Table Of Content

THORAX The Fournal of the British Thoracic Society VOLUME 49 President: DONALD LANE Executive Editor: S G Spiro Associate Editors: N C Barnes, J R Britton, P M A Calverley, R M du Bois, T W Evans, A R Gibbs, N Hoiby, D K Kaplan, G J Laurent, M R Miller, M D L Morgan, M F Muers, J O Warner, R J D Winter Technical Editor: Elizabeth Stockman Editorial Assistant: Angela Betchley Advisory Board S H Abman USA D M Geddes UK D M Mitchell UK M J Tobin USA J M Anto Spain P Goldstraw UK A J Peacock UK M Woodhead UK P J Barnes UK C Haslett UK R M Rudd UK Editor, British Medical Fournal E D Bateman South Africa P J Helms UK N A Saunders Australia P S Burge UK F D Martinez USA P D Sly Australia BM] Publishing Group VOLUME 49 - CONTENTS No 1 JANUARY 1994 Page Editorials 1 Preoperative screening for metastases in lung cancer M F Muers 3 Use of bronchoscopy in the diagnosis of infection in the immunocompromised host R P Baughman 8 Sequelae of the adult respiratory distress syndrome R Hert, R K Albert Original articles Analysis of published studies on the detection of extrathoracic metastases in patients presumed to have operable non-small cell lung cancer T K Hillers, M D Sauve, G H Guyatt Surgical resection for small cell carcinoma of the lung: a retrospective study E F Smit, H ¥ M Groen, W Timens, W # de Boer, P E Postmus Efficacy of short term versus long term tube thoracostomy drainage before tetracycline pleurodesis in the treatment of malignant pleural effusions A G Villanueva, A W Gray Jr, D M Shahian, W A Williamson, J F Beamis fr Peripheral mononuclear leucocyte B adrenoceptors and non-specific bronchial responsiveness to methacholine in young and elderly normal subjects and asthmatic patients M ¥ Connolly, 7 7 Crowley, C P Nielson, N B Charan, R E Vestal Risk factors for readmission to hospital for asthma in childhood E A Mitchell, ¥ M Bland, 7 M D Thompson Comparison of inhaled beclomethasone dipropionate 1000 pg twice daily and oral prednisone 10 mg once daily in asthmatic patients H G Bosman, R van Uffelen, 7 } Tamminga, L R Paanakker Differences in utilisation of asthma drugs between two neighbouring Swedish provinces: relation to prevalence of obstructive airway disease L Larsson, G Boéthius, M Uddenfeldt Influence of barn drying of fodder on respiratory symptoms and function in dairy farmers of the Doubs region of France ¥ C Dalphin, ¥ C Polio, D Pernet, M F Maheu, B Toson, A Dubiez, E Monnet, ¥ ¥ Laplante, A Depierre Maxiumum relaxation rate of the diaphragm during weaning from mechanical ventilation ¥ C Goldstone, M Green, ¥ Moxham Lung and respiratory muscle function in limb girdle muscular dystrophy 7-P Stiibgen, G ¥ Ras, C M Schultz, G Crowther Sleep hypoxia in myotonic dystrophy and its correlation with awake respiratory function A 7 Finnimore, R V Fackson, A Morton, E Lynch Re-evaluation of pneumonia requiring admission to an intensive care unit: a prospective study N S Dahmash, M N H Chowdhury Review series Pulmonary rehabilitation in chronic respiratory insufficiency: 6 — Travel for technology-dependent patients with respiratory disease F Sameets Technical note Correction of the single breath carbon monoxide transfer factor in exercise for variations in alveolar oxygen pressure A H Kendrick, G Laszlo Short reports Tracheal schwannoma: management by endoscopic laser resection V W Rusch, R A Schmidt Insertion of a self-expandable endotracheal metal stent using topical anaesthesia and a fibreoptic bronchoscope: a comfortable way to offer palliation D Coolen, H Slabbynck, D Galdermans, C Van Schaardenburg, L L Mortelmans Pleural fluid characteristics in pulmonary brucellosis E Kerem, O Diav, P Navon, D Branski Response to ketamine in status asthmaticus resistant to maximal medical treatment A Hemming, I MacKenzie, S Finfer Pancoast syndrome caused by a high grade B cell lymphoma P R Mills, L Y Han, R Dick, S W Clarke Letters to the editor Solenoid valve v weighted plunger in incremental inspiratory threshold loading P R Eastwood, D R Hillman; P A Bardsley, M D L Morgan. Familial predisposition to snoring D B Teculescu, E Mauffret-Stephan, C Gaultier. Formoterol dry powder in asthma P Bright; A Wallin Miscellaneous Book notices Notice - Correction No 2 FEBRUARY 1994 Editorials What role for theophylline? ¥ W Jenne Asthma and the common cold: can viruses imitate worms? P ¥ M Openshaw, D R O’Donnell Antibiotic penetration into lung tissues D Honeybourne Original articles Phagocyte function and cytokine production in community acquired pneumonia K Moussa, H ¥ Michie, I A Cree, A C McCafferty, # H Winter, D P Dhillon, S Stephens, R A Brown Simplified exercise test for the initial differential diagnosis of