PROCEEDINGS OF THE NUTRITION SOCIETY EDITED FOR THE NUTRITION SOCIETY J. C. MATHERS Proceedings of the English Group J. QUARTERMAN Proceedings of the Scottish Group D. A. T. SOUTHGATE Chairman of the Editorial board VOLUME 50, 1991 CAMBRIDGE UNIVERSITY PRESS CAMBRIDGE - LONDON - NEW YORK PUBLISHED BY THE SYNDICS OF THE CAMBRIDGE UNIVERSITY PRESS The Pitt Building, Trumpington Street, Cambridge CB2 1RP 40 West 20th Street, New York, NY 10011-4211, USA 10 Stamford Road, Oakleigh, Melbourne 3166, Australia © The Nutrition Society 1991 Printed in Great Britain by Lamport Gilbert Ltd Wantage Road, Reading, England [v] CONTENTS OF VOLUME 50, 1991 (All rights reserved) Task Force Report (5 July 1990) Does the Nutrition Society serve the needs of its overseas members? A. A. Jackson Assessment of Zinc Status (Workshop: 26-28 September 1989) The assessment of zinc status: a personal view. Peter J. Aggett Assessment of zinc status. R. P. H. Thompson Nutrition and the Schoolchild (Workshop: 26-28 September 1989) Food, vitamins and IQ. M. Nelson Nutrient intake in schoolchildren: some practical considerations. G. McNeill, L. Davidson, D. C. Morrison, I. K. Crombie, J. Keighran & J. Todman Nutrition education in Scottish schools. Notes taken by M. E. J. Lean from a presentation by Moira McFarlane Food choices and preferences of schoolchildren. Jane Thomas Diet Selection (Symposium Proceedings: 29/30 March 1990) Diet selection by animals: theory and experimental design. G. C. Emmans 59-64 Mechanisms of diet selection: the translation of needs into behaviour. Peter J. Rogers & John E. Blundell 65-70 Diet selection — an ecological perspective. R. Moss 71-75 Diet selection by grazing animals. John A. Milne 77-85 Diet selection of pigs and poultry. S. P. Rose & I. Kyriazakis 87-98 Sensory and experiential factors in the design of foods for domestic dogs and cats. J. W. S. Bradshaw 99-106 Development of food choice during infancy. Peter Wright 107-113 Obituary Notice Obituary Notice, R. H. Smith (1924-1991). A. B. McAllan Nutrient—Gene Interactions (Symposium Proceedings: 4-6 July 1990) Nutritional and hormonal regulation of genes for lipogenic enzymes. Alan A. Goodridge, Dominic A. Fantozzi, Stephen A. Klautky, Xiao-Jun Ma, Cesareo Roncero & Lisa M. Salatti 115-122 Trace element-gene interactions with particular reference to zinc. John K. Chesters 123-129 Molecular biology and vitamin D function. D. E. M. Lawson & E. Muir 131-137 Genetics of obesity and human energy metabolism. Claude Bouchard, Jean- Pierre Despres & Angelo Tremblay 139-147 vi CONTENTS Fibre Digestion in Farm Livestock (Symposium Proceedings: 4-6 July 1990) Effects of microbial synergism on fibre digestion in the rumen. Burk A. Dehority 149-159 Digestion of non-starch polysaccharides by non-ruminant omnivores. J. C. Mathers 161-172 Genetic modification of fibre digestion. Harry J. Gilbert & Geoffrey P. Hazlewood 173-186 Manipulation of fibre digestion in the rumen. E. R. Orskov 187-196 Clinical Aspects of Protein and Energy Metabolism (Symposium Proceedings: 4-6 July 1990) Whole-body protein and amino acid turnover in man: what can we measure with confidence? D. J. Millward, G. M. Price, P. J. H. Pacy & D. Halliday 197-216 Organ-specific measurements of protein turnover in man. Peter J. Garlick, Stephen D. Heys, Margaret A.M cNurlan & Jan Wernerman 217-225 Measurement of energy expenditure: the doubly-labelled-water method in clinical practice. W. A. Coward 227-237 Indirect calorimetry in critical care. James L. Mullen 239-244 Micronutrients and the Immune Response (Symposium Proceedings: 4-6 July 1990) Vitamin E and the immune response. J. Kelleher 245-249 Vitamin A and the immune function. Clive E. West, Jan H. W. M. Rombout, Akke