Table Of Content

SUBJECT INDEX ABP-SHBG gene complex structure and regulation, 771 Accessory sex organs, 307 ACTH, 679 basal secretion, 133 Adrenal, 599 Adrenal growth and insulin-like growth factors, 399 Adrenal steroidogenesis natriuretic peptides, 367 inhibition by threonine analogue, 421 Adrenal vascular events endothelin, 381 mast cells, 381 steroid secretion, 381 African catfish steroid glucuronides, 549 Aging, 679 glucocorticoid receptor, 679 neuroendrocine activity, 63 neuroendocrine dynamics, 679 Aldosterone secretion in vitro effects of endothelins, 437 Androgen, 599 Androgen receptor, 343, 349 Androgen action, 307 Androgen binding proteins oligosaccharides, 821 Androgen receptor abnormalities, 349 mRNA, 343 mutations, 349 Androgen receptor mRNA regulation by testosterone, 343 Androgen receptor protein regulation by testosterone, 343 Androgen regulation ornithine decarboxylase gene, 307 S-adenosylmethionine decarboxylase gene, 307 Androgen resistance, 349 Androgen sensitivity LNCaP-cells, 207 Antihormone action progestin receptor, 271 Apoptosis glucocorticoid regulated nuclease, 661 Arachidonic acid Leydig cell steroidogenesis, 465 Aromatase human breast cancer, 247, 255 Aromatase inhibitors clinical use, 247 overview, 255 Astrocytes, 105 XII Subject Index Atrial natriuretic peptide adrenal steroidogenesis, 367 Autoimmunity glucocorticoids, 619 regulation by sex steroids, 619, 649 Biosynthesis corticosteroid binding globulin, 755 neurosteroids, 71 Blood pressure sexual dimorphism and renin—angiotensin system, 511 Body composition effect of 19-nortestosterone, 607 Bone maintenance effect of clomiphene citrate, 725 effect of oestradiol, 725 Bone proliferation, 717 Brain dehydroepiandrosterone, 71 pregnenolone, 71 steroids, 1 testosterone metabolism, 673 thyroid hormone, | Brain natriuretic peptide adrenal steroidogenesis, 367 Breast cancer cells hormone resistance, 231 gene expression, 239 effect of growth factors, 215 Calf testis steroid 17a-hydroxylase, 431 Cancer endocrine aspects and epidemiology, 15 Cartilage human, 711 rabbit, 711 rat, 717 response to sex steroids, 711, 717 Cathepsin D regulation and steroid receptors, 231 CBG see: corticosteroid binding globulin Central neuron function steroid control, 123 Central peptidergic neurons glucocorticoid action, 93 Chimeric proteins oestrogen receptor, 333 Chromatin structure hormone-dependent promoters, 325 Congenital adrenal hyperplasia mineralocorticoids, 493 Contraception during lactation with progestins, 705 long acting contraceptives, 697 Corticostatic peptides, 391 Corticosteroid binding globulin biosynthesis and function, 755 interaction with cell membranes, 795 structure, 755 Subject Index Corticosteroid receptors dog brain, 63 Corticosteroids, 465 hippocampal activity, 83, 87 Corticosterone, 679 Cortisol-cortisone shuttle hypertension, 501 Cyclic AMP, 301, 465 Cytochrome P-450 C21SCC hydroxylase and lyase activity, 527 Cytokines hypothalamus-pituitary—adrenal axis, 613 Dehydroepiandrosterone actions in humans, 599 formation in brain, 71 metabolism in humans, 599 Dehydrogenase activity 3B-hydroxysteroid dehydrogenase, 545 Delta-16-steroids in human testis, 587 Dimerization of oestrogen receptor, 333 DNA-binding glucocorticoid receptor, 287 Dog brain corticosteroid receptors, 63 Effect of clomiphene citrate on bone maintenance, 725 gonadal steroids on opioid receptor, 113 oestradiol on bone maintenance, 725 Effects of corticosteroids on Leydig cell steroidogenesis, 465 hormones on SBP mRNA, 777 Elasmobranchs role of steroids in females, 571 Endocrine aspects of cancer, 15 Endothelin(s), 481 adrenal vascular events, 381 aldosterone secretion in vitro, 437 Epidemiology of cancer, 15 Epidermal growth factor co-operation with progestins, 239 