The Personalized Diet: The Pioneering Program to Lose Weight and Prevent Disease PDF
Preview The Personalized Diet: The Pioneering Program to Lose Weight and Prevent Disease
Copyright Neither this diet program nor any other diet program should be followed without first consulting a health care professional. If you have any special conditions requiring attention, you should consult with your health care professional regularly regarding possible modification of the program contained in this book. Copyright © 2017 by Eran Segal, PhD, and Eran Elinav, MD, PhD Cover design by Face Out Studios. Photography by Tamara Staples. Cover copyright © 2017 by Hachette Book Group, Inc. Hachette Book Group supports the right to free expression and the value of copyright. The purpose of copyright is to encourage writers and artists to produce the creative works that enrich our culture. The scanning, uploading, and distribution of this book without permission is a theft of the authors’ intellectual property. If you would like permission to use material from the book (other than for review purposes), please contact The publisher is not responsible for websites (or their content) that are not owned by the publisher. Interior illustrations © Noa David, Design, Photography & Printing Branch, Weizmann Institute of Science Library of Congress Cataloging-in-Publication Data Names: Elinav, Eran (Medical doctor), author. | Segal, Eran (Computational biologist), author. | Adamson, Eve, author. Title: The personalized diet : why one-size-fits-all diets don’t work / Eran Elinav, MD, PhD, and Eran Segal, PhD with Eve Adamson. Description: First edition. | New York : Grand Central Life & Style, 2017. Identifiers: LCCN 2017029726| ISBN 9781478918806 (hardback) | ISBN 9781478918783 (audio download) | ISBN 9781478918790 (ebook) Subjects: LCSH: Nutrition. | Weight loss. | BISAC: HEALTH & FITNESS / Nutrition. | HEALTH & FITNESS / Weight Loss. Classification: LCC RA784 .E45 2017 | DDC 613.2/5—dc23 LC record available at https://lccn.loc.gov/2017029726 ISBNs: 978-1-47891880-6 (hardcover), 978-1-47891879-0 (ebook) E3- 20171025-JV-NF CONTENTS Cover Title Page Copyright Dedication Acknowledgments INTRODUCTION: Welcome to the Future of Dieting PART I A Twenty-First-Century Epidemic and the Personalized Nutrition Solution CHAPTER 1: A Bread Story CHAPTER 2: Modern (Health) Problems CHAPTER 3: The Misinformation Highway CHAPTER 4: Everything You Thought You Knew about Nutrition May Be Wrong CHAPTER 5: The Universe Inside Your Gut—and Why It Matters CHAPTER 6: Blood Sugar: Your Ultimate Food Feedback Response CHAPTER 7: The Personalized Nutrition Project PART II The Personalized Diet Program CHAPTER 8: Testing Your Blood Sugar Responses CHAPTER 9: Fine-Tuning Your Personalized Diet CHAPTER 10: Your Personalized Diet Organizer CHAPTER 11: The Future of Dieting About the Authors Notes Newsletters To our teachers, colleagues, and students, for making our joint truth-pursuing journey an enjoyable and moving experience ACKNOWLEDGMENTS The Personalized Diet is a culmination of two years of extensive effort. It translates a large set of results and discoveries stemming from years of grueling scientific research performed at our two labs into a story that is easy to grasp for nonscientists and touches upon the very basis of our lives: our diet, health, risk of becoming obese and developing diabetes and many other “modern diseases,” and the mysterious bacteria that live within us and with us and make us who we are. We are grateful to our agent, Alex Glass, for recognizing that this story should be brought into the broad public and for initiating, assisting, and guiding us throughout the process. We are deeply indebted to Eve Adamson, who has spent countless hours brainstorming, writing, and editing with us, in an effort to bridge the gap between science and common knowledge, to make this book accessible to all. We couldn’t have done this without you! We thank our publisher, Grand Central Publishing, for believing in us and for taking this idea from its raw form, step-by-step through the journey of book creation. In this regard, we especially thank Sarah Pelz and Sheila Curry Oakes for their insights and help in editing the book. We are grateful to the Weizmann Institute of Science for providing us with the complete academic freedom to carry out research that is driven solely by our curiosity to explore the unknown in a way that we deem as most interesting. It is this boundary-free and limitless environment that allows a computer scientist and an immunologist the freedom to decide to study nutrition. The state-of-the- art infrastructure and support of our institute allows us to probe into the very secrets of life. We are deeply thankful to the many students, postdocs, research associates, technicians, and other lab members of the Segal and Elinav labs who have joined, from