The Sperm Cell - Production, Maturation, Fertilization, Regeneration PDF
Preview The Sperm Cell - Production, Maturation, Fertilization, Regeneration
Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information The Sperm Cell Second Edition © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information The Sperm Cell Production, Maturation, Fertilization, Regeneration Second Edition Editedby ChristopherJ.DeJonge UniversityofMinnesota,Minneapolis,MN,USA ChristopherL.R.Barratt UniversityofDundee,NinewellsHospital,Dundee,UK © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information UniversityPrintingHouse,CambridgeCB28BS,UnitedKingdom OneLibertyPlaza,20thFloor,NewYork,NY10006,USA 477WilliamstownRoad,PortMelbourne,VIC3207,Australia 4843/24,2ndFloor,AnsariRoad,Daryaganj,Delhi-110002,India 79AnsonRoad,#06-04/06,Singapore079906 CambridgeUniversityPressispartoftheUniversityofCambridge. ItfurtherstheUniversity’smissionbydisseminatingknowledgeinthepursuitof education,learningandresearchatthehighestinternationallevelsofexcellence. www.cambridge.org Informationonthistitle:www.cambridge.org/9781107126329 DOI:10.1017/9781316411124 (cid:2)C CambridgeUniversityPress2017 hispublicationisincopyright.Subjecttostatutoryexception andtotheprovisionsofrelevantcollectivelicensingagreements, noreproductionofanypartmaytakeplacewithoutthewritten permissionofCambridgeUniversityPress. Firstpublished2006 Reprintedinpaperbackformatin2011 Secondedition2017 PrintedintheUnitedKingdombyTJInternationalLtd.PadstowCornwall AcataloguerecordforthispublicationisavailablefromtheBritishLibrary. ISBN978-1-107-12632-9Hardback CambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracy ofURLsforexternalorthird-partyinternetwebsitesreferredtointhispublication, anddoesnotguaranteethatanycontentonsuchwebsitesis,orwillremain, accurateorappropriate. ............................................................................ Everyeforthasbeenmadeinpreparingthisbooktoprovideaccurateand up-to-dateinformationwhichisinaccordwithacceptedstandardsandpracticeat thetimeofpublication.Althoughcasehistoriesaredrawnfromactualcases,every eforthasbeenmadetodisguisetheidentitiesoftheindividualsinvolved. Nevertheless,theauthors,editorsandpublisherscanmakenowarrantiesthatthe informationcontainedhereinistotallyfreefromerror,notleastbecauseclinical standardsareconstantlychangingthroughresearchandregulation.heauthors, editorsandpublishersthereforedisclaimallliabilityfordirectorconsequential damagesresultingfromtheuseofmaterialcontainedinthisbook.Readersare stronglyadvisedtopaycarefulattentiontoinformationprovidedbythe manufacturerofanydrugsorequipmentthattheyplantouse. © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information Contents ListofContributors pagevii ForewordbyRyuzoYanagimachi x Preface xiii 1 Spermatogenesis:Clinicaland 9 ProteomicsofCapacitation 143 ExperimentalConsiderations 1 MarkA.Baker EllenGoossensandHermanTournaye 10 CurrentConceptsandUnresolved 2 SpermChromatinStabilityand QuestionsinHumanSpermCumulus SusceptibilitytoDamageinRelationto andZonaInteraction 152 ItsStructure 21 ChristopherJ.DeJongeandChristopherL.R. W.StevenWard Barratt 3 SpermUltrastructureinFertileMenand 11 Sperm-SpeciicWW-Domain-Binding MaleSterility:Revisiting Proteins 157 Teratozoospermia 36 RichardOko,MahmoudAarabi,JiudeMao, HectorE.Chemes HannaBalakierandPeterSutovsky 4 SpermRNAandItsUseasaClinical 12 FundamentalRoleforSperm Marker 59 PhospholipaseC(cid:2) inMammalian MeritxellJodar,EsterAntonandStephenA. Fertilization 177 Krawetz MichailNomikos,KarlSwannand F.AnthonyLai 5 RoleoftheEpididymisinSperm Maturation 73 13 MaleInfertilityandAssisted RobertSullivanandCle´menceBelleanne´e Reproduction 193 NigelPereira,QueenieV.Neri,TylerCozzubbo, 6 SeminalPlasmaPlaysImportantRolesin StephanieCheung,ZevRosenwaksand Fertility 88 GianpieroD.Palermo SusanS.SuarezandMarianaF.Wolfner 14 TheGeneticBasisofMale 7 PhysiologicalandPathologicalAspects Infertility 208 ofSpermMetabolism 109 AminS.Herati,PeterR.Butlerand ZamiraGibbandRobertJohnAitken DoloresJ.Lamb 8 RegulationofSpermBehaviour:The 15 TheSpermEpigenome 230 Role(s)of[Ca2+] Signalling 126 i TimothyG.JenkinsandDouglasT.Carrell StephenPublicover v © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information Contents 16 EnvironmentalFactorsandMale 18 MouseGenetics–HowDoesItInform Fertility 240 MaleFertilityResearch? 