The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications (American College of Laboratory Animal Medicine) PDF
Preview The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications (American College of Laboratory Animal Medicine)
American College of Laboratory Animal Medicine Series StevenH.Weisbroth,RonaldE.Flatt,andAlanL.Kraus,eds.: TheBiologyoftheLaboratoryRabbit,1974 JosephE.WagnerandPatrickJ.Manning,eds.: TheBiologyoftheGuineaPig,1976 EdwinJ.Andrews,BillyC.Ward,andNormanH.Altman,eds.: SpontaneousAnimalModelsofHumanDisease,Volume1,1979;VolumeII,1979 HenryJ.Baker,J.RussellLindsey,andStevenH.Weisbroth,eds.: TheLaboratoryRat,VolumeI:BiologyandDiseases,1979;VolumeII:ResearchApplications,1980 HenryL.Foster,J.DavidSmall,andJamesG.Fox,eds.: The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice, 1981; Volume II: Diseases, 1982; Volume Ill: Normative Biology, Immunology,andHusbandry,1983;VolumeIV:ExperimentalBiologyandOncology,1982 JamesG.Fox,BennettJ.Cohen,andFranklinM.Loew,eds.: LaboratoryAnimalMedicine,1984 G.L.VanHoosier,Jr.,andCharlesWMcPherson,eds.: LaboratoryHamsters,1987 PatrickJ.Manning,DanielH.Ringler,andChristianE.Newcomer,eds.: TheBiologyoftheLaboratoryRabbit,2ndEdition,1994 B.TaylorBennett,ChristianR.Abee,andRoyHenrickson,eds.: NonhumanPrimatesinBiomedicalResearch,VolumeI:BiologyandManagement,1995;VolumeII:Diseases,1998 DennisF.Kohn,SallyK.Wixson,WilliamJ.White,andG.JohnBenson,eds.: AnesthesiaandAnalgesiainLaboratoryAnimals,1997 JamesG.Fox,LynnC.Anderson,FranklinM.LoewandFredW.Quimby,eds.: LaboratoryAnimalMedicine,2ndEdition,2002 MarkA.Suckow,StevenH.WeisbrothandCraigL.Franklin,eds.: TheLaboratoryRat,2ndEdition,2006 JamesG.Fox,MurielT.Davisson,FredW.Quimby,StephenW.Barthold,ChristianE.NewcomerandAbigailL.Smith,eds.: TheMouseinBiomedicalResearch,2ndEdition,VolumeI:History,WildMice,andGenetics,2007;VolumeII:Diseases,2007;VolumeIII:Normative Biology,Husbandry,andModels,2007;VolumeIV:Immunology,2007 DavidBacker,ed: Flynn’sParasitesofLaboratoryAnimals,2007(Wiley) RichardE.Fish,MarilynJ.Brown,PeggyJ.DannemanandAliciaZ.Karas,eds.: AnesthesiaandAnalgesiainLaboratoryAnimals,2ndEdition,2008 JackR.HesslerandNoelD.M.Lehner,eds.: PlanningandDesigningAnimalResearchFacilities,2009 MarkA.Suckow,KarlaA.Stevens,andRonaldP.Wilson,eds.: TheLaboratoryRabbit,GuineaPig,HamsterandotherRodents,2011 J.Harkness,PTurner,SVandeWoude,CWheler,eds: BiologyandMedicineofRabbitsandRodents,5thEd,2012(Wiley) ChristianR.Abee,KeithMansfield,SuzetteTardifandTimothyMorris,eds.: NonhumanPrimatesinBiomedicalResearch,2ndEdition,VolumeI:BiologyandManagement,2012;VolumeII:Diseases,2012 KathrynBayneandPatriciaV.Turner,eds.: LaboratoryAnimalWelfare,2013 JamesG.FoxandRobertP.Marinieds.: BiologyandDiseasesoftheFerret,2E,2014(Wiley) M.MichaelSwindle,ed.: SwineintheLaboratory:Surgery,Anesthesia,ImagingandExperimentalTechniques,3E,2015(Taylor&Francis) JamesFox,(Editor-in-Chief),LynnAnderson,GlenOtto,KathleenPritchett-Corning,andMarkWhary,eds.: LaboratoryAnimalMedicine,3rdedition,2015 TrentonSchoebandKathrynEaton,eds.: Gnotobiotics,2017 RobertMarini,LynnWachtman,SuzetteTardif,KeithMansfieldandJamesFox,eds.: TheCommonMarmosetinCaptivityandBiomedicalResearch,2018 MarkSuckow,F.ClaireHankenson,RonaldWilsonandPatriciaFoley,eds.: TheLaboratoryRat,3rdEdition,2019 THE ZEBRAFISH IN BIOMEDICAL RESEARCH Biology, Husbandry, Diseases, and Research Applications Edited by Samuel C. Cartner Animal Resources Program, University ofAlabamaatBirmingham Birmingham, AL,United StatesofAmerica Judith S. Eisen Institute ofNeuroscience,University ofOregon Eugene,OR,United StatesofAmerica Susan C. Farmer University ofAlabama atBirmingham, Birmingham, AL, UnitedStatesofAmerica Karen J. Guillemin