Estradiol, 481 Estrogens, 511 Expression steroidogenic enzymes, 45 Fertility and ovarian follicle, 29 FSH and growth factor interaction in polycystic ovary syndrome, 405 Function corticosteroid binding globulin, 755 sex steroid binding protein, 735 Functional domains vitamin D binding protein, 787 Gene expression in breast cancer cells, 239 in rat brain oestrogen and progestin receptor, 53 XIV Subject Index Gene promoter glucocorticoid receptor, 317 Genomic structure of vitamin D binding protein, 787 Glial cells mineralocorticoid receptor, 105 glucocorticoid receptor, 105 Glioma, 105 Glucocorticoid action on central peptidergic neurons, 93 Glucocorticoid receptor activation, 287 DNA-binding, 287 gene promoter, 317 glial ceils, 105 glucocorticoid resistance, 353 hippocampus, 685 homologous down regulation, 317 in aging, 679 monoamine regulation, 685 neuroendocrine dynamics, 679 nuclear envelope binding protein, 279 nuclear localization peptide, 279 peptidergic neurons, 93 subunit structure, 287 Glucocorticoid receptor gene, 317 Glucocorticoid regulated nuclease and apoptosis, 661 Glucocorticoid resistance, 353 glucocorticoid receptor, 353 hepatoma cells, 353 Glucocorticoids autoimmunity, 619 stress, 619 Gonadal function and neuropeptides, 25 Gonadal steroids effect on opioid receptor, 113 Gonadotropin secretion in vivo model, 143 steroid control, 417 Granulosa cells oestrogen production, 405 Growth factor(s) effect of oestrogen, 215 breast cancer cells, 215 human prostate, 185, 193, 199 regulation of Leydig cell functions, 453 signal transduction pathways, 215 Growth hormone secretion sex steroid control, 165 Hepatoma cells glucocorticoid resistance, 353 Hippocampal activity and corticosteroids, 83, 87 Hippocampus glucocorticoid receptor, 685 Homologous down regulation glucocorticoid receptor, 317 Hormonal interactions polycystic ovary syndrome, 405 Hormonal regulation cathepsin D, 231 Hormone resistance breast cancer cell lines, 231 Hormone response element(s), 307 Hormone-dependent promoters and chromatin structure, 325 Human breast cancer aromatase, 247, 255 Human cancer cells SBP mRNA, 777 Human prostate growth factors, 199 effects of SHBG, 833 Human testicular delta-16-steroids, 587 118-Hydroxyandrostenedione level in osteoporose, 731 19-Nortestosterone effect on body composition, 607 Hydroxylase activity of cytochrome P-450 C21SCC, 527 21-Hydroxylase deficiency molecular pathology, 537 3B-Hydroxysteroid dehydrogenase dehydrogenase activity, 545 isomerase activity, 545 11£-Hydroxysteroid dehydrogenase heterogeneity in rat tissues, 533 Hypertension, 511 cortisol—cortisone shuttle, 501 steroids, 35 Hypothalamus, 93 opioid receptor, 113 Hypothalamus-pituitary—adrenal axis cytokines, 613 Immunological mechanisms stress-induced immunomodulation, 639 Immunomodulation stress, 639 Insulin, 599 relation to SHBG, 841 Insulin-like growth factors adrenal growth, 399 induction by oestrogens, 223 ovarian steroidogenesis, 411 Isomerase activity 3B-Hydroxysteroid dehydrogenase, 545 Lactation contraception by progestins, 705 Leydig cell functions regulation by growth factors, 453 Leydig cell steroidogenesis effects of corticosteroids, 465 release of arachidonic acid, 465 LHRH secretion in vivo model, 143 sex steroid control, 155 LNCaP androgen sensitivity, 207 formation of steroid glucuronides, 593 prostate cancer cells, 193 sublines, 207 Luteinizing hormone action on the testis, 441 Lyase activity of cytochrome P-450 C21SCC, 527 SBMB 40/4-4—Z XVI Subject Index Mast cells and adrenal vascular events, 381 Metabolism dehydroepiandrosterone, 599 neurosteroids, 71 Mineralocorticoid receptor glial cells, 105 mutations, 363 pseudohypoaldosteronism, 363 Mineralocorticoids congenital adrenal hyperplasia, 493 Molecular biology of sex