280 TinaKoldJensen,HanneFrederiksen,Katrine LauraO’HaraandLeeB.Smith BayandNielsE.Skakkebaek 17 SusceptibilityoftheTestistoLifestyle andEnvironmentalFactorsDuringthe LifeCourse 260 Index 297 RichardM.Sharpe Colourplatesaretobefoundbetweenpages178 and179. vi © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information Contributors MahmoudAarabi,MD,PhD Cle´menceBelleanne´e,PhD PostdoctoralFellow,DepartmentofHumanGenetics, AssociateProfessorattheDepartmentof SchoolofMedicine,McGillUniversity,Montreal,QC, Obstetrics,GynecologyandReproduction, Canada Universite´Laval,andReproduction,Mother andYouthHealthDivision,CHUdeQue´bec- RobertJohnAitken,PhD Universite´LavalResearchCenter,QC,Canada ProVice-Chancellor,FacultyofHealthandMedicine, LaureateProfessorofBiologicalSciences,Priority PeterR.Butler,BA ResearchCentreforReproductiveScienceand CenterforReproductiveMedicine,Baylor PresidentattheInternationalSocietyofAndrology, CollegeofMedicine,andtheScottDepartment heUniversityofNewcastle,Callaghan,NSW, ofUrology,BaylorCollegeofMedicine,Houston, Australia TX,USA EsterAnton,PhD DouglasT.Carrell,PhD AggregateProfessorattheDepartmentofCell DepartmentofSurgery(Urology)and Biology,PhysiologyandImmunology,Universitat DepartmentofHumanGenetics,Universityof Auto`nomadeBarcelona,Bellaterra(Cerdanyoladel UtahSchoolofMedicine,SaltLakeCity,UT, Valle`s),Spain USA MarkA.Baker,PhD HectorE.Chemes,MD,PhD HeadofReproductiveProteomics,Disciplineof LaboratoryofTesticularPhysiologyand BiologicalSciences,UniversityofNewcastle, Pathology,CEDIE-CONICET,Centerfor Callaghan,NSW,Australia ResearchinEndocrinology,NationalResearch Council,EndocrinologyDivision,BuenosAires HannaBalakier,PhD Children´sHospital,Argentina LaboratoryDirector,CReATeFertilityCentre, Toronto,ON,Canada StephanieCheung,BS RonaldO.PerelmanandClaudiaCohenCenterfor ChristopherL.R.Barratt,PhD ReproductiveMedicine,WeillCornellMedical ProfessorofReproductiveMedicineattheSchoolof College,NewYork,NY,USA Medicine,UniversityofDundee,NinewellsHospital, Dundee,UK TylerCozzubbo,BS RonaldO.PerelmanandClaudiaCohenCenterfor KatrineBay,PhD ReproductiveMedicine,WeillCornellMedical ScientiicWriter,DepartmentofGrowthand College,NewYork,NY,USA Reproduction,Rigshospitalet,Universityof Copenhagen,Denmark,andInternationalCenterfor ChristopherJ.DeJonge,PhD ResearchandResearchTraininginEndocrine Director,AndrologyProgramattheUniversityof DisruptionofMaleReproductionandChildHealth MinnesotaMedicalCenter,andAdjunctProfessorat (EDMaRC),Rigshospitalet,Universityof theDepartmentofUrology,UniversityofMinnesota, Copenhagen,Denmark Minneapolis,MN,USA vii © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information ListofContributors HanneFrederiksen,PhD DoloresJ.Lamb,PhD SeniorResearcherattheDepartmentofGrowthand CenterforReproductiveMedicine,BaylorCollege Reproduction,Rigshospitalet,Universityof ofMedicine,theScottDepartmentofUrology, Copenhagen,andInternationalCenterforResearch BaylorCollegeofMedicine,andtheDepartment andResearchTraininginEndocrineDisruptionof ofMolecularandCellularBiology,Baylor MaleReproductionandChildHealth(EDMaRC), CollegeofMedicine,Houston,TX, Rigshospitalet,UniversityofCopenhagen,Denmark USA ZamiraGibb,PhD JiudeMao,PhD PriorityResearchCentreforReproductiveScience ResearchAssistantProfessor,DivisionofAnimal andDisciplineofBiologicalSciences,heUniversity Sciences,UniversityofMissouri,Columbia,MO, ofNewcastle,Callaghan,NSW,Australia