Pneumocystis carinii pneumonia in HIV antibody positive patients ¥ Sauleda, 7.G ea, X Aran, M C Aguar, M Orozco-Levi, # M Broquetas Treatment compliance in adults with cystic fibrosis ¥ Abbott, M Dodd, D Bilton, A K Webb Microvascular exudative hyperresponsiveness in human coronavirus-induced common cold L Greiff, M Andersson, A Akerlund, P Wollmer, C Svensson, U Alkner, C G A Persson Response of the nose to exercise in healthy subjects and in patients with rhinitis and asthma F Serra-Batlles, } M Montserrat, ¥ Mullol, E Ballester, A Xaubet, C Picado Temporal association between hospital admissions for asthma in Birmingham and ambient levels of sulphur dioxide and smoke S Walters, R K Griffiths, ¥ G Ayres Asthma mortality and death certification in Northern Ireland S C Wright, A E Evans, D G Sinnamon, ¥ MacMahon Serum concentration of 7S collagen and prognosis in patients with the adult respiratory distress syndrome M Kawamura, F Yamasawa, A Ishizaka, R Kato, K Kikuchi, K Kobayashi, T Aoki, F Sakamaki, N Hasegawa, T Kawashiro, T Ishihara Effect of detergent on alveolar particle clearance due to large tidal ventilation ¥ Fohn, P Wollmer, M Dahlback, B Fonson Development of immunological assays to monitor pulmonary allograft rejection A C Cunningham, J A Kirby, I W Colquhoun, P A Flecknell, T Ashcroft, ? H Dark Obstructive apnoeas in Duchenne muscular dystrophy Y Khan, ¥ Z Heckmatt Review series Pulmonary rehabilitation in chronic respiratory insufficiency: 7 — Health-related quality of life among patients with chronic obstructive pulmonary disease 7 R Curtis, R A Deyo, L D Hudson Hypothesis Increase in asthma: a more toxic environment or a more susceptible population? A Seaton, D 7 Godden, K Brown Technical note Evaluation of a new electronic spirometer: the Vitalograph “Escort” spirometer N Wiltshire, A H Kendrick Short reports Pseudotumour of the lung caused by Mycobacterium malmoense infection in an HIV positive patient K Yoganathan, M W Elliott, Moxham, M Yates, A L Pozniak Surgical resection for pulmonary metastases of sweat gland carcinoma T Osaki, M Kodate, R Nakanishi, T Mitsudomi, T Shirakusa Tracheal stenosis due to bilateral arterial aneurysms N C Munro, D Soppitt, R A L Brewis Childhood tuberculosis in Leeds, 1982-90: social and ethnic factors and the role of the contact clinic in diagnosis ¥ M Goldman, C Teale, D B Cundall, S B Pearson Pulmonary barotrauma in submarine escape training C R Broome, L F Farvis, R F Clark Recurrent haemoptysis in a young woman: a case of malignant haemangiopericytoma of the lung T B Rothe, W Karrer, f¥-O Gebbers Letters to the editor Bronchodilators and bronchial hyperresponsiveness D R Taylor, M R Sears; C P van Schayck, C L A van Herwaarden + Extrapulmonary effects of fenoterol and salbutamol in normal subjects ¥ Crane, C Burgess, R Beasley, C Wong; B F Lipworth, D M Newnham, D G McDevitt Miscellaneous Book notices - Notices No 3 MARCH 1994 Editorials New insights into the pathogenesis of interstitial pulmonary fibrosis S A Fimenez Recent developments in research into sudden infant death C F Poets, D P Southall Occupational asthma among hospital health care personnel: a cause for concern? 7 P Hayes, M X FitzGerald Original articles Type I collagen formation in rat type II alveolar cells immortalised by viral gene products R Matsui, R H Goldstein, K Mihal, ¥ S Brody, M P Steele, A Fine Effect of fluticasone propionate on neutrophil chemotaxis, superoxide generation, and extracellular proteolytic activity in vitro C G Llewellyn-fFones, S L Hill, R A Stockley Clinical relevance of testing for antineutrophil cytoplasm antibodies (ANCA) with a standard indirect immunofluorescence ANCA test in patients with upper or lower respiratory tract symptoms A Davenport, R ¥ Lock, T B Wallington Circulating antibodies to lung protein(s) in patients with cryptogenic fibrosing alveolitis WA H Wallace, S N Roberts, H Caldwell, E Thornton, A P Greening, D Lamb, S E M Howie Transforming growth factor $, gene expression in human airways 7-D Aubert, B I Dalal, T R Bai, C R Roberts, S Hayashi, ¥ C Hogg Haemodynamic effects of atrial natriuretic peptide in hypoxic chronic obstructive pulmonary disease T K Rogers, W Sheedy, ¥ Waterhouse, P Howard, A H Morice Respiratory effort perception at rest and during carbon dioxide rebreathing in patients with dystrophia myotonica 7 E Clague, # Carter, ¥#C oakley, RH T Edwards, P M A Calverley Cross refractoriness between sodium metabisulphite and exercise induced asthma I Pavord, H Lazarowicz, D Inchley, D Baldwin, A Knox, A Tattersfield Comparison of sulphur dioxide and metabisulphite airway reactivity in subjects with asthma P I Field, M McClean, R Simmul, N Berend Role of