across the world, this journey of studying nutrition, the microbiome, and how both interact with the human body in promoting health or the risk of disease. From secretaries, to hourly students, to autoclaving personnel, to staff scientists, you are all part of our team. Your creativity, drive, intelligence, diligence, motivation, and endless effort are driving us forward in our quest to cure human disease. We are lucky to be working with such a talented team as yourselves. The stories in this book are your stories as well. I (Eran Segal) wish to thank Eran Elinav for being such a close collaborator and friend, and for just being there day and night, to consult and advise on both small and large issues alike. The different and complementary skills and knowledge that you bring always enrich me with a different and fresh perspective, making the end result much better and the way to get there enjoyable. I (Eran Elinav) would like to thank my partner in crime, Eran Segal, for being a long-standing scientific partner, colleague, and, of no less importance, friend. You come from a different background and speak a different scientific language, but you make our interaction a joyful and fulfilling intellectual and personal experience. We would both like to thank our mutual friend Professor Eran Hornstein (a third Eran!) for recognizing our common scientific interests and introducing us to each other on a cold New Haven afternoon in 2012, which was the beginning of what continues to be a long and fruitful partnership. And last, but not least, we are deeply thankful to our beloved families. Our parents, Rachel and Yoffi Segal, and Rivka and Yankale Elinav; our wives, Keren Segal and Hila Elinav; and our children, Shira, Yoav, and Tamar Segal, and Shira, Omri, and Inbal Elinav. For too many years, we have seen far too little of you, and even less so with the making of this book. But your love, partnership, and continuous support are what make our clock (and microbiome) tick. Keren, your passion for nutrition over the past two decades, which I once ignored, has finally caught up with me and become a major part of my world. I thank you both for that and for the endless discussions and advice that you gave me on the subject. Hila, your wisdom, common sense, healthy skepticism, and (as an infectious disease specialist) your endless knowledge of microbes are always instrumental to me. We will never stop arguing about the role of microbes and human excretions (yes, at dinner; yes, in front of the children) and having a laugh while at it. Keren and Hila, we could never have done any of this without the two of you. INTRODUCTION Welcome to the Future of Dieting Imagine that there was no single food that was bad for everyone or good for everyone—not chocolate, not kale, not cookies, not a big salad, not a banana, not coffee. Imagine something you love to eat—something you think is a terrible dietary choice (but that constantly tempts you, like a juicy, fat steak or a bowl of mint-chip ice cream)—is actually okay to eat and won’t have a negative impact on your health. What if a food you hate—something you force down because you think it is good for you and will help you lose weight or avoid health problems, something like rice cakes or steamed fish—is exactly the wrong thing for you? What if we told you that carb-loading with pasta before endurance sports might be bad for you and slow you down, that diet soda might be directly contributing to your weight gain, or that sushi might be making your blood sugar spike in a way that could increase your risk of diabetes? Imagine no longer having to suffer through painful diets that restrict too many foods. Imagine never having to go through another cleanse, another “induction phase,” another fast, another starvation diet. Imagine eating carbs again, eating fat again, or eating meat again, if that is what you’ve been longing for. And imagine not having to pay attention to the never-ending stream of confusing and contradictory dietary information telling you the foods to eat, or not eat, in order to lose weight or fight chronic disease. Imagine that science has finally begun to scratch the surface of the complex question about the optimal diet and that you no longer have to wonder what is right for you to eat, because you finally understand that there is no single correct diet philosophy that will work for all people. What if each person requires a different diet tailored to his or her own body composition? And that science is only beginning to discover a methodology so an individual can determine exactly what his or her diet should be? What if you finally understood how and why optimal nutrition must (and can) be personalized? What if you could use that information for the benefit of your own health and weight-loss efforts, right now?
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