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To myprofessor, Professor Shi Zhongan To mywife andchildren ForChurchillLivingstone: PublishingManager,HealthProfessions:Inta Ozols ProjectDevelopmentManager:DinahThorn ProjectManager:Jane Dingwall Designer:GeorgeAjayi Con tribu tors Primary contributors Secondary contributors Shen XiaoxiongMDPhD YangGuohuaMD ResearchScientist,DepartmentofEndocrinology, ProfessorofMedicine,BeijingUniversityofTCM and UniversityofCalifornia, LosAngeles, USA WangJing Hospital, Beijing,China YaoFengliMD Sun YijunMB FormerProfessorof Medicine,BeijingUniversityof Lecturerin Medicine,The InternationalTraining TCM, Beijing,China Centre,BeijingUniversityofTCM, Beijing,China YangYifanMDMSc MaLiangxiaoMB PrivatePractitionerand Lecturer,The Netherlands; Lecturerin Medicine,The InternationalTraining FormerLecturerin Medicine,BeijingUniversityof Centre, BeijingUniversityofTCM, Beijing,China TCM,Beijing,China JiangHongbingMD Professorand Directorof the Institutefor Basic Education,GuangxiCollegeofTCM,Guangxi,China CHURCHILLUVINGSlONE AnimprintofElsevierLimited ©ElsevierLimited2002.Allrightsreserved. TherightofSunPeilintobeidentifiedaseditorofthisworkhas beenassertedbyhiminaccordancewiththeCopyright,Designs andPatentsAct1988. Nopartofthispublicationmaybereproduced,storedina retrievalsystem,ortransmittedinanyformorbyanymeans, electronic,mechanical,photocopying,recordingorotherwise, withouteitherthepriorpermissionofthepublishersora licencepermittingrestrictedcopyingintheUnitedKingdom issuedbytheCopyrightUcensingAgency, 90TottenhamCourt Road,LondonWlT4LP.Permissionsmaybesoughtdirectly fromElsevier'sHealthSciencesRightsDepartmentin Philadelphia,USA:phone:(+1)2152387869,fax:(+1)215 2382239,e-mail:[email protected] completeyourrequeston-linevia theElsevierhomepage (http://www.elsevier.com).byselecting'CustomerSupport' andthen'ObtainingPermissions'. Firstpublished2002 Reprinted2004(twice) ISBN0443071276 BritishLibraryCataloguinginPublicationData AcataloguerecordforthisbookisavailablefromtheBritish Ubrary LibraryofCongressCataloginginPublicationData Acatalogrecordforthisbookisavailablefrom theUbraryof Congress Note Medicalknowledgeisconstantlychanging.Asnewinformation becomesavailable,changesintreatment,procedures,equipment andtheuseofdrugsbecomenecessary.Theeditors,contributors andpublishershavetakencaretoensurethattheinformation giveninthistextisaccurateanduptodate.However,readers arestronglyadvisedtoconfirmthattheinformation,especially withregardtodrugusage,complieswiththelatestlegislation andstandardsofpractice. _ yoursourceforbooks, jooma!sandmultimeclia inthe!malthsciences www.elsevlerhealth.com The pUJ!isher's Transferredtodigital print, 2007 policyistouse pIpIrIIIIIlIlllIc:II Printed and bound byCPI AntonyRowe, Eastbourne II'om_1nIbIeIolHtI I Preface This bookisaimedat studentsand practitionersof was roughlycompleted.In1996,Isentthis text to the acupunctureand Chineseherbs,as well as publishersand theyexpressedan interestin practitionersofWestern medicine. Bothbeginnersin publishingit. However,mytime wasso limited thatI TCMand experienced practitionerscan usethis book couldnotfinish the bookby myself. Iconsequently for reference, practice, teachingand research. inviteda few otherauthors,whoarequalified Mystudentshaveoftenasked me what the professorsand medicaldoctors inbothteachingand differenceisbetweenBisyndromeandpain clinicalpractice,to join this writingteam. Thanks to syndrome.Itcan be explainedin this way: the main theeffortsofall the authors, the draft manuscript complaintof Bisyndromein the earlystagesispain wasfinished beforethe summerof1998.Since thenit in the jointsandmuscles,butitseldominvolvesthe has takenall my sparetimeto revise, editand modify internalorgans. The chief causativefactor forBi the contentsand,since the onlytime availablefor me syndromeisinvasionofa mixtureof Wind, Cold and to workon itwasaftermy practicein the evening,it Damp.BecauseofthesuccessesofWesternmedicine wasquiteusualfor me to workuntil the middleof and good healthcare systems,itisunusual to see thenight! Luckily, Ihavecontinuallyreceived the