inflammation in nocturnal asthma T W Mackay, W A H Wallace, S E M Howie, P H Brown, A P Greening, M K Church, N ¥ Douglas Compliance with CPAP therapy in patients with the sleep apnoea/hypopnoea syndrome H M Engleman, S E Martin, N ¥ Douglas Short paper Effect of adding aminophylline infusion to nebulised salbutamol in severe acute asthma B M Z Zainudin, O Ismail, K Yusoff Review series Pulmonary rehabilitation in chronic respiratory insufficiency: 8 — Setting up a pulmonary rehabilitation programme C F Clark Pulmonary rehabilitation in chronic respiratory insufficiency: 9 - How to keep the customer satisfied T Clay Case reports Spontaneous migration of totally implanted venous catheter systems from subclavian into jugular veins D Roblin, } C Porter, R K Knight Anterior mediastinal mass in a young man 7 M Travaline, G ¥ Criner, P-M L Ming, F Kueppers imaging of bronchial carcinoid tumours with indium-111 pentetreotide K ¥ O’Byrne, N F O’Hare, P F Freyne, D A Luke, L ¥ Clancy, F S Pritchard, D N Carney Foregut duplication cyst presenting as neonatal respiratory distress and haemoptysis D P Burgner, R Carachi, T F Beattie Letters to the editor Improvement in sodium cromoglycate delivery from a spacer device M L Everard; C O’Callaghan + Photodynamic therapy for treatment of bronchial carcinomas G Sutedja, R Risse, FC van Mourik, P E Postmus; M R Hetzel - Reversal of bleomycin lung toxicity with corticosteroids F Kozielski + Variability in ciliary beat frequency in bronchiectasis G Di Benedetto Miscellaneous Book notice No 4 APRIL 1994 Editorials Consumer, carer, provider, purchaser — developing care for adults with cystic fibrosis: a specialist service A K Webb Bronchiolitis and asthma: are they related? L J Landau Ventilation in severe acute asthma: is there safety in numbers? K M Sim, B F Keogh Original articles Hospital care for adults with cystic fibrosis: an overview and comparison between special cystic fibrosis clinics and general clinics using a patient questionnaire S Walters, ¥ Britton, M E Hodson Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products B ¥ O’Connor, P ¥ Barnes, K F Chung Collagen breakdown products and lung collagen metabolism: an in vitro study on fibroblast cultures C Gardi, P Calzoni, P Marcolongo, E Cavarra, L Vanni, G Lungarella Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs M R Lang, G W Fiaux, M Gillooly, 7 A Stewart, D ¥ S Hulmes, D Lamb Oxygen and ”™Tc-MAA shunt estimations in patients with pulmonary arteriovenous malformations: effects of changes in posture and lung volume ¥ Ueki, 7 M B Hughes, A M Peters, G F Bellingan, M A M Mohammed, ¥ Dutton, W Ussov, D Knight, D Glass Effect of theophylline on exercise performance in patients with severe chronic obstructive pulmonary disease G Fink, C Kaye, ¥ Sulkes, U Gabbay, S A Spitzer Non-invasive beat to beat arterial blood pressure during non-REM sleep in obstructive sleep apnoea and snoring R F O Davies, ¥ Crosby, K Vardi-Visy, M Clarke, # R Stradling A respiratory survey in a black Johannesburg workforce K E Mokoetle, M de Beer, M R Becklake Prevalence of asthma and risk factors among Chinese, Malay, and Indian adults in Singapore 7 P Ng, K P Hui, Wan C Tan Oilseed rape and seasonal symptoms: epidemiological and environmental studies A Soutar, C Harker, A Seaton, M Brooke, I Marr Carcinoid tumours of the thymus D-Y Wang, D-B Chang, S-H Kuo, P-C Yang, Y-C Lee, H-C Hsu, K-T Luh Efficacy of video assisted thoracoscopic lung biopsy: an historical comparison with open lung biopsy F M Carnochan, W S Walker, E W ¥ Cameron Arterialised earlobe blood gas analysis: an underused technique A D Pitkin, C M Roberts, } A Wedzicha Short paper Community acquired lobar pneumonia in patients with HIV infection and AIDS R F Miller, N M Foley, D Kessel, A A Feffrey Review series Tropical respiratory medicine: Introduction A Bryceson Tropical respiratory medicine: 1 —- Pulmonary infections in the tropics: impact of HIV infection C L Daley Case reports Intralobar bronchopulmonary sequestration: antenatal diagnosis K ¥ Ng, N Hasan, E S Gray, R R feffrey, G G Youngson Progressive tracheal and superior vena caval compression caused by benign neurofibromatosis R E/ Oakley, G F Grotte Asphyxia while swallowing solid food caused by bronchial compression: a variant of the pneumonectomy syndrome K M Fong, K D McNeil, K P Kennedy, K S Matar, P H Cole, ¥ B Partridge False aneurysm following modified Blalock-Taussig shunt 7 Valliattu, P Fairaj, T Delamie, R Subramanyam, S Menon, H Vyas Letters to the editor Endobronchial nocardial infection D I Fielding, W A Oliver - Fluticasone propionate v beclomethasone dipropionate (BDP) in moderate to severe asthma R O’Driscoll; L