Institute ofMolecular Biology, University ofOregon,Eugene, OR,UnitedStatesofAmerica; Humans andthe Microbiome Program,CIFAR, Toronto, ON,Canada Michael L. Kent Departments ofMicrobiology and Biomedical Sciences, Oregon StateUniversity Corvallis, OR,UnitedStatesofAmerica George E. Sanders Department ofComparative Medicine, University ofWashington Seattle,WA, United StatesofAmerica AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1650,SanDiego,CA92101,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom Copyright©2020ElsevierInc.Allrightsreserved. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicormechanical,includingphotocopying, recording,oranyinformationstorageandretrievalsystem,withoutpermissioninwritingfromthepublisher.Detailsonhowtoseek permission,furtherinformationaboutthePublisher’spermissionspoliciesandourarrangementswithorganizationssuchastheCopyright ClearanceCenterandtheCopyrightLicensingAgency,canbefoundatourwebsite:www.elsevier.com/permissions. ThisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythePublisher(otherthanasmaybenotedherein). Notices Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperiencebroadenourunderstanding,changesin researchmethods,professionalpractices,ormedicaltreatmentmaybecomenecessary. Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingandusinganyinformation,methods, compounds,orexperimentsdescribedherein.Inusingsuchinformationormethodstheyshouldbemindfuloftheirownsafetyandthesafety ofothers,includingpartiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeanyliabilityforanyinjuryand/or damagetopersonsorpropertyasamatterofproductsliability,negligenceorotherwise,orfromanyuseoroperationofanymethods, products,instructions,orideascontainedinthematerialherein. LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary ISBN:978-0-12-812431-4 ForinformationonallAcademicPresspublicationsvisitour websiteathttps://www.elsevier.com/books-and-journals Publisher:AndreG.Wolff AcquisitionEditor:AndreG.Wolff EditorialProjectManager:BarbaraMakinster ProductionProjectManager:PoulouseJoseph CoverDesigner:GregHarris TypesetbyTNQTechnologies Dedication We dedicate this book to our late colleague, George Streisinger, PhD, without whom this volume would be unnecessary. Streisinger introduced the world to zebrafish as a genetic modeltostudydevelopmentofthevertebratenervoussystem.Becauseofhisuntimelydeath in 1984, Streisinger never knew that he founded an entirely new field of research using zebrafishasageneticmodeltoinvestigateeveryaspectofvertebratedevelopmentaswellas what goes awry in genetic, infectious, and environmental diseases. Streisinger was born in Budapest,Hungary,in1927andcametotheUnitedStateswithhisfamilyinthelate1930sto escape Nazi persecution. He had a penchant for biology and was the sole author of several publicationsinthe1940s,whilehewasstillinhighschool.StreisingerreceivedaBachelorof Science degree from Cornell University in 1950, received his doctorate in genetics from the University ofIllinoisin1953,andconducted postdoctoral researchat theCalifornia Institute of Technology until 1956, when he joined Cold Spring Harbor. In 1960, Streisinger took a facultypositionintheUniversityofOregon’snascentInstituteofMolecularBiology,wherehespenttheremainder ofhisscientificcareer.Asapostdoctoralfellow,Streisinger wasapioneeringmolecular biologistwhomade major contributionstothegeneticsofT-evenbacteriophages.AttheUniversityofOregon,heturnedhisattentiontomore complex systems, using the same types of mutational analysis to understand vertebrate development. Streisinger was elected to the United States National Academy of Sciences in 1975, during the early stages of his zebrafish research. His