Table Of Content

VOLUME 53 - CONTENTS No | JANUARY 1998 Page Editorials ] Long acting §, agonists and the risk of life threatening asthma _ P Ernst 3 The failing health care system for adult patients with cystic fibrosis S P Conway, D E Stableforth, A K Webb Conference report Eighth World Conference on Lung Cancer, Dublin, August 1997 R F Fergusson Original articles Case-control study of salmeterol and near-fatal attacks of asthma C Williams, L Crossland, ¥ Finnerty, ¥ Crane, S Holgate, N Pearce, R Beasley Determinants of management errors in acute severe asthma 7 Kolbe,M Vamos, W Fergusson, G Elkind Expression of growth factors and remodelling of the airway wall in bronchial asthma M Hoshino, Y Nakamura, ¥ 7 Sim Family size, childhood infections and atopic diseases C Bodner, D Godden, A Seaton, Aberdeen WHEASE Group Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes A Custovic, A Simpson, H Pahdi, R M Green, M D Chapman, A Woodcock Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance P Weiner, ¥ Waizman, M Weiner, M Rabner, R Magadle, D Zamir Comparison of the functional results of single lung transplantation for pulmonary fibrosis and chronic airway obstruction RA Chacon, P A Corris, } H Dark, G F# Gibson Review series Health effects of passive smoking 4: Parental smoking, middle ear disease and adenotonsillectomy in children DP Strachan, D G Cook Lung infections: Introduction SL Hill Lung infections 1: Role of bacteria in the pathogenesis and progression of acute and chronic lung infection RA Stockle Occasional review Allergen avoidance in the treatment of asthma and atopic disorders A Custovic, A Simpson, M D Chapman, A Woodcock Case reports Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica ¥-Y Shih, P-R Hsueh, ¥-L Chang, L-N Lee, Y-C Chen, M-F Chen, K-T Luh Infection with feline Chlamydia psittaci MM M Cotton, M R Partridge Letters to the editor Adrenocortical activity in children J Doull « Fenoterol and asthma deaths ” B Grant * Home environment and asthma’ R Siebers, P Fitzharris, 7 Crane Notices + Correction No 2 FEBRUARY 1998 Editorials Sputum induction to assess airway inflammation: is it an inflammatory stimulus? ID Pavord Is the lung important as a privileged site for the human immunodeficiency virus? ¥ R Clarke, D M Mitchell, R $ Coker, D Israel-Biet Original articles Changes in sputum composition between two inductions performed on consecutive days O Holz, K Richter, R A Forres, P Speckin, M Miicke, H Magnussen Effect of repeated sputum induction on cell counts in normal volunteers 7% A Nightingale, D F Rogers, P F Barnes Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma A Jatakanon, S Lim, S A Kharitonov, K F Chung, P F Barnes Measurement of sniff nasal and diaphragm twitch mouth pressure in patients PD Hughes,M I Polkey, D Kyroussis, C-H Hamnegard, ¥ Moxham, M Green Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91 P Dubois, E Degrave, O Vandenplas Radiofrequency resection of bronchial tumours in combination with cryotherapy: evaluation of a new technique A Marasso, V Bernardi, R Gai, E Gallo, G M Massaglia, M Onoscuri, S B Cardaci Short paper Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle f, adrenergic tolerance in mild asthma DH Yates, M Worsdell, P ¥ Barnes Science matters Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option? 7 FC Tomee, G H Koéter, P S Hiemstra, H F Kauffman Review series Health effects of passive smoking — 5: Parental smoking and allergic sensitisation in children D P Strachan, D G Cook Lung infections — 2: Branhamella catarrhalis: epidemiological and clinical aspects of a human respiratory tract pathogen TJ F Murphy VOLUME 53 - CONTENTS No | JANUARY 1998 Page Editorials ] Long acting §, agonists and the risk of life threatening asthma _ P Ernst 3 The failing health care system for adult patients with cystic fibrosis S P Conway, D E Stableforth, A K Webb Conference report Eighth World Conference on Lung Cancer, Dublin, August 1997 R F Fergusson Original articles Case-control study of salmeterol and near-fatal attacks of asthma C Williams, L Crossland, ¥ Finnerty, ¥ Crane, S Holgate, N Pearce, R Beasley Determinants of management errors in acute severe asthma 7 Kolbe,M Vamos, W Fergusson, G Elkind Expression of growth factors and remodelling of the airway wall in bronchial asthma M Hoshino, Y Nakamura, ¥ 7 Sim Family size, childhood infections and atopic diseases C Bodner, D Godden, A Seaton, Aberdeen WHEASE Group Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes A Custovic, A Simpson, H Pahdi, R M Green, M D Chapman, A Woodcock Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance P Weiner, ¥ Waizman, M Weiner, M Rabner, R Magadle, D Zamir Comparison of the functional results of single lung transplantation for pulmonary fibrosis and chronic airway obstruction RA Chacon, P A Corris, } H Dark, G F# Gibson Review series Health effects of passive smoking 4: Parental smoking, middle ear disease and adenotonsillectomy in children DP Strachan, D G Cook Lung infections: Introduction SL Hill Lung infections 1: Role of bacteria in the pathogenesis and progression of acute and chronic lung infection RA Stockle Occasional review Allergen avoidance in the treatment of asthma and atopic disorders A Custovic, A Simpson, M D Chapman, A Woodcock Case reports Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica ¥-Y Shih, P-R Hsueh, ¥-L Chang, L-N Lee, Y-C Chen, M-F Chen, K-T Luh Infection with feline Chlamydia psittaci MM M Cotton, M R Partridge Letters to the editor Adrenocortical activity in children J Doull « Fenoterol and asthma deaths ” B Grant * Home environment and asthma’ R Siebers, P Fitzharris, 7 Crane Notices + Correction No 2 FEBRUARY 1998 Editorials Sputum induction to assess airway inflammation: is it an inflammatory stimulus? ID Pavord Is the lung important as a privileged site for the human immunodeficiency virus? ¥ R Clarke, D M Mitchell, R $ Coker, D Israel-Biet Original articles Changes in sputum composition between two inductions performed on consecutive days O Holz, K Richter, R A Forres, P Speckin, M Miicke, H Magnussen Effect of repeated sputum induction on cell counts in normal volunteers 7% A Nightingale, D F Rogers, P F Barnes Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma A Jatakanon, S Lim, S A Kharitonov, K F Chung, P F Barnes Measurement of sniff nasal and diaphragm twitch mouth pressure in patients PD Hughes,M I Polkey, D Kyroussis, C-H Hamnegard, ¥ Moxham, M Green Asthma and airway hyperresponsiveness among Belgian conscripts, 1978-91 P Dubois, E Degrave, O Vandenplas Radiofrequency resection of bronchial tumours in combination with cryotherapy: evaluation of a new technique A Marasso, V Bernardi, R Gai, E Gallo, G M Massaglia, M Onoscuri, S B Cardaci Short paper Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle f, adrenergic tolerance in mild asthma DH Yates, M Worsdell, P ¥ Barnes Science matters Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option? 7 FC Tomee, G H Koéter, P S Hiemstra, H F Kauffman Review series Health effects of passive smoking — 5: Parental smoking and allergic sensitisation in children D P Strachan, D G Cook Lung infections — 2: Branhamella catarrhalis: epidemiological and clinical aspects of a human respiratory tract pathogen TJ F Murphy Occasional reviews 129 Structural and inflammatory changes in COPD: a comparison with asthma PK Jeffery 137 New therapies for chronic obstructive pulmonary disease P # Barnes Case reports 148 Commentary FL Raymond 149 Opitz oculo-genito-laryngeal syndrome: a rare cause of recurrent aspiration pneumonia in an adult D de Silva, A Osborne, S A Simpson, ¥ C S Dean, A Seaton Familial primary spontaneous pneumothorax consistent with true autosomal dominant inheritance P ¥ Morrison, RC Lowry, N C Nevin Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to “sensitisation” to isocyanates? C Leroyer, L Perfetti, A Cartier, J7-L Malo Letters to the editor Atopy phenotype S Thomas, N Morton, S Holgate + Lung volume reduction surgery M D L Morgan, DA Waller, S ¥ Singh D A Lomas, N Caine, F C Wells Book review - Notice No 3 MARCH 1998 Editorials 157 Gene therapy for cystic fibrosis: what message for the recipient? 7A Dodge 159 Pneumococcal serotypes and their clinical relevance M Kalin Conference report 163 1997 Winter Meeting of the British Thoracic Society 7A Innes Original articles 166 Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study __L Grievink, H A Smit, M C Ocké, P van ‘t Veer, D Kromhout ~“ nN Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects M A Sapienza, S A Kharitonov, I Horvath, K Fan Chung, P F Barnes Geographical distribution of tuberculosis notifications in national surveys of England and Wales in 1988 and 1993: report of the Public Health Laboratory Service/British Thoracic Society/Department of Health Collaborative Group L P Ormerod, A Charlett, C Gilham, }H Darbyshire, ?M Watson 182 Non-tuberculous mycobacteria in cystic fibrosis %K Torrens, P Dawkins, S P Conway, E Moya 186 Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats A Azuma, T Furuta, T Enomoto, Y Hashimoto, K Uematsu, N Nukariya, A Murata, S Kudoh 190 Videothoracoscopic treatment of oesophageal leiomyoma GC Roviaro,M Maciocco, F Varoli, C Rebuffat, C Vergani, A Scarduelli Short paper 193 Preferential binding of lysozyme to elastic fibres in pulmonary emphysema _ __B Shteyngart, S Chaiwiriyakul, +} Wong, ¥ O Cantor Science matters 197 Gene therapy for cystic fibrosis: which postman, which box? PG Middleton, E W F W Alton 200 New ideas on the pathophysiology and treatment of lung disease D F Rogers, G ¥ Laurent Review series Health effects of passive smoking — 6: Parental smoking and childhood asthma: longitudinal and case-control studies D P Strachan, D G Cook Lung infections — 3: Pseudomonas aeruginosa and other related species R Wilson, R B Dowling Occasional review Pulmonary vasculitis A Burns Case reports Non-Hodgkin’s lymphoma arising in cryptogenic fibrosing alveolitis 7 R Orchard, C D Eraut, A G Davison A vibrating trachea M # Doherty, D P S Spence, D Graham, B M G Cheetham, X Q Sun,f E Earis Upper airways sarcoidosis presenting as obstructive sleep apnoea RN H Shah, PR Mills, P ¥ M George, J A Wedzicha Letters to the editor Why are there so few papers or elderly patients in Thorax? M Mamun; A } Knox, ¥ Britton + Passive smoking in children with asthma T Ashcroft; reply I Crombie, L Irvine Book review + Notices No 4 APRIL 1998 Editorials Brittle asthma: fiend or phantom? M R Hetzel Improved survival in ARDS: chance, technology or experience? S Baudouin Lung research funding in the UK: the British Lung Foundation perspective W MacNee, I M Walden Original articles Rapid onset asthma: a severe but uncommon manifestation % Kolbe, W Fergusson, ¥G arrett Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning N Awadh, N L Miiller,C S Park, R T Abboud, ¥M FitzGerald Chlamydia pneumoniae and asthma _ P # Cook, P Davies, W Tunnicliffe, ?G Ayres, D Honeybourne, R Wise Induction of IL-8 production in human alveolar macrophages and human bronchial epithelial cells in vitro by swine dust L Palmberg, B-M Larsson, P Malmberg, K Larsson Clinical features and prognosis of life time non-smokers with severe a,-antitrypsin deficiency N Seersholm, A Kok-fensen Effects of theophylline and ipratropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease M Tsukino, K Nishimura, A Ikeda, T Hajiro, H Koyama, T Izumi Clinical profiles of Chinese patients with diffuse panbronchiolitis K WT Tsang,C GC Oo, M S M Ip, W-k Lam, H Ngan, E Y T Chan, B Hawkins, C-s Ho, R Amitani, E Tanaka, H Itoh Medium term results of lung transplantation for end stage pulmonary sarcoidosis S Walker, G Mikhail, N Banner, } Partridge, A Khaghani, M Burke, M Yacoub Totally implantable venous access devices in children with cystic fibrosis: incidence and type of complications ¥ Deerojanawong, S M Sawyer, A M Fink, K B Stokes, C F Robertson Short papers Comparison of nose and face mask CPAP therapy for sleep apnoea JIL Mortimore, A T Whittle, N ¥ Douglas Reduced mortality in association with the acute respiratory distress syndrome (ARDS) SC Abel, S F Finney, S ¥ Brett, B F Keogh, C } Morgan, T W Evans Review series Health effects of passive smoking — 7: Parental smoking, bronchial reactivity and peak flow variability in children D G Cook, D P Strachan Lung infections — 4: Pathogenesis of lower respiratory tract infections due to Chlamydia, Mycoplasma, Legionella and viruses P Andersen Occasional reviews High resolution computed tomography in asthma A N Mclean, M W Sproule, M D Cowan, N C Thomson Brittle asthma 7 G Ayres, ¥ F Miles, P ¥ Barnes Case reports Commentary: “Histiocytosis X” DV Parums Recurrence of recipient Langerhans’ cell histiocytosis following bilateral lung transplantation SB Habib, ¥ Congleton, D Carr, ¥ Partridge, B Corrin, D M Geddes, N Banner, M Yacoub, M Burke Recurrence of Langerhans’ cell granulomatosis following lung transplantation E Gabbay, ¥ H Dark, T Ashcroft, D Milne, G ¥ Gibson, M Healy, P A Corrts Letters to the editor Should steroids be first choice for asthma? G Strube; reply M Rudolf + The tobacco epidemic in Japan H Kawane + Tobacco advertising ban in Europe S G Spiro Notice No 5 MAY 1998 Editorials Typing of mycobacteria using spoligotyping AC Hayward, # M Watson Bisphosphonates and glucocorticoid-induced osteoporosis: implications for patients with respiratory diseases S Cowan, S Morin, P Ernst Burkholderia cepacia: another twist and a further threat A K Webb, 7 R Govan The new prescription: industrial injuries benefits for smokers? A Seaton Coal miners’ respiratory disease litigation R Rudd Rapid communication Randomised placebo controlled trial of daytime function after continuous positive airway pressure (CPAP) therapy for the sleep apnoea/hypopnoea syndrome H M Engleman, S E Martin, R N Kingshott, TW Mackay, I ¥ Deary, N ¥ Douglas Original articles Pulmonary tuberculosis in Harare, Zimbabwe: analysis by spoligotyping RS Heyderman, M Goyal, P Roberts, S Ushewokunze, S Zizhou, B G Marshall, R Makombe, ¥ D A Van Embden, P R Mason, R ¥ Shau A double blind placebo controlled study to determine the effects of intermittent cyclical etidronate on bone mineral density in patients on long term oral corticosteroid treatment P Pitt, F Li, P Todd, D Webber, S Pack, C Moniz Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects LG Heaney, L ¥ M Cross, L P A McGarvey, K D Buchanan, M Ennis, C Shaw How long should Atrovent be given in acute asthma? C Brophy, B Ahmed, S Bayston, A Arnold, D McGivern, M Greenstone Injury to murine airway epithelial cells by pollen enzymes Z Hassim, S E Maronese, R K Kumar Diagnosis of pulmonary arteriovenous malformations by colour Doppler ultrasound and amplitude ultrasound angiography H-C Wang, P-H Kuo, Y-S Liaw, C-} Yu, S-H Kuo, K-T Luh, P-C Yang Short paper Detection of