M Fabbri - Accuracy of CT appearances of fibrosing alveolitis D M Hansell, A U Wells, K T Tung Miscellaneous Book notices + IWotice + Correction Proceedings British Thoracic Society winter meeting 1993 No 5 MAY 1994 Editorials Infection with Mycobacterium kansasti P D O Davies Paediatric lung transplantation: the agony and the ecstasy B F Whitehead, M R De Leval Lung growth: implications for the development of disease P ¥ Helms Original articles Mycobacterium kansasii pulmonary infection: a prospective study of the results of nine months of treatment with rifampicin and ethambutol Research Committee, British Thoracic Society Effects of submental stimulation for several consecutive nights in patients with obstructive sleep apnoea W Hida, S Okabe, H Miki, Y Kikuchi, O Taguchi, T Takishima, K Shirato Effects of body position, hyperinflation, and blood gas tensions on maximal respiratory pressures in patients with chronic obstructive pulmonary disease Y F Heijdra, P N R Dekhuijzen, C L A van Her waarden, H T M Folgering Effect of lung transplantation on diaphragmatic function in patients with chronic obstructive pulmonary disease Th Wanke, M Merkle, D Formanek, U Zifko, G Wieselthaler, H Zwick, W Klepetko, O C Burghuber Reliability and validity of the chronic respiratory questionnaire (CRQ) P J Wijkstra, E M TenVergert, R Van Altena, V Otten, D S Postma, J Kraan, G H Koéter Relation of lung function, maximal inspiratory pressure, dyspnoea, and quality of life with exercise capacity in patients with chronic obstructive pulmonary disease P ¥ Wijkstra, E M TenVergert, Th W van der Mark, D S Postma, R Van Altena, } Kraan, G H Koéter Lung structure and function in cigarette smokers 7 C Hogg, J L Wright, B R Wiggs, H O Coxson, A O Saez P D Pare Effect of increasing doses of beta agonists on spirometric parameters, exercise capacity, and quality of life in patients with chronic airflow limitation R Jaeschke, G H Guyatt, A Willan, D Cook, S Harper, ¥ Morris, H Ramsdale, R Haddon, M Newhouse Effect of inhaled frusemide on responses of airways to bradykinin and adenosine 5’-monophosphate in asthma K Rajakulasingam, R Polosa, M K Church, P H Howarth, S T Holgate Activity of the renin-angiotensin system in acute severe asthma and the effect of angiotensin IT on lung function E A Millar, R M Angus, G Hulks, ¥ ¥ Morton, 7 M C Connell, N C Thomson Eosinophilic activation in cystic fibrosis D Y Koller, M Gotz, I Eichler, R Urbanek Ultrasound assessment of normal hemidiaphragmatic movement: relation to inspiratory volume 7 G Houston, R M Angus, M D Cowan, N C McMillan, N C Thomson Imaging of pulmonary disease in scleroderma with JOOIX scintigraphy P Diot, E Diot, E Lemarie, ¥ L Guilmot, J L Baulieu, E Asquier, C Valat, A Delarue, A Le Pape Short paper Localised pulmonary resection for bronchiectasis in hypogammaglobulinaemic patients A ¥ Cohen, C Roifman, 7 BM Mullen, B Reid, G Weisbrod, G P Downey Review series Tropical respiratory medicine: 2 — Impact of human immunodeficiency virus on tuberculosis in developing countries P P Nunn, A M Elliott, K P W ¥ McAdam Case reports Fluoroscopically guided percutaneous gastrostomy in patients with cystic fibrosis R F McLoughlin, G O’Connor, ¥ Dowsett, M X Fitzgerald, R G Gibney Pulmonary Mycobacterium malmoense and aspergillus infection: a fatal combination? F G E Boilert, P ¥ Sime, W MacNee, G K Crompton Contralateral haemorrhagic metastases (“‘choriocarcinoma syndrome’”’) after pneumonectomy for primary pulmonary choriocarcinoma J] Durieu, N Berger, R Loire, 7 P Gamondes, P H Guillaud, ¥ F Cordier Endobronchial HIV associated lymphoma T C Keys, M A Judson, C E Reed, S A Sahn Removal of a dental post from the bronchus by interventional cardiovascular techniques 7 S R Gibbs, L ¥ Murdoch, P Goldstraw, N P Buller Letters to the editor Guidelines for care during bronchoscopy ¥ Brimacombe, A Berry; ¥ Harvey - Computerised polysomnography S Andreas; N ¥ Douglas - Chronic obstructive airways disease: terminology C McGavin - Endobronchial valves A Barbato, A Novello, F Tormena - LTOT in COPD C R Swinburn; L F Restrick, 7 A Wedzicha Miscellaneous Book notices Notices No 6 JUNE 1994 Editorials Diffuse panbronchiolitis and cystic fibrosis: East meets West N Hoiby Early lung growth and chronic airflow obstruction S O Shaheen, D } P Barker Tuberculosis and HIV: light after darkness ¥ M Grange, ¥ L Stanford, G A W Rook, P Onyebujoh, P A Bretscher Original articles Bronchial responsiveness and acute bronchodilator response in chronic obstructive pulmonary disease and diffuse panbronchiolitis H Koyama, K Nishimura, T Mio, A Ikeda, N Sugiura, T Izumi Effect of long term treatment with oxitropium bromide on airway secretion