The ultimate Netter Collection is back! Netter’s timeless work, now arranged and informed by modern text and radiologic imaging! TTTThhhheeee lllloooonnnngggg----aaaawwwwaaaaiiiitttteeeedddd uuuuppppddddaaaatttteeee ooooffff TTTThhhheeee NNNNeeeetttttttteeeerrrr CCCCoooolllllllleeeeccccttttiiiioooonnnn ooooffff MMMMeeeeddddiiiiccccaaaallll IIIIlllllllluuuussssttttrrrraaaattttiiiioooonnnnssss,,,, aaaallllssssoooo kkkknnnnoooowwwwnnnn aaaassss tttthhhheeee CCCCIIIIBBBBAAAA ““““ggggrrrreeeeeeeennnn bbbbooooooookkkkssss,,,,”””” iiiissss nnnnoooowwww bbbbeeeeccccoooommmmiiiinnnngggg aaaa rrrreeeeaaaalllliiiittttyyyy!!!! 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Hansen, PhD Atlas of Human Anatomy, Netter’s Anatomy Flash Cards, 5th Edition, 9781416059516 3rd Edition, 9781437716757 More great Netter resources... FLASH CARDS (cid:377) Netter’s Musculoskeletal Flash Cards, 9781416046301 (cid:377) Netter’s Advanced Head & Neck Flash Cards, 9781416046318 (cid:377) Netter’s Physiology Flash Cards, 9781416046288 (cid:377) Netter’s Histology Flash Cards, 9781416046295 (cid:377) Netter’s Neuroscience Flash Cards, 2nd Edition, 9781437709407 HANDBOOKS/POCKETBOOKS (cid:377) Netter’s Clinical Anatomy, 2nd Edition, 9781437702729 (cid:377) Netter’s Concise Radiologic Anatomy, 9781416056195 (cid:377) Netter’s Concise Orthopaedic Anatomy, 2nd Edition, 9781416059875 (cid:377) Netter’s Concise Neuroanatomy, 9781933247229 (cid:377) Netter’s Surgical Anatomy Review P.R.N., 9781437717921 Get Netter’s Anatomy Atlas for the iPad and Netter flash card apps! Available at the iTunes App Store Netter transforms your perspective. It’s how you know. Browse our complete collection of Netter titles - mynetter.com VOLUME 6 The Netter Collection OF MEDICAL ILLUSTRATIONS Musculoskeletal System Part III—Biology and Systemic Diseases 2nd Edition A compilation of paintings prepared by FRANK H. NETTER, MD Edited by Joseph P. Iannotti MD, PhD Maynard Madden Professor and Chairman Orthopaedic and Rheumatologic Institute Cleveland Clinic Lerner College of Medicine Cleveland, Ohio Richard D. Parker, MD Professor and Chairman Department of Orthopaedic Surgery Orthopaedic and Rheumatologic Institute Cleveland Clinic Lerner College of Medicine Cleveland, Ohio Additional Illustrations by Carlos A. G. Machado, MD CONTRIBUTING ILLUSTRATORS John A. Craig, MD Tiffany S. DaVanzo, MA, CMI Kristen Wienandt Marzejon, MS, MFA James A. Perkins, MS, MFA 1600 John F. Kennedy Blvd. Ste. 1800 Philadelphia, PA 19103-2899 THE NETTER COLLECTION OF MEDICAL ILLUSTRATIONS: ISBN: 978-1-4160-6379-7 MUSCULOSKELETAL SYSTEM, PART III: BIOLOGY AND SYSTEMIC DISEASES, Volume 6, Second Edition Copyright © 2013 by Saunders, an imprint of Elsevier Inc. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Permission for Netter Art figures may be sought directly from Elsevier’s Health Science Licensing Department in Philadelphia, PA: phone 1-800-523-1649, ext. 3276, or (215) 239-3276; or email [email protected] Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. ISBN: 978-1-4160-6379-7 Senior Content Strategist: Elyse O’Grady Content Development Manager: Marybeth Thiel Publishing Services Manager: Patricia Tannian Senior Project Manager: John Casey Senior Design Manager: Lou Forgione Working together to grow libraries in developing countries Printed in China www.elsevier.com | www.bookaid.org | www.sabre.org Last digit is the print number: 9 8 7 6 5 4 3 2 1 ABOUT THE SERIES Dr. Frank H. Netter exemplified the CUSHING’S SYNDROME IN A PATIENT WITH THE CARNEY COMPLEX distinct vocations of doctor, artist, and teacher. Even more important— he unified them. Netter’s illustrations always began with meticulous research into the forms of the body, a philosophy that steered his broad and deep medical understanding. He often said: “Clarifi- Carney complex is characterized cation is the goal. No matter how beau- by spotty skin pigmentation. Pigmented lentigines and blue tifully it is painted, a medical illustration nevi can be seen on the face– including the eyelids, vermillion has little value if it does not make clear bcoonrdjuenrsc otifv athee, tlhipes s, cthleera–and the a medical point.” His greatest challenge labia and scrotum. and greatest success was charting a Additional features of the middle course between artistic clarity Carney complex can include: Myxomas: cardiac atrium, and instructional complexity. That suc- cutaneous (e.g., eyelid), and mammary cess is captured in this series, beginning Testicular large-cell in 1948, when the first comprehensive calcifying Sertoli cell tumors collection of Netter’s work, a single Gsercoewretthin-hgo prmituointaery adenomas Dr. Frank Netter at work. volume, was published by CIBA Phar- Psammomatous melanotic schwannomas maceuticals. It met with such success that over the fol- lowing 40 years the collection was expanded into an 8-volume series—each devoted to a