steroid binding protein, 735 Molecular pathology of 21-hydroxylase deficiency, 537 Monoamine regulation of glucocorticoid receptor, 685 Mouse kidney, 307 mRNA * androgen receptor, 343 vitamin D binding protein, 787 Muscle damage by oestrogen and tamoxifen, 689 Mutations androgen receptor, 349 mineralocorticoid receptor, 363 Myc proto-oncogene induction in uterus by oestrogens, 223 Natriuretic peptides, 367 Neuroendocrine activity in aged dogs, 63 Neuroendocrine dynamics aging and glucocorticoid receptor, 679 Neuroendocrine mechanisms stress-induced immunomodulation, 639 Neuropeptides, 93 gonadal function, 25 Neurosteroids, biosynthesis and metabolism, 71 Nuclear envelope binding protein for glucocorticoid receptor, 279 Nuclear localization peptide for glucocorticoid receptor, 279 Oestrogen effect on growth factor, 215 muscular damage, 689 production in granulosa cells, 405 production and polycystic ovary syndrome, 405 Oestrogen receptor chimeric proteins, 333 dimerization, 333 gene expression in rat brain, 53 Oestrogens induction of IGFs and myc proto-oncogene, 223 Oligodendrocytes, 105 Oligosaccharides androgen binding proteins, 821 structure/function relationship, 821 Opioid receptor, 113 effect of gonadal steroids, 113 hypothalamus, 113 Ornithine decarboxylase gene androgen regulation, 307 Ovarian follicle and fertility, 29 Ovary insulin-like growth factors, 411 Oxytocin, 481 Subject Index Oxytocin receptor steroid modulation in uterus, 481 Peptidergic neurons glucocorticoid receptor, 93 Pheromones steroid glucuronides in African catfish, 549 Phospholipase A2 and testis function, 465 Polycystic ovary syndrome FSH and growth factor interaction, 405 hormonal interactions, 405 oestrogen production, 405 Pregnenolone in brain, 71 Progesterone, 481 Progestin receptor antihormone action, 271 gene expression in rat brain, 53 isoforms, 271 Progestins contraception, 705 co-operation with EGF, 239 Promoter function, 317 Proopiomelanocortin, 301 Prostaglandins, 465 Prostate effect of steroids, 175 Prostate cancer cells growth factors, 185, 193 LNCaP, 193 steroids, 193 Prostate tumor, 349 Proto-oncogenes, 215 Pseudohypoaldosteronism mineralocorticoid receptor, 363 Receptor androgen, 343, 349 corticosteroid, 63 glucocorticoid, 93, 105, 133, 279, 287, 301, 317, 679 luteinizing hormone, 21 mineralocorticoid, 105, 133, 363, 679 oestrogen, 53, 231 opioid, 113 oxytocin, 481 progestin, 21, 53, 231 sex steroid binding protein, 805 vasopressin, 481 Regulation ABP/SHBG gene, 771 steroidogenic genes, 45 Regulation by testosterone androgen receptor protein, 343 Renin-angiotensin system blood pressure dimorphism, 511 Reptiles role of steroids in females, 571 SBP see: sex hormone binding protein XVIII Subject Index SBP mRNA effects of hormones, 777 human cancer cells, 777 Sex hormone binding globulin ancestral gene, 763 effect on human prostatic carcinoma, 833 in regulatory system, 813 pathophysiology, 841 relation to insulin, 841 relation to vitamin K dependent protein S, 763 Sex steroid binding protein function, 735 molecular biology, 735 receptor, 805 structure, 735 Sex steroid control growth hormone secretion, 165 LHRH secretion, 155 Sex steroids autoimmunity, 619 effect of cartilage, 717 effect on cartilage cells, 711 regulation of autoimmunity, 649 stress, 619 Sexual dimorphism blood pressure, 511 SHBG see: sex hormone binding globulin see: sex hormone binding protein Signal transduction pathways growth factors, 215 Steroid 17a-hydroxylase calf testis, 431 purification and properties, 431 Steroid biosynthesis transcriptional regulation, 517 Steroid control central neuron function, 123 gonadotropin secretion, 417 Steroid glucuronides as male pheromones in African Catfish, 549 formation by LNCaP cells, 593 levels in circulation, 