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The Role of Psychodynamic Assessment in Diagnosis and Treatment of Personality Disorders Reliability and Validity of the Developmental Profle Theo Ingenhoven Dedicated to Robert E. Abraham for all his wise lessons This thesis was supported by the Symfora group, Centers for Mental Healthcare Amersfoort, Erasmus University Rotterdam, the Developmental Profle Foundation in Amsterdam, and the J.E. Jurriaanse Stichting. Cover design: Harrald and Job Kerklaan: Ko-productions Printed by: Spinhex & Industrie, Amsterdam ISBN/EAN: 978-90-9024532-4 © Copyright: T.J.M. Ingenhoven. Utrecht, 2009. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any and with love to Aglaé means, electronic or mechanical, including photocopying, recording or any information storage and Merlijne and Clarinde retrieval system, without written permission of the copyright owner. Promotiecommissie Promotoren: Prof.dr. J. Passchier The Role of Psychodynamic Assessment Prof.dr. W. van den Brink in Diagnosis and Treatment of Personality Disorders Overige leden: Prof.dr. J.J. van Busschbach Reliability and Validity of the Developmental Profle Prof.dr. J. Dekker Prof.dr. M. Hengeveld De betekenis van psychodynamische diagnostiek voor Co-promotor: Dr. H.J. Duivenvoorden diagnose en behandeling van persoonlijkheidsstoornissen Betrouwbaarheid en validiteit van het Ontwikkelingsprofel. Proefschrift ter verkrijging van de graad van Doctor aan de Erasmus Universiteit Rotterdam, op gezag van de rector magnifcus Prof.dr. H.G. Schmidt en volgens besluit van het College voor Promoties De openbare verdediging zal plaatsvinden op dinsdag 24 november 2009 om 13.30 uur in Rotterdam. door Theodorus Josephus Maria Ingenhoven geboren te Tilburg Contents Chapter 7 T reatment Disrupting Behaviors during Psychotherapy of Patients with Personality Disorders: The Predictive Power of Psychodynamic Personality Diagnosis. Theo Ingenhoven, Wim van den Brink, Jan Passchier & Hugo Duivenvoorden Introduction Chapter 8 P redictive Value of Psychodynamic Personality Assessment for Chapter 1 Perspectives on Diagnosis of Personality. Scope of the Thesis Outcome of Inpatient Psychotherapy for Personality Disorders. Theo Ingenhoven, Hugo Duivenvoorden, Jan Passchier & Wim van den Brink Chapter 2 M aking Diagnosis more Meaningful. The Developmental Profle: a Psychodynamic Assessment of Personality Epilogue Theo Ingenhoven & Robert Abraham Chapter 9 General Discussion Reliability of Psychodynamic Personality Assessment Summary Samenvatting Chapter 3 The Developmental Profle: Preliminary Results on Interrater List of Publications Reliability and Construct Validity Dankwoord H enricus Van, Theo Ingenhoven, Ico van Foeken, Adriaan van ’t Spijker, Curriculum Vitae Philip Spinhoven & Robert Abraham. Chapter 4 Interrater Reliability for Kernberg’s Structural Interview for Assessing Personality Organization T heo Ingenhoven, Hugo Duivenvoorden, Janneke Brogtrop, Anne Lindenborn, Wim van den Brink & Jan Passchier Convergent Validity of the Developmental Profle Chapter 5 “ Here and Now” or “There and Then”? Convergent Validity of Psychodynamic Personality Assessments using Different Interview Methods. T heo Ingenhoven, Wim van den Brink, Jan Passchier & Hugo Duivenvoorden Predictive Validity of the Developmental Profle Chapter 6 Treatment Duration and Premature Termination of Psychotherapy in Personality Disorders: Predictive Validity of the Developmental Profle assessing Psychodynamic Personality Diagnosis. Theo Ingenhoven, Hugo Duivenvoorden, Jan Passchier & Wim van den Brink Introduction Chapter 1 Perspectives on Diagnosis of Personality Scope of the Thesis 12 introduction | chapter 1 introduction | chapter 1 13 The aim of this thesis is to improve our understanding of the role of psychodynamic models, and their assessment procedures, in diagnosis and treatment of patients with personality disorders. In this introduction we briefy describe the current status of personality disorders and their treatment (1.1); diagnostic strategies for personality disorders (1.2); the Developmental Profle as the instrument for psychodynamic personality diagnosis in study (1.3); a Contents of this chapter comprehensive model for establishing reliability and validity by empirical research (1.4); and the treatment center where we conducted our research (1.5). Finally, we present the aims of this thesis and the research questions involved (1.6), and 1.1 Personality disorders and their current treatment briefy outline the contents of this thesis (1.7) 1.2 Diagnostic strategies for personality disorders 1.3 Psychodynamic diagnosis and the Developmental Profle 1.4 V alidation strategies for diagnostic models and their assessment procedures 1.1 Personality disorders and their current treatment 1.5 Intensive treatment for personality disorders 1.6 Scope of this thesis: aims and research questions Personality disorder is a common psychiatric diagnosis, whether as a primary focus 1.7 Contents of the thesis for therapy, or as a co-morbid diagnosis complicating the course and outcome of 1.8 References the treatment of other psychiatric disorders. The lifetime prevalence of personality disorders within the general population is estimated to be about 10-12%. Its presence is associated with substantial impairment, loss of social functioning, increased family