IgG and IgA against the mycobacterial antigen A60 in patients with extrapulmonary tuberculosis M Alifano, R De Pascalis, M Sofia, S Faraone, M Del Pezzo, I Covelli Review series Health effects of passive smoking — 8: Passive smoking and risk of adult asthma and COPD: an update D B Coultas Genetics and pulmonary medicine: Introduction 7 Britton, }H opkin Genetics and pulmonary medicine — 1: The genetics of cystic fibrosis lung disease D ¥ Davidson, D F Porteous Occasional reviews Coal mining and chronic obstructive pulmonary disease: a review of the evidence D Coggon,A N Taylor Public health aspects of obstructive sleep apnoea G ¥ Gibson Sleep apnoea and its impact on public health ¥% Wright, T Sheldon Systematic review of the efficacy of nasal CPAP N F Douglas Cardiovascular aspects of obstructive sleep apnoea and their relevance to the assessment of the efficacy of nasal continuous positive airway pressure therapy RF O Davies Measurement of airway hyperresponsiveness: new considerations 4 Létvall, M Inman, P O’Byrne Clinical impact of bone and calcium metabolism changes in sarcoidosis G Rizzato Case reports Chronic Burkholderia cepacia bronchiectasis in a non-cystic fibrosis individual M ¥ Ledson, M ¥ Gallagher, M F Walshaw Cross infection between cystic fibrosis patients colonised with Burkholderia cepacia M # Ledson, M F Gallagher, ¥ E Corkill, CA Hart, M ¥ Walshaw Letters to the editor Inhibition of T cell proliferation by human alveolar macrophages ¥M Grange; reply P G Holt, JF W Upham + Adenosine and adenosine antagonism in asthma _ C Persson; reply S T Holgate Book reviews + Notice No 6 JUNE 1998 Editorials Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis BG Marshall, R ¥ Shaw Surgery for lung cancer S W Fountain Severity of chronic asthma A # Woolcock, D Dusser, I Fajac Original articles Improving surgical resection rate in lung cancer C Laroche, F Wells, R Coulden, S Stewart, M Goddard, E Lowry, A Price, D Gilligan Surgery for combined type small cell lung carcinoma R Hage, ¥ R F Elbers, A Brutel de la Riviere, ¥M M van den Bosch Cross sectional study of exhaled nitric oxide levels following lung transplantation <A 7 Fisher, E Gabbay, T Small, S Doig, ¥H Dark, P A Corris Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis Y Takemoto, M Sakatani, S Takami, T Tachibana, ¥ Higaki, T Ogihara, T Miki, T Katsuya, T Tsuchiyama, A Yoshida, H Yu, Y Tanio, E Ueda IgG subclasses in the serum and sputum from patients with bronchiectasis SL Hill, # L Mitchell, D Burnett, R A Stockley Idiopathic pulmonary fibrosis: survival in population based and hospital based cohorts D W Mapel, W C Hunt, R Utton, K B Baumgartner, } M Samet, D B Coultas Randomised controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary disease ¥ Bourbeau,M Y Rouleau, S Boucher Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'- monophosphate in asthma DA Taylor, 7 L McGrath, L M Orr, P F Barnes, B ¥ O’Connor Differences in asthma management between white European and Indian subcontinent ethnic groups living in socioeconomically deprived areas in the Birmingham (UK) conurbation H Moudgil, D Honeybourne Short papers Domiciliary nocturnal intermittent positive pressure ventilation in patients with respiratory failure due to severe COPD: long term follow up and effect on survival S E Jones, S Packham, M Hebden, A P Smith Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels C Kroegel, M Schiiler, M Férster, R Braun, P R Grahmann Review series Genetics and respiratory disease 2: Alpha,-antitrypsin deficiency, cirrhosis and emphysema R Mahadeva, D A Lomas Occasional reviews The donor lung: conservation of a precious resource CA Keller Pathophysiology and treatment of Cheyne-Stokes respiration M T Naughton Psychosocial aspects of asthma in adults BD W Harrison Case reports Commentary: bronchiectasis and inflammatory bowel disease RA Stockley Bronchiectasis in association with coeliac disease R Mahadeva, C Flower, ¥ Shneerson Bronchiectasis following colectomy for Crohn’s disease 7 E Eaton, N Lambie, A U Wells Letter to the editor Evolution of OSA _S F Quan, P Lévy, F L Pépin Book review + Notice No 7 JULY 1998 Editorial Regulation of granulocyte apoptosis and implications for anti-inflammatory therapy FE R Chilvers, A G Rossi, ¥ Murray, C Haslett Occasional note Lump sum compensation for asbestos related lung disease JT Williams, P Slade, ¥R aeburn BTS guidelines Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998 Joint Tuberculosis Committee of the British Thoracic Society Original articles Birth weight, childhood lower respiratory tract infection, and adult lung function SO Shaheen, 4A C Sterne, $S Tucker, C du V Florey Cryptococcosis in HIV negative patients: findings on chest radiography LD ¥ Roebuck, D A Fisher, B F Currie Risk of non-fatal cardiac failure and ischaemic heart disease with long acting 8, agonists RM Martin, N R Dunn, S N Freemantle, R D Mann Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects ¥ A Nightingale, D F Rogers, L A Hart, S A Kharitonov, K F Chung, P # Barnes Effect of exercise induced hypoxaemia on myocardial repolarisation in severe chronic obstructive pulmonary disease RP Smith, M K Johnson,f Ashley, S T Rudkin, R ¥ White Glucocorticoids decrease c-fos expression in human nasal polyps in vivo ¥~ N Baraniuk, G Wong, M Ah, M Sabol, T Troost Short papers Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive pulmonary disease M Confalonieri, E Mainardi, R Della Porta, S Bernorio, L Gandola, B Beghée, A Spanevello Pituitary adenylate cyclase activating peptides relax human pulmonary arteries by opening of K,,,. and K channels L Bruch, S Rubel, A Kastner, K Gellert, M Gollasch, C Witt Review series Genetics and pulmonary medicine 3: Genetic susceptibility to tuberculosis in human populations R Bellamy Occasional reviews Iron metabolism in the lower respiratory tract F Mateos, ¥ H Brock, 7 L Pérez-Arellano Role of transcription factors in inflammatory lung diseases JI Rahman, W MacNee Pulmonary neuronal M. muscarinic receptor function in asthma and animal models of hyperreactivity 8 W Costello, D B Jacoby, A D Fryer Case reports Commentary PA Corris Single lung transplantation for adult respiratory distress syndrome after paraquat poisoning M Licker, A Schweizer, L Hohn, D R Morel, A Spiliopoulos Heart lung transplantation in a patient with end stage lung disease due to common variable immunodeficiency A T Hill, R A Thompson, ¥ Wallwork, D E Stableforth Letters to the editor COPD Guidelines M Perry;reply M G Pearson, P M A Calverley * COPD Guidelines R Jones * Travel by air for patients with COPD R K Sinha; reply M G Pearson, P M A Calverley + Guidelines on pulmonary embolism C WH Davies; reply A Miller «+M alignant neoplasms in pulmonary sarcoidosis ¥ M Reich; reply N Seersholm, ¥ Vestbo, K Viskum Book review + Notices No 8 AUGUST 1998 Editorials Is sleep disordered breathing associated with increased mortality? ¥A Fleetham Small airways: a time to revisit? D ¥ Evans, M Green Original articles Increased mortality among sleepy snorers: a prospective population based study E Lindberg, C Janson, K Svdardsudd, T Gislason, } Hetta, G Boman The prevalence of clinically significant sleep apnoea syndrome in the Netherlands A Knuistingh Neven, H A M Middelkoop, B Kemp, H A C Kamphuisen, M P Springer Evaluation of an auto-CPAP device for treatment of obstructive sleep apnoea 7H Ficker,G H Wiest, G Lehnert, B Wiest, EG Hahn Association of years of occupational quartz exposure with spirometric airflow limitation in Norwegian men aged 30-46 years S Humerfelt,G E Eide, A Gulsvik Fluticasone propionate 750 yg/day versus beclomethasone dipropionate 1500 pg/day: comparison of efficacy and adrenal function in paediatric asthma D Fitzgerald, P Van Asperen, C Mellis, M Honner, L Smith, G Ambler Individual allergens as risk factors for bronchial responsiveness in young adults S Chinn, D Farvis, C Luczynska, P Burney Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress JI Horvath, L E Donnelly, A Kiss, P Paredi, S A Kharitonov, P ¥ Barnes Influence of atmospheric nitric oxide concentration on the measurement of nitric oxide in exhaled air M Corradi, A Pelizzoni, M Majori, A Cuomo, E de’ Munari, A Pesci Acute inhalation of cigarette smoke increases lower respiratory tract nitric oxide concentrations D C Chambers, W S Tunnicliffe, 7 G Ayres 680 Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide LP Ho, FA Innes, A P Greening 685 Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways of patients with bronchiectasis M Gaga, A M Bentley, M Humbert, ¥}B arkans, F O’Brien, C G Wathen, A B Kay, S R Durham Interstitial laser photocoagulation of normal lung parenchyma in rats D / Fielding, G Buonaccorsi, A Hanby, M R Hetzel, S G Bown Review series Genetics and pulmonary medicine 4: Pulmonary embolism M Laffan Occasional reviews Current role of positron emission tomography in thoracic oncology V ¥ Lowe, K S Naunheim Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists Y Amrani, RA Panettieri Fr Case report Human syngamosis: the first case in Korea H Y Kim, S M Lee, J-E Foo, M 7 Na, M H Ahn, D Y Min Letters to the editor Cyclo-oxygenase A Sampson, S Holgate, K F Austen, A Szczeklik; reply 7 A Mitchell, M G Belvisi + Intrapleural streptokinase 7% Porter, A P Banning Notice No 9 SEPTEMBER 1998 | Pz Editorials Quality of life in cystic fibrosis D ¥ French Management of persistent dry cough F O’Connell Respiratory intensive care in Europe: lessons forthe UK M W Elliott, S V Baudouin Original articles Quality of life in patients with cystic fibrosis and their parents: what is important besides disease severity? D Staab, K Wenninger, N Gebert, K Rupprath, S Bisson, M Trettin, K D Paul, K M Keller, U Wahn Long term follow up of changes in FEV, and treatment intensity during Pseudomonas aeruginosa colonisation in patients with cystic fibrosis M Ballmann, P Rabsch, H von der