single body system. In this second edition of the legendary series, we are delighted to offer Netter’s timeless work, now arranged and informed by modern text and radiologic imaging contributed by field-leading doctors and teachers from world-renownedmedical institutions, and supple- mented with new illustrations created by artists working PPNAD adrenal glands are usually of normal size and most are studded with black, brown, or red nodules. Most of the pigmented in the Netter tradition. Inside the classic green covers, nodules are less than 4 mm in diameter and interspersed in the adjacent atrophic cortex. students and practitioners will find hundreds of original works of art—the human body in pictures—paired with A brand new illustrated plate painted by Carlos Machado, MD, for The Endocrine System, Volume 2, 2nd ed. the latest in expert medical knowledge and innovation and anchored in the sublime style of Frank Netter. Noted artist-physician, Carlos Machado, MD, the The single-volume “blue book” that paved the way for primary successor responsible for continuing the Netter the multivolume Netter Collection of Medical Illustrations series affectionately known as the “green books.” tradition, has particular appreciation for the Green Book series. “The Reproductive System is of special significance for those who, like me, deeply admire Dr. Netter’s work. In this volume, he masters the representation of textures of different surfaces, which I like to call ‘the rhythm of the brush,’ since it is the dimension, the direction of the strokes, and the interval separating them that create the illusion of given textures: organs have their external surfaces, the surfaces of their cavities, and texture of their parenchymas realistically represented. It set the style for the subsequent volumes of Netter’s Collection—each an amazing combination of painting masterpieces and precise scientific information.” Though the science and teaching of medicine endures changes in terminology, practice, and discovery, some things remain the same. A patient is a patient. A teacher is a teacher. And the pictures of Dr. Netter—he called them pictures, never paintings—remain the same blend of beautiful and instructional resources that have guided physicians’ hands and nurtured their imaginations for more than half a century. The original series could not exist without the dedi- cation of all those who edited, authored, or in other ways contributed, nor, of course, without the excellence of Dr. Netter. For this exciting second edition, we also owe our gratitude to the Authors, Editors, Advisors, Dr. Carlos Machado at work. and Artists whose relentless efforts were instrumental in adapting these timeless works into reliable references for today’s clinicians in training and in practice. From all of us with the Netter Publishing Team at Elsevier, we thank you. THE NETTER COLLECTION OF MEDICAL ILLUSTRATIONS v PAlatBe 1O-1 UT THE EDITORS Musculoskeletal System: PART III Joseph P. Iannotti, MD, PhD, is Maynard Madden Dr. Iannotti has published two textbooks on the Richard D. Parker, MD, is Chairman of the Depart- Professor of Orthopaedic Surgery at the Cleveland shoulder, one in its second edition and the other in its ment of Orthopaedic Surgery at the Cleveland Clinic Lerner College of Medicine and Chairman of third edition. He has authored over 250 original peer- Clinic and Professor of Surgery at the Cleveland Clinic the Orthopaedic and Rheumatologic Institute at the reviewed articles, review articles, and book chapters. Lerner College of Medicine. Dr. Parker is an expert of Cleveland Clinic. He is Medical Director of the Ortho- Dr. Iannotti has over 13 awarded patents and 40 the knee, ranging from nonoperative treatment to all paedic Clinical Research Center and has a joint appoint- pending patent applications related to shoulder pros- aspects of surgical procedures including articular carti- ment in the department of bioengineering. thetics, surgical instruments, and tissue-engineered lage, meniscus, ligament, and joint replacement. He has Dr. Iannotti joined the Cleveland Clinic in 2000 from implants. published more than 120 peer-reviewed manuscripts, the University of Pennsylvania, leaving there as a He has received awards for his academic work from numerous book chapters, and has presented his work tenured professor of orthopaedic surgery and Head of the American Orthopaedic Association, including the throughout the world. Dr. Parker received his under- the Shoulder and Elbow Service. Dr. Iannotti received North American and ABC traveling fellowships and graduate degree at Walsh College in Canton, Ohio, his his medical degree from Northwestern University in the Neer research award in 1996 and 2001 from the medical education at The Ohio State University College 1979, completed his orthopaedic residency training American Shoulder and Elbow Surgeons. He has of