593 Steroid metabolites, 465 Steroid modulation _ oxytocin receptor, 481 vasopressin receptor, 481 Steroid receptor superfamily cloning of new members, 263 Steroid receptors cathepsin D, 231 transfection, 231 Steroid secretion adrenal vascular events, 381 Steroidal fatty acid esters, 577 Steroidogenesis, 465 insulin-like growth factors, 411 Steroidogenic enzymes expression, 45 Steroidogenic genes regulation, 45 Subject Index Steroids brain, 1 hypertension, 35 prostate, 175 prostate cancer cells, 193 Strength effect of testosterone, 607 Stress, 679 glucocorticoids, 619 immunomodulation, 639 sex steroids, 619 testis function, 473 Structure corticosteroid binding globulin, 755 sex steroid binding protein, 735 Structure/function relationship oligosaccharides, 821 Subunit structure glucocorticoid receptor, 287 S-adenosylmethionine decarboxylase androgen regulation, 307 Tamoxifen muscle damage, 689 Testicular feminization, 349 Testis action of luteinizing hormone, 441 stress induced changes, 473 Testosterone, 511 effect on strength, 607 metabolism in avian hypothalamus, 557 regulation of androgen receptor mRNA, 343 Testosterone metabolism in brain, 673 Threonine analogue inhibition of adrenal steroidogenesis, 421 Thyroid hormone brain, 1 Transcription, 301 Transcriptional regulation of steroid biosynthesis, 517 Transfection of steroid receptors, 231 Uterus, 481 myc proto-oncogene, 223 oxytocin receptor, 481 vasopressin receptor, 481 Vasopressin, 481, 511 Vasopressin receptor steroid modulation, 481 uterus, 481 Vitamin D binding protein functional domains, genomic structure and mRNA expression, 787 Vitamin K dependent protein S ancestral gene, 763 relation to sex hormone binding globulin, 763 Zona glomerulosa cells aldosterone secretion in vitro, 437

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The Journal of Steroid Biochemistry and Molecular Biology 1991: Vol 40 Index PDF

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SUBJECT INDEX ABP-SHBG gene complex structure and regulation, 771 Accessory sex organs, 307 ACTH, 679 basal secretion, 133 Adrenal, 599 Adrenal growth and insulin-like growth factors, 399 Adrenal steroidogenesis natriuretic peptides, 367 inhibition by threonine analogue, 421 Adrenal vascular events endothelin, 381 mast cells, 381 steroid secretion, 381 African catfish steroid glucuronides, 549 Aging, 679 glucocorticoid receptor, 679 neuroendrocine activity, 63 neuroendocrine dynamics, 679 Aldosterone secretion in vitro effects of endothelins, 437 Androgen, 599 Androgen receptor, 343, 349 Androgen action, 307 Androgen binding proteins oligosaccharides, 821 Androgen receptor abnormalities, 349 mRNA, 343 mutations, 349 Androgen receptor mRNA regulation by testosterone, 343 Androgen receptor protein regulation by testosterone, 343 Androgen regulation ornithine decarboxylase gene, 307 S-adenosylmethionine decarboxylase gene, 307 Androgen resistance, 349 Androgen sensitivity LNCaP-cells, 207 Antihormone action progestin receptor, 271 Apoptosis glucocorticoid regulated nuclease, 661 Arachidonic acid Leydig cell steroidogenesis, 465 Aromatase human breast cancer, 247, 255 Aromatase inhibitors clinical use, 247 overview, 255 Astrocytes, 105 XII Subject Index Atrial natriuretic peptide adrenal steroidogenesis, 367 Autoimmunity glucocorticoids, 619 regulation by sex steroids, 619, 649 Biosynthesis corticosteroid binding globulin, 755 neurosteroids, 71 Blood pressure sexual dimorphism and renin—angiotensin system, 511 Body composition effect of 19-nortestosterone, 607 Bone maintenance effect of clomiphene citrate, 725 effect of oestradiol, 725 Bone proliferation, 717 Brain dehydroepiandrosterone, 71 pregnenolone, 71 steroids, 1 testosterone metabolism, 673 thyroid hormone, | Brain natriuretic