in chronic bronchitis and diffuse panbronchiolitis ¥ Tamaoki, A Chiyotani, E Tagaya, N Sakai, K Konno Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices M Hindle, H Chrystyn Evaluation of asymptomatic subjects with low forced expiratory ratios (FEV,/VC) S Kivity, A Solomon, Y Schwarz, I Trajber, M Topilsky Regional lung clearance during cough and forced expiration technique (FET): effects of flow and viscoelasticity A Hasani, D Pavia, J E Agnew, S W Clarke Changes in snoring characteristics after 30 days of nasal continuous positive airway pressure in patients with non-apnoeic snoring: a controlled trial F Sériés, 1 Marc Potential role of recombinant secretory leucoprotease inhibitor in the prevention of neutrophil mediated matrix degradation C G Llewellyn-Fones, D A Lomas, R A Stockley Analysis of restriction fragment length polymorphism for the HLA-DR gene in Japanese patients with sarcoidosis H Kunikane, S Abe, E Yamaguchi, 7 M R Aparicio, A Wakisaka, T Yoshiki, Y Kawakami Clonal analysis of lung and blood T cells in patients with sarcoidosis M ¥ Garlepp, A H Rose, ¥ E Dench, B W S Robinson Computed tomographic scanning of the lung in patients with allergic bronchopulmonary aspergillosis and in asthmatic patients with a positive skin test to Aspergillus fumigatus R M Angus, M-L Davies, M D Cowan, C McSharry, N C Thomson Non-specific fluorescent whitener stains in the rapid recognition of pulmonary dirofilariasis: a report of 20 cases L K Green, M Q Ansari, M R Schwartz, J Y Ro, L C Alpert Short papers Ultrasound guided pericardial drainage and intrapericardial instillation of mitomycin C for malignant pericardial effusion L-N Lee, P-C Yang, D-B Chang, C-} Yu, ¥#-C Ko, Y-S Liaw, R-G Wu, K-T Luh Adult respiratory distress syndrome: has there been a change in outcome predictive measures? 7 Lee, FJ S Turner, C ¥ Morgan, B F Keogh, T W Evans Review series Tropical respiratory medicine: 3 —- Histoplasmosis and pulmonary involvement in the tropics S Houston Occasional review Matrix metalloproteases and lung disease C M O’Connor, M X FitzGerald Technical note Effects of sample storage time, temperature and syringe type on blood gas tensions in samples with high oxygen partial pressures ¥ ¥ Pretto, P D Rochford Case reports Continuous non-invasive monitoring of evolving acute severe asthma during sleep P C Deegan, W T McNicholas Intralobar pulmonary sequestration and mediastinal bronchogenic cyst R G Grewal, C K Yip Diffuse pulmonary fibrosis and the Hermansky—Pudlak syndrome: clinical course and postmortem findings S P Reynolds, B H Davies, A R Gibbs Osteochondroma of the rib: an unusual cause of haemothorax N K Harrison, } Wilkinson, ¥ O’ Donohue, D Hansell, M N Sheppard, P G Goldstraw, A G Davison, A ¥ Newman Taylor Intravenous azithromycin as salvage therapy in a patient with Legionnaire’s disease L Dorrell, B Fulton, E L C Ong Sauna builder’s asthma caused by obeche (Triplochiton scleroxylon) dust K Reijula, V Kujala, ¥ Latvala Letters to the editor Pulmonary infiltrates following bone marrow transplantation M Polkey, ¥ Patel, P # Rees - Surgical resection for small cell lung cancer D ¥ Girling, D Machin, R ¥ Stephens; P E Postmus, E F Smit - Measurement of distal airspace size W M Thurbeck - Mediastinal paraganglioma presenting as an intracardiac mass with SVC obstruction M N Sheppard - Emotional aspects of asthma N More, N Singh, A Athawale, A C Shah Miscellaneous Book notices Notices No 7 JULY 1994 Editorials Management of the patient with occupational lung disease A Seaton Pseudomonas cepacia in cystic fibrosis D E Stableforth, D L Smith The heart and lungs at extreme altitude 7 T Reeves, CH Welsh, P D Wagner Original articles Dynamic changes in the zone of apposition and diaphragm length during maximal respiratory efforts D K McKenzie, S C Gandevia, R B Gorman, F C G Southon Histamine induced changes in breathing pattern may precede bronchoconstriction in selected patients with bronchial asthma A Fanelli, R Duranti, M Gorini, A Spinelli, F Gigliotti, G Scano Potentiating effect of inhaled acetaldehyde on bronchial responsiveness to methacholine in asthmatic subjects S Myou, M Fujimura, K Nishi, M Matsuda, T Ohka, T Matsuda Effect of an oral gold compound, auranofin, on non-specific bronchial hyperresponsiveness in mild asthma M Honma, G Tamura, K Shirato, T Takishima Effects of short term and long term treatment with inhaled corticosteroids on bone metabolism in patients with airways obstruction H A M Kerstjens, D S Postma,J J van Doormaal, A K van Zanten, P L P Brand, P N R Dekhuijzen, G H Koéter on behalf of the Dutch CNSLD Study Group Effect of loop diuretics on cholinergic neurotransmission in human airways in