Medicine, and completed his orthopaedic residency at at the University of Pennsylvania in 1984, and earned won the orthopaedic resident teaching award in 2006 The Mt. Sinai Medical Center in Cleveland, Ohio. He his doctorate in cell biology from the University of for his role in research education. He was awarded the received his fellowship training with subspecialization Pennsylvania in 1987. Mason Sones Innovator of the Year award in 2012 in sports medicine through a clinical research fellowship Dr. Iannotti has a very active referral surgical practice from the Cleveland Clinic. in sports medicine, arthroscopy, knee and shoulder that is focused on the treatment of complex and revision He has served in many leadership roles at the national surgery in Salt Lake City, Utah. He obtained his CSS problems of the shoulder, with a primary interest in the level that includes past Chair of the Academic Affairs (Certificate of Subspecialization) in orthopaedic sports management of complex shoulder problems in joint Council and the Board of Directors of the American medicine in 2008 which was the first year it was replacement and reconstruction. Academy of Orthopaedic Surgery. In addition he has available. Dr. Iannotti’s clinical and basic science research served and chaired several committees of the American Prior to joining Cleveland Clinic in 1993, Dr. Parker program focuses on innovative treatments for tendon Shoulder and Elbow Surgeons and was President of this acted as head of the section of sports medicine at The repair and tendon tissue engineering, prosthetic design, International Society of Shoulder and Elbow Surgeons Mt. Sinai Medical Center. His current research focuses software planning, and patient-specific instrumenta- in 2005-2006. He is now Chairman of the Board of on clinical outcomes focusing on articular cartilage, tion. Dr. Iannotti has had continuous extramural Trustees of the Journal of Shoulder and Elbow Surgery. meniscal transplantation, PCL, and the MOON funding for his research since 1981. He has been (Multicenter Orthopaedic Outcomes Network) ACL the principal or co-principal investigator of 31 registry. In addition to his busy clinical and administra- research grants totaling $9.4 million. He has been a tive duties he also serves as the head team physician for co-investigator on 13 other research grants. Dr. the Cleveland Cavaliers, is currently President of the Iannotti has been an invited lecturer and visiting pro- NBA Physician Society, and serves as a knee consultant fessor to over 70 national and international academic to the Cleveland Browns and Cleveland Indians. He institutions and societies, delivering over 600 lectures lives in the Chagrin Falls area with his wife, Jana, and both nationally and internationally. enjoys biking, golfing, and swimming in his free time. vi THE NETTER COLLECTION OF MEDICAL ILLUSTRATIONS PREFACE Frank Netter produced nearly 20,000 medical illus- this series will prove to be useful to a wide spectrum of trations spanning the entire field of medicine over both students and teachers at every level. a five-decade career. There is not a physician that has Part I covers specific disorders of the upper limb not used his work as part of his or her education. Many including anatomy, trauma, and degenerative and educators use his illustrations to teach others. One of acquired disorders. Part II covers these same areas in the the editors of this series had the privilege and honor to lower limb and spine. Part III covers the basic science be an author of portions of the original “Green Book” of the musculoskeletal system, metabolic bone disease, of musculoskeletal medical illustrations as a junior rheumatologic diseases, musculoskeletal tumors, the faculty, and it is now a special honor to be part of this sequelae of trauma, and congenital deformities. updated series. The series is jointly produced by the clinical and Many of Frank Netter’s original illustrations have research staff of the Orthopaedic and Rheumatologic stood the test of time. His work depicting basic muscu- Institute of the Cleveland Clinic and Elsevier. The loskeletal anatomy and relevant surgical anatomy and editors thank each of the many talented contributors to exposures have remained unaltered in the current this three-volume series. Their expertise in each of series. His illustrations demonstrated the principles their fields of expertise has made this publication of treatment or the manifestation of musculoskeletal possible. We are both very proud to work with these diseases and were rendered in a manner that only a colleagues. We are thankful to Elsevier for the oppor- physician-artist could render. tunity to work on this series and for their support This edition of musculoskeletal illustrations has been and expertise throughout the long development and updated with modern text and our current under- editorial