peptide adrenal steroidogenesis, 367 Breast cancer cells hormone resistance, 231 gene expression, 239 effect of growth factors, 215 Calf testis steroid 17a-hydroxylase, 431 Cancer endocrine aspects and epidemiology, 15 Cartilage human, 711 rabbit, 711 rat, 717 response to sex steroids, 711, 717 Cathepsin D regulation and steroid receptors, 231 CBG see: corticosteroid binding globulin Central neuron function steroid control, 123 Central peptidergic neurons glucocorticoid action, 93 Chimeric proteins oestrogen receptor, 333 Chromatin structure hormone-dependent promoters, 325 Congenital adrenal hyperplasia mineralocorticoids, 493 Contraception during lactation with progestins, 705 long acting contraceptives, 697 Corticostatic peptides, 391 Corticosteroid binding globulin biosynthesis and function, 755 interaction with cell membranes, 795 structure, 755 Subject Index Corticosteroid receptors dog brain, 63 Corticosteroids, 465 hippocampal activity, 83, 87 Corticosterone, 679 Cortisol-cortisone shuttle hypertension, 501 Cyclic AMP, 301, 465 Cytochrome P-450 C21SCC hydroxylase and lyase activity, 527 Cytokines hypothalamus-pituitary—adrenal axis, 613 Dehydroepiandrosterone actions in humans, 599 formation in brain, 71 metabolism in humans, 599 Dehydrogenase activity 3B-hydroxysteroid dehydrogenase, 545 Delta-16-steroids in human testis, 587 Dimerization of oestrogen receptor, 333 DNA-binding glucocorticoid receptor, 287 Dog brain corticosteroid receptors, 63 Effect of clomiphene citrate on bone maintenance, 725 gonadal steroids on opioid receptor, 113 oestradiol on bone maintenance, 725 Effects of corticosteroids on Leydig cell steroidogenesis, 465 hormones on SBP mRNA, 777 Elasmobranchs role of steroids in females, 571 Endocrine aspects of cancer, 15 Endothelin(s), 481 adrenal vascular events, 381 aldosterone secretion in vitro, 437 Epidemiology of cancer, 15 Epidermal growth factor co-operation with progestins, 239 Estradiol, 481 Estrogens, 511 Expression steroidogenic enzymes, 45 Fertility and ovarian follicle, 29 FSH and growth factor interaction in polycystic ovary syndrome, 405 Function corticosteroid binding globulin, 755 sex steroid binding protein, 735 Functional domains vitamin D binding protein, 787 Gene expression in breast cancer cells, 239 in rat brain oestrogen and progestin receptor, 53 XIV Subject Index Gene promoter glucocorticoid receptor, 317 Genomic structure of vitamin D binding protein, 787 Glial cells mineralocorticoid receptor, 105 glucocorticoid receptor, 105 Glioma, 105 Glucocorticoid action on central peptidergic neurons, 93 Glucocorticoid receptor activation, 287 DNA-binding, 287 gene promoter, 317 glial ceils, 105 glucocorticoid resistance, 353 hippocampus, 685 homologous down regulation, 317 in aging, 679 monoamine regulation, 685 neuroendocrine dynamics, 679 nuclear envelope binding protein, 279 nuclear localization peptide, 279 peptidergic neurons, 93 subunit structure, 287 Glucocorticoid receptor gene, 317 Glucocorticoid regulated nuclease and apoptosis, 661 Glucocorticoid resistance, 353 glucocorticoid receptor, 353 hepatoma cells, 353 Glucocorticoids autoimmunity, 619 stress, 619 Gonadal function and neuropeptides, 25 Gonadal steroids effect on opioid receptor, 113 Gonadotropin secretion in vivo model, 143 steroid control, 417 Granulosa cells oestrogen production, 405 Growth factor(s) effect of oestrogen, 215 breast cancer cells, 215 human prostate, 185, 193, 199 regulation of Leydig cell functions, 453 signal transduction pathways, 215 Growth hormone secretion sex steroid control, 165 Hepatoma cells glucocorticoid resistance, 353 Hippocampal activity and corticosteroids, 83, 87 Hippocampus glucocorticoid receptor, 685 Homologous down regulation glucocorticoid receptor, 317 Hormonal