J. van der Zijpp & S. Reinder Sijtsma 251-262 6-Carotene and the immune response. Adrianne Bendich 263-274 Selenium and the immune response. R. J. Turner & Julie M. Finch 275-285 Health Implications of Nutrient-Gene Interactions (Symposium Proceedings: 4-6 July 1990) Possible dietary factors in the induction of diabetes and its inheritance in man, with studies in mice. John M. Stowers & Stanley B. W. Ewen 287-298 Atopy, allergy and the alimentary canal. Elspeth Young 299-303 Fructose intolerance: diet and inheritance. Timothy M. Cox 305-309 Recent Research on the Placenta (Symposium Proceedings: 4-6 July 1990) Current perspectives on placental development and its integration with fetal growth. J. M. Bassett 311-319 Energy and substrate requirements of the placenta and fetus. William W. Hay Jr. 321-336 Placental transport studied by means of isolated plasma membrane vesicles. C. A. R. Boyd 337-343 Perfusion of isolated human placenta. K. R. Page 345-347 Human placental trophoblast culture: one-sided and two-sided models. David L. Bloxham 349-354 In vivo méasurements of placental transport and metabolism. William W. Hay Jr. 355-362 Placental corticotrophin-releasing hormone: activator of the pituitary—adrenal axis in human pregnancy. E. A. Linton, C. D. A. Wolfe & P. J. Lowry 363-370 CONTENTS Modifying the Energy Density of Human Diets (Symposium Proceedings: 4-6 July 1990) Determinants of energy density with conventional foods and artificial feeds. Geoffrey Livesey 371-382 Dietary energy density on using sugar alcohols as replacements for sugar. Aren J. H. Van Es 383-390 Changes in dietary energy with novel proteins and fats. Peter N. Gillatt & S. M. Lee 391-397 Modification of energy density with inhibitors of carbohydrate and fat digestion. Rodney H. Taylor 399-408 Slimming (Symposium Proceedings: 6/7 September 1990) Moderator’s remarks. J. V. G. A. Durnin Obesity and health: why slim? Mary A. T. Flynn & Michael J. Gibney A diet for slimming? Carol A. Bowyer Physiological responses to slimming. Andrew M. Prentice, Gail R. Goldberg, Susan A. Jebb, Alison E. Black, Peter R. Murgatroyd & Erik O. Diaz Exercise for slimming. J. F. Andrews The association of slimming with eating disorders. Ann Leader The Media and slimming. Margaret Ashwell The safety of dieting. J. S. Garrow The Sir David Cuthbertson Medal Lecture 1990 (22/23 November 1990) The effects of injury and joint disease on muscle mass and protein turnover. J. N. Alastair Gibson 501-512 Mediterranean Food and Health (Symposium Proceedings: 21 February 1991) The Mediterranean diet: fish and olives, oil on troubled waters. 7. A. B. Sanders 513-517 The Mediterranean Italian diet: keys to contemporary thinking. Flaminio Fidanza 519-526 Diabetes and hormonal control of glucose homeostasis Hypothalamic regulatory peptides and the regulation of food intake and energy balance: signals or noise? Gareth Williams, Pauline E. McKibbin & H. David McCarthy 527-544 Gut hormones in glucose homeostasis. V. Marks, Linda Morgan, J. Oben & R. Elliott 545-552 Metabolic control of insulin gene expression and biosynthesis. Kevin Docherty, Andrew R. Clark, Valerie Scott & Stuart W. Knight 553-558 Direct and indirect actions of nutrients in the regulation of insulin secretion from the pancreatic \ cells. Peter R. Flatt, Christopher R. Barnett, Omar Shibier & Sara K. Swanston-Flatt 559-566 Regulation of hepatic glucose metabolism by insulin and counter-regulatory hormones. Keith Snell 567-575 Abnormalities of glucose homeostasis in diabetes. Malcolm Nattrass 577-581 Abnormalities of cholesterol metabolism in diabetes. Gerald H. Tomkin & Daphne Owens 583-589 Vill CONTENTS Disturbances of micronutrients and antioxidant status in diabetes. J. J. Strain 