Hardt Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol LL PA McGarvey, L G Heaney, } T Lawson, B T Fohnston, C M Scally, M Ennis, D R T Shepherd, b MacMahon Asthma control during long term treatment with regular inhaled salbutamol and salmeterol D R Taylor, G I Town, G P Herbison, D Boothman-Burrell, E M Flannery, B Hancox, E Harré, K Laubscher, V Linscott, C M Ramsay, G Richards, with the technical assistance of ¥ Cowan, N Holbrook, C McLachlan, S Rigby Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time F L Faul, C T Leonard, C M Burke, V ¥ Tormey, L W Poulter Core guidelines for the discharge home of the child on long term assisted ventilation in the United Kingdom = E Fardine, C Wallis Exertional dyspnoea in patients with airway obstruction, with and without CO, retention S G M Cloosterman, I D Hofland, C P van Schayck, H Th M Folgering Exhalation flow and pressure-controlled reservoir collection of exhaled nitric oxide for remote and delayed analysis P Paredi, S Loukides, S Ward, D Cramer, M Spicer, S A Kharitonov, P ¥ Barnes Influence of nasal obstruction on auto-CPAP behaviour during sleep in sleep apnoea/hypopnoea syndrome C Lafond, F Sériés Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function E ¥ Fensen, B Pedersen, R Frederiksen, R Dahl Short paper Effect of the number of peak expiratory flow readings per day on the estimation of diurnal variation P F G Gannon, D T Newton, C F A Pantin, P S Burge Review series Genetics and pulmonary medicine — 5: Genetics of drug resistant tuberculosis A Telenti Occasional reviews Intermediate respiratory intensive care units in Europe: a European perspective S Nava, M Confalonieri, C Rampulla Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease L Fabbri, B Beghé, G Caramori, A Papi, M Saetta Case reports 809 Serum KL-6 level as a monitoring marker in a patient with pulmonary alveolar proteinosis M Nakajima, T Manabe, Y Niki, T Matsushima Reactivation of coccidioidomycosis in a fit American visitor FM K Williams, V Markides, ¥E dgeworth, A F Williams Letters to the editor Comparison of outcome measures in patients with COPD M Ferrer, ¥ Alonso, L Prieto, ¥ M Anto; reply R Harper, ¥ Brazier, ¥ Waterhouse * CFA with preserved lung volumes WN Strickland, ¥M B Hughes; reply M F Doherty, P M A Calverley * Serum adenosine deaminase activity in pleural effusion V Singh, S Kharb, P S Ghalaut, A Fanmeja 814 Book reviews + Notice No 10 OCTOBER 1998 Page Editorials 815 The acute respiratory distress syndrome: fibrosis in the fast lane R Marshall, G Bellingan, G Laurent 818 Improving donor lung evaluation: a new approach to increase organ supply for lung transplantation A F Fisher, ¥}H Dark, P A Corris A fresh look at p-dimer in suspected pulmonary embolism A C Miller Original articles Fibroproliferation and mast cells in the acute respiratory distress syndrome 7 M Liebler, Z Qu, B Buckner, M R Powers, ¥ T Rosenbaum Usefulness of p-dimer, blood gas, and respiratory rate measurements for excluding pulmonary embolism P Egermayer, G I Town, ¥G Turner, D C Heaton, A L Mee, M E F Beard Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma Y Nakamura, M Hoshino, ¥ ¥ Sim, K Ishu, K Hosaka, T Sakamoto Air pollution, pollens, and daily admissions for asthma in London 1987-92 H R Anderson, A Ponce de Leon, ¥#M Bland, ¥ S Bower, } Emberlin, D P Strachan An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen ¥ Temelkovski, S P Hogan, D P Shepherd, P S Foster, R K Kumar Pulmonary artery pressure variation in patients with connective tissue disease: 24 hour ambulatory pulmonary artery pressure monitoring DA Raeside,G Chalmers, ¥C lelland, R Madhok, A F Peacock Survey of non-invasive ventilation (NIPPV) in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) inthe UK M # Doherty, M A Greenstone Increased levels of exhaled carbon monoxide in bronchiectasis: a new marker of oxidative stress I Horvath, S Loukides, T Wodehouse, S A Kharitonov, P ¥ Cole, P ¥ Barnes Mycobacterium tuberculosis DNA in tissues affected by sarcoidosis M L Wilsher, R E Menzies, M C Croxson Short papers Updating UK estimates of age, sex and period specific cumulative constant tar cigarette consumption per adult BA Forey, P N Lee, ¥ S Fry Silver/silver chloride electrodes for measurement of potential difference in human bronchi I Fayac, ¥ Lacronique, A Lockhart, ¥ Dall’Ava-Santucci, D ¥ Dusser Endogenous nitric oxide in patients with stable COPD: correlates with severity of disease E Chm, L Bianchi, M Pagani, N Ambrosino Review series Health effects of passive smoking — 9: Parental smoking and spirometric indices in children D G Cook, D P Strachan, I M Carey Genetics and pulmonary medicine — 6: Immotile cilia syndrome: past, present, and prospects for the future BA Afzelius Occasional review Respiratory illness: a complementary perspective G T Lewith Case reports 905 Disseminated Penicillium marneffei infection presenting as a right upper lobe mass in an HIV positive patien