Table Of Content

VOLUME CONTENTS JANUARY 1999 Foreword: P.G r ner Preface to Molecular and Cellular Themes in Cancer Research: P. A. Hall and D. P. Lar Perspective: Cancer Care and the New Biology: S. B. Kaye Molecular Epidemiology of Human Cancer Risk: Gene-environment Interactions and p53 Mutation Spectrum in Human Lung Cancer: W. P. Bennett, S. Perwez Hussain, K. H. Vahakangas M.A. Khan, P. G. Shields and C. C. Harris Inherited and Inducible Chromosomal Instability: a Fragile Bridge Between Genome Integrity Mechanisms and Tumourigenesis: E. G. Wright Chromosomes, 11q and Cancer: a Review: J. Koreth, C. J. Bakkenist and J.O 'D. McGee Perspective: Chromosomal Translocations Can Affect Genes Controlling Gene Expression and Differentiation- -Why are these Functions Targeted?: T. H. Rabbitts insights into Cancer from Transgenic Mouse Models: K. F. Macleod and T. Jacks Field Cancerization, Clonality, and Epithelial Stem Cells: the Spread of Mutated Clones in Epithelial Sheets: S. B. Garcia, H. S. Park, M. Novelli and N. A. Wright Genetic Events and the Role of TGFf in Epithelial Tumour Progression: R Perspective: Tumour Spread—the Problems of Latency: |. R. Hart Perspective: Defectsi n Cell Cycle Control and Cancer: J. Bartek, J. Lukas ar Cellular Senescence and Cancer: D. Wynford- Thomas The p53 Pathway: C. Prives and P. A. Hal Apoptosiasn d Therapy: C. A. Schmitt and S. W. Lowe New Approaches to Cancer Therapies: R. Fahraeus, P. Fischer, E. Krausz and D. P. Lanse How Shall We Apply the New Biology to Diagnostics in Surgical Pathology? BIOSIS), BIOSIS Previews, CAB Abstracts Service ambridge Scientific Abstrac 1 Cancer, Current Contents—Clinical Medicine (institute tor Scient nformation er BIOBASE/Current Awareness ir ological Sciences : CABI), Medical & Psychc review MPPS), Medica Database cology Information Service, Reference Update (ISI), Research Alert (1S! yy (CABI Science Citation index (ISI), SciSearch nowr Science Citation eterir tin (CABI), VINITI-Russian A ¢ VOLUME CONTENTS JANUARY 1999 Foreword: P.G r ner Preface to Molecular and Cellular Themes in Cancer Research: P. A. Hall and D. P. Lar Perspective: Cancer Care and the New Biology: S. B. Kaye Molecular Epidemiology of Human Cancer Risk: Gene-environment Interactions and p53 Mutation Spectrum in Human Lung Cancer: W. P. Bennett, S. Perwez Hussain, K. H. Vahakangas M.A. Khan, P. G. Shields and C. C. Harris Inherited and Inducible Chromosomal Instability: a Fragile Bridge Between Genome Integrity Mechanisms and Tumourigenesis: E. G. Wright Chromosomes, 11q and Cancer: a Review: J. Koreth, C. J. Bakkenist and J.O 'D. McGee Perspective: Chromosomal Translocations Can Affect Genes Controlling Gene Expression and Differentiation- -Why are these Functions Targeted?: T. H. Rabbitts insights into Cancer from Transgenic Mouse Models: K. F. Macleod and T. Jacks Field Cancerization, Clonality, and Epithelial Stem Cells: the Spread of Mutated Clones in Epithelial Sheets: S. B. Garcia, H. S. Park, M. Novelli and N. A. Wright Genetic Events and the Role of TGFf in Epithelial Tumour Progression: R Perspective: Tumour Spread—the Problems of Latency: |. R. Hart Perspective: Defectsi n Cell Cycle Control and Cancer: J. Bartek, J. Lukas ar Cellular Senescence and Cancer: D. Wynford- Thomas The p53 Pathway: C. Prives and P. A. Hal Apoptosiasn d Therapy: C. A. Schmitt and S. W. Lowe New Approaches to Cancer Therapies: R. Fahraeus, P. Fischer, E. Krausz and D. P. Lanse How Shall We Apply the New Biology to Diagnostics in Surgical Pathology? BIOSIS), BIOSIS Previews, CAB Abstracts Service ambridge Scientific Abstrac 1 Cancer, Current Contents—Clinical Medicine (institute tor Scient nformation er BIOBASE/Current Awareness ir ological Sciences : CABI), Medical & Psychc review MPPS), Medica Database cology Information Service, Reference Update (ISI), Research Alert (1S! yy (CABI Science Citation index (ISI), SciSearch nowr Science Citation eterir tin (CABI), VINITI-Russian A ¢ VOLUME CONTENTS VOLUME 187, NUMBER 2 JANUARY Editoria The E-cadherin/Epidermal Growth Factor Receptor Interaction: A Hypothesis of Reciprocal and Reversible Control of Intercellular Adhesion and Cell Proliferation: A. U. Jawhari, M. J. G. Farthing and M. Pignatell Review Article Somatic Hypermutation and B-cell Malignancies: J. Spencer and D. K. Dunn-Walters Ori iginal Papers Cadherin- 11 is Highly Expressed in Rhabdomyosarcomas and During Differentiation of Myoblasts in vitro: M. A. Markus, C. Reichmuth, M. J. Atkinson, U. Reich, |. Hoffmann, R. Balling, U. Anderer and H. Hofler Down-regulation of CD44 Standard and Variant Isoforms During the Development and Pro- gression of Uterine Cervical Tumours: M. Saegusa, M. Hashimura, D. Machida and |. Okayasu CD44 Expression in Sinonasal Melanomas: Is Loss of Isoform Expression Associated with Advanced Tumour Stage?: S. Regauer, A. Ott, A. Berghold and A. Behan Lack of Class II Transactivator Causes Severe Deficiency of HLA-DR Expression in Small Cell Lung Cancer: T. Yazawa, H. Kamma, M. Fujiwara, M. Matsui, H. Horiguchi, H. Satoh, M. Fujimoto, K. Yokoyama ind T. Ogata Cyclin-dependent Kinase Inhibitor p27“'?' Expression and Interaction with Other Cell Cycle- associated Proteins in Mammary Carcinoma: C. E. Gillett, P. Smith, G. Peters, X. Lu and D. M. Barnes Correlation Between p53, c-erbB-2, and Topoisomerase Ilia Expression, DNA Ploidy, Hormonal Receptor Status and Proliferation in 356 Node-negative Breast Carcinomas: Prognostic Impli- cations: P. Rudolph, H. Olsson, G. Bonatz, V. Ratjen, H. Bolte, B. Baldetorp, M. Ferno, R. Parwaresch and P_ Alm Clinicopathological Implications of Parathyroid Hormone-related Protein in Human Colorectai Tumours: M. Nishihara, M. Ito, T. Tomioka, A. Ohtsuru, T. Taguchi and T. Kanematsu Synthesis of Basement Membrane by Gastrointestinal Cancer Cell Lines: T. Akashi, T. Miyagi N. Ando, Y. Suzuki, T. Nemoto, Y. Eishi, K. Nakamura, T. Shirasawa, N. Osa, N. Tanaka and R. E. Burgeson Expression of Growth Regulatory Genes in a SCID Mouse-Human Model of Intestinal Epithelial Regeneration: A. Sattar, S.C. Robson, H. R. H. Patel, B. Angus and F. C. Campbell Amplification of the Androgen Receptor Gene is Associated with p53 Mutation in Hormone- refractory Recurrent Prostate Cancer: P. A. Koivisto and |. Rantala Tenascin is Differentially Expressed in Endometrium and Endometriosis: D. J. Harrington, B. A. Lessey Rai, A. Bergavist, S. Kennedy, S. Manek, D. H. Barlow and H. J. Mardon The Histopathology of Fibrous Dysplasia of Bone in Patients with Activating Mutations of the Gsa Gene: Site-specific Patterns and Recurrent Histological Hallmarks: M. Riminucci, B. Liu, A. Corsi A. Shenker, A. M. Spiegel, P. Gehron Robey andP . Bianco Lymphocyte Targeting of the Brain in Adoptive Transfer Cryolesion-EAE: J. Lake, R. O. Weller M. J. Phillips and M. Needhan