The Plasticity of Skeletal Muscle: From Molecular Mechanism to Clinical Applications

295 Pages·2017·4.26 MB·English

by  Kunihiro Sakuma (eds.)

Kunihiro Sakuma Editor
The Plasticity of
Skeletal Muscle
From Molecular Mechanism
to Clinical Applications
123
The Plasticity of Skeletal Muscle
Kunihiro Sakuma
Editor
The Plasticity of Skeletal
Muscle
From Molecular Mechanism to Clinical
Applications
123
Editor
KunihiroSakuma
InstituteforLiberalArts,EnvironmentandSociety
TokyoInstituteofTechnology
Tokyo,Japan
ISBN978-981-10-3291-2 ISBN978-981-10-3292-9 (eBook)
DOI10.1007/978-981-10-3292-9
LibraryofCongressControlNumber:2017933679
©SpringerNatureSingaporePteLtd.2017
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Preface
In humans, skeletal muscle is the most abundant tissue in the body, comprising
40–50%ofbodymassandplayingvitalrolesinlocomotion,heatproductionduring
periods of cold stress, and the overall metabolism. It is essential for our quality
of life to have healthy muscles. Skeletal muscle possesses a high plasticity for
environmentalstimulationsuchasneuronal,mechanical,hormonal,and/orimmune
factors.Forexample,theincreaseofmechanicalstressinducesmusclehypertrophy
probably due to the upregulation of protein synthesis and of transcription in
muscle-specificstructuralcomponents.Thisbookisaboutskeletalmuscles,molec-
ular mechanism of muscle hypertrophy [AMP-activated protein kinase (AMPK)
and ribosome biogenesis], and atrophy [ubiquitin-proteasome system, autophagy,
cytokine, redox regulation (nitric oxide), and transient receptor potential cation
channels(TRPC)].Inparticular,itisaveryintriguingandcurrenttopicthatchanges
in ribosome biogenesis and translational capacity correlate finely with changes in
musclemassinbothgrowthandwastingconditions.
Muscle loss occurs as a consequence of normal aging (sarcopenia) and several
chronic diseases (cachexia). Muscle loss is also common in muscular dystrophy,
in which markedly loss of various membranous structural proteins occurs around
musclefibers.Thisbookincludesvariousinterventionssuchastherapeuticapproach
usingmuscleandpluripotentstemcellsornutritionalandpharmacologicalapproach
for muscle wasting such as muscular dystrophy, sarcopenia, etc. In addition,
this book also highlights the myokine [interleukin, brain-derived neurotrophic
factor (BDNF), or secreted protein acidic and rich in cysteine (SPARC)] that is
produced and released by muscle cells in response to muscular contractions and
conductsvariousfunctionalroles(e.g.,preventionofseveralcancers).Furthermore,
this book introduces versatile role of peroxisome proliferator-activated receptor
gamma coactivator 1-alpha (PGC-1’) for the mitochondrial biogenesis, formation
of neuromuscular junction, and so on. At present, no other book covering similar
topics is available as a resource book. The majority of this book discusses which
factors modulate the muscle mass of skeletal muscle and which interventions are
effectiveforvariousmusculardisordersbyreferencingcurrentliteratures.
v
vi Preface
For the completion of this book, I want express my personal thanks to all the
chapter contributors who spent substantial effort and their valuable time to make
this publication possible. I am also thankful to Ms. Hemalatha Gunasekaran who
helped me with her excellent editorial assistance. This book can be interesting for
graduate students, postdocs, teachers, physicians, and executives in biotech and
pharmaceuticalcompanies,aswellasresearchersinthefieldsofmolecularbiology
andregenerativemedicineinskeletalmuscle.
Tokyo,Japan KunihiroSakuma
Contents
1 Pluripotent Stem Cells and Skeletal Muscle
Differentiation:ChallengesandImmediateApplications.............. 1
Elena Garreta, Andrés Marco, Cristina Eguizábal,
Carolina Tarantino, Mireia Samitier, Maider Badiola,
JoaquínGutiérrez,JosepSamitier,andNuriaMontserrat
2 RoleoftheUbiquitin-ProteasomePathwayinSkeletalMuscle ....... 37
YasuoKitajimaandNaokiSuzuki
3 StemCellTherapyinMuscleDegeneration............................. 55
