CCDS McGhie, Jackie Clinical Research Fellow Chief sonographer King’s College Hospital Department of Cardiology London, UK The Thoraxcenter Erasmus University Medical Center de Agustín, Jose Alberto Rotterdam, the Netherlands Senior Staff Universidad Complutense de Madrid Meijboom, Folkert J., MD, PhD, FESC University Clinic San Carlos GUCH & pediatric cardiologist Madrid, Spain Dept of Pediatrics and Cardiology University Medical Centre Utrecht, von Bardeleben, Stephan, MD Utrecht, the Netherlands Director, Echocardiography Department of Cardiology Monaghan, Mark J., PhD, FRCP(Hon), FACC, FESC University Hospital Mainz Professor of Echocardiography Mainz, Germany Director, Noninvasive Cardiology King‘s College Hospital Buck, Thomas, MD, FACC, FESC London, UK Associate Professor of Medicine Assistant Director, Department of Cardiology Plicht, Björn, MD Director, Echocardiography Senior Cardiologist West German Heart Center Essen Department of Cardiology University Hospital Essen West German Heart Center Essen Essen, Germany University Hospital Essen Essen, Germany Franke, Andreas, MD, FESC Associate Professor of Medicine Roelandt, Jos R.T.C., MD, PhD, FESC Head, Department of Cardiology, Angiology and Professor of Cardiology Intensive Care Medicine Emeritus Chairman Thoraxcenter Klinikum Region Hannover – Klinikum Siloah Erasmus University Medical Center Hannover, Germany Rotterdam, the Netherlands Kisslo, Joseph, MD Simpson, John M., MD, FRCP, FESC Professor of Medicine Consultant in Paediatric and Fetal Cardiology Duke University Medical Center Director of Paediatric Echocardiography Durham, NC, USA Evelina Children’s Hospital Guy’s and St Thomas’ NHS Foundation Trust Kühl, Harald P., MD London, UK Associate Professor of Medicine Head, Department of Cardiology Thiele, Karl E., ME Städtisches Klinikum München – Klinikum Harlaching Principal Scientist Munich, Germany Philips Healthcare Andover, MA, USA XII List of authors van der Zwaan, Heleen Senior Staff Department of Cardiology The Thoraxcenter Erasmus University Medical Center Rotterdam, the Netherlands Zamorano, Jose L., MD, FESC Professor of Medicine Universidad Complutense de Madrid Director, Cardiovascular Institute University Clinic San Carlos Madrid, Spain

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