Thermal sensors

408 Pages·2014·24.386 MB·English

by  Islas, León, Qin, Feng

CURRENT TOPICS IN MEMBRANES, VOLUME 74
Series Editors
ROBERT BALABAN
National Heart, Lung and Blood Institute
National Institutes of Health
Bethesda, Maryland, USA
SIDNEY A. SIMON
Department of Neurobiology
Duke University Medical Centre
Durham, North Carolina, USA
VOLUME SEVENTY FOUR
C T
URRENT OPICS IN
MEMBRANES
Thermal Sensors
Edited by
(cid:1)
LEON D. ISLAS
Department of Physiology, School of Medicine,
National Autonomous University of Mexico (UNAM),
Mexico City, Mexico
FENG QIN
Department of Physiology & Biophysics,
State University of New York Buffalo,
New York, USA
Amsterdam(cid:129)Boston(cid:129)Heidelberg(cid:129)London
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CONTRIBUTORS
EvanO.Anderson
DepartmentofCellular&MolecularPhysiology,YaleSchoolofMedicine,NewHaven,
CT,USA
DavidBaez
CentroInterdisciplinariodeNeurocienciadeValparaíso,FacultaddeCiencias,Universidad
deValparaíso,Valparaíso,Chile
SviatoslavN.Bagriantsev
DepartmentofCellular&MolecularPhysiology,YaleUniversitySchoolofMedicine,
NewHaven,CT,USA
MatthewR.Cohen
DepartmentofPharmacology,CaseWesternReserveUniversitySchoolofMedicine,
Cleveland,OH,USA;DepartmentofPhysiology&Biophysics,CaseWesternReserve
UniversitySchoolofMedicine,Cleveland,OH,USA
QinFeng
DepartmentofPhysiology&Biophysics,StateUniversityofNewYork,Buffalo,New
York,USA
GonzaloFerreira
LaboratoriodeCanalesIo(cid:1)nicos,DepartamentodeBiofísica,FacultaddeMedicina,
UniversidaddelaRepu(cid:1)blica,Montevideo,Uruguay
YuichiroFujiwara
LaboratoryofIntegrativePhysiology,GraduateSchoolofMedicine,OsakaUniversity,
Suita,Japan
CarlosGonzalez
CentroInterdisciplinariodeNeurocienciadeValparaíso,FacultaddeCiencias,Universidad
deValparaíso,Valparaíso,Chile
ElenaO.Gracheva
DepartmentofCellularandMolecularPhysiology,YaleUniversitySchoolofMedicine,
NewHaven,CT,USA;PrograminCellularNeuroscience,Neurodegenerationand
Repair,YaleUniversitySchoolofMedicine,NewHaven,CT,USA
EnriqueHern(cid:1)andez-García
DepartamentodeNeurodesarrolloyFisiología,Divisio(cid:1)ndeNeurociencias,Institutode
FisiologíaCelular,UniversidadNacionalAuto(cid:1)nomadeMéxico,DistritoFederal,México
HongzhenHu
TheCenterfortheStudyofItch,WashingtonUniversityPainCenter,TheDepartmentof
Anesthesiology,WashingtonUniversitySchoolofMedicineinSt.Louis,St.Louis,MO,
USA
j
ix
x Contributors
Leo(cid:1)nD.Islas
DepartmentofPhysiology,SchoolofMedicine,NationalAutonomousUniversityof
Mexico(UNAM),MexicoCity,Mexico
RamonLatorre
CentroInterdisciplinariodeNeurocienciadeValparaíso,FacultaddeCiencias,Universidad
deValparaíso,Valparaíso,Chile
WillemJ.Laursen
DepartmentofCellularandMolecularPhysiology,YaleUniversitySchoolofMedicine,
NewHaven,CT,USA;PrograminCellularNeuroscience,Neurodegenerationand
Repair,YaleUniversitySchoolofMedicine,NewHaven,CT,USA
JialieLuo
TheCenterfortheStudyofItch,WashingtonUniversityPainCenter,TheDepartmentof
Anesthesiology,WashingtonUniversitySchoolofMedicineinSt.Louis,St.Louis,MO,
USA
LinlinMa
DepartmentofPhysiologyandMembraneBiology,UniversityofCaliforniaSchoolof
Medicine,Davis,CA,USA
RodolfoMadrid
DepartamentodeBiología,FacultaddeQuímicayBiología,UniversidaddeSantiagode
Chile,Santiago,Chile
VeraY.Moiseenkova-Bell
DepartmentofPharmacology,CaseWesternReserveUniversitySchoolofMedicine,
Cleveland,OH,USA;DepartmentofPhysiology&Biophysics,CaseWesternReserve
UniversitySchoolofMedicine,Cleveland,OH,USA
YasushiOkamura
LaboratoryofIntegrativePhysiology,GraduateSchoolofMedicine,OsakaUniversity,
Suita,Japan
MaríaPertusa
DepartamentodeBiología,FacultaddeQuímicayBiología,UniversidaddeSantiagode
Chile,Santiago,Chile
MichaelPusch
IstitutodiBiofisica,CNR,Genova,Italy
NataliaRaddatz
CentroInterdisciplinariodeNeurocienciadeValparaíso,FacultaddeCiencias,Universidad
deValparaíso,Valparaíso,Chile;CentreforPlantBiotechnologyandGenomics,
UniversidadPolitécnicadeMadrid,PozuelodeAlarco(cid:1)n(Madrid),Spain
TamaraRosenbaum
DepartamentodeNeurodesarrolloyFisiología,Divisio(cid:1)ndeNeurociencias,Instituto
deFisiologíaCelular,UniversidadNacionalAuto(cid:1)nomadeMéxico,DistritoFederal,
México
Contributors xi
EveR.Schneider
DepartmentofCellular&MolecularPhysiology,YaleSchoolofMedicine,NewHaven,
CT,USA
JieZheng
DepartmentofPhysiologyandMembraneBiology,UniversityofCaliforniaSchoolof
Medicine,Davis,CA,USA
GiovanniZifarelli
IstitutodiBiofisica,CNR,Genova,Italy
PREFACE
Thermal biology of organisms is fundamentally determined by the activity
of specialized receptors. Generally known as thermal receptors, these mol-
ecules are principally membrane-associated or integral membrane proteins.
Among them, and as is found in many sensory systems, the main players
are ion channels. Although the existence of thermally activated currents
in sensory neurons was proposed in the decade of the 1980s, it was not
until 1996 that it was demonstrated that sensory neurons poses heat
activated currents, followed by the landmark discovery and cloning of
the heat activated TRPV1 ion channel in 1997, which the field really
took off.
Sincethen,researchersinthefieldhaveidentifiedalargenumberofpro-
teins that have the exotic property of being activated by temperature
changes. These mainly belong to the relatively new family of polymodal
TRPionchannels,andcanbefoundindifferentflavors.Someareactivated
by cold, some by heat and there are variations in the ranges of temperature
that they are responsive to. Some other ion channels, distinct from TRP
channels, including proton channels, nonvoltage-dependent potassium
channelsandchloridechannelshavealsobeenfoundtorespondwithexcep-
tional sensitivity to changes in temperature and to contribute to thermal
physiology.
Although very young, the field of thermal receptor biology and
biophysics has attracted many talented investigators; thus, the number of
insights into these proteins keeps increasing and the findings are ever more
surprising.
Thisvolumeinthelong-runningseriesCurrentTopicsinMembranesseeks
toprovideanuptodateviewofthebasicconceptsandmainrecentfindings,
from the pens of some of the leading workers in the field of thermal
receptors.
The book is organized in such a way that it first presents the current
knowledge and leading theories put forward to explain the mechanisms of
thermal sensitivity at the molecular level. Later chapters explore insights
obtainedbymodernstructuralexperimentsandexploretheamazingdiver-
sity of functions and mechanisms displayed by these fascinating membrane
proteins.
j
xiii
xiv PREFACE
We wouldliketo thankSidneyA. Simonfor his generousinvitation to
participate in editing this volume and to all the authors of the chapters for
their invaluable contributions and patience during this project.