manypatientswith Bisyndromein the secondor supportof my family overthisperiod.Itwasan later stages.As aconsequence,treatmentofBi enormous pleasurefor me to see the manuscript syndromefocuses on dispellingexternal pathogenic finallycompleted. factors. However, painsyndromecan be caused by Thefirst partof the bookisan intensiveinquiry manyotherkindsof pathogenicfactors as wellas into the generalaspectsofthe aetiologyof pain,its Wind,Coldand Damp. In this sense,itcan be said pathology,treatmentprinciples,acupuncturepoint that pain syndromeactuallyencompasses till' selectionand stepsin treatment.This partservesas a contentsofBisyndrome. generalguidefor readers. Theideafor writing this bookcameto me 8years The otherpartsdivide the discussionon paininto ago when Iwasbusy writingabookon Bisyndrome. 46chaptersaccording toanatomicalregions. These Duringthe courseof this, Ifound thatmany pain chapters providedescriptionsofnotonlythe syndromescouldnot be clearly described or included aetiologyand pathologyfor eachtypeofpain,but in thebook, so Ibegantocollect togetherdata on also the differenttreatments withChineseherbsand pain controlinTCM and drewon my ownexperience acupuncture. For each topic, key pointsare given asaclinician and teacheras well as thatofmy tutor, aboutdifferentiation,explanationsofherbsand Professor ShiZhongan,and my colleagues. Besides acupointsselected for the treatmentand individual supplyingme with knowledge, theyalso gaveme a modifications,in orderto presentreaderswith lotofencouragement.Slowlythe bookgraduallytook practicaland easilyaccessibleinformation. shape. However,becauseof my busyclinicalpractice Sinceit is difficult to find onestandard classic and extensiveteachingbothat homeand abroad, it herbal formula thatfits all complaints,mostof the tookmeabout2yearsbeforeone chapterof the book prescriptionsmentioned in the herbal treatments xviii PREFACE havebeenmodifiedaccording to the individual Wesincerelyhopethatourcolleagues,friendsand situation. Moreover,sincenotall thereaderswill readerswill providesuggestionsandcommentsafter feelconfidentabouttheirknowledgeofindividual readingthis book sothatitcanbemodifiedforany Chineseherbs,usefulpatentremediesare also futureedition. suggested. Nevertheless,itshouldbe bornein mind Allthe authorsofthis book wouldfeelhappyif thatthereisneverone patentremedythatcan this book servesits purposeinhelpingto alleviate alleviateaspecific painsufficientlywithoutthe pain andtreatillness. additionofacupuncturetreatmentfor individual complaints. Belgium, 2002 Sun Peilin Acknowledgements Thisbook would not havebeenpublished inits writingstyle in somepartsofthe book. Iam indebted presentstate withoutthe helpofmanyfriends and toMrs ZhouWeifor continuallyprovidingme with colleagues. Inparticular,Iam deeply indebtedtomy somuchessentialinformationfor the book, and also tutor, ProfessorShiZhonganfrom NanjingUniversity toProfessorChenZhiqiangforhis contributionon ofTraditionalChineseMedicine,China. He acupuncture treatmentin the section on back pain. I encouragedmeso muchin studying, practisingand am very grateful toMrYaoZhiguofor spendingso teachingTCMbothinChinaand abroad. He taught muchofhis sparetime in producingthe basic layout me not onlyhowtostudyat university,butalso how ofthe book, and also to the staffofChurchill totreatpeople. In particular,Iwould like tothank Livingstone,in particularInta Ozols, DinahThorn him at the age of84forwritingaforeword and andMartinaPaul, for theirexpertiseandefficiency. skilfullyundertakingthe ancientstyle ofChinese Finally,lowemuchtomy wife,Yuqing,and my calligraphyfor the title ofthis book. threechildren,for allowingme todevotea Iam gratefultoDr Robert Rinehartforhis many considerablepartofmy sparetime tothe bookthat good suggestionsin writing this bookand also to we wouldotherwisehavespenttogether. MrJanSchroenand Mrs Ineke vande Hamfortheir help incheckingthe Englishandcorrectingthe Sun Peilin In troduction Discussion on pain TraditionalChineseMedicine(TCM)isprobablyoneoftheoldestcomplementarytherapiesand continuouslypractisedsystemsofmedicineinthe world.Developedthroughempiricalobserv ationby