process. standing of the pathogenesis, diagnosis, and treatment of a wide array of diseases and conditions. We have Joseph P. Iannotti added new illustrations and radiographic and advanced Richard D. Parker imaging to supplement the original art. We expect that THE NETTER COLLECTION OF MEDICAL ILLUSTRATIONS vii PlIaNte 1T-1 RODUCTIONS TO THE FIRST EDITION Musculoskeletal System: PART I INTRODUCTION TO PART I—ANATOMY, neoplasms of bones and soft tissues. Part III, on which Dr. Edmund S. Crelin, professor at Yale University, PHYSIOLOGY, AND METABOLIC DISORDERS I am still at work, will include fractures and dislocations is a long-standing friend (note that I do not say “old” I had long looked forward to undertaking this volume and their emergency and definitive care, amputations friend because he is so young in spirit) with whom I on the musculoskeletal system. It deals with the most (both surgical and traumatic) and prostheses, sports have collaborated a number of times on other phases of humanistic, the most soul-touching, of all the subjects injuries, infections, peripheral nerve and plexus injuries, embryology. He is a profound student and original I have portrayed in The CIBA Collection of Medical burns, compartment syndromes, skin grafting, arthros- investigator of the subject, with the gift of imparting Illustrations. People break bones, develop painful or copy, and care and rehabilitation of handicapped his knowledge simply and clearly, and is in fact a tal- swollen joints, are handicapped by congenital, develop- patients. ented artist himself. mental, or acquired deformities, metabolic abnormali- But classification and organization of this voluminous Dr. Frederick Kaplan (now Freddie to me), assistant ties, or paralytic disorders. Some are beset by tumors material turned out to be no simple matter, since many professor of orthopaedics at the University of Pennsyl- of bone or soft tissue; some undergo amputations, disorders fit equally well into several of the above vania, was invaluable in guiding me through the either surgical or traumatic; some occasionally have groups. For example, osteogenesis imperfecta might difficult subjects of musculoskeletal physiology and reimplantation; and many have joint replacement. The have been classified as metabolic, congenital, or devel- metabolic bone disease. I enjoyed our companionship list goes on and on. These are people we see about us opmental. Baker’s cyst, ganglion, bursitis, and villon- and friendship as much as I appreciated his knowledge quite commonly and are often our friends, relatives, or odular synovitis might have been considered with and insight into the subject. acquaintances. Significantly, such ailments lend them- rheumatic, developmental, or in some instances even I was delighted to have the cooperation of Dr. Henry selves to graphic representation and are stimulating with traumatic disorders. Pathologic fractures might be Mankin, the distinguished chief of orthopaedics at subject matter for an artist. covered with fractures in general or with the specific Massachusetts General Hospital and professor at When I undertook this project, however, I grossly underlying disease that caused them. In a number of Harvard University, for the complex subject of rickets underestimated its scope. This was true also in regard instances, therefore, empiric decisions had to be made in its varied forms—nutritional, renal, and metabolic. to the previous volumes of the CIBA Collection, but in this connection, and some subjects were covered He is a great but charming and unassuming man. in the case of this book, it was far more marked. When under several headings. I hope that the reader will be There were many others, too numerous to mention we consider that this project involves every bone, joint, considerate of these problems. In addition, there is here individually, who gave to me of their knowledge and muscle of the body, as well as all the nerves and much overlap between the fields of orthopedics, neurol- and time. They are all credited elsewhere in this book blood vessels that supply them and all the multitude of ogy, and neurosurgery, so that the reader may find it but I thank them all very much herewith. I will write disorders that may affect each of them, the magnitude advantageous to refer at times to my atlases on the about the great people who helped me with other parts of the project becomes enormous. In my naiveté, I nervous system. of Volume 8 when those parts are published. originally thought I could cover the subject in a single I must express herewith my thanks and appreciation Finally, I give great credit and thanks to the person- book, but it soon became apparent that this was impos- for the tremendous help which my very knowledgeable nel of the CIBA-GEIGY Company and to the company sible. Even two books soon proved inadequate for such collaborators gave to me