591-604 Interrelationships between obesity and diabetes. Lieselotte Herberg 605-617 Hypoglycaemic and anti-hyperglycaemic drugs for the control of diabetes. C. J. Bailey 619-630 Diet components in the management of diabetes. Robert W. Welch 631-639 Traditional dietary adjuncts for the treatment of diabetes mellitus. Sara K. Swanston-Flatt, Peter R. Flatt, Caroline Day & Clifford J. Bailey 641-651 Nutrition in a changing Europe What is nutritional surveillance? W. P. T. James & Ann Ralph 653-6059 The decision making process in nutritional surveillance in Europe. Anna Ferro-Luzzi & Catherine Leclercq 661-672 Nutritional surveillance: experiences from developing countries. S. J. Ismail 673-679 Nutritional surveys: ongoing activities in Europe. B. P. M. Bloemberg & D. Kromhout 681-685 Nutritional implications of political and economic changes in Eastern Europe. W. B. Szostak & W. Sekula 687-693 A case study: Bulgaria. M. Haralanova 695-701 The nutritional implications of changing food systems in Eastern Europe. Bruce Traill & Spencer Henson 703-718 Diet and disease in East and West Germany. Lenore Kohlmeier & Reinhard Dortschy 719-727 ABSTRACTS OF COMMUNICATIONS 4-6 July 1990 The effect of the oestrous cycle in rats on fat and protein selection. H. G. Anantharaman-Barr & J. Décombaz Stable isotope studies of albumin synthesis during normal pregnancy. O. S. Olufemi, T. Lind, P. G. Whittaker & D. Halliday Asymmetric enhancement of cAMP in human placental tissues after treatment with bPTH(1-34). J. M. A. Williams, K. R. Page, D. R. Abramovich, C. G. Dacke & T. M. Mayhew Interactions between feed protein, carbohydrate and fat on the lactational performance of rats. N. C. Friggens, D. E. F. Hay & J. D. Oldham Critical nutrient proportions for lactational success in rats. N. C. Friggens, D. E. F. Hay & J. D. Oldham Effects of long-term feeding of high-fat diets containing triolein or medium- chain triacylglycerols to lactating rats on the disposal of a meal containing the '4C-labelled lipid. Paulo F. A. Souza & Dermot H. Williamson How is the energy budget balanced in well-nourished lactating women? G. R. Goldberg, H. L. Davies, A. M. Prentice, W. A. Coward, M. Sawyer, J. Ashford, P. R. Murgatroyd & A. E. Black Effect of a milk-free diet on fetal cord blood milk antibody levels: a study of normal and atopic mothers. J. A. Lovegrove, S. M. Hampton, Jane Morgan & V. Marks Serum and cord blood levels of anti-ovalbumin and anti-gliadin IgG in atopic and non-atopic pregnant women. R. Morris, S. Hampton, Jane Morgan & V. Marks CONTENTS Seasonality in children’s growth rates in Southern Ethiopia. F. Branca, G. Pastore, T. Demissie & A. Ferro-Luzzi Growth of stunted children given nutritional supplementation and psychosocial stimulation. S. P. Walker, S. M. Grantham-McGregor, C. A. Powell, D. T. Simeon & J. H. Himes The effects of nutritional supplementation on the development of stunted children. S. M. Grantham-McGregor, C. A. Powell, S. P. Walker, P. Fletcher & J. H. Himes Total energy expenditure during childhood and adolescence. P. S$. W. Davies, M. B. E. Livingstone, A. M. Prentice, W. A. Coward, S. E. Jagger, C. Stewart, J. J. Strain & R. G. Whitehead Comparison of simultaneous measures of energy intake and expenditure in children and adolescents. M. B. E. Livingstone, P. S. W. Davies, A. M. Prentice, W. A. Coward, A. E. Black, J. J. Strain & P. G. McKenna Distribution of energy intake in relation to calculated basal metabolic rate and adiposity in a national cohort study. Fiona B. Key, Alison A. Paul, T. J. Cole & M. E. J. Wadsworth 24 h Energy expenditure and basal metabolic rate in female twins. G. McNeill, J. Love, J. S. Smith & D. C. Morrison Does genetic variation influence energy expenditure