VOLUME CONTENTS FEBRUARY 1999 DNA Chip Technology: K. M. Kurian, C. J. Watson and A. H. Wyllie Re The Transition from Hyperplasia to Invasive Carcinoma of the Breast: S. R. Lakhar Cyclin D1 Gene Amplification and Overexpression are Present in Ductal Carcinoma jn situ of the Breast: C. B. J. Vos, N. T. ter Haar, J. L. Peterse, C. J. Cornelisse and M. J. van de Vijver Angiogenesis and Expression of Thymidine Phosphorylase by Inflammatory and Carcinoma Cells in Ductal Carcinoma in situ of the Breast: A. H. S. Lee, E. A. Dublin and L. G. Bobrow Urinary Tissue Factor Levels in Patients with Breast and Colorectal Cancer: B. A. Lwaleed and J. L. Francis Early re of Cyclo-oxygenase-2 during Sporadic Colorectal Carcinogenesis: X. Hao, A. E B M. Wallace, H. Wang, T. C. Willcocks, J. Maclouf, J. M. Polak, S. Knight and |. C. Talbot p21 AFIICIPT Exoression in Colorectal Carcinoma Correlates with Advanced Disease Stage and p53 Mutations: G. Viale, C. Pellegrini, G. Mazzarol, P. Maisonneuve, M. L. Silverman and S. Bosar Chromosomal Abnormalities in Renal Cell Neoplasms Associated with Acquired Renal Cystic Disease. A Series Studied by Comparative Genomic Hybridization and Fluorescence in situ - -—eeconagney J. Gronwald, A. S. Baur, H. Holtgreve-Grez, A. Jauch, F. Mosimann, P. Jichlinski, J.-P. Wauters id L. Guillou Improving the Prognostic Value of Histopathological Grading and Clinical Staging in Renal Cell Carcinomas by Means of Computer-assisted Microscopy: C. Francois, C.D ecaestecker, O. de Lathouwer C. Moreno, A. Peltier, T. Roumeguere, A. Danguy, J.-L. Pasteels, E.W espes, |. Salmon, R. van Velthoven and R Kiss immunostaining for Vasostatin | Distinguishes Between Ileal and Lung Carcinoids: R. T Cunningham, K. M. Pogue, W. J. Curry, C. F. Johnston, J. M. Sloan and K. D. Buchanan Frequent Expansion of Epstein-Barr Virus (EBV) Infected Cells in Germinal Centres of Tonsils from an Area with a High Incidence of EBV-associated Lymphoma: |. Araujo, H.-D. Foss, M. Hummel Anagnostopoulos, H. S. Barbosa, A. Bittencourt and H. Stein The Mucous Neck Cell in the Human Gastric Corpus: A Distinctive, Functional Cell Lineage: A. M Hanby, R. Poulsom, R. J. Playford and N. A. Wright Localization of Syndecan-1 in Human Gastric Mucosa Associated with Ulceration: H. Tanabe K. Yokota and Y. Kohgo inducible Nitric Oxide Synthase Expression in Vascular and Glomerular Structures of Human Chronic Allograft Nephropathy: P. Romagnan C. Pupill L. Lasagni, M. C. Baccari, F. Bellin A. Amorosi, E. Bertoni and M. Serio Interferon-y-induced ICAM-1 and CD40 Expression, Complete Lack of HLA-DR and CD80 (B7.1), and inconsistent HLA-ABC Expression in Basal Cell Carcinoma: A Possible Role for Interleukin-10? A. J. W. Kooy, E. P. Prens, A. van Heukelum, V. D. Vuzevski, T. van Joost and B. Tank IL-1$ and IFN-y Induce the Regenerative Epidermal Phenotype of Psoriasis in the Transwell Skin Organ Culture System. IFN-y Up-regulates the Expression of Keratin 17 and Keratinocyte Transglutaminase via Endogenous IL-1 Production: L. Wei, R. Debets, J. J. Hegmans, R. Benner and E P. Prens Differentiation-specific Regulation of Transgene Expression in a Diploid Epithelial Cell Line Derived from the Normal F344 Rat Liver: M. Ott, P. Rajvanshi, R. P. Sokhi, G. Alpini, E. Aragona M. Dabeva., D. A.A Shafritz and S. Gupta Osteoblastic Differentiation and mRNA Analysis of STRO-1-positive Human Bone Marrow Stromal Cells