theChineseoverthousandsofyears, thisuniquemedicalsystemisused totreatawide rangeofdiseases,and isofespecial usein treatingvarious kindsofpain. Everyonewill, at some time or another, suffer from painor disability. Pain isan unpleasant experience associated with actual or potential tissue damage. It may arise from accident or injury,cancer,arthritis,amultitudeofphysicalailmentsorevenemotionaldistress.Itmayaffect the head,neck,torso orany oftheextremitiesaswellasinternalorgans,causingdifferentkinds ofpain,such asheadache,neckpain, throatpain,shoulderpain,jointpain, abdominalpain and lowerbackpain. No matterwhat the cause, pain, especiallychronic pain, transcends simply physical hurt. It limits theactivitiesofeverydayliving and canerodethe sufferer'sabilitytofunction. However, pain is,in reality,nature'sway ofprotectingthe bodyfrom potential tissue damage,becauseit servesasawarningsignal,alertingthepersonthatsomethingiswrong. Inthissense wecansay that toavoid pain istoavoidsevere injury. How do modernmedicine and TCMexplain theoccurrenceofpain? Modernmedicalresearch has discovered that pain signals are transmitted by specialised nervoussystemcells(receptors), whicharefound throughouttheskinand otherbodytissues.Thesecellsrespondtoinjury,inflam mation or tissue damage. Immediatelyafter receiving these messages, the signals travel by elec tricaland chemical means, from receptors throughsensoryneurons to the spinal cord and then through interneurons in the spinal cord to the brain, where they are finally interpreted as pain. TCMtakesadifferent view:that thebody maintainsabalance betweentheprinciples ofYinand Yang,and betweenQiand Blood.Qiand Bloodtravel throughthebodyalong well-defined path wayscalledchannels. WhenthereisnotenoughQiandBlood(EmptinessorDeficiency),orwhen they are stuck inonearea (Fullnessor Excess),there isan imbalancebetweenYinand Yang,the Internal organs arenot functioning optimally,andillnessand pain develop. Pain, whetheracute or chronic, could havea varietyofcauses. Acute pain isusuallycharac terised byacute onset, ashortduration, normalfunctioning ofboth the peripheraland central nervoussystems,apredictablecourseand, in mostcases, a goodoutcome. In terms ofmodern medicine, acute painusuallyisthe resultofan injury,surgery, inflammationor medicalillness. Acute pain often goes awaywiththe healingprocess. Chronic pain, however, isdifferent; itis the kind of pain thatmost peopleworry aboutas it lastsbeyondthe expectedtime for healing; thatis,itdoes not go away when itissupposed to. 3 4 GENERAL INTRODUCTION Chronic pain is often difficult to relieve or cure • toenhancethe qualityoflife completely, and may occur even if there is no tissue • toreducerelianceon inappropriatemedications. damageor physicalcause.Theexactcauses ofchronic pain are not fully understood,or,in otherwords, one Points from different channels are, according to TCM could say that there is no adequate medical explan theory, energeticallyconnected to specific organs and ation formanychronicpaincases. body structures. The purpose of acupuncture treat Pain can be extremely debilitating and frequently mentfor painis to use selected points on these chan requires uniquetreatmentapproaches.Insomecasesit nels to activateQi and Bloodcirculation, and balance can be seen that the damaged tissues have been Yinand Yang.Duringthe treatment, moxibustionand repaired,butnevertheless the paincontinues. Besides pointmassageare also often appliedsimultaneously. tissuedamage,there aresomeotherclinicalsymptoms Acupuncturetreatmentforpainisvariedandbased associated with pain, such as muscle tension, spasm, largelyon whatis causing the patient's suffering; the stiffness, or weakness. There could also be some treatments for acute and chronic pain are often quite degree of immobilisation of an injured part by the different. In chronic pain patients, treatment that had patient in order to avoid painfrom movement. It has proved useful for acute pain management may lose alsobeen observedthat, whateverthecauseofchronic its effectiveness, be inappropriateor even be counter pain, feelings of frustration, angerand