To the late John Paul Morgan, M.D., chemist, genius, New Yorker, musician, scientist, professor, and friend, who passed away on February 15, 2008. His book Marijuana Myths/Marijuana Facts: A Review of the Scientific Evidence, coauthored with Lynn Zimmer, Ph.D., and published by the Lindesmith Center in 1997, helped debunk the following myths: Marijuana’s harms have been proven scientifically. Marijuana has no medicinal value. Marijuana is highly addictive. Marijuana is a gateway drug. Marijuana offenses are not severely punished. Marijuana policy in the Netherlands is a failure. Marijuana kills brain cells. Marijuana causes an amotivational syndrome. Marijuana impairs memory and cognition. Marijuana can cause permanent mental illness. Marijuana causes crime. Marijuana interferes with male and female sex hormones. Marijuana use during pregnancy damages the fetus. Marijuana use impairs the immune system. Marijuana is more damaging to the lungs than tobacco. Marijuana’s active ingredient, THC, gets trapped in body fat. Marijuana use is a major cause of highway accidents. Marijuana-related hospital emergencies are increasing, particularly among youth. Marijuana is more potent today than in the past. Marijuana use can be prevented. The Pot Book “The Pot Book traces the secret history of marijuana, examines the disconnect between seventy years of prohibition and the American public’s personal attitudes toward pot, and offers a clear-eyed look at all the uses of cannabis, including the growing list of its widespread medicinal benefits. Consulting with the top experts in the field, Dr. Julie Holland presents the current science and makes a compelling case for the need for further research, unencumbered by anti-drug hysteria, as well as an immediate change to our nation’s puritanical drug laws.” JOHN DIOSO, DEPUTY MANAGING EDITOR OF ROLLING STONE “The most-up-to-date and reliable source of information on the exploding frontiers of cannabis science written by the top experts in the field. I highly recommend this book.” STEVEN HAGER, HIGH TIMES CREATIVE DIRECTOR “Dr. Julie Holland has assembled a virtual dream team of cannabis experts for this marijuana magnum opus.” STEVE BLOOM, PUBLISHER OF CELEBSTONER.COM, COAUTHOR OF POT CULTURE AND REEFER MOVIE MADNESS, AND FORMER EDITOR OF HIGH TIMES “Dr. Holland’s brilliant compendium of marijuana facts and cultural insights from the best medical minds and scientific researchers, while acknowledging the potential for abuse, makes a compelling case for cannabis as the most ancient, benign, and uplifting inebriant/sacrament/medicine humanity has ever known. Just say Know.” ALEX AND ALLYSON GREY, ARTISTS AND COFOUNDERS OF THE CHAPEL OF SACRED MIRRORS (COSM) “The Pot Book reveals the truth about cannabis in one timely, evenhanded volume. Dr. Julie Holland has brought together the top experts discussing every aspect of this persistently misunderstood plant. The Pot Book is now the best single source for information and insights on marijuana.” NEAL M. GOLDSMITH, PH.D., AUTHOR OF PSYCHEDELIC HEALING “Are you a lover or hater of the pot world? In either case this book is for you, if you want to be enlightened. I knew the book was a winner as soon as I held it and felt the good vibrations. Read it and tell your friends.” TOMMY CHONG, COMEDIAN, ACTOR, AND CANNABIS ACTIVIST Contents Cover Image Title Page Dedication Epigraph Foreword by Lester Grinspoon, M.D. Introduction PART ONE An Overview of Cannabis Introduction to Part One Chapter 1. The Subjective Effects of Cannabis Matthew G. Kirkpatrick and Carl L. Hart, Ph.D. SOURCE OF MARIJUANA EDUCATION SUBJECTIVE EFFECTS IN THE LABORATORY THE IMPORTANCE OF THE INDIVIDUAL’S HISTORY OF MARIJUANA USE SUBJECTIVE EFFECTS AND ABUSE POTENTIAL CONCLUSION Chapter 2. Early/Ancient History Chris Bennett CANNABIS IN CHINA ANCIENT MIDEAST HISTORY Chapter 