The Many Faces of Osteoarthritis PDF
Preview The Many Faces of Osteoarthritis
The Many Faces of Osteoarthritis Vincent C. Hascall Klaus E. Kuettner Editors Springer Basel AG Editors Vincent C. Hascall Klaus E. Kuettner Orthopaedic Research Center Department of Biochemistry Department of Biomedical Engineering Rush Medical College at Rush Presbyterian-St. Luke's The Cleveland Clinic Foundation Medical Center 9500 Euclid Avenue 1653 West Congress Parkway Cleveland, OH 44195 Chicago, IL 60612-3864 USA USA A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA Deutsche Bibliothek Cataloging-in-Publication Data The many faces of osteoarthritis / Vincent C. Hascall ; Klaus E. Kuettner ed .. - Basel ; Boston; Berlin: Birkhauser, 2002 ISBN 978-3-0348-9450-0 ISBN 978-3-0348-8133-3 (eBook) DOI 10.1007/978-3-0348-8133-3 ISBN 978-3-0348-9450-0 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of iIIustrations, recitation, broadcasting, reproduction on micro films or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2002 Springer Basel AG Originally published by Birkhiiuser Verlag in 2002 Softcover reprint of the hardcover 1s t edition 2002 Printed on acid-free paper produced from chlorine-free pulp. TCF = Cover design: Micha Lotrovsky, CH-4106 Therwil, Switzerland Cover iIIustration: Ditfraction enhanced x-ray imaging (DEI) of human synovial joint cartilage. The top image is one of an intact human knee joint taken with the DEI technique at the National Synchrotron Light Source at Brookhaven National Laboratory. The bottom two pictures are a DE image of a portion of a talar dome (Ieft) and its histological pro file stained with Safranin-O/fast green (right). In both DE images, the articular cartilage is clearly visible. Furthermore, the contrast heterogeneity that gives the appearance of a lesion in the lower DE image is histologically validated. (The top image with friendly permission of Carol A. Muehleman and Matthias E. Aurich, the bottom pictures reprinted from Osteoarthritis and Cartilage, volume 10, Mollenhauer J, Aurich ME, Zhong Z, Muehleman C, Cole AA, Masnah M. Oltulu O, Kuettner KE, Margulis A, Chapman LD. Ditfraction-enhanced x-ray imaging of articular cartilage. pp. 163-171 (2002) by permission of the publisher WB Saunders.) ISBN 978-3-0348-9450-0 987654321 www.birkhăuser-science.com Contents List of contributors xiii Preface ........... . xxv The life of Klaus E. Kuettner xxix Acknowledgements ... .. xxxix The many phases of osteoarthritis Jody Buckwalter Introduction ..................................................................... . 3 Audrey McAlinden, Naoshi Fukui and Linda 1. Sandell Type IIA procollagen NH2-propeptide functions as an antagonist of bone morphogenetic proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Matthew L. Warman Genetics and osteoarthritis .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 17 Ada Cole, Hans Hauselmann, Johannes Flechtenmacher, Klaus Huch, Holger Koepp, Wolfgang Eger, Matthias E. Aurich, Bernd Rolauffs, Arkady Margulis, Carol Muehleman, Allan Valdellon and Klaus E. Kuettner Metabolic differences between knee and ankle ................................. 27 Marc C. Hochberg Prevention of lower limb osteoarthritis: Data from The Johns Hopkins Precursors Study ............. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Thorvaldur Ingvarsson The inheritance of hip osteoarthritis in Iceland .................................. 39 Contents Lydia K. Wachsmuth, Beate Durchfeld-Meyer, Nadine I. Jahn, Nicole Verzi;l, Uwe H. Dietz, Nicole Gerwin, Manfred Keil, Hans-Ludwig Schmidts and Ruth X. Raiss Dynamics of matrix loss in the spontaneous osteoarthritic mouse strain STR-1 N ............... .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 45 Discussion ................................................ . . .................. 51 Morphogenics, development and repair A. Hari Reddi Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 63 Frank P. Luyten, Cosimo De Bari and Francesco Dell'Accio Identification and characterization of human cell populations capable of forming stable hyaline cartilage in vivo ....................................... 