fear make the productive. pain more intenseand more difficult totreat. The Chinese do not limit the use of Chinese herbs In short, pain, especially chronic pain, interferes andacupuncturetoalleviatingpain; they use combin with normallifeandphysicalactivities.Wecouldeven ations of herbs and acupuncture to treat the whole say that such pain can often diminish the quality of range of diseases that are encountered in association people's life in terms of their psychology, sociology withthe pain. TheseincludeTCMtherapiesforhyper and physiology. Itis,finally,one ofthe most frequent tension, hypotension, allergy, asthma, diabetes, causes ofsufferinganddisabilityin the world today. stomach ulcers, depression, infections, etc. It is clear that many diseases respond better to modem medi cine, whereas some may respond better to Chinese herbal medicines and acupuncture. However, in the Pain control by TCM majority of cases Chinese herbal medicine and acupuncturemayeitherbeareasonablealternativefor, orbe usedin conjunctionwith modem medicine. For In Western medicineit is quitecommonto find or be this reason allTCMschools and universitiesin China told that doctors are unable to find the real cause of continue to offer courses and training in both TCM pain in patients even after extensive examination. and modem medicine at present. During Chinese Patients are often told: 'There is nothing wrong with herbalandacupuncturetreatment,itshouldbe kept in you',or 'Sorry, we cando nothingaboutit,andyou'll mind that essential contact and communication with have to learn to live with it' or even 'Itis all in your otherspecialistsmustbemaintained,forinstancewith head'. It is poor practice, however, for a doctor to neurologists,neurosurgeons,orthopaedists,internists, make such comments to patients; they don't have to radiologists,andphysicalandoccupationaltherapists, live in pain. Fortunately, since acupuncture has so that patientsreceive the necessarysupportat their acquired a very good reputation as a treatment for timeofgreatestneed. relieving pain, many physicians are now referring In China, increasingly acupuncturists are applying their patientsforan acupunctureorherbal evaluation, acupuncture todiminish pain directlyor decrease the or patients are starting to investigate the potential of amountofdrugs needed for the control ofpain, even acupunctureand herbaltreatmentforthemselves. during surgery. This well-known practice indicates Intermsofpaincontrol, theeffectsofChineseherbal that acupuncture potentially has anaesthetic effects. and acupuncturetreatmentinclude: After conducting thousands of experiments on both • torelieve paincompletely,orgiveasmuchrelief animals and people, researchers become firmly con aspossible vinced that acupuncture was indeed effective in its • toreducepainlevels own right for anaesthesia. In consequence, acupunc • toimprovethe ability todeal with pain ture hasbeenused quitesuccessfullyinplaceofchem • toregulatethe emotions icalanaesthesiaformanytypesofsurgeryinthelast30 • toincrease the energy years in China. It has been shown to be effective in • toincrease the ability toperformeveryday gastric (YeQianget aI1984), dental (LinGuochuetal functions 1984)andthyroid surgery(ZhuangXinliang1984).Itis INTRODUCTION 5 also potentially indicated for those patients unable to lation (i.e,thechannels).Itisanobjective fact that pain tolerateregularanaesthesia. Becauseofitsefficiencyin is always transmitted along certain pathways. These acupuncture anaesthesia, doctors in many hospitals, pathways are closely related with channel theory in especially the affiliated hospitalsofTCMuniversities, TCM. An interesting observation is that when use acupunctureroutinelyin casesofthyroidectomy. acupunctureneedlingisused inthe treatmentofpain, Theadvantagesofacupunctureanaesthesiainclude: and when the needle sensation (Deqi) is reported along a particular channel, the greatest reduction in • fewer side-effectsthan withchemical anaesthesia sensitivity to pain is be found in a line along the • morecooperationfrom the patientduringthe middle of the channel (Fujian Provincial Research operation Institutefor Traditional Chinese Medicine 1979).This • a lackofdisturbanceofthe brain and memory reduction in sensitivity decreases gradually as one following anaesthesia moves from the centre of the channel to its outer • the patientremainingalertduringthe procedure boundary-thatistosay,the more the needleismoved • rapid recoveryoffunctional activitiesafter the towards the central line of the channel, the less the operation,etc.. patientfeelsthe pain. Observationhas alsoshownthat The disadvantages of acupuncture anaesthesia pain transmission along the course of the channels is include: greatly diminished when certain methods are used to promote the circulation of the channel (Li Baojiao • a feeling ofpullingand tuggingduringthe 1981).Pain transmission along the channels is, con operation versely, greatly increased when certain methods are • inadequacywithchildrenandsome senile patients used toblock the channelcirculation. • inabilitytoreplaceall kindsofchemical anaesthesia • sometimesaneed forlocalchemicalanaesthesia,etc. Pain-gate theory Another theory suggests that pain impulses are Modern research on pain blocked from reaching the spinal cord or brain at control by acupuncture various 'gates' within the nervous system. Research studies have shown that both peripheral and central nerves are very important in pain relief by aCtlpunc Over the past thirty years, both patients and profes ture (Lu Guowei et al 1979,Shanghai no. 1 People's sionals have been asking questions about how Hospital1977,WuJianpinget aI1979). acupuncture works in a modern, scientific sense? Inthe peripheralnervoussystemacupuncturewhen What are the mechanisms? Is there any scientificevi used to treat paincan, firstly,block the conduction of dencethat supportsthe effectivenessofacupuncture? sensory fibres in the algetic nerves (Lu Guowei et al In order to reply to these questions, since the 1970s 1979,Qiu Maolianget al 1989);secondly, it can cause scientistsand practitionersboth inChinaand in other downward inhibition of the dorsal horn cell conduc countrieshave beenconductinganumberofscientific tion inthespinalcord resultingfrom the noxiousstim studies and clinical trials, which are described in this ulation (Qiu Maoliang et al 1989).It is the peripheral section. This research has tended to substantiate the nerves that receive and conduct the acupuncture ancienttheoriesoftraditionalChinesemedicine.Other 'message';the II,IIIand IVfibres could all participate recent research has revealed that human beings are in the pain-reliefprocess. complexbioelectricsystems(Becker1985),and on this In the central nervous system the structures at basis the mechanicsofacupuncturecan nowbebetter various levels, including the spinal cord, brain stem, understood. thalamus, caudate nucleus and cortex, participate in To date, a few theories have been suggested con the processofpainreliefby acupuncture. cerning these questions. SPINALCORD Transmission ofpain impulses along acupuncture channels Scientific research has found that acupuncture can causepostsynapticinhibitionintheposteriorhomofthe Thefirst theory isthat mostpain impulsestravelalong spinal cord (Qiu Maoliang et al 1989).It has also been thesamepathwaysasthoseofthe traditionalQicircu- found that the acupuncture 'message' is conducted to 6 GENERAL INTRODUCTION the medulla oblongata from the anterior funiculus of medial reticular structure of the brain stem and the the spinalcord, and then to the medial reticularstruc medianraphenucleiare also veryimportant. ture (Qiu Maoliang et al 1989).Afterwards, it is con ducted downwards to the posterior funiculus of the spinalcord, whereitcauses postsynapticinhibitionby Stimulation of endorphins depolarising the fine afferent nerve endings. This has theeffectofpartiallyblockingtheafferentimpulsefrom A third theory suggests that acupuncture stimulates thefinefibres. the brain's production of polypeptides that reduce painsensitivity.Scientistshavediscovered thatoneof its possiblemechanismsis thatit increases the release BRAINSTEMAND PARAFASCICULAR of natural pain-relieving molecules known as endor NUCLEUS