vitro G M Verleden, 7 L Pype, G Deneffe, M G Demedts Characterisation of the B adrenergic response cascade in fetal guinea pig lung M E Lyon, C A Lefebvre, D F Davis Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue M M E Bridgeman, M Marsden, C Selby, D Morrison, W MacNee Characterisation of an oxidative response inhibitor produced by Streptococcus pneumoniae F E Perry, C F Elson, T ¥ Mitchell, P W Andrew, ¥ R Catterall Fertility in men with primary ciliary dyskinesia presenting with respiratory infection N C Munro, D C Currie, K S Lindsay, T A Ryder, A Rutman, A Dewar, M A Greenstone, W F Hendry, P # Cole Specification and quantitation of circulating immune complexes in the serum of patients with active pulmonary sarcoidosis N Schoenfeld, B Schmolke, M Schmitt, N Remy, P Ellensohn, U Wahn, R Loddenkemper Value of DNA analysis in addition to cytological testing in the diagnosis of malignant pleural effusions F R de Castro, T Molero, O Acosta, G Fulia-Serda, } Caminero, P Cabrera, T Carrillo Survival of patients with severe «,-antitrypsin deficiency with special reference to non-index cases N Seersholm, A Kok-fFensen, A Dirksen Effect of short term hormone replacement in the treatment of obstructive sleep apnoea in postmenopausal women P A Cistulli, D ¥ Barnes, R R Grunstein, C E Sullivan Breathing pattern and central ventilatory drive in mild and moderate generalised myasthenia gravis F Garcia Rio, C Prados, E Diez Tejedor, S Diaz Lobato, R Alvarez-Sala, ¥ Villamor, } M Pino Transient iron overload with bleomycin detectable iron in the plasma of patients with adult respiratory distress syndrome ¥ M C Gutteridge, G ¥ Quinlan, T W Evans Short paper Modification of concentration-response curves to inhaled methacholine after the pollen season in subjects with pollen induced rhinitis L Prieto, M Lopez, ¥ M Berto, A Peris Review series Tropical respiratory medicine: 4 — Acute tropical infections and the lung S Johnson, R Wilkinson, R N Davidson Case reports Bordetella bronchiseptica pneumonia in a patient with AIDS 7 de la Fuente, C Albo, A Rodriguez, B Sopena, C Martinez Colonisation of lung allografts with Pseudomonas aeruginosa in heart-lung transplant recipients with cystic fibrosis V Tsang, T L Pitt, M E Kaufmann, H Gaya, M E Hodson, M Yacoub Improved gas exchange after pneumonectomy in an adult with incomplete pulmonary vein atresia T S van der Werf, G P M Mannes, ¥ M Hew, R G Grevink, Th W van der Mark, T Ebels, G H Koéter Spontaneous improvement in a patient with the hepatopulmonary syndrome assessed by serial exercise tests K B Saunders, S S D Fernando, H R Dalton, A fFoseph Late asthmatic response to inhaled glacial acetic acid S Kivity, E Fireman, Y Lerman Letters to the editor Diagnosis of PCP in HIV seropositive patients C ¥ Skinner, R ¥ Coker, D M Mitchell; ¥ Gea, ¥ Sauleda, JF M Broquetas - Setting up a pulmonary rehabilitation programme R Garnham Miscellaneous Book notices Notices No 8 AUGUST 1994 Editorials Passive smoking and the health of children ¥% M Couriel Tracheal gas insufflation: a useful adjunct to ventilation? ¥ 4%M arini Role of free radicals in the pathogenesis of cystic fibrosis R K Brown, F # Kelly Original articles Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses SM S Nasser, G S Bell, R ¥ Hawksworth, K E Spruce, R MacMillan, A } Williams, T H Lee, 7 P Arm Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma SM S Nasser, G § Bell, S Foster, K E Spruce, R MacMillan, A ¥ Williams, T H Lee, ¥ P Arm Asymptomatic bronchial hyperreactivity and the develoment of asthma and other respiratory tract illnesses in children A Fones Nebuliser performance, pharmacokinetics, airways and systemic effects of salbutamol given via a novel nebuliser delivery system (““Ventstream”) D M Newnham, B 7 Lipworth Systemic effects of salbutamol and salmeterol in patients with asthma ¥ A Bennett, E T Smyth, I D Pavord, P F Wilding, A E Tattersfield Comparison of circadian variations using FEV, and peak expiratory flow rates among normal and asthmatic subjects S Troyanov, H Ghezzo, A Cartier¥,7- L Malo Resting energy expenditure and nutritional state of patients with increased oxygen cost of breathing due to emphysema, scoliosis and thoracoplasty M K Sridhar, R Carter, M E F Lean, S W Banham Relation of smoking to immunoreactive endothelin in the bronchiolar epithelial cells M O Shokeir, P Paré, F L Wright Transforming growth factor B in normal human lung: preferential location in bronchial epithelial cells A Magnan, I Frachon, B Rain, M Peuchmaur, G Monti, B Lenot, M Fattal, G Simonneau, P Galanaud, D Emilie Pulmonary sarcoidosis with a diffuse ground glass pattern on the chest radiograph A Tazi, T Desfemmes-Baleyte, P