publication in 1981 of the methodology for producing clonal lines of homozygous zebrafish broke new ground and enabled scientists around the world to envision incorporating zebrafish into their research pro- grams.Streisingerwasamasteratbalancinghisscientificandotherinterests.Forexample,hewasanextraordinary culinarian,ahighlysought-aftergoatshowjudge,andaseriousantiwaractivist.Despitenotlivingtoseeitcometo fruition, Streisingerset thetonefor afieldinwhichresearchersaretrulycollegial,sharingresourcesandreagents, and working across local and international boundaries to move science forward. We imagine that he would be delighted and also completely amazed at how this field he started has progressed. With this volume, we salute George Streisinger and his legacy. Samuel C. Cartner Judith S. Eisen Susan C. Farmer Karen J. Guillemin Michael L. Kent George E. Sanders v Contributors JohnAliucci AquaticsSystemsEngineeringSpecialist, PeterCurrie AustralianRegenerativeMedicineInstitute, CharlesRiverLaboratories,Frederick,MD,UnitedStatesof MonashUniversity,Clayton,VIC,Australia America LouisR.D’Abramo DepartmentofBiology,Universityof AndrewJ.Aman DepartmentofBiology,Universityof AlabamaatBirmingham,Birmingham,AL,UnitedStatesof Virginia, Charlottesville,VA,UnitedStatesofAmerica America MichaelJ.F.Barresi SmithCollege, Northampton,MA, AlanJ.Davidson DepartmentofMolecular Medicineand UnitedStatesofAmerica Pathology,SchoolofMedicalSciences,FacultyofMedical& CarrieL.Barton ZebrafishColonyManager,Sinnhuber HealthSciences,TheUniversity ofAuckland, Auckland, AKL,NewZealand AquaticResearch Laboratory,Corvallis,OR,UnitedStates ofAmerica CuongQ.Diep DepartmentofBiology,IndianaUniversity DianaP.Baumann Head,Reptile&Aquatics,Stowers ofPennsylvania,Indiana,PA,UnitedStatesofAmerica InstituteforMedicalResearch,KansasCity,MO,United BruceW.Draper UniversityofCaliforniaDavis,Department StatesofAmerica ofMolecularandCellularBiology,OneShieldsAve.,Davis, IngoBraasch Department ofIntegrative Biologyand CA,UnitedStatesofAmerica PrograminEcology,EvolutionaryBiology andBehavior, EarleDurboraw AnimalResourcesProgram,Universityof MichiganStateUniversity,East Lansing,MI,UnitedStates AlabamaatBirmingham,Birmingham,AL,UnitedStatesof ofAmerica America SusanE.Brockerhoff Biochemistry,Universityof JudithS.Eisen InstituteofNeuroscience,Universityof Washington, Seattle,WA,UnitedStatesofAmerica Oregon,Eugene,OR,UnitedStatesofAmerica ShawnM.Burgess TranslationalandFunctional Genomics SusanC.Farmer UniversityofAlabamaat Birmingham, Branch,National HumanGenomeResearchInstitute, Birmingham,AL,UnitedStatesofAmerica NationalInstitutes ofHealth,Bethesda,MD,UnitedStates JosephR.Fetcho Dept.ofNeurobiologyandBehavior, ofAmerica CornellUniversity,Ithaca,NY,UnitedStatesofAmerica SamuelC.Cartner AnimalResourcesProgram,University KayFischer OregonVeterinary DiagnosticLaboratory, ofAlabamaatBirmingham,Birmingham,AL,UnitedStates OregonState University,Corvallis,OR,UnitedStatesof ofAmerica America DanielCastranova EuniceKennedyShriver National L.AdeleFowler DepartmentofBiology,Universityof InstituteofChildHealthandHumanDevelopment, AlabamaatBirmingham,Birmingham,AL,UnitedStatesof NationalInstitutes ofHealth,Bethesda,MD,UnitedStates America ofAmerica MarinaVeneroGalanternik National InstituteofChild DawnisM.Chow Dept.ofNeurobiologyandBehavior, HealthandHumanDevelopment, NationalInstitutes of CornellUniversity,Ithaca,NY,UnitedStatesofAmerica Health,Bethesda, MD,United StatesofAmerica WhitneyM.Cleghorn Biochemistry,Universityof JuliaGanz DepartmentofIntegrative Biology,Michigan Washington, Seattle,WA,UnitedStatesofAmerica StateUniversity,EastLansing,MI,UnitedStatesofAmerica JasonCockington