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The Mediterranean Diet The Mediterranean Diet An Evidence-Based Approach Second edition Edited by Victor R. Preedy Ronald Ross Watson Academic Press is an imprint of Elsevier 125 London Wall, London EC2Y 5AS, United Kingdom 525 B Street, Suite 1650, San Diego, CA 92101, United States 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom © 2020 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library ISBN: 978-0-12-818649-7 For information on all Academic Press publications visit our website at https://www.elsevier.com/books-and-journals Publisher: Charlotte Cockle Acquisitions Editor: Megan Ball Editorial Project Manager: Kelsey Connors Production Project Manager: Sruthi Satheesh Cover Designer: Matthew Limbert Typeset by SPi Global, India xvii Itziar Abete (337), Centre for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Youssef Aboussaleh (103), Department of Life Sciences, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco Giulia Accardi (547), Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy Anna Aiello (547), Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy Ahmad Alkhatib (363), Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan; School of Health and Life Sciences, Teesside University, Tees Valley, United Kingdom Inar Alves Castro (537), University of São Paulo, Faculty of Pharmaceutical Sciences, São Paulo, Brazil Isabel Andújar (565), Faculty of Pharmacy, University of Valencia; European University of Valencia, Valencia, Spain Smaragdi Antonopoulou (483), Department of Nutrition and Dietetics, Harokopio University, Athens, Greece Aleksandra Arsic (267), Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Belgrade, Serbia Eirini-Iro Arvanitidou (129), Department of Rehabilitation and Sport Sciences, Faculty of Health and Social Sciences, Bournemouth University, Bournemouth, United Kingdom Carla Assaf-Balut (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos; Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, Spain Ana Barabash (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain Mario Barbagallo (257), Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy Sara Bastida (191,409), Department of Nutrition and Food Science, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain Giovanni Beccari (503), Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia, Italy Juana Benedí (191), Departamento de Farmacología, Farmacognosia y Botánica, Pharmacy School, Complutense University, Madrid, Spain Najla Bentrad (239), Faculty of Biological Sciences, Department of Biology and Physiology of Organisms, University of Sciences and Technology Houari Boumediene (USTHB), Algiers, Algeria M. Rosa Bernal-Lopez (517), Internal Medicine Department, Regional University Hospital of Malaga, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga, Spain; Ciber Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain Marialaura Bonaccio (495), Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS), Italy Americo Bonanni (495), Science Communication Unit, IRCCS Neuromed, Pozzilli (IS), Italy Elena Bordiú (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid, Spain Francesco Bottalico (103), International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Bari, Italy Contributors xviii Contributors Barbara Boutopoulou (327), Faculty of Nursing, National and Kapodistrian University of Athens, Athens, Greece; Respiratory and Allergy Unit, 3rd Pediatric Department of National and Kapodistrian University of Athens, University General Hospital “Attikon”, Athens, Greece Silvio Buscemi (285), Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo; Clinical Nutrition and Metabolism Laboratory, Policlinico "P. Giaccone" University Hospital, Palermo, Italy Alfonso Luis Calle-Pascual (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain Montaña Cámara (293), Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain Giuseppina Candore (547), Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy Roberto Capone (103), International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Bari, Italy Marina Caputo (89), SCDU of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy Gianluigi Cardone (103), International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Bari, Italy Calogero Caruso (547), Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy Giulia Caso (191), Erasmus Traineeship, Complutense University, Madrid, Spain; Nutrition and Food Science School, University of Milan, Milan, Italy Itandehui Castro-Quezada (119), Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain; Health Department, El Colegio de la Frontera Sur, San Cristóbal de las Casas, Mexico Laura Cebadera-Miranda (293), Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain Ana B. Cerezo (347), Nutrition and Food Science Department, Toxicology and Legal Medicine, Area of Nutrition and Food Science, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain Davide Corleo (285), Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo; Clinical Nutrition and Metabolism Laboratory, Policlinico "P. Giaccone" University Hospital, Palermo, Italy Rúbia C.G. Corrêa (209), Mountain Research Center (CIMO), Instituto Politécnico de Bragança, Bragança, Portugal; University Center of Maringá (UniCesumar), Program of Master in Science, Technology and Food Safety, Maringá, Paraná, Brazil Lorenzo Covarelli (503), Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia, Italy Beata Czarczyńska-Goślińska (229), Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Poznan, Poland Sergio Davinelli (357), Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, Italy Laura del Valle (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, Spain Cristina Delgado-Andrade (151), Instituto de Ciencia y Tecnología de Alimentos y Nutrición, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain Christiana A. Demetriou (381), Department of Primary Care and Population Health, University of Nicosia Medical School; Department of Electron Microscopy/ Molecular Pathology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus Paraskevi Detopoulou (483), Department of Nutrition, General Hospital Korgialenio-Benakio, Athens, Greece Francesco Di Gioia (209), Department of Plant Science, Pennsylvania State University, State College, PA, United States E.J. Diamantopoulos (371), 4th Department of Internal Medicine & Unit of Medical Angiology, Evangelismos State General Hospital, Athens, Greece Ligia J. Dominguez (257), Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy Maria Benedetta Donati (495), Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS), Italy Contributors xix Konstantinos Douros (327), Respiratory and Allergy Unit, 3rd Pediatric Department of National and Kapodistrian University of Athens, University General Hospital “Attikon”, Athens, Greece Alejandra Durán (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid, Spain Hamid El Bilali (103), International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Bari, Italy Khaoula El Kinany (57), Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco Karima El Rhazi (57), Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco Mahmut Cerkez Ergoren (97), Department of Medical Biology, Faculty of Medicine; Research Center of Experimental Health Sciences (DESAM), Near East University, Nicosia, Cyprus Vincenzo De Feo (555), Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy Isabel C.F.R. Ferreira (209), Mountain Research Center (CIMO), Instituto Politécnico de Bragança, Bragança, Portugal Melissa Formica (453), Barwon Health (University Hospital Geelong), Geelong, VIC, Australia Elizabeth Fragopoulou (483), Department of Nutrition and Dietetics, Harokopio University, Athens, Greece Florinda Fratianni (555), Institute of Food Sciences, Research National Council, Avellino, Italy Giovanni de Gaetano (495), Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS), Italy José J. Gaforio (165,527), Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences University of Jaén, Jaén; Center for Advanced Studies in Olive Grove and Olive Oils University of Jaén, Jaén; Agri-food Campus of International Excellence (ceiA3), Córdoba; Center for Networked Biomedical Research in Epidemiology and Public Health (CIBER- ESP), Carlos III Health Institute, Madrid, Spain Cristina Galarregui (337), Centre for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain Cristina Gallardo-Escribano (517), Internal Medicine Department, Regional University Hospital of Malaga, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga; Ciber Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid; Clinical Analysis Department, Regional University Hospital of Malaga, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga, Spain Paola Galozzi (393), Rheumatology Unit, Department of Medicine, DIMED, Padova, Italy Fabio Galvano (285), Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy Maria Garces-Martin (517), Internal Medicine Department, Regional University Hospital of Malaga, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga; Ciber Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain Vanessa Garcia-Larsen (57), Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States M. Carmen Garcia-Parrilla (347), Nutrition and Food Science Department, Toxicology and Legal Medicine, Area of Nutrition and Food Science, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain Alba Garcimartín (191), Departamento de Farmacología, Farmacognosia y Botánica, Pharmacy School, Complutense University, Madrid, Spain Jan Geliebter (429), Department of Microbiology & Immunology, Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, United States Elena S. George (67), Institute for Physical Activity and Nutrition, School of Exercise & Nutrition Science, Faculty of Health, Deakin University, Melbourne, VIC, Australia Ekavi N. Georgousopoulou (67), School of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia; Medical School, Australian National University, Canberra, ACT, Australia; Centre for Health and Medical Research, ACT Health Directorate, Canberra, ACT, Australia; Department of Nutrition-Dietetics, School of Health Science & Education, Harokopio University, Athens, Greece E. Gesteiro (409), ImFine Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, Madrid, Spain Konstantinos Gkiouras (79), Laboratory of Clinical Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece Ana María Gómez-Pérez (275), Department of Endocrinology and Nutrition; Biomedical Research Institute of Málaga (IBIMA), Virgen de la Victoria University Hospital, Malaga, Spain xx Contributors Dimitrios G. Goulis (79,473), Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece E. Gouveri (371), 4th Department of Internal Medicine & Unit of Medical Angiology, Evangelismos State General Hospital, Athens, Greece; Diabetes center Dr. Tews, Gelnhausen, Germany Maria G. Grammatikopoulou (79,473), Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, Alexander Campus, Thessaloniki, Greece Andreas Hadjisavvas (381), Department of Electron Microscopy/Molecular Pathology; Cyprus School of Molecular Medicine, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus Asma Hamida-Ferhat (239), Laboratory of Medical Botany, University of Algiers, Faculty of Medicine, Department of Pharmacy; CHU Mustapha, Pierre and Marie Curie Center, Pharmacy Department, Algiers, Algeria Roy J. Hardman (453), Centre for Human Psychopharmacology, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University of Technology, Melbourne, VIC, Australia Ruth Hornedo-Ortega (347), MIB, Oenology Research Unit, EA 4577, USC 1366 INRA, ISVV, Université de Bordeaux, Bordeaux, France Licia Iacoviello (495), Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS); Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy Marcello Iriti (179), Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy Magdalena Jeszka-Skowron (229), Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Poznan, Poland Maria G. Kakkoura (381), Department of Electron Microscopy/Molecular Pathology, Cyprus Institute of Neurology and Genetics; Respiratory Physiology Laboratory, Medical School, University of Cyprus, Nicosia, Cyprus Spyridon N. Karras (73), Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece E. Knox (465), Andalusian School of Public Health, Granada, Spain Kalliopi Kotsa (73), Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece Theocharis Koufakis (73), Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece Despina Koumpagioti (327), Faculty of Nursing, National and Kapodistrian University of Athens; P & A Kyriakou Children's Hospital, Athens, Greece Kyriacos Kyriacou (381), Department of Electron Microscopy/Molecular Pathology; Cyprus School of Molecular Medicine, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus Nuria García de la Torre (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos; Instituto de Investigación Sanitaria del Hospital San Carlos; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain Maria Lampropoulou (473), Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, Alexander Campus, Thessaloniki, Greece Maria A. Loizidou (381), Department of Electron Microscopy/Molecular Pathology; Cyprus School of Molecular Medicine, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus Antonino De Lorenzo (285), Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy Adrián Macho-González (191), Department of Nutrition and Food Science, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain Emmanuella Magriplis (25,41), Department of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece G. Marakomichelakis (371), 4th Department of Internal Medicine & Unit of Medical Angiology, Evangelismos State General Hospital, Athens, Greece J. Alfredo Martínez (337), Centre for Nutrition Research, Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona; Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain Contributors xxi Laura De Martino (555), Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy F. Xavier Medina (13), Department of Food and Nutrition, Faculty of Health Sciences, and UNESCO Chair on Food, Culture and Development, Universitat Oberta de Catalunya (UOC), Barcelona, Spain Duane D. Mellor (67), Aston Medical School, Aston University, Birmingham, United Kingdom Alessandro Menotti (111), Association for Cardiac Research, Rome, Italy Marta Mesías (151), Instituto de Ciencia y Tecnología de Alimentos y Nutrición, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain María Molina-Vega (275), Department of Endocrinology and Nutrition; Biomedical Research Institute of Málaga (IBIMA), Virgen de la Victoria University Hospital, Malaga, Spain Patricia Morales (293), Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain Juan A. Moreno (165), Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, Center of Biomedical Research, Granada University, Granada, Spain J.J. Muros (465), Department of Didactics of Musical, Artistic and Corporal Expression; Research Group AGR-279 Food Science and Nutrition, University of Granada, Granada, Spain Filomena Nazzaro (555), Institute of Food Sciences, Research National Council, Avellino, Italy Tzortzis Nomikos (483), Department of Nutrition and Dietetics, Harokopio University, Athens, Greece Francesca Oliviero (393), Rheumatology Unit, Department of Medicine, DIMED, Padova, Italy Giovanni Ottomano Palmisano (103), International Centre for Advanced Mediterranean Agronomic Studies (CIHEAM-Bari), Bari, Italy Rocío M. de Pablos (347), Biochemistry and Molecular Biology Department, Faculty of Pharmacy; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital/CSIC, Universidad de Sevilla, Seville, Spain Demosthenes B. Panagiotakos (67), Department of Nutrition- Dietetics, School of Health Science & Education, Harokopio University, Athens, Greece; Faculty of Health, University of Canberra, Canberra, ACT, Australia Christopher Papandreou (3), Human Nutrition Unit, Department of Biochemistry and Biotechnology, Pere i Virgili Research Institute, Rovira i Virgili University, Tarragona, Spain Spyridon A. Petropoulos (209), Department of Agriculture, Crop Production and Rural Environment, University of Thessaly, Nea Ionia, Magnissia, Greece Flavia Prodam (89), SCDU of Pediatrics, Department of Health Sciences; SCDU of Endocrinology, Department of Translational Medicine; Interdis- ciplinary Research Center of Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy Paolo