Soler, D Valeyre, A ¥ Hance, #-P Battesti Psychosocial functioning of young adults with cystic fibrosis and their families C Blair, A Cull, C P Freeman Effect of antibiotic treatment on inflammatory markers and lung functien in cystic fibrosis patients with Pseudomonas cepacia D Peckham, S Crouch, H Humphreys, B Lobo, A Tse, A ¥ Knox Characteristics of patients with drug resistant and drug sensitive tuberculosis in East London between 1984 and 1992 N Al Jarad, S Parastatides, E A Paul, C D Sheldon, H Gaya, R M Rudd, D W Empey Short paper Nasal masks for domiciliary positive pressure ventilation: patient usage and complications D ¥ Meecham Fones, G M Braid, 7 A Wedzicha Review series Contribution of multiple inert gas elimination technique to pulmonary medicine: Introduction R Rodriguez-Roisin Contribution of multiple inert gas elimination technique to pulmonary medicine: 1 — Principles and information content of the multiple inert gas elimination technique ~ Roca, P D Wagner Occasional review Effects of cigarette smoke on epithelial cells of the respiratory tract ¥%A Dye, K B Adler Case reports Congenital oesophagobronchial fistula in an adult involving left main bronchus M Moreno Azcoita, ¥ C Ruiz de Adana, L Sanchez Urdazpal, C Carcamo, 7 M Fover Navalon, 7 L Ramos Rodriguez Congenital cutis laxa with a dominant inheritance and early onset emphysema _ E Corbett, H Glaisyer, C Chan, B Madden, A Khaghani, M Yacoub Pulmonary blastoma in an adult presenting as a chronic loculated effusion: a diagnostic problem N-K Chin, C-N Lee, Y-S Lee, W-C Tan Tracheobronchomegaly: an unusual presentation of a rare condition DL Smith, N Withers, B Holloway, FV Collins Occupational asthma due to indirect exposure to lauryl dimethyl benzyl ammonium chloride used in a floor cleaner P Sherwood Burge, M N Richardson Letter to the editor Mycobacterium malmoense and carcinoma of lung R E Meigh, A G Arnold Miscellaneous Book notices No 9 SEPTEMBER 1994 Editorials 845 Treatment of empyema thoracis D K Kaplan 847 Chest radiology in cystic fibrosis: is scoring useful? D ¥ Shale 848 Does analysis of bronchoalveolar lavage fluid provide a tool to monitor disease progression or to predict survival in patients with HIV-1 infection? G Agostini, G Semenzato Original articles Role of streptokinase in the treatment of acute loculated parapneumonic pleural effusions and empyema D Bouros, S Schiza, P Panagou, F Drositis, N Siafakas Intrapleural streptokinase in the management of empyema R F H Taylor, M B Rubens, M C Pearson, N C Barnes The chest radiograph in cystic fibrosis: a new scoring system compared with the Chrispin-Norman and Brasfield scores S P Conway, M N Pond, I Bowler, D L Smith, E ¥ Simmonds, D N Foanes, G Hambleton, E # Hiller, D E Stableforth, P Weller, #M Littlewood Critical evaluation of three chest radiograph scores in cystic fibrosis S M Sawyer, ¥ B Carlin, M DeCampo, G Bowes Desensitisation of neutrophil responses by systemic interleukin 8 in cystic fibrosis Y Dai, T P Dean, M K Church, # O Warner, F K Shute Pneumococcal antigen detection in bronchoalveolar lavage fluid from patients with pneumonia P Fiménez, M Meneses, F Saldias, M Velasquez Dietary sodium intake and the risk of airway hyperreactivity in a random adult population 7 Britton, I Pavord, K Richards, A Knox, A Wisniewski, S Weiss, A Tattersfield Impaired voluntary drive to breathe: a possible link between depression and unexplained ventilatory failure in asthmatic patients G M Alien, I Hickie, S C Gandevia, D K McKenzie Excursion-volume relation of the right hemidiaphragm measured by ultrasonography and respiratory airflow measurements E Cohen, A Mier, P Heywood, K Murphy, ¥ Boultbee, A Guz Diaphragmatic movement in hemiplegic patients measured by ultrasonography E Cohen, A Mier, P Heywood, K Murphy, ¥ Boultbee, A Guz Clinical significance of upper airway dysfunction in motor neurone disease E Garcia-Pachon, ¥ Marti, M Mayos, P Casan, F Sanchis Lung function reference values in Singaporean children aged 6-18 years G F Connett, S H Quak, M L Wong, F Teo, B W Lee Clinical and functional characteristics of patients two years after being affected by the soybean asthma epidemic in Barcelona 7 Sabria, 7 M Anto, ¥ Sunyer, ¥ Roca, F Morell, R Rodriguez-Roisin, M F Rodrigo, R Codina Relation of pulmonary lymphangioleiomyomatosis to use of the oral contraceptive pill and fertility in the UK: a national case control study J Wahedna, S Cooper, ¥ Williams, I C Paterson, ¥ R Britton, A E Tattersfield Long term non-invasive domiciliary assisted ventilation for respiratory failure following thoracoplasty M Fackson, I Smith, M King, F Shneerson Short papers Atrial natriuretic peptide levels in