AustraliaNewZealandAssociation of DanielA.Gorelick CenterforPrecision Environmental AquariumProfessionals inc.,Brisbane, QLD,Australia Health,BaylorCollegeofMedicine, Houston,TX,United AllisonB.Coffin Integrative PhysiologyandNeuroscience, StatesofAmerica;DepartmentofMolecularandCellular WashingtonStateUniversityVancouver,WA,UnitedStates Biology,BaylorCollegeofMedicine,Houston,TX,United ofAmerica StatesofAmerica ChereenCollymore AnimalCareandVeterinaryServices, KarenJ.Guillemin Institute ofMolecular Biology, UniversityofOttawa, Ottawa,ON,Canada UniversityofOregon,Eugene,OR,UnitedStatesof JamesD.Cox DirectorofAnimalandBiologicalServices, America;HumansandtheMicrobiomeProgram,CIFAR, HHMI-JaneliaResearchCampus,Ashburn,VA,United Toronto,ON,Canada StatesofAmerica LaurenM.Habenicht OfficeofLaboratory Animal MarcusJ.Crim IDEXXBioAnalytics,Columbia,MO,United Resources,CenterforComparativeMedicine,Universityof StatesofAmerica ColoradoDenver|AnschutzMedicalCampus,Aurora, CO,UnitedStatesofAmerica xiii xiv Contributors HughS.Hammer University ofPittsburgh,Pittsburgh,PA, KatrinaN.Murray ZebrafishInternationalResource UnitedStatesofAmerica;TheUniversityofAlabamaat Center,UniversityofOregon,Eugene,OR,UnitedStates Birmingham,Birmingham,AL,UnitedStatesofAmerica ofAmerica AlexandriaM.Hudson Integrative Physiologyand JamesT.Nichols DepartmentofCraniofacial Biology, Neuroscience,WashingtonStateUniversityVancouver,WA, UniversityofColoradoAnschutzMedicalCampus,Aurora, UnitedStatesofAmerica CO,UnitedStatesofAmerica MichaelG.Jonz DepartmentofBiology,Universityof LaurenPandolfo National InstituteofChildHealthand Ottawa,Ottawa,ON,Canada Development,NationalInstitutesofHealth,Bethesda,MD, JanKaslin AustralianRegenerativeMedicineInstitute, UnitedStatesofAmerica MonashUniversity,Clayton,Melbourne, VIC,Australia DavidM.Parichy DepartmentofBiologyandDepartment MichaelL.Kent Departments ofMicrobiologyand ofCell Biology,University ofVirginia,Charlottesville, VA, UnitedStatesofAmerica BiomedicalSciences,OregonStateUniversity,Corvallis, OR,United StatesofAmerica NarendraH.Pathak SmithCollege, Northampton,MA, DavidKimelman DepartmentofBiochemistry,Universityof UnitedStatesofAmerica Washington,Seattle,WA,UnitedStatesofAmerica GregoryC.Paull DepartmentofBiosciences,Universityof RonaldY.Kwon Department ofOrthopaedicsandSports Exeter,Exeter,Devon,UnitedKingdom Medicine,University ofWashington, Seattle,WA, United RandallT.Peterson CollegeofPharmacy,University of StatesofAmerica;InstituteforStemCellandRegenerative Utah,SaltLakeCity,UT,United StatesofAmerica Medicine,UniversityofWashington,Seattle,WA,United JenniferB.Phillips Institute ofNeuroscience,Universityof StatesofAmerica;DepartmentofMechanicalEngineering, Oregon,Eugene,OR,UnitedStatesofAmerica UniversityofWashington,Seattle,WA,UnitedStatesof JohnH.Postlethwait InstituteofNeuroscience,University America ofOregon,Eugene,OR,UnitedStatesofAmerica DavidLains ZebrafishInternationalResourceCenter, MorganProchaska DepartmentofBiology,Clarkson UniversityofOregon,Eugene,OR,UnitedStatesof University,Potsdam,NY,UnitedStatesofAmerica America DavidW.Raible Department ofBiologicalStructure, ChristianLawrence BostonChildren’sHospital, Boston, UniversityofWashington,Seattle,WA,UnitedStatesof MA,UnitedStatesofAmerica America JohanLedin DepartmentofOrganismalBiology,Sciencefor AlbertoRissone TranslationalandFunctionalGenomics LifeLaboratory,UppsalaUniversity,Uppsala,Sweden Branch,NationalHumanGenomeResearchInstitute, CaroleJ.Lee DepartmentofBiosciences, Universityof NationalInstitutes ofHealth,Bethesda, MD,UnitedStates Exeter,Exeter,Devon,UnitedKingdom ofAmerica JianlongLi DepartmentofBiology,ClarksonUniversity, ErikSanders