3. Recent History David Malmo-Levine KING AND THE ANTI-ASIAN RIOT CANNABIS: THE MOST POPULAR PATENT MEDICINE? FLEXNER AND THE CLOSING OF THE PRO-HERB MEDICAL SCHOOLS HEARST, ANSLINGER, AND MURPHY FDR, MELLON, AND ROCKEFELLER IT GOES ON AND ON . . . THE TREE OF LIFE AND HEAVEN OR HELL RECOMMENDED READING Chapter 4. The Botany of Cannabis Lyle E. Craker, Ph.D., and Zoë Gardner NOMENCLATURE BOTANICAL HISTORY MORPHOLOGY APPLICATIONS CONCLUSION Chapter 5. Cannabis Grow Revolution Danny Danko INDICA VS. SATIVA MALES VS. FEMALES SOIL VS. HYDROPONICS VEGETATIVE VS. FLOWERING GROWTH INDOOR VS. OUTDOOR ORGANIC VS. CHEMICAL: FERTILIZATION ORGANIC VS. CHEMICAL: PEST CONTROL THE MEDICAL MARIJUANA REVOLUTION THE FUTURE OF CANNABIS Chapter 6. The Endocannabinoid System Gregory L. Gerdeman, Ph.D., and Jason B. Schechter, Ph.D. THE CANNABINOID RECEPTORS THE ENDOCANNABINOIDS NEURONAL FREQUENCY AND SYNCHRONY: SETTING TEMPO WITH ECBS REFRAMING THE DISCUSSION: THE “ENDOCANNABINOID SYSTEM” Chapter 7. Anandamide and More Raphael Mechoulam, Ph.D., and Lumír Hanuš THE PLANT CONSTITUENTS THE ENDOCANNABINOIDS Chapter 8. Cannabis Laws in the United States Allen St. Pierre LISTING OF STATE-BY-STATE (AND FEDERAL) CANNABIS LAWS AND PENALTIES Chapter 9. On Ending Prohibition Ethan Nadelmann, J.D., Ph.D. PART TWO Risks of Use and Harm Reduction Introduction to Part Two Chapter 10. Medical Risks and Toxicology William Holubek, M.D. TERMINOLOGY PHARMACOKINETICS AND PHARMACODYNAMICS DRUG TESTING GENERAL TOXICITY MANAGEMENT OF MARIJUANA INTOXICATION MARIJUANA AND CANCER CONCLUSION Chapter 11. Pulmonary Harm and Vaporizers Mitch Earleywine, Ph.D. LUNG CANCER LUNG FUNCTION BRONCHOSCOPE EXAMINATIONS AND BIOPSIES RESPIRATORY ILLNESSES HEALTHIER LUNGS FOR CANNABIS SMOKERS ORAL ADMINISTRATION VAPORIZERS HOLDING HITS RESIN STRONGER MARIJUANA ABSTAINING FROM CIGARETTES CONCLUSION Chapter 12. Cannabis and Cognition Caroline B. Marvin and Carl L. Hart, Ph.D. RELEVANT CANNABINOID NEUROPHARMACOLOGY DIRECT EFFECTS OF CANNABIS ON COGNITION LONG-TERM EFFECTS OF CANNABISON COGNITION CONCLUSION Chapter 13. Mental Health Risks Associated with Cannabis Use Cheryl Corcoran, M.D. CAN CANNABIS USE CAUSE PSYCHOSIS? CAN CANNABIS LEAD TO ANXIETY? CAN CANNABIS LEAD TO DEPRESSION? CONCLUSION Chapter 14. How Real Is the Risk of Addiction? Ryan Vandrey, Ph.D., and Margaret Haney, Ph.D. TOLERANCE WITHDRAWAL UNCONTROLLED USE USE DESPITE PHYSICAL OR PSYCHOLOGICAL PROBLEMS CONCLUSION Chapter 15. Driving Under the Influence Paul Armentano DRUGGED DRIVING: TRUE THREAT OR FALSE PANIC? CRUISING ON CANNABIS: CLARIFYING THE DEBATE DEFINING A RATIONAL “DRUGGED DRIVING POLICY” Chapter 16. Arrest Statistics and Racism Harry G. Levine, Ph.D. Chapter 17. Getting Busted Is Not So Funny An Interview with Tommy Chong Julie Holland, M.D. Chapter 18. The Collateral Consequences of Cannabis Convictions Richard Glen Boire, J.D. EXECUTIVE SUMMARY CONCLUSION POLICY RECOMMENDATIONS Chapter 19. Harm Reduction Psychotherapy Andrew Tatarsky, Ph.D. HARM REDUCTION ACUTE HARMS CHRONIC HARMS FINDING YOUR HEALTHIEST RELATIONSHIP TO MARIJUANA CONCLUSION PART THREE The Clinical Use of Cannabis Introduction to Part Three Chapter 20. The Clinical Applications of Medical Marijuana An Interview with Andrew Weil, M.D. Julie Holland, M.D. Chapter 21. Medical Marijuana Research An Interview with Donald Abrams, M.D. Julie Holland, M.D. Chapter 22. MAPS and the Federal Obstruction of Medical Marijuana Research Rick Doblin, Ph.D. Chapter 23. The Government’s Pot Farm An Interview with Mahmoud a. ElSohly, Ph.D. Julie Holland, M.D. Chapter 24. Cannabinoids and Psychiatry Julie Holland, M.D. THE PSYCHOACTIVE EFFECTS OF CANNABIS ANTI-PSYCHOTIC EFFECTS OF CBD: CANNABIS AND SCHIZOPHRENIA DEPRESSION BIPOLAR DISORDER POST-TRAUMATIC STRESS DISORDER AND OTHER ANXIETY DISORDERS
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