interactions polycystic ovary syndrome, 405 Hormonal regulation cathepsin D, 231 Hormone resistance breast cancer cell lines, 231 Hormone response element(s), 307 Hormone-dependent promoters and chromatin structure, 325 Human breast cancer aromatase, 247, 255 Human cancer cells SBP mRNA, 777 Human prostate growth factors, 199 effects of SHBG, 833 Human testicular delta-16-steroids, 587 118-Hydroxyandrostenedione level in osteoporose, 731 19-Nortestosterone effect on body composition, 607 Hydroxylase activity of cytochrome P-450 C21SCC, 527 21-Hydroxylase deficiency molecular pathology, 537 3B-Hydroxysteroid dehydrogenase dehydrogenase activity, 545 isomerase activity, 545 11£-Hydroxysteroid dehydrogenase heterogeneity in rat tissues, 533 Hypertension, 511 cortisol—cortisone shuttle, 501 steroids, 35 Hypothalamus, 93 opioid receptor, 113 Hypothalamus-pituitary—adrenal axis cytokines, 613 Immunological mechanisms stress-induced immunomodulation, 639 Immunomodulation stress, 639 Insulin, 599 relation to SHBG, 841 Insulin-like growth factors adrenal growth, 399 induction by oestrogens, 223 ovarian steroidogenesis, 411 Isomerase activity 3B-Hydroxysteroid dehydrogenase, 545 Lactation contraception by progestins, 705 Leydig cell functions regulation by growth factors, 453 Leydig cell steroidogenesis effects of corticosteroids, 465 release of arachidonic acid, 465 LHRH secretion in vivo model, 143 sex steroid control, 155 LNCaP androgen sensitivity, 207 formation of steroid glucuronides, 593 prostate cancer cells, 193 sublines, 207 Luteinizing hormone action on the testis, 441 Lyase activity of cytochrome P-450 C21SCC, 527 SBMB 40/4-4—Z XVI Subject Index Mast cells and adrenal vascular events, 381 Metabolism dehydroepiandrosterone, 599 neurosteroids, 71 Mineralocorticoid receptor glial cells, 105 mutations, 363 pseudohypoaldosteronism, 363 Mineralocorticoids congenital adrenal hyperplasia, 493 Molecular biology of sex steroid binding protein, 735 Molecular pathology of 21-hydroxylase deficiency, 537 Monoamine regulation of glucocorticoid receptor, 685 Mouse kidney, 307 mRNA * androgen receptor, 343 vitamin D binding protein, 787 Muscle damage by oestrogen and tamoxifen, 689 Mutations androgen receptor, 349 mineralocorticoid receptor, 363 Myc proto-oncogene induction in uterus by oestrogens, 223 Natriuretic peptides, 367 Neuroendocrine activity in aged dogs, 63 Neuroendocrine dynamics aging and glucocorticoid receptor, 679 Neuroendocrine mechanisms stress-induced immunomodulation, 639 Neuropeptides, 93 gonadal function, 25 Neurosteroids, biosynthesis and metabolism, 71 Nuclear envelope binding protein for glucocorticoid receptor, 279 Nuclear localization peptide for glucocorticoid receptor, 279 Oestrogen effect on growth factor, 215 muscular damage, 689 production in granulosa cells, 405 production and polycystic ovary syndrome, 405 Oestrogen receptor chimeric proteins, 333 dimerization, 333 gene expression in rat brain, 53 Oestrogens induction of IGFs and myc proto-oncogene, 223 Oligodendrocytes, 105 Oligosaccharides androgen binding proteins, 821 structure/function relationship, 821 Opioid receptor, 113 effect of gonadal steroids, 113 hypothalamus, 113 Ornithine decarboxylase gene androgen regulation, 307 Ovarian follicle and fertility, 29 Ovary insulin-like growth factors, 411 Oxytocin, 481 Subject Index Oxytocin receptor steroid modulation in uterus, 481 Peptidergic neurons glucocorticoid receptor, 93 Pheromones steroid glucuronides in African catfish, 549 Phospholipase A2 and testis function, 465 Polycystic ovary syndrome FSH and growth factor interaction, 405 hormonal interactions, 405 oestrogen production, 405 Pregnenolone in brain, 71 Progesterone, 481 Progestin receptor antihormone action, 271 gene expression in rat brain, 53 isoforms, 271 Progestins contraception, 705 co-operation with EGF, 239 Promoter function, 317 Proopiomelanocortin, 301 Prostaglandins, 465 Prostate effect of steroids, 175 Prostate cancer cells growth factors, 185, 193 LNCaP, 193 steroids, 193 Prostate tumor, 349 Proto-oncogenes, 215 Pseudohypoaldosteronism mineralocorticoid receptor, 363 Receptor androgen, 343, 349 corticosteroid, 63 glucocorticoid, 93, 105, 133, 279, 287, 301, 317, 679 luteinizing hormone, 21 mineralocorticoid, 105, 133, 363, 679 oestrogen, 53, 231 opioid, 113 oxytocin, 481 progestin, 21, 53, 231 sex steroid binding protein, 805 vasopressin, 481 Regulation ABP/SHBG gene, 771 steroidogenic genes, 45 Regulation by testosterone androgen receptor protein, 343 Renin-angiotensin system blood pressure dimorphism, 511 Reptiles role of steroids in females, 571 SBP see: sex hormone binding protein XVIII Subject Index SBP mRNA effects of hormones, 777 human cancer cells, 777 Sex hormone binding globulin ancestral gene, 763 effect on human prostatic carcinoma, 833 in regulatory system, 813 pathophysiology, 841 relation to insulin, 841 relation to vitamin K dependent protein S, 763 Sex steroid binding protein function, 735 molecular biology, 735 receptor, 805 structure, 735 Sex steroid control growth hormone secretion, 165 LHRH secretion, 155 Sex steroids autoimmunity, 619 effect of cartilage, 717 effect on cartilage cells, 711 regulation of autoimmunity, 649 stress, 619 Sexual dimorphism blood pressure, 511 SHBG see: sex hormone binding globulin see: sex hormone binding protein Signal transduction pathways growth factors, 215 Steroid 17a-hydroxylase calf testis, 431 purification and properties, 431 Steroid biosynthesis transcriptional regulation, 517 Steroid control central neuron function, 123 gonadotropin secretion, 417 Steroid glucuronides as male pheromones in African Catfish, 549 formation by LNCaP cells, 593 levels in circulation, 593 Steroid metabolites, 465 Steroid modulation _ oxytocin receptor, 481 vasopressin receptor, 481 Steroid receptor superfamily cloning of new members, 263 Steroid receptors cathepsin D, 231 transfection, 231 Steroid secretion adrenal vascular events, 381 Steroidal fatty acid esters, 577 Steroidogenesis, 465 insulin-like growth factors, 411 Steroidogenic enzymes expression, 45 Steroidogenic genes regulation, 45 Subject Index Steroids brain, 1 hypertension, 35 prostate, 175 prostate cancer cells, 193 Strength effect of testosterone, 607 Stress, 679 glucocorticoids, 619 immunomodulation, 639 sex steroids, 619 testis function, 473 Structure corticosteroid binding globulin, 755 sex steroid binding protein, 735 Structure/function relationship oligosaccharides, 821 Subunit structure glucocorticoid receptor, 287 S-adenosylmethionine decarboxylase androgen regulation, 307 Tamoxifen muscle damage, 689 Testicular feminization, 349 Testis action of luteinizing hormone, 441 stress induced changes, 473 Testosterone, 511 effect on strength, 607 metabolism in avian hypothalamus, 557 regulation of androgen receptor mRNA, 343 Testosterone metabolism in brain, 673 Threonine analogue inhibition of adrenal steroidogenesis, 421 Thyroid hormone brain, 1 Transcription, 301 Transcriptional regulation of steroid biosynthesis, 517 Transfection of steroid receptors, 231 Uterus, 481 myc proto-oncogene, 223 oxytocin receptor, 481 vasopressin receptor, 481 Vasopressin, 481, 511 Vasopressin receptor steroid modulation, 481 uterus, 481 Vitamin D binding protein functional domains, genomic structure and mRNA expression, 787 Vitamin K dependent protein S ancestral gene, 763 relation to sex hormone binding globulin, 763 Zona glomerulosa cells aldosterone secretion in vitro, 437

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