phinsby thebrain(QiuMaoliangetaI1989).Theseare verysimilar to opiates (such as morphine), which are In the brainstem,electroacupuncturehas been found potentanaestheticagents.InChinathis workwasper to control the activity of hyperalgetic neurons in the formed and directed in the 19708by Professor Han reticularstructureofthe midbrain(QiuMaoliangetal Jisheng, an internationally known researcher of 1989). In animal experiments, it was found that acupuncture, when a research programme to study electroacupuncture stimulation of the median raphe acupuncture-inducedanaesthesiawasinitiatedduring nuclei could raise the pain threshold in the animals, theCulturalRevolution.His studiesshowedthatelec improving their ability to resist the pain (Qiu trical stimulation of inserted acupuncture needles MaoliangetaI1989). Impairmentofthelocus ceruleus causedreleaseofdifferentamountsofendorphincom increased the capacity for pain relief by electro poundsinto the central nervous system (HanJisheng acupuncture, whereas activation and stimulation of et al 1979).This is the key mechanism that is most this structure decreased its pain-relief capacity. widely used as explanation for the effect of acupunc Researches also showed that acupuncture treatment turetreatmentinrelievingpain. Thisisnotacomplete led to the release of neural impulses from the grey explanation, however, of all of acupuncture's pain matteraroundthe aqueductofthe midbrain,the giant alleviating mechanisms, because acupuncture has nucleus in the medial reticular structure of the brain other physiological effects besides decreasing pain stemandthe medianraphenuclei(QiuMaoliangetat sensitivity. For instance, it often increases local blood 1989).From here, ascendingimpulsesinhibitelectrical circulationinareasofmusclespasm,and candecrease activity of the hyperalgetic cells in the parafascicular the muscular contraction that often causes or con nucleus of the thalamus, and descending impulses tributestopainfulconditions.Thus,local actionssuch inhibit the activity of neurons transmitting pain as decreasing tissueswelling(due to betterblood cir impulses in the posterior hom of the spinal cord, so culation) and lessening muscle spasm may, in tum, relievingthe pain. Theparafascicularnucleushasbeen release pressure on nerves or interior organs, contri found to be oneof the importantkey locations in the butingtothe painrelief. transmissionofpainimpulses. Effects onneurotransmitters CAUDATE NUCLEUS Research has established that when the caudate Anothertheorysuggestsacentral nervoussystemcon nucleusis stimulated, the painthreshold isincreased, nectionthatinducestheproductionorsecretionofother which could increase the pain-relieving effect of chemicals in the body such as neurotransmitters, hor electroacupuncture,whereasinhibitionofthe caudate mones and lymphokines, etc. Though most of these nucleus decreases the pain-relieving effect (Qiu chemicals areusedupfairlyquickly,clinicalexperience Maolianget aI1989). indicates that acupuncture generally has cumulative Generally speaking, when the pain impulse enters effects.Thus, acupuncturemustprovidesometraining the central nervous system, it can take a circuitous effectinthebody'sautonomicmechanismsthat control routetothe cerebrum.Theposteriorhomofthe spinal andregulatethe physiologicalreactions topain. cord and the parafascicular nucleusare two key loca Acupuncture treatments have been found to affect tions in the reception and transmission of pain severalneurotransmitters,resultinginchangesintheir impulses.Thecaudatenucleus,thegreymatteraround blood serum levels. In particular, acupuncture may the aqueductofthe midbrain, the giantnucleusin the bringaboutthe followingbiochemicalchanges.

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Although Chinese medicine views pain as one aspect of a pattern, focusing on pain as the main presenting symptom is a practical approach to arriving at a diagnosis. This text gives a thorough and analytical review of the diagnosis and treatment options for pain, using acupuncture and Chinese herbal
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