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THE JOURNAL OF 4 NUTRITION OFFICIAL PUBLICATION OF THE AMERICAN INSTITUTE OF NUTRITION | Editor WILLARD J. VISEK University of Illinois College of Medicine 190 Medical Sciences Bldg. 506 South Mathews Urbana, Illinois 61801 Assistant Editor KATHRYN K. HARDEN Associate Editors LINDSAY H. ALLEN JOHN D. FERNSTROM JOANNE R. LUPTON University of California - Davis ' Univ.of Pittsburgh School of Medicine Texas A&M University Department of Nutrition 1 Department of Psychiatry Department of Animal Science 3113 Meyer Hall | Western Psychiatric inst. and Clinic Human Nutrition Section Davis, California 95616-8669 | 3811 O'Hara Street 218 Kleberg i Pittsburgh, PA 15213 College Station, Texas 77843-2471 JOSEPH R. PROHASKA PETER J. REEDS JUDITH STORCH JOHN W. SUTTIE University of Minnesota - Duluth Baylor Colli:ge of Medicine Rutgers University University of Wisconsin-Madison Department of Biochemistry and Department of Pediatrics Cook College Departments of Biochemistry Molecular Biology Children’s Nutrition Research Center Department of Nutritional Science and Nutritional Sciences 10 University Drive 1100 Bates Lipman Drive - Thompson Hall 420 Henry Mall Duluth, Minnesota 55812-2487 Houston, Texas 77030 New Brunswick, NJ 08903-0231 Madison, Wisconsin 53706 Regional Correspondents Pacific Rim: | Latin America and the Caribbean: Western Europe: David L. Topping Jorge L. Rosado Anton C. Beynen CSIRO Division of Human Nutrition National Institute of Nutrition Utrecht University Glenthorne Laboratory Vasco de Quiroga No 15 Faculty of Veterinary Medicine Major Road, O'Halloran Hill SA 5158 Tlalpan, Mexico City, DF P.O. Box 80,166 Australia Mexico 14000 3508 TD Utrecht, The Netherlands Fax: 61-83770004 Fax: 525-655-1076 Fax: 31-30-537997 |i ‘Biographical and Historical Editors Thomas H. Jukes Kenneth J. Carpenter University of California University of California 6701 San Pablo Avenue Department of Nutritional Science Oakland, California 946()8-1239 119 Morgan Hall Berkeley, California 94720-0001 } ! |' Editorial Board ! David H. Baker George C. Fahey, Jr. James O. Hill Jack Odle John L. Beard Susan K. Fried Farook Jahoor Andrew M. Prentice Phyllis E. Bowen Kevin L. Fritsche Janet King Robert D. Reynolds Linda J. Brady Daniel D. Gallaher Allen S. Levine Richard D. Semba lan Bremner H. Rex Gaskins Alice H. Lichtenstein Martha H. Stipanuk Alvin Chan Stephen R. Glore Roy J. Martin Jon A. Story Sylvia Christakos Frank R. Greer Michael |. McBurney Keith P. West Michael T. Clandinin Jessi: F. Gregory, Ill Donald B. McCormick Richard J. Wood Steven K. Clinton Judith Hallfrisch Roger B. McDonald William D. Woodward Rosalind Coleman Edward D. Harris Mary C. McKenna Akira Yoshida Kathryn G. Dewey Suzanne Hendrich Suzanne Murphy Regina G. Ziegler | VOLUME 126 JANUARY -D ECEMBER 1996 'P UBLISHED MONTHLY BY THE AMERICAN INSTITUTE OF NUTRITION | ! Bethesda, Maryland | i | | | | THE JOURNAL OF NUTRITION® ®Trademark registered, U.S. Patent Office Copyright © 1996 by THE AMERICAN INSTITUTE OF NUTRITION All rights reserved CONTENTS No. 1 JANUARY 1996 GUIDE FOR AUTHORS Guide for Authors (Revised January 1996] Manuscript Submission and Copyright Release Form CRITICAL REVIEW Plant Wax ennai A New Approach to Estimating Intake and Diet Composition in Herbivores. H. Dove and R. W. Mayes ARTICLES Biochemical and Molecular Roles of Nutrients Manganese Protects against Heart Mitochondrial Lipid Peroxidation in Rats Fed High Levels of Polyunsatu- rated Fatty Acids. Elise A. Malecki and J. L. Greger Dietary Fish Oil Confers Direct Antiarrhythmic Properties on the Myocardium of Rats. Salvatore Pepe and Peter L. McLennan Soybean Isoflavones Improve Cardiovedcalar Risk Factors without Affecting the Reproductive System of Peripubertal Rhesus Monkeys. Mary |S . Anthony, Thomas B. Clarkson, Claude L. Hughes, /r., Timothy M. Morgan and Gregory L. Burke ..: Modulation of Lysyl Oxidase by Dietary Copper in Rats. Robert B. Rucker, Nadia Romero-Chapman, Toniel Wong, Jill Lee, Francene M. Steinberg, Carl McGee, Michael S. Clegg, Karen Reiser, Taru Kosonen, Janet Y. Uriu-Hare, Jerome Murphy and Curl L. Keen Biotin Deficiency Decreases Ornithine ‘Transcarbamylase Activity and mRNA in Rat Liver. Yuichi Maeda, Sumio Kawata, Yoshiaki Inui, Kazuto Fukuda, Takumi Igura and Yuji Matsuzawa Methionine Reduces the Valproic Acid-Induced Spina Bifida Rate in Mice without Altering Valproic Acid Kinetics. Katharine Ehlers, Mohamed M. A. Elmazar and Heinz Nau Higher Postpartum Hepatic Triacylglyce ‘rol Concentrations in Dairy Cows with Free rather than Restricted Access to Feed During the Dry Period ‘Are Associated with Lower Activities of Hepatic Glycerolphosphate Acyltransferase. A. Marc Van den Top, Math J. H. Geelen, Theo Wensing, G. Henk Wentink, Arie Th. