the treatment of elderly patients with aggressive non-hodgkin's lymphoma

168 Pages·2005·1 MB·English

THE TREATMENT OF ELDERLY PATIENTS WITH
AGGRESSIVE NON-HODGKIN’S LYMPHOMA
Jeanette K Doorduijn
The Treatment of Elderly Patients with Aggressive Non-Hodgkin’s Lymphoma
© Jeanette Karin Doorduijn
ISBN-10: 9090196900
ISBN-13: 9789090196909
2005 Rotterdam, The Netherlands
Publication of this thesis was financially supported by:
Amgen B.V., Breda; Novartis Pharma B.V., Arnhem; Roche Nederland B.V., Woerden; Schering
Nederland B.V., Weesp; Zeneus Pharma B.V., Eindhoven
Design: Megla, Ursula Lavrencic
Printing: Littera Picta
The Treatment of Elderly Patients with
Aggressive Non-Hodgkin’s Lymphoma
De behandeling van oudere patiënten met een
agressief non-Hodgkin lymfoom
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam
op gezag van de
rector magnificus
Prof.dr. S.W.J. Lamberts
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 5 oktober 2005, om 13.45 uur
door
Jeanette Karin Doorduijn
geboren te Delft
Promotiecommissie
Promotor: Prof.dr. P. Sonneveld
Overige leden: Prof.dr. J.C. Kluin-Nelemans
Prof.dr. H.A.P. Pols
Prof.dr. F.F.H. Rutten
The miracle isn’t that I finished...
The miracle is that I had the courage to start.

Contents and publications
Chapter 1 Introduction 9
Chapter 2 CHOP compared with CHOP plus granulocyte colony-stimulating
factor in elderly patients with aggressive non-Hodgkin’s lymphoma.
Journal of Clinical Oncology. 2003;21:3041-50 63
Chapter 3 Correspondence and reply.
Journal of Clinical Oncology. 2005; in press 87
Chapter 4 Self-reported quality of life in elderly patients with aggressive
non-Hodgkin’s lymphoma treated with CHOP chemotherapy.
European Journal of Haematology; 2005;75:116-23. 95
Chapter 5 Economic evaluation of prophylactic granulocyte colony
stimulating factor during chemotherapy in elderly patients
with aggressive non-Hodgkin’s lymphoma.
Haematologica. 2004;89:1109-17 115
Chapter 6 Etoposide, mitoxantrone and prednisone: a salvage regimen with
low toxicity for refractory or relapsed non-Hodgkin’s lymphoma.
Haematologica. 2000;85:814-9 133
Chapter 7 Summary and concluding remarks / Samenvatting 149
List of abbreviations 161
List of publications 162
Curriculum vitae 165
Dankwoord 166

INTRODUCTION
Chapter 1