Finally, our special recognition to Helene Kabes for her tolerance and
constant support in compiling and editing the chapters.
Leo(cid:1)n D. Islas
Mexico City
Feng Qin
Buffalo, NY
PREVIOUS VOLUMES IN SERIES
Current Topics in Membranes and Transport
Volume23GenesandMembranes:TransportProteinsandReceptors*(1985)
EditedbyEdwardA.AdelbergandCarolynW.Slayman
Volume24MembraneProteinBiosynthesisandTurnover(1985)
EditedbyPhilipA.KnaufandJohnS.Cook
Volume25RegulationofCalciumTransportacrossMuscleMembranes(1985)
EditedbyAdilE.Shamoo
Volume26Na+–H+Exchange,IntracellularpH,andCellFunction*(1986)
EditedbyPeterS.AronsonandWalterF.Boron
Volume27TheRoleofMembranesinCellGrowthandDifferentiation(1986)
EditedbyLazaroJ.MandelandDaleJ.Benos
Volume28PotassiumTransport:PhysiologyandPathophysiology*(1987)
EditedbyGerhardGiebisch
Volume29MembraneStructureandFunction(1987)
EditedbyRichardD.Klausner,ChristophKempf,andJosvanRenswoude
Volume30CellVolumeControl:FundamentalandComparativeAspectsinAnimal
Cells(1987)
EditedbyR.Gilles,ArnostKleinzeller,andL.Bolis
Volume31MolecularNeurobiology:EndocrineApproaches(1987)
EditedbyJeromeF.Strauss,III,andDonaldW.Pfaff
Volume32MembraneFusioninFertilization,CellularTransport,andViralInfection
(1988)
EditedbyNejatDu€zgu€nesandFelixBronner
Volume33MolecularBiologyofIonicChannels*(1988)
EditedbyWilliamS.Agnew,ToniClaudio,andFrederickJ.Sigworth
Volume34CellularandMolecularBiologyofSodiumTransport*(1989)
EditedbyStanleyG.Schultz
Volume35MechanismsofLeukocyteActivation(1990)
EditedbySergioGrinsteinandOriD.Rotstein
*PartoftheseriesfromtheYaleDepartmentofCellularandMolecularPhysiology
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Volume36Protein–MembraneInteractions*(1990)
EditedbyToniClaudio
Volume37ChannelsandNoiseinEpithelialTissues(1990)
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Volume38OrderingtheMembraneCytoskeletonTrilayer*(1991)
EditedbyMarkS.MoosekerandJonS.Morrow
Volume39DevelopmentalBiologyofMembraneTransportSystems(1991)
EditedbyDaleJ.Benos
Volume40CellLipids(1994)
EditedbyDickHoekstra
Volume41CellBiologyandMembraneTransportProcesses*(1994)
EditedbyMichaelCaplan
Volume42ChlorideChannels(1994)
EditedbyWilliamB.Guggino
Volume43MembraneProtein–CytoskeletonInteractions(1996)
EditedbyW.JamesNelson
Volume44LipidPolymorphismandMembraneProperties(1997)
EditedbyRichardEpand
Volume45TheEye’sAqueousHumor:FromSecretiontoGlaucoma(1998)
EditedbyMortimerM.Civan
Volume46PotassiumIonChannels:MolecularStructure,Function,andDiseases(1999)
EditedbyYoshihisaKurachi,LilyYehJan,andMichelLazdunski
Volume47Amiloride-SensitiveSodiumChannels:PhysiologyandFunctionalDiversity
(1999)
EditedbyDaleJ.Benos
Volume48MembranePermeability:100YearssinceErnestOverton(1999)
EditedbyDavidW.Deamer,ArnostKleinzeller,andDouglasM.Fambrough
Volume49GapJunctions:MolecularBasisofCellCommunicationinHealthandDisease
EditedbyCamilloPeracchia
Volume50GastrointestinalTransport:MolecularPhysiology
EditedbyKimE.BarrettandMarkDonowitz