Emilio Puddu (111), Association for Cardiac Research, Rome, Italy; EA 4650, Signalisation, élec- trophysiologie et imagerie des lésions d’ischémie reperfusion myocardique, UNICAEN, Caen, France Leonardo Punzi (393), Centre for Gout and Metabolic Bone and Joint Diseases, Rheumatology, SS Giovanni and Paolo Hospital, Venice, Italy José L. Quiles (165), Department of Physiology, Institute of Nutrition and Food Technology, Center of Biomedical Research, Granada University, Granada, Spain Cristina Ramirez-Perez (165), Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, Center of Biomedical Research, Granada University, Granada, Spain Cesar L. Ramirez-Tortosa (165), Department of Pathological Anatomy, San Cecilio Hospital of Granada, Granada, Spain MCarmen Ramírez-Tortosa (165), Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, Center of Biomedical Research, Granada University, Granada, Spain Tristan Richard (347), MIB, Oenology Research Unit, EA 4577, USC 1366 INRA, ISVV, Université de Bordeaux, Bordeaux, France Roberta Ricotti (89), SCDU of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy José-Luis Ríos (565), Faculty of Pharmacy, University of Valencia, Valencia, Spain Carmen Rodríguez-García (527), Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Jaén, Spain Blanca Román-Viñas (119), Community Nutrition Research Centre of the Nutrition Research Foundation, University of Barcelona Science Park, Barcelona; Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain xxii Contributors Emilio Ros (141), Lipid Clinic, Endocrinology and Nutrition Service, August Pi i Sunyer Biomedical Research Institute, Hospital Clinic, Barcelona; CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute (ISCIII), Madrid, Spain Miguel Angel Rubio (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid; Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, Spain M. Isabel Ruiz-Moreno (517), Internal Medicine Department, Regional University Hospital of Malaga, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga; Ciber Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain Carlotta Sacerdote (381), Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy Jordi Salas-Salvadó (3), Human Nutrition Unit, Department of Biochemistry and Biotechnology, Pere i Virgili Research Institute, Rovira i Virgili University, Tarragona, Spain Francisco J. Sánchez-Muniz (191,409), Department of Nutrition and Food Science, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain Cristina Sánchez-Quesada (527), Center for Advanced Studies in Olive Grove and Olive Oils; Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Jaén; Agri- food Campus of International Excellence (ceiA3), Córdoba, Spain Giovanni Scapagnini (357), Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, Italy Bianca Scolaro (537), NYU School of Medicine, Department of Medicine, New York, NY, United States Isabel Seiquer (151), Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain Lluís Serra-Majem (13,119), Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria (ULPGC); Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas de Gran Canaria; Community Nutrition Research Centre of the Nutrition Research Foundation, University of Barcelona Science Park; International Foundation of Mediterranean Diet (IFMED), Barcelona; Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain Paolo Sfriso (393), Rheumatology Unit, Department of Medicine, DIMED, Padova, Italy Paolo Spinella (393), Clinical Nutrition Unit, Department of Medicine, DIMED, Padova, Italy Xenophon Theodoridis (129), Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa; Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece Francisco J. Tinahones (275), Department of Endocrinology and Nutrition; Biomedical Research Institute of Málaga (IBIMA), Virgen de la Victoria University Hospital, Malaga, Spain; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn CB06/003), Instituto de Salud Carlos III, Madrid, Spain Francesco Tini (503), Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia, Italy Raj Tiwari (429), Department of Microbiology & Immunology, Department of Otolaryngology, School of Medicine, New York Medical College, Valhalla, NY, United States Antigoni Tranidou (79), Department of Endocrinology, Diabetes and Metabolism, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece Ana M. Troncoso (347), Nutrition and Food Science Department, Toxicology and Legal Medicine, Area of Nutrition and Food Science, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain Fotini Tsofliou (129), Department of Rehabilitation and Sport Sciences, Faculty of Health and Social Sciences, Bournemouth University, Bournemouth, United Kingdom Gulten Tuncel (97), Department of Medical Biology, Faculty of Medicine; Research Center of Experimental Health Sciences (DESAM), Near East University, Nicosia, Cyprus Johanna Valerio (313), Endocrinology and Nutrition Department, Hospital Clínico San Carlos, Madrid, Spain Elena Maria Varoni (179), Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy Alberto Vilches-Perez (517), Internal Medicine Department, Regional University Hospital of Malaga, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga; Ciber Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid; Endocrinology and Nutrition Department, University Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga, Spain Paolo Vineis (381), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

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