USA, EllenGoossens,PhD QueenieV.Neri,MSc BiologyoftheTestisResearchUnit,VrijeUniversiteit RonaldO.PerelmanandClaudiaCohenCenterfor Brussel,Brussels,Belgium ReproductiveMedicine,WeillCornellMedical College,NewYork,NY,USA AminS.Herati,MD,PhD CenterforReproductiveMedicine,BaylorCollegeof MichailNomikos,PhD Medicine,andtheScottDepartmentofUrology, CollegeofBiomedicalandLifeSciences,Cardif BaylorCollegeofMedicine,Houston,TX,USA University,Cardif,UK TimothyG.Jenkins,PhD LauraO’Hara,PhD DepartmentofSurgery(Urology),UniversityofUtah PostdoctoralResearchFellowattheMRC SchoolofMedicine,SaltLakeCity,UT,USA CentreforReproductiveHealth,Universityof Edinburgh,heQueen’sMedicalResearchInstitute, TinaKoldJensen,MD,PhD Edinburgh,UK ConsultantattheDepartmentofGrowthand Reproduction,Rigshospitalet,Universityof RichardOko,PhD Copenhagen,Denmark,andDepartmentof Professor,DepartmentofBiomedicalandMolecular EnvironmentalMedicine,InstituteofPublicHealth, Sciences,SchoolofMedicine,Queen’sUniversity, UniversityofSouthernDenmark,Odense,Denmark Kingston,ON,Canada MeritxellJodar,PhD GianpieroD.Palermo,MD,PhD PostdoctoralFellow,MolecularBiologyof RonaldO.PerelmanandClaudiaCohenCenterfor ReproductionandDevelopmentResearchGroup, ReproductiveMedicine,WeillCornellMedical Institutd’InvestigacionsBiome`diquesAugustPii College,NewYork,NY,USA Sunyer(IDIBAPS),UniversityofBarcelona, Barcelona,Spain NigelPereira,MD RonaldO.PerelmanandClaudiaCohenCenterfor StephenA.Krawetz,PhD ReproductiveMedicine,WeillCornellMedical AssociateDirectorattheC.S.MottCenterforHuman College,NewYork,NY,USA GrowthandDevelopmentandCharlotteB.Failing ProfessorofFoetalherapyandDiagnosis, StephenPublicover,PhD DepartmentofObstetricsandGynecology,Centerfor ReaderinReproductivePhysiology,Schoolof MolecularMedicineandGenetics,C.S.MottCenter Biosciences,UniversityofBirmingham,Edgbaston, forHumanGrowthandDevelopment,WayneState Birmingham,UK UniversitySchoolofMedicine,Detroit,MI,USA ZevRosenwaks,MD F.AnthonyLai,PhD RonaldO.PerelmanandClaudiaCohenCenterfor Professor,CollegeofBiomedicalandLifeSciences, ReproductiveMedicine,WeillCornellMedical CardifUniversity,Cardif,UK College,NewYork,NY,USA viii © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information ListofContributors RichardM.Sharpe,PhD PeterSutovsky,PhD HonoraryProfessorattheMRCCentrefor Professor,DivisionofAnimalSciences,and ReproductiveHealth,heQueen’sMedicalResearch DepartmentsofObstetrics,Gynecology&Women’s Institute,heUniversityofEdinburgh,Edinburgh, Health,SchoolofMedicine,UniversityofMissouri, UK Columbia,MO,USA NielsE.Skakkebaek,MD KarlSwann SeniorResearcherattheDepartmentofGrowthand CollegeofBiomedicalandLifeSciences,Cardif Reproduction,Rigshospitalet,Universityof University,Cardif,UK Copenhagen,Denmark,andInternationalCenterfor ResearchandResearchTraininginEndocrine DisruptionofMaleReproductionandChildHealth HermanTournaye,MD,PhD (EDMaRC),Rigshospitalet,Universityof CentreofReproductiveMedicine,University Copenhagen,Denmark HospitalUZBrussel,Brussels,Belgium LeeB.Smith,PhD W.StevenWard,PhD Professor,ChairofGeneticEndocrinologyandHead ProfessorandDirectorattheDepartmentof ofMaleHealthResearch,MRCCentrefor Anatomy,BiochemistryandPhysiology,Institute ReproductiveHealth,UniversityofEdinburgh,he forBiogenesisResearch,andChief,Research Queen’sMedicalResearchInstitute,Edinburgh,UK DivisionandLakshmiDeviandDevrajSharma SusanS.Suarez,PhD EndowedChair,DepartmentofObstetricsand DepartmentofBiomedicalSciences,Cornell GynecologyandWomen’sHealth,JohnA.Burns UniversityCollegeofVeterinaryMedicine,Ithaca, SchoolofMedicine,UniversityofHawaiiatManoa, NY,USA Honolulu,HI,USA RobertSullivan,PhD MarianaF.Wolfner,PhD ProfessorattheDepartmentofObstetrics, DepartmentofMolecularBiologyandGenetics, GynecologyandReproduction,Universite´Laval,and CornellUniversity,Ithaca,NY,USA Reproduction,MotherandYouthHealthDivision, CentrederechercheduCHUdeQue´bec-Universite´ Laval,QC,Canada ix © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-1-107-12632-9 — The Sperm Cell 2nd Edition Frontmatter More Information Foreword Eggs are made for sperm. Sperm are made for eggs. spring.Whatisfoundinonespeciesmustbeextrapo- Allother(body)cellsaremadetosupport,directlyor latedtootherspecieswithcaution. indirectly,thedevelopmentofeggsandspermandthe Today,itistheoreticallypossibletoreproduceany survivaloftheirunitedproduct:thezygote–thenext mammals without males. In fact, hundreds of cows generation. he prime function of spermatozoa is to have already been produced by somatic cell nuclear deliver the male genome safely into eggs. Any errors transfer. Clearly, males are not essential for ani- during sperm formation, maturation and union with mal and human reproduction. Why are there males? eggswillresultinseriousproblemsinthemale’sfertil- At the beginning of life on Earth, there were no ityandinthewellbeingoftheofspring. males.Femalesreproducedbythemselves.Duringthe hisbookcoversourcurrentknowledgeof(1)the courseofevolution,abisexualmodeofreproduction formationofspermatozoa,(2)thepreparationofsper- emerged,andithasbeenmaintainedinmostanimals, matozoaforfertilization,(3)theunionofspermatozoa includinghumans.Comparedwithanimalspropagat- witheggs,(4)theawakeningof‘sleeping’eggsbysper- ingunisexually(femalesonly),animalsusingabisex- matozoaleadingtoembryodevelopment,(5)genomic ualmodeofreproductionseemtobelessvulnerableto and nongenomic (e.g. environmental) factors afect- extinctioninthefaceofconstantlychanging,compet- ingthedevelopmentandfertilityofspermatozoa,and itiveenvironments.Technically,humancloning(non- (6) the challenges of overcoming male (sperm) fer- sexualreproduction)ispossibletoday.Inotherwords, tility problems. Information compiled in each chap- humanscanreproducewithoutmales.Isthiswhatwe ter should be considered a stepping stone to better desire? A few years ater the birth of Dolly (a cloned understandingandbettercontrolofmalefertilityand sheep)andmanyclonedmice,Igavetalkstogroupsof infertility. peopleaboutanimalandhumancloning.Attheendof he very irst chapter of this book mentions the mytalkIaskedtheaudienceiftheywantedtolivein possibleproductionof‘artiicialhumanspermatozoa’ aworldwithoutmen.Withnoexception,womendid from pluripotent stem cells such as human iPSCs. notwanttoliveintheworldwithoutmen.‘Itwouldbe Obviously,itisnotappropriatetouseliveanimalsor boring.Wecannotusemen?hatwouldbehorrible.’ get assistance from live animal cells to achieve this Menareneededbywomen,andwewillstaythatway. goal. To eliminate or minimize the stress and risks WhenIstartedresearchasanundergraduatestu- thesecellswouldfaceduringtheirtransformationinto dent, I thought everything written in books and haploidcells,wemustlearnmuchmoreaboutwhatis research papers was a fact. I now know that what is reallyhappeninginthenaturalenvironmentofsper- written is authors’ interpretations or just a part of matogeniccells,withinthetestes.helastchaptercon- the whole story. Many things written in books and sidersthevalueofthemouseasamodelforthestudy reportedinoriginalpaperswillbemodiiedandeven ofmammalianfertilityandinfertility.Isthemousea discarded during the next 40–50 years. Science pro- perfect animal model to use for the study of fertil- gressesthatway. ityandinfertilityofallmammals,includinghumans? hecomprehensivecollectionoftopics thatcom- Althoughthemouseiscertainlyoneofthemostheav- posethisneweditionofheSpermCellprovideread- ilyusedmodelanimalsforstudyingmammalianfer- ers with a map and compass to chart a course for tilityandreproduction,wemustrememberthateach futureinvestigations.Itisthereaders’taskaterreading animalusesspecies-speciictacticstoproduceitsof- thesehighlytopicalresearchareastodeterminewhat x © in this web service Cambridge University Press www.cambridge.org
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