Therapeutic Platform of Bioactive Lipids: Focus on Cancer PDF
Preview Therapeutic Platform of Bioactive Lipids: Focus on Cancer
THERAPEUTIC PLATFORM OF BIOACTIVE LIPIDS Focus on Cancer THERAPEUTIC PLATFORM OF BIOACTIVE LIPIDS Focus on Cancer Edited by Manjari Singh, PhD First edition published 2023 Apple Academic Press Inc. CRC Press 1265 Goldenrod Circle, NE, 6000 Broken Sound Parkway NW, Palm Bay, FL 32905 USA Suite 300, Boca Raton, FL 33487-2742 USA 760 Laurentian Drive, Unit 19, 4 Park Square, Milton Park, Burlington, ON L7N 0A4, CANADA Abingdon, Oxon, OX14 4RN UK © 2023 by Apple Academic Press, Inc. Apple Academic Press exclusively co-publishes with CRC Press, an imprint of Taylor & Francis Group, LLC Reasonable efforts have been made to publish reliable data and information, but the authors, editors, and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library and Archives Canada Cataloguing in Publication Title: Therapeutic platform of bioactive lipids : focus on cancer / edited by Manjari Singh, PhD. Names: Singh, Manjari, 1991- editor. Description: First edition. | Includes bibliographical references and index. Identifiers: Canadiana (print) 20220449104 | Canadiana (ebook) 20220449198 | ISBN 9781774910849 (hardcover) | ISBN 9781774910856 (softcover) | ISBN 9781003301608 (ebook) Subjects: LCSH: Lipids—Metabolism. | LCSH: Lipids—Therapeutic use. | LCSH: Cancer—Treatment. Classification: LCC QP751 .T44 2023 | DDC 612.3/97—dc23 Library of Congress Cataloging-in-Publication Data CIP data on file with US Library of C o ngress ISBN: 978-1-77491-084-9 (hbk) ISBN: 978-1-77491-085-6 (pbk) ISBN: 978-1-00330-160-8 (ebk) About the Editor Manjari Singh, PhD Assistant Professor, Department of Pharmaceutical Sciences, Assam University (A Central University), Silchar, Assam–788011, India Manjari Singh, PhD, is working as an Assistant Professor in the Department of Pharmaceutical Sciences, Assam Central University, Silchar, India. Her current research focuses on estrogen-positive mammary gland cancer, poly- unsaturated fatty acids (FAs), tumor hypoxia, tumor microenvironment, and molecular biology. She received her PhD degree from Babasaheb Bhimrao Ambedkar University, Lucknow, where she investigated targeting estrogen- dependent breast cancer metastasis using in vitro and in vivo rodent models. She received UGC-RGNF during her PhD. She also worked as an Assistant Professor in the KIET Group of Institutions, Ghaziabad. She taught subjects like pharmacology, pathophysiology, clinical pharmacy, and drug interaction to BPharm students. Dr. Singh is a member of multiple editor/reviewer boards of different reputed journals and is a recipient of several research grants. She has published 37 journal papers (authored/co-authored) and several book chapters to date. Contents Contributors .............................................................................................................ix Abbreviations .........................................................................................................xiii Preface ................................................................................................................... xxi Introduction ..........................................................................................................xxiii PART I: Chemistry of Bioactive Lipids ................................................................1 1. Ceramide: A Sphingolipidic Weapon Against Cancer .................................3 Suvadeep Mal, Udita Malik, Suman Das, and Sudhir Kumar Paidesetty 2. Lipoxins: Emerging Players in the Resolution of Cancer .........................33 Rati Kailash Prasad Tripathi 3. Role of Resolvins as a Bioactive Lipid in the Treatment of Cancer .........59 Suman Das, Suvadeep Mal, and Udita Malik 4. Sphingosine-1-Phosphate: An Important Target to Fight Against Cancer ....................................................................................73 Udita Malik, Suvadeep Mal, Suman Das, and Dilipkumar Pal PART II: Formulations Based on Bioactive Lipids ...........................................87 5. Bioactive Lipids for the Treatment of Cancer ............................................89 Biswajit Basu, Tiyas Pal, Swarupananda Mukherjee, and Bhupendra G. Prajapati 6. Role of Exosomes as Natural Conveyors of Bioactive Lipids in Cancer .........................................................................123 Sapna Jain and Jonathan Pillai PART III: Mechanisms of Bioactive Lipids ......................................................141 7. Identification of Bioactive Lipid Drug Targets by Computational Techniques .........................................................................143 Aakriti Garg, Ruchika Sharma, Santanu Kaity, and Anoop Kumar viii Contents 8. Metabolism of Lipids in Malignant Solid Tumors Hypoxia and Drug Targets .........................................................................163 Lakhveer Singh, Sakshi Bajaj, Manjari Singh, Gaurav Kaithwas, and Manjusha Choudhary 9. Novel Targeting Therapy for Colorectal Cancer with Special Emphasis on KRAS and PI3K Pathway ......................................193 Ram Kumar Sahu, Aseem Setia, and Jiyauddin Khan 10. Role of Lipid-Soluble Bioactive Substance from Avocado for Inhibition of Prostate and Other Cancers ................................................215 Dilipkumar Pal and Khushboo Raj 11. Role of Lipopolysaccharides in the Pathogenesis of Cancer ...................231 Siddhant Mitra and Sugato Banerjee 12. Role of Lysophosphatidic Acid on Cancer ................................................249 Dilipkumar Pal and Supriyo Saha 13. Role of Omega-3 Polyunsaturated Fatty Acids-Derived Lipid Metabolites on Cancer Hacks ..........................................................265 Souvik Mukherjee, Gaurav Kaithwas, Manjari Singh, and Subhasis Banerjee Index .....................................................................................................................283 Contributors Sakshi Bajaj Ch. Devi Lal College of Pharmacy, Yamuna Nagar, Haryana, India Subhasis Banerjee Department of Pharmaceutical Sciences, Gupta College of Technological Sciences, Asansol, West Bengal, India, E-mail: [email protected] Sugato Banerjee Department of Pharmacology and Toxicology and Dean I/C National Institute of Pharmaceutical Education and Research (NIPER) Kolkata Biswajit Basu Associate Professor, Bengal School of Technology, Sugandha, Delhi Road, Hooghly, West Bengal–712102, India, E-mail: [email protected] Manjusha Choudhary University Institute of Pharmaceutical Sciences, Kurukshetra University Kurukshetra, Haryana, India Suman Das Department of Biotechnology, Goa University, Taleigao, Goa–403206, India, E-mail: [email protected] Aakriti Garg School of Pharmaceutical Sciences, Apeejay Stya University, Gurgaon, Haryana, India Sapna Jain Implants, Devices, and Drug Delivery Systems (ID3S) Lab, Center for Biodesign and Diagnostics (CBD), Translational Health Science and Technology Institute (THSTI), Faridabad–121001, Haryana, India Gaurav Kaithwas Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareily Road, Lucknow, Uttar Pradesh, India Santanu Kaity Mylan Laboratories Limited, R&D Center, Bollaram, Hyderabad, Telangana, India Jiyauddin Khan School of Pharmacy, Management and Science University, Shah Alam–40100, Selangor, Malaysia Anoop Kumar Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India, Tel.: 011-29552039, E-mail: [email protected] Suvadeep Mal Department of Pharmaceutical Chemistry, Siksha ‘O’ Anusandhan University (Deemed to be University), Campus-2, Ghatikia, Kalinga Nagar, Bhubaneswar, Odisha–731003, India
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