67 Holger E. Koepp, Johannes Flechtenmacher, Klaus Huch, Eugene 1. -M.A. Thonar, Gene A. Homandberg and Klaus E. Kuettner Osteogenic protein-1 promotes proteoglycan synthesis and inhibits cartilage degeneration mediated by fibronectin-fragments. . . . . . . . . . . . . . .. 77 Susan Chubinskaya, David C. Rueger, Richard A. Berger and Klaus E. Kuettner Osteogenic protein-1 and its receptors in human articular cartilage. . . . . . . . . . . .. 81 veronique Lefebvre, Benoit de Crombrugghe and Richard R. Behringer The transcription factors L-Sox5 and Sox6 are essential for cartilage formation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 91 Arthur Veis, Kevin Tompkins and Michel Goldberg Amelogenin peptides have unique milieu-dependent roles in morphogenic path determination ............................................ 101 Discussion ..... .................................................................. 1W Matrix molecules in cartilage and other tissues Dick Heinegard Introduction ..... . . .............................................. 115 vi Contents Karl E. Kadler and David F. Holmes Electron microscope studies of collagen fibril formation in cornea, skin and tendon: Implications for collagen fibril assembly and structure in other tissues ....................................................... . . ..... 117 Tim Hardingham Hyaluronics and aggrecanics ..................................................... 131 Anders Aspberg Lectin domains in hyaluronan-binding proteoglycans ........................... 147 Mats Paulsson, Andreas R. Klatt, Birgit Kobbe, D. Patrie Nitsche and Raimund Wagener The matrilins: A novel family of extracellular adaptor proteins .................. 151 Thomas M. Schmid, Jui-Lan Su, Kathie M. Lindley, Vitaliy Soloveychik, Lawrence Madsen, Joel A. Block, Klaus E. Kuettner and Barbara L. Schumacher Superficial zone protein (SlP) is an abundant glycoprotein in human synovial fluid with lubricating properties ......................................... 159 Frank Zaucke, Robert Dinser, Patrik Maurer and Mats Paulsson Establishment of in vitro cell culture models for the investigation of the pathogenesis of cartilage diseases ............................................... 163 Discussion ................................................................... . .. 167 Hyaluronan and joint biology Vince Hascall Introduction ...................................................................... 177 Roger M. Mason, Peter 1. Coleman, David Scott and 1. Rodney Levick Role of hyaluronan in regulating jointfluid flow ................................. 179 Endre A. Balazs and Charles Weiss Elastoviscous hyaluronan in the synovium in health and disease ................ 189 Wannarat Yingsung, Lisheng Zhuo, Masahiko Yoneda, Naoki Ishiguro, Hisashi Iwata and Ko;i Kimata The covalent complex formation of hyaluronan with heavy chains of inter-a-trypsin inhibitor family is important for its functions .................... 207 vii Contents Janet Y. Lee, Ryan B. Rountree, David M. Kingsley and Andrew P. Spicer In vivo investigation of hyaluronan and hyaluronan synthase-2 function during cartilage and joint development .......................................... 213 Cheryl B. Knudson, Kathleen T. Rousche, Richard S. Peterson, Geraldine Chow and Warren Knudson CD44 and cartilage matrix stabilization .......... . . ........................ 219 Discussion ......................... 231 Skeletal turnover in health and arthritis Robin Poole Introduction ...................................................................... 239 I Frederick Woessner Metalloproteinases and osteoarthritis ............................................ 241 Haya ben-Zaken, Rosa Schneiderman, Hannah Kaufmann and Alice Maroudas Age-dependent changes in some physico-chemical properties of human articular cartilage ...................... . ................................ 247 Theodore R. Oegema, Jr. The role of the bone/cartilage interface in osteoarthritis ........................ 253 Wim B. van den Berg, Peter M. van der Kraan, Alwin Scharstuhl, Henk M. van Beuningen, Andrew Bakker. Peter L.E.M. van Lent. Fons A.I von de Loo Dualistic role of TGF~ in osteoarthritis cartilage destruction and osteophyte formation ......................... . ................................ 