in cystic fibrosis? A. O’Rawe, J. A. Dodge, A. O. Redmond, I. McIntosh & D. J. H. Brock Increased thermic effect of a standard meal in chronically energy-deficient human subjects. L. S. Piers, M. J. Soares & P. S. Shetty Family food availability and anthropometric status in Gilan, Iran. F. Rabiee & C. Geissler Diet quality, environment and nutritional status in Gilan, Iran. F. Rabiee & C. Geissler Knowledge, diet, and stock decisions of small independent retailers with regard to ‘healthy’ foods. B. J. Tighe, A. Wise & P. Cooper Individuality of portion weights of fat spreads. Catherine H. Kellet & A. Wise How much does the public know about fat intake and heart disease? Janet Cade & Janice Tate General practitioners’ knowledge, attitudes and practices regarding overweight and obesity. Janet Cade & Shaun O'Connell The effect of energy supplementation on noradrenaline-induced thermogenesis, thermic effect of a meal and basal metabolic rate in chronically energy- deficient human subjects. M. Vaz, R. N. Kulkarni, L. S. Piers, M. J. Soares, A. V. Kurpad & P. S. Shetty Aerobic capacity and post-exercise recovery characteristics of chronically energy-deficient labourers. R. N. Kulkarni, A. V. Kurpad & P. S. Shetty Potentiation as a possible mechanism to explain differences in dose response v. single dose infusion of noradrenaline while estimating thermogenic responses in human subjects. A. V. Kurpad, R. N. Kulkarni, M. Vaz & P. S. Shetty The effect of a graded infusion of adrenaline on metabolic rate, forearm electro-myographic activity and oxygen consumption. /. W. Gallen, I. A. Macdonald, K. C. F. Fone & D. G. Maggs The effect on the doubly- and triply-labelled water methods of water hydrogen incorporation into body fat in growing pigs. Paul Haggarty, Brian A. McGaw, Malcolm F. Fuller, Susannah L. Christie & William W. Wong x CONTENTS Evaluation of dual photon absorptiometry for the assessment of body compo- sition. N. J. Fuller, A. Laskey, K. F. Szaz, S. A. Jebb & M. Elia The use of 24 h urine nitrogen to detect bias in the reported habitual food intake of individuals assessed from weighed dietary records. S. Bingham, A. Welch, A. Cassidy, S. Runswick & C. Gill Chronic undernutrition in very-low-birth-weight infants who develop broncho- pulmonary dysplasia. D. C. Wilson, B. G. McClure, H. L. Halliday, M. McCreid & J. A. Dodge Fruit consumption and lung function. B. D. Cox, D. E. Walters, Sharon E. Erzinclioglu & Margaret J. Whichelow Food frequency v. weighed intake data in Scottish men. C. Bolton-Smith & A. C. Milne Nutrient intakes from current, ex- and never smokers: results from the Scottish Heart Health Study. C. Bolton-Smith, M. Woodward, C. A. Brown, W. C. S. Smith & H. Tunstall-Pedoe In vivo measurement of changes in body composition: validation against 12 d continuous whole-body calorimetry. Susan A. Jebb, W. A. Coward, P. R. Murgatroyd, Gail R. Goldberg & A. M. Prentice Does consumption of alcohol with a meal promote fat storage? B. J. Sonko, G. R. Goldberg, P. R. Murgatroyd, W. A. Coward & A. M. Prentice The effect of previous feeding patterns on the oxidation and tissue ('4C) lipid accumulation after a meal containing (1-'*C) triolein in the rat. Alison E. Tedstone, Vera Ilic & Dermot H. Williamson The effect of ageing on glutamine metabolism in skeletal muscle of the rat. M. Parry-Billings, B. Leighton, G. D. Dimitriadis, J. Bond & E. A. Newsholme Lysine metabolism in young turkeys fed on diets containing different levels of lysine. C. Linda Saunderson & Paul E. Waibel The effect of dietary amino acid imbalance on respiration in chick liver. N. S. Jessop, G. Allan, G. Walker & J. P. F. D’Mello The influence of glycine and cysteine supplementation on the metabolic response