the sleep apnoea/hypopnoea syndrome T W Mackay, M F Fitzpatrick, S Freestone, M R Lee, N ¥ Douglas Pleural abrasion via axillary thoracotomy in the era of video assisted thoracic surgery D A Simansky, A Yellin Review series Contribution of multiple inert gas elimination technique to pulmonary medicine — 2: Chronic pulmonary diseases: chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis A G N Agusti, J A Barbera Case reports Transient right-to-left shunting through a patent foramen ovale secondary to unilateral diaphragmatic paralysis P ¥ Cordero, P Morales, V Mora, ¥ Cebrian, F Vallterra, ¥ Gudin, E Benlloch, V Marco Bronchial obstruction due to respiratory mucosal sloughing in toxic epidermal necrolysis A Dasgupta, F O'Malley, R Mallya, ¥ G Williams Pneumothorax following thoracic radiation therapy for Hodgkin’s disease M G Penniment, P C O’Brien Total lung collapse after pulmonary infarction S Aithan, ¥ Khan, M Bazarbashi Letter to the editor Pneumocystis pneumonia in HIV antibody positive patients R Rodriguez-Roisin, ¥ A Barbera, F Roca; F Gea, F Sauleda, ¥ M Broquetas Miscellaneous Notice No 10 OCTOBER 1994 Editorials Preoperative computed tomographic scanning for staging lung cancer P Armstrong Why use erythromycin? R ¥ White The pneumococcus: host-organism interactions and their implications for immunotherapy and immunoprophylaxis F E Perry, ¥ R Catterall Original articles Preoperative staging of carcinoma of the bronchus: can computed tomographic scanning reliably identify stage III tumours? P G White, H Adams, M D Crane, E G Butchart Results of chemotherapy in 30 AIDS patients with symptomatic pulmonary Kaposi’s sarcoma J L Cadranel, S Kammoun, S Chevret, A Parrot, M Denis, C Winter, M-F Carette, W Rozenbaum, G M Akoun, C M Mayaud Delivery of beclomethasone dipropionate from a spacer device: what dose is available for inhalation? C O’Callaghan, M Cant, C Robertson Perception of airflow obstruction and associated breathlessness in normal and asthmatic subjects: correlation with anxiety and bronchodilator needs L-P Boulet, I Cournoyer, F Deschesnes, P Leblanc, A Nouwen Salmeterol xinafoate in the treatment of mild to moderate asthma in primary care K P Jones, on behalfo f a UK study group Prospective controlled evaluation of the effect of a community based asthma education centre in a multiracial working class neighbourhood 7 Garrett, 7M Fenwick, G Taylor, E Mitchell, $ Stewart, H Rea Relation between exposure to fluoride and bronchial responsiveness in aluminium potroom workers with work-related asthma-like symptoms V Seyseth, } Kongerud, ¥ Ekstrand, ¥ Boe Effect of inspiratory pressure support on exercise tolerance and breathlessness in patients with severe stable chronic obstructive pulmonary disease S E # Keilty, 7 Ponte, TA Fleming, ¥ Moxham Effects of angiotensin converting enzyme inhibition on sodium excretion in patients with hypoxaemic chronic obstructive pulmonary disease A G Stewart, 7 C Waterhouse, C G Billings, P Baylis, P Howard Penetration of amoxycillin/clavulanic acid into bronchial mucosa with different dosing regimens I M Gould, G Harvey, D Golder, T M S Reid, S ¥ Watt, ¥ A R Friend, 7 S Legge, ¥ G Douglas 1002 Rise in total IgE as an indicator of allergic bronchopulmonary aspergillosis in cystic fibrosis F L Marchant, ¥ O Warner, A Bush 1006 Use of the 1 tuberculin unit (TU) Mantoux test in the assessment of tuberculous infection in children following neonatal BCG vaccination E W Hoskyns, H Simpson, P Monk 1010 Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung A M Cantlay, C A D Smith, W A Wallace, P-L Yap, D Lamb, D $ Harrison 1015 Fetal lung compliance in premature and term lambs after two methods of in utero repair of diaphragmatic hernia D W Parsons, W D A Ford, 7 C Cool, A ¥ Martin, R E M Staugas, ¥ D Kennedy Short papers 1020 Thoracic splenosis S Madjar, D Weissberg 1022 Effects of nedocromil sodium in the treatment of non-allergic subjects with chronic obstructive pulmonary disease 7 W de Fong, D S Postma, T W van der Mark, G H Koéter 1024 Effect of inhaled menthol on citric acid induced cough in normal subjects A H Morice, A E Marshall, K S Higgins, T ¥ Grattan Review series Contributions of multiple inert gas elimination technique to pulmonary medicine: 3 — Bronchial asthma R Rodriguez-Roisin, ¥ Roca Case reports Upper airway obstruction due to inoperable intrathoracic goitre treated by tracheal endoprosthesis M Noppen, M Meysman, E Dhondt, L Gepts, B Velkeniers, L Vanhaelst, W Vincken Massive haemothorax secondary to angiosarcoma A ¥ McCleary Delayed resolution of pulmonary oedema after cocaine/heroin abuse P G H M Raijmakers, A B F Groeneveld, M C M de Groot, G F F Teule, L G Thijs