AquaticsLabServicesLLC,St.Peters,MO, Potsdam,NY,UnitedStatesofAmerica UnitedStatesofAmerica ChristineLieggi CenterofComparativeMedicine and GeorgeE.Sanders DepartmentofComparativeMedicine, Pathology,MemorialSloanKetteringCancerCenterand UniversityofWashington,Seattle,WA,UnitedStatesof WeillCornell Medicine,NewYork,NY,UnitedStatesof America America JustinL.Sanders DepartmentBiomedicalSciences,Oregon ChristianaLo¨hr OregonVeterinary DiagnosticLaboratory, StateUniversity,Corvallis,OR,United StatesofAmerica; OregonState University,Corvallis,OR,UnitedStatesof OregonVeterinaryDiagnosticLaboratory,OregonState America;DepartmentofBiomedicalSciences,OregonState University,Corvallis,OR,UnitedStatesofAmerica University,Corvallis,OR,UnitedStatesofAmerica KelleeR.Siegfried UniversityofMassachusettsBoston, KimberlyL.McArthur Dept.ofNeurobiologyandBehavior, BiologyDepartment, 100MorrisseyBlvd.,Boston,MA, CornellUniversity,Ithaca,NY,UnitedStatesofAmerica; UnitedStatesofAmerica Dept.ofBiology,SouthwesternUniversity,Georgetown,TX, NatalieL.Smith DepartmentofBiochemistry,Universityof UnitedStatesofAmerica Washington,Seattle,WA,UnitedStatesofAmerica BraedanM.McCluskey DepartmentofBiology,University SeanT.Spagnoli BiomedicalSciences, OregonState ofVirginia,Charlottesville, VA, UnitedStatesofAmerica UniversityCollegeofVeterinary Medicine,Corvallis,OR, NorikoMikeasky DepartmentofBiology,IndianaUniversity UnitedStatesofAmerica ofPennsylvania,Indiana,PA,UnitedStatesofAmerica AmberN.Stratman NationalInstitute ofChildHealthand DonnaMulrooney OregonVeterinary Diagnostic HumanDevelopment,NationalInstitutes ofHealth, Laboratory,OregonState University,Corvallis,OR,United Bethesda,MD,UnitedStatesofAmerica StatesofAmerica xv Contributors EricD.Thomas GraduatePrograminNeuroscience, StephenA.Watts Department ofBiology,Universityof UniversityofWashington, Seattle,WA, UnitedStatesof AlabamaatBirmingham,Birmingham,AL,UnitedStatesof America America DavidTraver DepartmentofCellular andMolecular BrantM.Weinstein NationalInstitute ofChildHealthand Medicine,SectionofCellandDevelopmentalBiology, HumanDevelopment, NationalInstitutes ofHealth, DivisionofBiologicalSciences,UniversityofCalifornia,San Bethesda,MD,UnitedStatesofAmerica Diego,CA,UnitedStatesofAmerica MonteWesterfield Institute ofNeuroscience,Universityof FrankJ.Tulenko AustralianRegenerativeMedicine Oregon,Eugene,OR,UnitedStatesofAmerica Institute,MonashUniversity,Clayton,VIC,Australia ChristopherM.Whipps SUNY-ESF,StateUniversityofNew CharlesR.Tyler DepartmentofBiosciences, Universityof YorkCollegeofEnvironmental ScienceandForestry, Exeter,Exeter,Devon, UnitedKingdom EnvironmentalandForestBiology,Syracuse,NY,United KennethN.Wallace DepartmentofBiology,Clarkson StatesofAmerica University,Potsdam,NY,UnitedStatesofAmerica TravisJ.Wiles InstituteofMolecularBiology,Universityof ChongminWang EuniceKennedyShriverNationalInstitute Oregon,Eugene,OR,UnitedStatesofAmerica ofChildHealthandHumanDevelopment,National MichaelB.Williams DepartmentofBiology,Universityof InstitutesofHealth,Bethesda,MD,UnitedStatesof AlabamaatBirmingham,Birmingham,AL,UnitedStatesof America America ClaireJ.Watson DepartmentofOrthopaedicsandSports JeffreyA.Yoder DepartmentofMolecularBiomedical Medicine,University ofWashington,Seattle,WA,United Sciences,CollegeofVeterinary Medicine, NorthCarolina StatesofAmerica;InstituteforStemCellandRegenerative StateUniversity,Raleigh,NC,UnitedStatesofAmerica Medicine,UniversityofWashington,Seattle,WA,United TejiaZhang CollegeofPharmacy,UniversityofUtah,Salt StatesofAmerica LakeCity,UT,UnitedStatesofAmerica AmandaWatts Institutional AnimalCareandUse JeffreyR.Zynda Principal&SciencePracticeLeader, Committee,UniversityofAlabamaatBirmingham, PerkinsandWill, Boston,MA,UnitedStatesofAmerica Birmingham,AL,UnitedStatesofAmerica List of reviewers BruceRiley TexasA& M University,CollegeStation, TX,United States of America Stowers Institute for Medical Research,Kansas City, MO,United Statesof America CarrieCarmichael University ofSaskatchewan, Saskatoon,SK, Canada DavidJanz Northwestern University,Evanston,IL,United States of America DavidMcLean Icahn School ofMedicine at Mount Sinai, New York,NY, United States ofAmerica FlorenceMarlow University of Oregon, Eugene, OR, United States ofAmerica JohnPostlewait Children’s ofAlabama/UniversityofAlabama, Birmingham, AL, United Statesof America MatthewS.Alexander University ofOregon, Eugene, OR, United States ofAmerica MonteWesterfield xvii Preface TheAmericanCollegeofLaboratoryAnimalMedicine(ACLAM)wasestablishedin1957tosupporteducation, training,andresearchinlaboratoryanimalmedicineandtorecognizespecialistsintheveterinaryfieldbyprovidinga routeforcertification.AmissionoftheACLAMistoprovidescholarlyinformationtoensureconsistentstandardsfor laboratoryanimalcareandimprovereproducibilityofscientificresearch.Tothisend,ACLAMhassponsoredaseries of reference books on the biology, husbandry, diseases, and use of the most frequently studied animal models of humanandanimaldisease.Thefirstoneonthelaboratoryrabbitwaspublishedin1974.Nowwithover15volumesin theset, theyofferstate-of-the-art reference materialsfor biomedicalresearchers.The Zebrafish in Biomedical Research addstothisseriesandisthefirstcomprehensivepublicationonthisimportantanimalresearchmodel. Thecontentsofthisbookinclude51chaptersdividedintofivemainsections:Introduction,Biology,Husbandry, Diseases,andScientificResearch.TheIntroductionincludesacomprehensivereviewofthehistoryofthezebrafishin biomedical research, followed by chapters reviewing taxonomy, genetics, natural geographical distribution, and behaviorofwildpopulations.TheBiologysectionincludeschaptersonthedevelopment,anatomy,andphysiologyof organ systems. The Husbandry section provides extensive coverage of facility design, housing systems and their maintenance,waterquality,breeding,colonymanagement,nutrition,andothersupportactivities.Thereisalsoabrief reviewoftheregulations,policies,andguidelinespertainingtotheuseofzebrafishinresearchintheUnitedStates. The section on Diseases provides up-to-date information on the idiopathic, parasitic, bacterial, fungal, and viral diseases of zebrafish. Biomedical researchers and laboratory animal professionals will find the chapter on special proceduresfordiseasediagnosisandtreatmentveryhelpful.ScientificResearchcoversthemajorusesofthezebrafish inbiomedicalresearchasmodelsfordevelopmental,behavioral,andgeneticdiseases.Inaddition,thereisachapter reviewing the novel uses of zebrafish in understanding the hostemicrobeepathogen interaction. The final two chaptersreviewthezebrafishasaplatformfortechnologydevelopmentandtoxicologyanddrugscreening. Allthecontributorsareexpertsintheirspecialtiesandtheapplicationofthezebrafishmodeltotheirresearch.As withallvolumesintheACLAMseries,theauthorsandeditorshavedonatedtheirtimeandefforttothispublication. Permissionfeesrequiredfortheuseoffigures,tables,etc.,werepaidbytheUniversityofAlabamaatBirmingham.All theseeffortsweremadeinthenameoffosteringcontinuingeducationinlaboratoryanimalscienceandpromoting responsibleuseofanimalsinbiomedicalresearch.Aspecialthanksisextendedtoreviewersofeachchapterandthe authors’andeditors’homeinstitutionsforallowingthemtoworksodiligentlyonthisbook.Theauthorsandeditors appreciatethehelpfulsupportfromtheElsevierstaff. SamuelC.Cartner JudithS.Eisen SusanC.Farmer KarenJ.Guillemin MichaelL.Kent GeorgeE.Sanders xix
The list of books you might like