to Escherichia coli endotoxin in rats fed on diets of marginal protein adequacy. R. F. Grimble, R. Hailwood, A. A. Jackson & C. Persaud Glycine and cysteine supplementation influences weight gain and liver gluta- thione, protein and zinc of rats fed on diets of marginally inadequate protein content. R. F. Grimble, A. A. Jackson & C. Persaud The influence of the dietary protein intake on the response of whole body protein synthesis and degradation to feeding. G. M. Price, D. J. Millward, P. J. H. Pacy & D. Halliday Assessment of protein metabolism in man with '°N-labelled soya bean. M. A. McNurlan, A. El-Khoury, E. Milne & E. B. Fern Bicarbonate recovery: feeding v. time. D. Wenham, P. J. Pacy, D. Halliday, G. M. Price & D. J. Millward Protein conservation in the obese Zucker rat during fasting. N. G. Wijesinghe, D. J. Millward & J. P. W. Rivers Effects of food restriction on sodium and potassium balances in pregnant rats. M. P. Vaquero & M. P. Navarro The effect of inhibiting the bio-availability of additional vitamin Bg on nitrogen utilization in the pig. J. N. Swart, H. P. Spangenberg & H. C. Barnard Intrinsic labelling of peas, chicken meat, eggs, goat’s milk and human milk with Zn. T. E. Fox, S. J. Fairweather-Tait, J. Eagles & S. G. Wharf CONTENTS Apparent zinc absorption by rats from foods labelled intrinsically and extrin- sically with ©’Zn. S. J. Fairweather-Tait, T. E. Fox, S. G. Wharf, J. Eagles, H. M. Crews & R. Massey Zinc nutritive status and immunocompetence in anorexia nervosa. A. Marcos, P. Varela, M. P. Navarro, G. Morande Influence of tea on the availability of copper. M. P. Vaquero, M. Veldhuizen, C. J. A. van den Hamer & G. Schaafsma The effect of non-starch polysaccharide on urea kinetics in normal adult males consuming a low-protein diet. M. Langran, B. J. Moran, Jane Murphy, S. A. Wootton & A. A. Jackson The effect of non-starch polysaccharides on the magnitude and composition of faecal energy in normal healthy adults. Jane Murphy, S. A. Wootton, M. Langran & A. A. Jackson Influence of soluble non-starch polysaccharides and food intake on mucosal cell turnover and some gastrointestinal peptides in the rat. J. T. Johnson & Jennifer M. Gee The effect of low, medium and high molecular weight grades of guar gum on postprandial blood glucose and plasma insulin in non-insulin-dependent diabetics. S. J. Gatenby, P. R. Ellis, L.M . Morgan, F. M. Dawoud & P. A. Judd The effect of guar wheatflakes on postprandial blood glucose, plasma insulin and C-peptide levels in healthy subjects. R. M. Fairchild, P. R. Ellis, S. Luzio, A. Pyrne & M. A. Mir Effect of zinc supplementation on intestinal permeability and morbidity among Bangladeshi children with persistent diarrhoea syndrome. S. K. Roy, R. Haider, A. Tomkins & R. H. Behrens Energy metabolism of pigs of high genetic potential: effects of protein and energy intake. D. S. Rao & K. J. McCracken Effects of feeding level and sex on nitrogen retention and serum insulin-like growth factor-1 in growing pigs. J. A. Taylor, D. N. Salter, W. H. Close, G. H. Laswai & A. Hudson Immune function tests, iron metabolism and susceptibility to infection in primary undernutrition and refeeding. John Murray & Anne Murray Effects of vitamin C on sorbitol in eye lens of guinea-pigs made diabetic with streptozotocin. C. J. Bates & P. H. Evans Vitamin C in stimulated and unstimulated leucocytes in culture. C. J. Schorah, D. J. Royle & S. W. Evans Plasma ascorbate concentrations in human malaria. J. Knowles, D. I. Thurnham, A. V. S. Hill, M. Greenwood & C. M. Tang The effect of vitamin E deficiency on immune function in Wistar rats. L. Purkins, J. Kelleher & R. V. Heatley Tissue concentrations of vitamin E, selenium and thiobarbituric acid