261 Discussion ..................................... . ................................. 267 From biomarkers to surrogate outcome measures in osteoarthritis Stefan Lohmander Introduction ...................................................................... 273 David R. Eyre, Lynne M. Atley and Jiann-Jui Wu Collagen cross-links as markers of bone and cartilage degradation ............. 275 viii Contents Tore Saxne, Dick Heinegard and Bengt Mansson Markers of joint tissue turnover in osteoarthritis. . .... 285 Thomas Aigner, Pia M. Gebhard and Alexander Zien Gene expression profiling by the cDNA array technology: Molecular portraying of chondrocytes . . . . . . . . . . . ........ 293 Ivan G. Otterness and Dolores Vazquez-Abad Clinical evaluation of markers for osteoarthritis. . ..... 297 Wolfgang Eger, Stefan Soder, Dietmar Thomas, Thomas Aigner and Gunther Zeiler Joint degradation in rapidly destructive and hypertrophic osteoarthritis ofthe hip . . . . . . . . . . . ....... 303 Tamayuki Shinomura, Kazuo Ito and Magnus Hook Differential gene trap: A new strategy for identifying genes regulated during cartilage differentiation ............ . . 309 Discussion .......................313 Assessment of jOint damage in osteoarthritis Paul Dieppe Introduction ... . ................ 323 Charles G. Peterfy Imaging cartilage changes in osteoarthritis .. 329 Carol Muehleman, Jurgen A. Mollenhauer, Matthias E. Aurich, Klaus E. Kuettner, Zhong Zhong, Ada Cole and Dean Chapman Diffraction enhanced x-ray imaging of articular cartilage. . . . . . . . . . . . . ........ 351 lain Watt Bone changes in osteoarthritis ........ 355 Joel A. Block Radiographic joint space width (JSW): A marker of disease progression in osteoarthritis of the hip . . . . . . . . .. .363 Gabriella Cs-Szabo, Deborah Ragasa, Richard A. Berger and Klaus E. Kuettner Small proteoglycans in knee and ankle cartilage. . . . . . . . . . . . . ..... 369 ix Contents Discussion ........................................................................ 373 Biomechanics and cartilage metabolism Alan Grodzinsky Introduction ...................................... . . ....................... 383 Robert J. Wilkins, Bethan Hopewell and Jill P.G. Urban Fixed charge density and cartilage biomechanics ................................ 387 Moonsoo Jin, Alan J. Grodzinsky, Thomas H. Wuerz, Gregory R. Emkey, Marcy Wong and Ernst B. Hunziker Influence of tissue shear deformation on chondrocyte biosynthesis and matrix nano-electromechanics ................................................... 397 Robert L. Sah The biomechanical faces of articular cartilage in growth, aging, and osteoarthritis ............................................................... . . 409 John D. Kisiday, Moonsoo Jin, Bodo Kurz, Han-Hwa Hung, Carlos Semino, Shuguang Zhang and Alan J. Grodzinsky Cartilage tissue engineering using a new self-assembling peptide gel scaffold .. 423 Matthias E. Aurich, JDrgen A. Mollenhauer, Klaus E. Kuetlner and Ada A. Cole Differential effects of IL-1 ~ on human knee and ankle chondrocytes ........... 429 Discussion ........................................................................ 433 Biomechanics, motor control and osteoarthritis Mark Grabiner Introduction ...................................................................... 441 Thomas P. Andriacchi Dynamic function and imaging in the analysis of osteoarthritis at the knee ..... 443 Eugene J.-M.A. Thonar, Debra E. Hurwitz, Thomas P. Andriacchi, Mary Ellen Lenz and Leena Sharma Linking the biology of osteoarthritis to locomotion mechanics .................. 453 x Contents Terese L. Chmielewski, Katherine S. Rudolph, Michael 1. Axe, G. Kelley Fitzgerald and Lynn Snyder-Mackler Movement patterns of individuals with good potential to dynamically stabilize their knees after acute ACL rupture .......... . ..461 Lynn Snyder-Mackler and Terese Chmielewski Neuromuscular control of the ACL deficient knee: Implications for the development of osteoarthritis. . ........ . " .465 Discussion .. . .. 473 Photos from the conference .. 481 Index .... . .. 489 xi
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