burden and high health care costs. Limited evidence available so far suggests that patients with personality disorder are extensive users of psychiatric services and other mental health care resources (Soeteman et al., 2008). The effectiveness of psychotherapy and pharmacotherapy for personality disorders is well documented with favorable randomized clinical trails, meta-analyses and systematic reviews (CBO, 2008; Leichsenring et al., 2008; Rinne & Ingenhoven, 2007; a and b Ingenhoven et al., 2009 ). Generally, psychotherapy is advocated as a cost-effective and necessary intervention (Beecham et al., 2005; Bartak et al., 2007). But not every patient with a personality disorder seems to beneft from psychotherapeutic treatment. Research suggests that improvement during psychotherapy is signifcantly associated with the length of treatment duration (number of outpatient sessions, weeks in day hospital or inpatient treatment), but outcome does not seem to be systematically correlated with sociodemographic features, pre-treatment descriptive psychiatric diagnoses on DSM IV Axis I and Axis II, and with symptom severity at admission (Ford, Fisher and Larson, 1997; Bateman & Fonagy, 1999; Vermote, 2005; Leichsenring & Rabung, 2008; Spinhoven, Giesen-Bloo, van Dyck & Arntz, 2008). Yet, it is of clinical interest to know which personality disorder patients will beneft from intensive psychotherapy programs, and which patients will not. Research fndings suggest that different types of patients may respond in different ways to 14 introduction | chapter 1 introduction | chapter 1 15 different kinds of treatments (Blatt, 1992, 1994), and that the major determinants disorders (although some DSM-IV instruments for the assessment of personality of therapeutic success appear to depend on the patients’ personality characteristics. disorders, like SCID-II, have partly incorporated this strategy). The psychological qualities a patient brings in to the treatment are often assumed 3) T he strategy of exhaustion “depicts diagnosis as a two-stage process” (Sackett, 1991, to be highly important in determining treatment outcome (Lambert & Asay, 1984). p. 13). The frst step of this dragnet strategy is to collect all relevant data (without However, very little is known about which personality characteristics have the power paying immediate attention to them), followed by the second step of “sifting to predict the outcome of psychotherapy in personality disorder patients. Personality through the data for the diagnosis”. In clinical interviews this strategy is seldom characteristics are regarded as one of the most relevant clinical factors predicting the used, but in the use of self-report questionnaires for the assessment of personality course and outcome of treatment. Although DSM-IV is still regarded to be the standard traits, this strategy is rather common. when it comes to the diagnostic classifcation of personality disorders, there is no 4) T he hypothetico-deductive strategy is the most common strategy in the diagnostic process evidence for the clinical utility of Axis II diagnosis in individual case formulations, in routine clinical practice. “It is the formulation, from the earliest clues of a short or clinical decision making like planning the most appropriate psychotherapeutic list of potential diagnoses…., followed by…. maneuvers that will best reduce the treatment offer. As today, it is unclear which patient will beneft most from what kind length of the list” (Sackett, 1991, p. 16). This is done by gathering data that disprove of treatment. Therefore, emphasis is placed on the development of diagnostic models or support working hypotheses. In the personality domain this strategy is explicitly and assessment strategies to unfold relevant personality characteristics in predicting used as a specifc assessment procedure for diagnostic purposes in the “Structural longitudinal course and treatment effectiveness, i.e. patient-treatment matching. Interview” as developed by Kernberg (1984). In the consulting room, clinicians traditionally rely heavily on the hypothetical- 1.2 Diagnostic strategies for personality disorders deductive approach to construct a clear picture of the unique complains and problems of the individual in the light of his/her habitual behavioral patterns and social From the perspective of a traditional medical approach Sacket et al. (1991) performances (van Yperen & Hirs, 1995). During the diagnostic process (fgure 1), distinguishes four clinical strategies to come to a diagnosis: pattern recognition; the clinicians integrate data derived from all different domains: disease specifc clinical multiple-branching or arborization strategy; the strategy of exhaustion or dragnet history, biography, psychiatric and family history, self-report questionnaires and strategy; and the hypothetico-deductive approach. other specifc assessment procedures (Gabbard, 1994). These data can be obtained 1) Pattern recognition is described as “the instantaneous realization that the patient’s from a direct confrontation with the patient, his/her relatives or by reports of earlier presentation conforms to a previously learned picture (or pattern) of disease” treatment efforts. During this hypothetico-deductive and integrative process clinicians (Sackett, 1991, p. 5). In psychiatry, examples of this “gestalt method” are the are