Using Primary in vitro Culture and Poly (A) PCR: R. J. Byers, J. Brown, C. Brandwood P. Wood, W. Staley, L. Hainey J. Freemont and J. A. Hoyland VOLUME CONTENTS VOLUME 187, NUMBER 4 MARCH Editorial Ductal Carcinoma in Situ in Breast Carcinogenesis: P. J. van Diest Review Article Comparative Genomic Hybridization as a Tool in Tumour Cytogenetics: L. A. James Or ginal Papers Comparative Genomic Hybridization of Ductal Carcinoma in Situ of the Breast—Evidence of Multiple Genetic Pathways: H. Buergei, F. Otterbach, R. Simon, C. Poremba, R. Diallo, T. Decker L. Riethdorf, C. Brinkschmidt, B. Dockhorn-Dworniczak and W. Boecker Widespread Chromosomal Abnormalities in High-grade Ductal Carcinoma jin Situ of the Breast Comparative Genomic Hybridization Study of Pure High-grade DCIS: —£. Moore, H. Magee J. Coyne, T. Gorey and P. A. Dervan In Vivo Patterns of BCL-2 Family Protein Expression in Breast Carcinomas in Relation to Apoptosis: P. Rochaix, S. Krajewski, J. C. Reed, F. Bonnet, J.-J. Voigt and P. Brousset Immunolocalization of the Fodrin, E-Cadherin and f-Catenin Adhesion Complex in infiltrating Ductal Carcinoma of the Breast—Comparison with an in Vitro Model: R. T. Sormunen, A. S.-Y. Leong J. P. Vaaraniemi, S. S. E. Fernandaond S. M. Eskelinen Absence of Microsatellite Instability in Breast Carcinomas with Both p53 and c-erbB-2 Alterations: C. Formantici, R. Orlandi, C. Ronchini, S. Pilotti, G. N. Ranzani, M. |. Colnaghi and S. Ménard Gastric Carcinomas with Microsatellite Instability: Clinical Features and Mutations to the 7GF-f Type ll Receptor, IGFil Receptor and BAX Genes: B. J. lacopetta, R. Soong, A. K. House and R. Hamelin Structural Differences Between Valine-12 and Aspartate-12 Ras Proteins May Modify Carcinoma Aggression: F. Al-Mulla, E. J. Milner-White, J. J. Going and G. D. Birnie Apoptosis and Proliferation in Relation to Histopathological Variables and Prognosis in Hepato- cellular Carcinoma: A. Tannapfel, F. Geissler, F. Kockerling, A. Katalinic, J. Hauss and C. Wittekind in Situ Expression Patterns of Melanoma-inhibiting Activity (MIA) in Melanomas and Breast Cancers: A.-K. Bosserhoff, M. Moser, R. Hein, M. Landthaler and R. Buettner Renal Cell Carcinomas and Pancreatic Adenocarcinomas Produce Nidogen jin Vitro and in Vivo J. Oivula, J. Lohi, T. Tani, L. Kangas, T. Kiviluoto, E. Kivilaakso, R. Butkowsaknid |. Virtanen inference Network-based Analyses of the Histopathological Effects of Androgen Deprivation on Prostate Cancer: R. Montironi, A. Santinelli, R.P omante, P. W. Hamilton, D. Thompson and P. H. Bartels p53 Overexpression in Oral Mucosa in Relation to Smoking: M. G. C. T. van Oijen, J. G. van de Craats and P. J. Slootweg Immunoreactive Interleukin 4 and Interferon-y Expression by Type Il Alveolar Epithelial Cells in Interstitial Lung Disease: W. A. H. Wallace and S. E. M. Howie Galectin-3 Modulates Rat Mesangial Cell Proliferation and Matrix Synthesis During Experimental Glomerulonephritis Induced by Anti-Thy1.1 Antibodies: S. Sasaki, OQ.B ao and R. C. Hughes Dual Colour Fluorescence in Situ Hybridization to Paraffin-embedded Samples to Deduce the Presence of the der(X)t(X;18) (p11.2:q11.2) and Involvement of Either the SSX7 or SSX2 Gene a Diagnostic and Prognostic Aid for Synovial Sarcoma: Y.