so graciously. In this Part I, itself for having done so much to ease my burden in an extensive undertaking and, accordingly, three books there was first of all Dr. Russell Woodburne, a truly producing this book. Specifically, I would like to are now planned. This book, Part I, Volume 8 of the great anatomist and professor emeritus at the Univer- mention Mr. Philip Flagler, Dr. Milton Donin, Dr. Roy CIBA Collection, covers basic gross anatomy, embry- sity of Michigan. It is interesting that during our long Ellis, and especially Mrs. Regina Dingle, all of whom ology, physiology, and histology of the musculoskeletal collaboration I never actually met with Dr. Woodburne, did so much more in that connection than I can tell system, as well as its metabolic disorders. Part II, now and all our communications were by mail or phone. about here. in press, covers rheumatic and other arthritic disorders, This, in itself, tells of what a fine understanding and as well as their conservative and surgical management meeting of the minds there was between us. I hope and Frank H. Netter, 1987 (including joint replacement), congenital and devel- expect that in the near future I will have the pleasure opmental disorders, and both benign and malignant of meeting him in person. viii THE NETTER COLLECTION OF MEDICAL ILLUSTRATIONS Introductions to the First Edition INTRODUCTION TO PART II— and hand infections, compartment syndromes, amputa- were not only collaborators and consultants in this DEVELOPMENTAL DISORDERS, TUMORS, tions, both traumatic and surgical, replantation of limbs undertaking but who have become my dear and RHEUMATIC DISEASES, AND JOINT and digits, prostheses, and rehabilitation, as well as a esteemed friends. These are Dr. Bob Hensinger, my REPLACEMENT number of related subjects. consulting editor, who guided me through many puz- In my introduction to Part I of this atlas, I wrote of how As I stated in my above-mentioned previous intro- zling aspects of the organization and subject matter of awesome albeit fascinating I had found the task of duction, some disorders, however, do not fit exactly into this atlas; Drs. Alfred and Genevieve Swanson, pioneers pictorializing the fundamentals of the musculoskeletal a precise classification and are therefore covered piece- in the correction of rheumatically deformed hands system, both its normal structure as well as its multitu- meal herein under several headings. Furthermore, a with Silastic implants, as well as in the classification dinous disorders and diseases. As compactly, simply, and considerable number of orthopedic ailments involve and study of congenital limb deficits; Dr. William succinctly as I tried to present the subject matter, it still also the fields of neurology and neurosurgery, so readers Enneking, who has made such great advances in the required three full books (Parts I, II, and III of Volume may find it helpful to refer in those instances to my diagnosis and management of bone tumors; Dr. Ernest 8 of The CIBA Collection of Medical Illustra- atlases on the anatomy and pathology of the nervous (“Chappy”) Conrad III; the late Dr. Charley Frantz, tions). Part I of this trilogy covered the normal system (Volume 1, Parts I and II of The CIBA Collec- who first set me on course for this project, and Dr. anatomy, embryology, and physiology of the musculo- tion of Medical Illustrations). Richard Freyberg, who became the consultant on the skeletal system as well as its diverse metabolic diseases, Most meaningfully, however, I herewith express my rheumatic diseases plates; Dr. George Hammond; Dr. including the various types of rickets. This book, Part sincere appreciation of the many great physicians, sur- Hugo Keim; Dr. Mack Clayton; Dr. Philip Wilson; II, portrays its congenital and developmental disorders, geons, orthopedists, and scientists who so graciously Dr. Stuart Kozinn; and Dr. Russell Windsor. neoplasms—both benign and malignant—of bone and shared with me their knowledge and supplied me with Finally, I also sincerely thank Mr. Philip Flagler, Ms. soft tissue, and rheumatic and other arthritic diseases, so much material on which to base my illustrations. Regina Dingle, and others of the CIBA-GEIGY orga- as well as joint replacement. Part III, on which I am still Without their help I could not have created this atlas. nization who helped in more ways than I can describe at work, will cover trauma, including fractures and dis- Most of these wonderful people are credited elsewhere in producing this atlas. locations of all the bones and joints, soft-tissue injuries, in this book under the heading of “Acknowledgments” sports injuries, bums, infections including osteomyelitis but I must nevertheless specifically mention a few who Frank H. Netter, MD, 1990 Sketch appearing in the front matter of Part III of the first edition. THE NETTER COLLECTION OF MEDICAL ILLUSTRATIONS ix