H McShane, C M Tang, C P Conlon 906 Flitting radiographic shadows: an unusual presentation of cancer in the lungs WM Edmondstone 908 Book reviews - Notices No 11 NOVEMBER 1998 Page Editorials 909 Asthma in African cities P Cullinan 911 Infections in asthma and allergy SA Lewrs 913 Viruses and asthma exacerbations N G Papadopoulos, S L Fohnston Rapid communication Telomerase activity in human pleural mesothelioma K Dhaene, R Hiibner, S Kumar-Singh, B Weyn, E Van Marck Original articles Prevalence of exercise induced bronchospasm in Kenyan school children: an urban-rural comparison L W Ne’ang’a, ¥ A Odhiambo, M W Mungai, C M Gicheha, P Nderitu, B Maingi, P T Macklem, M R Becklake Early childhood infection and atopic disorder JIS Faroogi, 7 M Hopkin Repeatability of lung function tests during methacholine challenge in wheezy infants C Delacourt, M-R Benoist, S Waernessyckle, P Rufin, J-¥ Brouard, F de Blic, P Scheinmann Environmental correlates of impaired lung function in non-smokers with severe a,-antitrypsin deficiency PiZZ E Putulainen, G Tornling, S Eriksson Effect of breathing circuit resistance on the measurement of ventilatory function D P Fohns,CM Ingram, S Khov, P D Rochford, E H Walters Impact of nasal ventilation on survival in hypercapnic Duchenne muscular dystrophy A K Simonds, F Muntoni, S Heather, S Fielding Comparison of spontaneous and induced sputum for investigation of airway inflammation in chronic obstructive pulmonary disease A Bhowmik, TA R Seemungal, R F Sapsford, 7 L Devalia, } A Wedzicha Efficacy of nasal continuous positive airway pressure therapy in chronic heart failure: importance of underlying cardiac rhythm 7 UL Kiely, P Deegan, A Buckley, P Shiels, B Maurer, W T McNicholas Gastro-oesophageal reflux related cough and its response to laparoscopic fundoplication C # Allen, M Anvari Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and pulmonary fibrosis associated with collagen vascular disorders N Dobashi, ¥#F ujita, Y Ohtsuki, I Yamadori, T Yoshinouchi, T Kamei, M Tokuda, S Hojo, H Okada, ¥ Takahara Effects of Aspergillus fumigatus culture filtrate on antifungal activity of human phagocytes in vitro T Murayama, R Amitani, Y Ikegami, R Kawanami, W F Lee, R Nawada Review series Genetics and pulmonary medicine 7: Somatic mutations in the development of lung cancer M Roland, R M Rudd Occasional reviews Methodology of bronchial responsiveness S Chinn Renal and hormonal abnormalities in chronic obstructive pulmonary disease (COPD) P Palange Airway hyperresponsiveness in asthma: not just a matter of airway inflammation V Brusasco, E Crimi, R Pellegrino Case report 999 Commentary: Retransplantation in a patient with cystic fibrosis D Geddes 1000 Retransplantation in a patient with cystic fibrosis M McCloskey, A P Maxwell, V Hall, A O B Redmond, 7 S Elborn Letter to the editor Rifampicin containing antituberculosis medication GF Cavell, D C S Hutchison, B C Whiteman Book review +« Notice No 12 DECEMBER 1998 Page Editorials 1003 DNase in cystic fibrosis: the challenge of assessing response and maximising benefit 7A Innes 1005 Societal and health care benefits of early use of inhaled steroids T Haahtela, T Klaukka 1007 Augmentation therapy for severe @,-antitrypsin deficiency: is the jury still out on atrial? 7 K Stoller Rapid communication 1010 Effects of formoterol on histamine induced plasma exudation in induced sputum from normal subjects L Greiff, P Wollmer, M Andersson, C Svensson, C G A Persson Original articles Long term effects of aerosolised rhDNase on pulmonary disease progression in patients with cystic fibrosis C E Milla Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis ¥ Hull, A H Thomson Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease R Mahadeva, S Stewart, D Bilton, D A Lomas First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma L Blais, S Suissa, J-F Boivin, P Ernst Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids RG Stirling, S A Kharitonov, D Campbell, D S Robinson, S R Durham, K F Chung, P ¥ Barnes for the Asthma and Allergy Group Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence T Nicolai, S Illi, E von Mutius Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D.,, and bronchial responsiveness to methacholine S O’Sullivan, S-E Dahlen, K Larsson, B-M Larsson, P Malmberg, M Kumlin, L Palmberg Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique ¥ Thorn, R Rylander Cross-colonisation with Pseudomonas aeruginosa of patients in an intensive care unit DC ¥ ¥ Bergmans, M # M Bonten, F H van Tiel, C A Gaillard, S van der Geest, R M Wilting, P W de Leeuw, E E Stobberingh Urinary cGMP concentrations in severe primary pulmonary hypertension M Bogdan, M Humbert, ¥ Francoual, C Claise, P Duroux,G Simonneau, A Lindenbaum Short paper Glucocorticoid insensitive asthma: a one year clinical follow up pilot study P Demoly, DF affuel, M Mathieu, H Sahla, P Godard, F-B Michel, ¥} Bousquet Occasional reviews 1066 Review of