Robin Duelen, Domiziana Costamagna,
andMaurilioSampaolesi
4 TheAutophagy-DependentSignalinginSkeletalMuscle.............. 93
KunihiroSakuma,MikiAizawa,HidetakaWakabayashi,
andAkihikoYamaguchi
5 CytokinesinSkeletalMuscleGrowthandDecay....................... 113
ArkadiuszOrzechowski
6 TheRoleofRibosomeBiogenesisinSkeletalMuscleHypertrophy... 141
VandreCasagrandeFigueiredoandJohnJ.McCarthy
7 ComprehensiveApproachtoSarcopeniaandCachexiaTreatment .. 155
HidetakaWakabayashiandKunihiroSakuma
8 The Role and Regulation of PGC-1’ and PGC-1“
inSkeletalMuscleAdaptation ............................................ 179
SéverineLamonandAaronP.Russell
9 CharacteristicsofSkeletalMuscleasaSecretoryOrgan.............. 195
WataruAoi
vii
viii Contents
10 BiologicalRoleofTRPC1inMyogenesis,Regeneration,
andDisease.................................................................. 211
EllaW.Yeung,Kwok-KuenCheung,andKeng-TingSun
11 ROS and nNOS in the Regulation of Disuse-Induced
SkeletalMuscleAtrophy................................................... 231
JeffreyM.HordandJohnM.Lawler
12 ParticipationofAMPKintheControlofSkeletalMuscleMass...... 251
TatsuroEgawa
13 Therapeutic Potential of Skeletal Muscle Plasticity
andSlowMuscleProgrammingforMuscularDystrophy
andRelatedMuscleConditions........................................... 277
GordonS.Lynch
About the Editor
ProfessorKunihiroSakuma Ph.D.,currentlyworksattheDepartmentforLiberal
Arts in Tokyo Institute of Technology. He is a physiologist working in the field
of skeletal muscle. He was awarded a sports science diploma in 1995 by the
UniversityofTsukubaandstartedscientificworkattheDepartmentofPhysiology,
AichiHumanScienceCenter,focusingonthemolecularmechanismofcongenital
muscular dystrophy and normal muscle regeneration. His interest later was turned
tothemolecularmechanismandtheattenuatingstrategyofsarcopenia(age-related
muscleatrophy).Preventingsarcopeniaisimportantformaintainingahighquality
oflifeintheagedpopulation.Hisopinionistoattenuatesarcopeniabyimproving
autophagicdefectusingnutrient-andpharmaceutical-basedtreatments.
ix
Chapter 1
Pluripotent Stem Cells and Skeletal Muscle
Differentiation: Challenges and Immediate
Applications
ElenaGarreta,AndrésMarco,CristinaEguizábal,CarolinaTarantino,
MireiaSamitier,MaiderBadiola,JoaquínGutiérrez,JosepSamitier,
andNuriaMontserrat
Abstract Recent advances in the generation of skeletal muscle derivatives from
pluripotent stem cells (PSCs) provide innovative tools for muscle development,
disease modeling, and cell replacement therapies. Here, we revise major relevant
findings that have contributed to these advances in the field, by the revision of
howearlyfindingsusingmouseembryonicstemcells(ESCs)setthebasesforthe
derivationofskeletalmusclecellsfromhumanpluripotentstemcells(hPSCs)and
patient-derivedhuman-inducedpluripotentstemcells(hiPSCs)totheuseofgenome
editingplatformsallowingfordiseasemodelinginthepetridish.
Keywords Pluripotent stem cells • Differentiation • Genome editing • Disease
modeling
E.Garreta•A.Marco•C.Tarantino•M.Samitier•N.Montserrat((cid:2))
Pluripotentstemcellsandactivationofendogenoustissueprogramsfororganregeneration,
InstituteforBioengineeringofCatalonia(IBEC),Barcelona,Spain
CentrodeInvestigaciónBiomédicaenRedenBioingeniería,BiomaterialesyNanomedicina
(CIBER-BBN),Madrid,Spain
e-mail:[email protected]
C.Eguizábal
BasqueCenterforTransfusionandHumanTissues,Galdakao,Spain
M.Badiola
Nanobioengineeringgroup,InstituteforBioengineeringofCatalonia(IBEC),BaldiriReixac
15-21,08028Barcelona,Spain
J.Gutiérrez
DepartmentofEngineering:Electronics,UniversityofBarcelona,08028Barcelona,Spain
J.Samitier
CentrodeInvestigaciónBiomédicaenRedenBioingeniería,BiomaterialesyNanomedicina
(CIBER-BBN),Madrid,Spain
Nanobioengineeringgroup,InstituteforBioengineeringofCatalonia(IBEC),BaldiriReixac
15-21,08028Barcelona,Spain
©SpringerNatureSingaporePteLtd.2017 1
K.Sakuma(ed.),ThePlasticityofSkeletalMuscle,
DOI10.1007/978-981-10-3292-9_1