-J. Lu, S. Birdsall, B. Summersgill D. Smedley, P. Osin, C. Fisher and J. Shipley Announcement VOLUME CONTENTS VOLUME 187, NUMBER 5 APRIL 1999 tditoria Serrated Adenoma and Colorectal Cancer: J. R. Jass AHeview Ar4 ticle The Clinical Manipulation of Angiogenesis: Pathology, Side-effects, Surprises, and Opportunities with Novel Human Therapies: W. D. Thompson, W. W. Li and M. Maragoudakis Original Papers ‘Serrated’ Adenoma of the Colorectum, with Reference to its Gastric Differentiation and its Malignant Potential: T. Yao, T. Kouzuki, M. Kajiwara, N. Matsui, M. Oya and M. Tsuneyoshi Analysis of /GF2 Gene Imprinting in Breast and Colorectal Cancer by Allele Specific-PCR: K. Yun H. Soejima, A. H. Merrie, J. L.M cCalanld A. E. Reeve An Immunohistochemical Examination of the Expression of E-Cadherin, a- and fly-Catenins, and a2- and fi-integrins in Invasive Breast Cancer: M. A. Gonzalez, S. E. Pinder, P. M. Wencyk, J. A. Bell C. W. Elston, R. |. Nicholson, J. F. R. Robertson, R. W. Blamey and| . O. Ellis Functional Loss of E-Cadherin and Cadherin-11 Alleles on Chromosome 16q22 in Colonic Cancer: E. Braungart, C. Schumacher, E. Hartmann, H. Nekarda, K.-F. Becker, H. Hofler and M. J. Atkinson Apoptotic and Proliferative Activity in the Neoplastic Progression of Barrett's Oesophagus: a Comparative Study: C. E. Whittles, L. R. Biddlestone, A. Burton, H. Barr, J. A. Z. Jankowski, P. J.W arner and N. A. Shepherd Patterns of Expression of Trefoil Peptides and Mucins in Gastric Polyps With and Without Malignant Transformation: A. M. M. F. Nogueira, J. C. Machado, F. Carneiro, C. A. Reis, P. Gott and M. Sobrinho-Sim6des A20 RNA Expression is Associated with Undifferentiated Nasopharyngeal Carcinoma and Poorly Differentiated Head and Neck Squamous Cell Carcinoma: J. D. Codd, J. R. Salisbury, G. Packham and L. J. Nicholson TP53 Alterations in Relation to the Cell Cycle-associated Proteins p21, Cyclin D1, CDK4, RB, MDM2, and EGFR in Cancers of the Uterine Corpus: H. Skomedal, G. B. Kristensen, J. M. Nesland A.-L. Borresen-Dale, C. Tropé and R. Holm Expression of p27/Kip1 is Down-regulated in Human Prostate Carcinoma Progression: P. L Fernandez, Y. Arce, X. Farré, A. Martinez, A. Nadal, M. J. Rey, N. Peiré, E.C ampo andA . Cardesa Immunocytochemical Detection and Mapping of a Cytokeratin 18 Neo-epitope Exposed During Early Apoptosis: M. P. G. Leers, W. Kolgen, V. Bjorklund, T. Bergman, G. Tribbick, B. Persson, P. Bjorklund F.C. S. Ramaekers, B. Bjorklund, M. Nap, H. Jornvall and B. Schutte D-type Cyclins in Adult Human Testis and Testicular Cancer: Relation to Cell Type, Proliferation, Differentiation, and Malignancy: J. Bartkova, E. Rajpert-de Meyts, N. E. Skakkebaek and J. Bartek Dominant Human Herpesvirus Type 8 RNA Transcripts in Classical and Aids-related Kaposi's Sarcoma: J. Linderoth, E. Rambech and M. Dictor Iimmunohistochemical Screening for Oncogenic Tyrosine Kinase Activation: K. Pulford, G. Delsol G. Roncador, S. Biddolph, M. Jones and D. Y .M ason Further Characterization of the Human Clear Cell Sarcoma Cell Line HS-MM Demonstrating a Specific t(12;22)(q13;q12) Translocation and Hybrid EWS/ATF-1 Transcript: H. Sonobe T. Takeuchi, T. Taguchi, K. Shimizu, J. lwata, M. Furihata and Y. Ohtsuki Letters to the Editor Re. Expression of Transforming Growth Factor # lsoforms in Osteosarcoma Variants: P. Kloen Author's Reply: A. Franchi The Potential Diagnostic Use of K-ras Codon 12 and p53 Alterations in Brush Cytology from the Pancreatic Head Region: A. Deery Authors’ Reply: P. D. J. Sturm, L. A. Noorduyn and G. J. A. Offerhaus