reactive substances in ruminant calves depleted of vitamin E, or selenium, or both. D. M. Walsh, S. Kennedy & D. G. Kennedy Inhibitory effect of isomeric cis and trans C-18 monoenoic fatty acids on A6-desaturase activity in human vascular endothelial cells. K. W. J. Wahle, Lesley Milne & C. R. A. Earl Inhibition of enzyme efflux from damaged skeletal muscle: a non-antioxidant role for a-tocopherol? Joanne Pheonix, R. H. T. Edwards & M. J. Jackson xii CONTENTS Measurement and significance of hepatic menaquinones in rats fed on low-fibre diets. M. J. Shearer, N. Kazim & J. C. Mathers The effect of high viscosity guar gum flour on the rate of glucose absorption and net insulin production in the portal blood of the pig. F. G. Roberts, A. G. Low, S. Young, H. A. Smith & P. R. Ellis Effects of sucrose-feeding on in vivo rates of hepatic fatty acid, cholesterol and glycogen synthesis in rats given dietary guar gum or volatile fatty acid salts. Laurentina M. R. Pedroso, J. C. Mathers & Heather J. Finlayson Effects of ageing on the caecal fermentation response to oat-feeding in rats. J. C. Mathers, Julia Kennard & O. F. W. James Effects of dietary fibre (grass) level and time of day on caecal concentrations cf volatile fatty acids and uric acid in the fowl. C. J. Savory & Anne I. Knox Continuous in vitro incubation as a model to study microbial metabolism in the hind-gut of pigs. G. Breves & J. Dreyer Effect of carbohydrate source and protein level on selected plasma character- istics and acetate metabolism of ovine perirenal adipose tissue in vitro. N. D. Scollan & N. S. Jessop Effect of intraruminal propionate infusion on rumen fermentation and whole body glucose turnover rate in forage-fed steers. C. J. Seal, C. S. Roper & D. S. Parker Digestibility of wheat middlings by the weaned pig: comparison of balance and indicator methods. Devina McClean, K. King & K. J. McCracken Patterns of children’s malnutrition in an area of Southern Somalia with multiethnic composition. F. Branca, A. Alas Ali & T. D’Arca Anthropometric indices and risk of mortality allowing for socio-economic differences among Ugandan children. V. Vella, A. Tomkins, I. Cortinovis, T. Marshall, J. Ndiku & V. Ayatomizek Malnutrition as a risk factor for mortality from infectious diseases among Ugandan children. V. Vella, A. Tomkins, J. Ndiku & V. Ayatomizek Impact of Ascaris lumbricoides and other intestinal helminths on intestinal permeability and growth in Bangladeshi children. C. A. Northrop-Clewes, P. G. Lunn, E. Rousham & C. G. N. Mascie-Taylor Sire effects on growth and carcass characteristics of Friesian steers during the finishing period. K. J. McCracken, C. A. Moore, R. W. J. Steen, E. F. Unsworth, D. J. Kilpatrick & F. J. Gordon The influence of adrenalectomy on the ‘anabolic’ effect of testosterone implants in rats. C. J. H. Woodward, R. E. Oakey & E. M. Whitaker Metabolism in vivo of essential fatty acids in man using linoleic acid labelled with carbon-13 stable isotope. A. Smith, Moira Thomas & K. W. J. Wahle The contractile characteristics of rat skeletal muscle following consumption of a low-protein diet. L. B. Levy & S. A. Wootton Characterization of the haemodynamic responses to the ingestion of a high-fat and a high-carbohydrate meal in young subjects. M. B. Sidery, I. A. Macdonald & L. J. Fullwood The effect of a low-fat diet on hormone and metabolite concentrations following a mixed meal in healthy subjects. Linda M. Morgan, Jacki A. Tredger, Jacqueline Wilkinson, Christine M. Williams, A. Zampelas & Vincent Marks Fasting and postprandial hormone and metabolite concentrations in normal and diabetic subjects taking dietary fish-oil supplements. Christine M. Williams, F. Moore, J. Wright, A.Z ampelas & L. Morgan