psychosocial stress and asthma: an integrated biopsychosocial approach R # Wright, M Rodriguez, S Cohen 1075 Cellular responses to hypoxia in the pulmonary circulation SO Brij, A ¥ Peacock 1080 Clinical usefulness of high resolution computed tomography in cryptogenic fibrosing alveolitis A Wells Case reports 1088 Commentary DM Hansell 1089 Diagnosis of pulmonary sequestration by spiral CT angiography 7 Franco, R Aliaga, M L Domingo, P Plaza 1092 Interventricular septal shift due to massive pulmonary embolism shown by CT pulmonary angiography: an old sign revisited 7B Oliver, 7H Reid, ¥ T Murchison Letters to the editor 1094 Cardiac risks with § agonists B Lindmark; R M Martin, N R Dunn, R D Mann, S N Freemantle + Genetics and tuberculosis GH Bothamley * Chlamydia pneumoniae and asthma F Blasi, L Allegra, P Tarsia; D L Hahn + Non-Hodgkin’s lymphoma with CFA — A Nicholson, B Corrin; T R Orchard, C D Eraut, A G Davison 1096 Book reviews * Correction Supplement No 1 BTS Recommendations to Respiratory Physicians for Organising the Care of Patients with Lung JUNE 1998 Cancer Introduction Recommendations Treatment Organisation of cancer units in the UK Appendix 1: Grading scheme for recommendations in the guidelines References Supplement No 2 1998 Year in Review AUGUST 1998 Introduction D # Hendrick, DM Mitchell In search of a cause of cryptogenic fibrosing alveolitis (CFA): one initiating factor or many? M Turner-Warwick Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease H Koyama, D M Geddes Update on the “Dutch hypothesis” for chronic respiratory disease 7 Véestbo, E Prescott Diving and the risk of barotrauma E W Russi Spiral computed tomographic scanning and magnetic resonance angiography for the diagnosis of pulmonary embolism PA Grenier, C Beigelman Strategy and cost in investigating solitary pulmonary nodules M K Gould, G A Lillington The cost to society of smoking cesstion D Cohen, G Barton Persistent respiratory effects in survivors of the Bhopal disaster WS Beckett Role of the indoor environment in determining the severity of asthma A Woodcock, A Custovic Effects of anti-IgE in asthmatic subjects A ¥ Frew Oral appliances for the management of snoring and obstructive sleep apnoea _ L S Bennett, R ¥ O Davies, F R Stradling Use of fibrinolytic agents in the management of complicated parapneumonic effusions and empyemas S A Sahn Supplement No 3 The Cardiovascular Implications of Sleep Disordered Breathing OCTOBER 1998 Introduction 3¥A Fleetham “he study of human sleep: a historical perspective WC Dement Sleep apnoea and snoring: potential links with vascular disease C E Sullivan, SG McNamara Sleep apnoeain women WN Edwards, I Wilcox, C E Sullivan Epidemiological insights into the public health burden of sleep disordered breathing: sex differences in survival among sleep clinic patients 7 Young, L Finn Sleep apnoea and autonomic function C W Zwillich “Syndrome Z”: the interaction of sleep apnoea, vascular risk factors and heart disease I Wilcox, S G McNamara, F L Collins, R R Grunstein, C E Sullivan Heart block in patients with sleep apnoea H F Becker, U Koehler, A Stammnitz, ¥H Peter Prognosis and sleep disordered breathing in heart failure J Wilcox, S G McNamara, T Wessendorf, GN Willson, A F Piper, C E Sullivan Impact of treatment of sleep apnoea on left ventricular function in congestive heart failure M T Naughton Treatment of central sleep apnoea in congestive heart failure with nasal ventilation GN Willson, I Wilcox, A‘¥ Piper, W E Flynn, R R Grunstein, C E Sullivan CPAP therapy: outcomes and patient use N ¥ Douglas, H M Engleman Intelligent CPAP systems: clinical experience H Teschler,M Berthon-fFones Supplement No 4 British Thoracic Society Winter Meeting 1998 Programme and Abstracts DECEMBER 1998 Supplement No 5 Smoking Cessation Guidelines and their Cost Effectiveness DECEMBER 1998 Part 1: Smoking Cessation Guidelines for Health Professionals About these guidelines Recommendations Section 1: Introduction Section 2: Recommendations for the primary care team Section 3: Recommendations for all health professionals Section 4: Recommendations for smoking cessation specialists Section 5: Nicotine replacement therapy Section 6 Other populations and topics $13 Hospital patients $13 Pregnant smokers S13 Young people S13 Low income smokers $14 Sex $14 Weight gain $14 Other treatments $14 No Smoking Day $14 Telephone help lines $14 Training Section 7: Recommendations for health commissioners References Part 2: Guidance for Commissioners on the Cost Effectiveness of Smoking Cessation Interventions About this guidance Section 1: Introduction Section 2: The case for smoking cessation Section 3: Effectiveness Section 4: Cost Section 5: Cost effectiveness Section 6: Conclusions Appendices Appendix 1: Key cost effectiveness studies Appendix 2: A review of smoking cessation cost effectiveness studies Appendix 3: An introduction to discounting Appendix 4: Incremental cost effectiveness References