infuenced by “explanatory ideas” (Sackett, 1991, p16), schemata and paradigms instantaneous recognition of schizophrenic catatonia or severe Parkinsonism induced derived from current classifcation systems based on a variety of theoretical models. by anti-psychotic medication. Most of the time personality disorders are not reliable These models give guidance through the labyrinth of concepts and constructs that recognized at frst glance since the outwardly presentation of the persona, the mask, crosses their minds. can represent the facade behind which maladaptive personality traits can be hidden. Assessment procedures for personality characteristics, such as self-report The patient can present himself stronger than he is (“faking good”), or even worse questionnaires, specifc semi-structured interview methods, and inferential techniques (“faking bad”). So, more time and other information are needed to build up a like projection tests can be helpful to gather data in a more specifc and formalized clear picture before drawing fnal conclusions and, therefore, pattern recognition is way, which enable us to bring to the surface underlying traits, structural derivates or probably not the most suitable strategy for identifying personality disorder diagnosis. psychodynamic characteristics of the patients’ personality. Most of these instruments 2) In the multiple-branching or arborization strategy, the diagnostic process follows “preset rely on the dragnet strategy. paths by a method in which the response to each diagnostic inquiry automatically Data derived from different sources should be integrated, during the diagnostic determines the next inquiry to be carried out and, ultimately, the correct diagnosis” process, to enable the clinician to come to a fnal conclusion, the individualized (Sackett, 1991, p. 6). In DSM-IV we fnd several decision trees for the differential diagnostic case formulation. So, theory based classifcations, diagnostic processes diagnosis of axis I disorders, but not for personality disorders on Axis II. However, and assessment procedures are not fully mutual exchangeable, but have their own such algorithms are not common in the literature on the diagnosis of personality underpinnings and can be complementary to one another. Today, our multi-conceptual, 16 introduction | chapter 1 introduction | chapter 1 17 multi-method and multi-trait approach relies on integration of information derived from Figure 2 divergent sources during the diagnostic process. Personality: diagnostic instruments As stated elsewhere (Abraham et al, 2001; Abraham, 2005; Ingenhoven, 2005), Theoretical explanation Figure 1 Assessment? Diagnosis? Classification? Diagnostic process Assessment Classification intake Ideal Nosologic instrument system interviews global problem description Hypothesis tests hypothesis type disorder questionnaires specific diagnostics Clinical Empirical etc. deduction observation validation Diagnostic case formulation classification advise e.g. DSM IV treatment purposes. However, the explicit “a-theoretical” background of these efforts limit the van Yperen & Giel, 1995 possibility to explain the way people with specif c personality disorders feel, think and act. Unfortunately, these diagnostic labels also do not give suff cient information to instruments and methods for personality diagnostics should (1) be related to relevant allocate patients to specif c treatment approaches, and the predictive power of these clinical observations to make the functional signif cance of habitual behavior explicit; instruments with respect to effective treatment allocation has never been established. (2) have a theoretical-explanatory frame of reference to arrange the observations Although these descriptive phenomenological and a-theoretical approaches have in a meaningful hierarchical way in order to explain their clinical signif cance, and attributed to a common nosologic nomenclature, and to basic epidemiological (3) should be constructed in a way that empirical research is feasible to establish knowledge about personality disorders, it is unlikely that they will contribute to the its reliability and aspects of its internal and external validity. An ideal instrument for process of indication and treatment allocation to specif c treatment approaches in personality diagnosis should simultaneously satisfy all three conditions (f gure 2), but clinical practice, because of the lack of an explanatory framework. in clinical practice such an ideal instrument does not exist yet. All current instruments have their advantages and disadvantages when it comes to the clinical-observational, Theory driven understanding of habitual behavioral patterns theoretical-explanatory, and statistical-empirical requirements. The theoretical understanding of personality pathology can be approached from a number of viewpoints, e.g. the psychodynamic, interpersonal, cognitive, and Clinical observations as a conceptual point of departure evolutionary-biological perspective (Clarkin & Lenzenweger, 1996). Psychodynamic Based on the descriptive-phenomenological tradition of clinical psychiatry we f nd models provide a rich frame of reference for understanding the “structural” or the current operationalization of several personality disorders distinguished as discrete “motivational” aspects of human behavior. Based on principles of the object relation categories within the Diagnostic and Statistical Manuals such as DSM-IV and ICD-10 theory, Kernberg (1984) signif cantly extended the traditional psychiatric interview (f gure 3). Diagnostic instruments, such as the SCID-II and the IPDE, were developed in his Structural Interview (f gure 3). Relying both on direct clinical observations in order to establish reliable measures for empirical research and clinical diagnostic and theoretical anchor points like reality testing, identity characteristics and 18 introduction | chapter 1 introduction | chapter 1 19 defense mechanisms, Kernberg uses a hypothetico-deductive strategy to f nd the Till today, its predictive and incremental value for treatment allocation is hardly tested. patients’ underlying “personality organization”. This process takes place during the Despite its recommendations for clinical diagnosis and treatment planning, the Structural Interview. Although, the reliability and validity of this clinical model and MMPI-2 lacks a solid theoretically based explanatory system (Eurelings-Bontekoe, its accompanying assessment procedure were hardly empirical evaluated during the Onnink, Williams & Snellen, 2008). last decades, this hierarchical model is frequently used by clinicians who search for a global orientation with respect to their patients’ ego-strength. Other efforts to bridge the gap between observational-exploratory models and 1.3 P sychodynamic diagnosis and the empirical standards can be found in the ongoing research on defense mechanisms and Developmental Prof le attachment styles, using self-questionnaires or specif c diagnostic interviews. From a theoretical developmental-psychological stance the Developmental Prof le (Abraham, 1993, 1997, 2005; Abraham et al, 2001) attempts to standardize Figure 3 psychodynamic personality diagnostics for clinical diagnosis and treatment planning, and to make it more accessible for empirical validation. Its semi-structured interview Personality: diagnostic instruments relies on the dragnet strategy and provides a comprehensive overview of adaptive and Theoretical explanation maladaptive behavioral patterns during the past ten years of life. The DP describes Structural Interview the degree to which psychosocial functioning is determined by mature adaptive and by “early” maladaptive behavioral patterns (Abraham, 1993; Abraham & van Dam, 2004). DP consists of a matrix of 10 Developmental Levels (rows) and 9 Developmental Lines TCI Development Profile (columns) (Table 1). Each Developmental Level describes a central characteristic in the development of psychosocial capacities. These central characteristics are, in ascending order of development, Lack of Structure, Fragmentation, Self-centeredness, Symbiosis, Resistance, Rivalry, Individuation, Solidarity, Generativity, and Maturity (Appendix 1; this chapter). Each DP-level score is made on the basis of the nine psychosocial domains representing the Developmental Lines (Appendix 2; this chapter), referring to Social Attitudes, Object NEO-PI-R Relations, Self-Images, Norms, Needs, Cognitions, Problem Solving (thoughts and feelings), Problem Solving Clinical Empirical (actions), and Miscellaneous Themes. Developmental levels in the DP matrix are hierarchically observation DSM-IV MMPI-2 validation organized, according to the degree to which they affect psychosocial functioning, and range from a primarily primitive level (Lack of Structure) to ultimately mature level (Maturity). These Levels are not assumed to be mutually exclusive. The lowest six Developmental Levels (Lack of Structure, Fragmentation, Self-centeredness, Symbiosis, Resistance and The empirical approach as the leading principle Rivalry) refer to maladaptive behaviors, while the highest four Developmental Levels Current instruments for personality diagnostics that are primarily developed from (Individuation, Solidarity, Generativity and Maturity) refer to adaptive functioning. an empirical perspective are for instance the NEO-PI-R (Big Five) and the MMPI-2, DP is assessed with a semi-structured interview. A detailed description is obtained (f gure 3). Although the Big Five is based on a lexical theory of normal personality of the patients’ daily functioning over the past ten years, by focusing on the way the characteristics and is extensively tested on its reliability and validity, it lacks a solid patient functions in the context of family and friendships, education and work, sports theoretical-explanatory frame of reference to explain psychopathologic behavioral and hobbies. Other issues include distressing events and feelings of fear, anger, guilt, patterns in a clinical useful way. This makes it diff cult for clinicians to rely directly on shame, and self-esteem. The interview lasts 2–3 hours and is usually spread over the results of this instrument because the scorings on the domains and facets, and the two sessions. To interpret the verbatim information derived from the interviews, a prof le derived from it, f rst have to be “translated” or “theoretically interpreted” for scoring protocol is used. This protocol describes in observational terms all 90 items practical clinical purposes. The MMPI-2 is confronted with the same limitations. comprising the DP-matrix (10 DP-levels x 9 PD-lines). The rater indicates on a

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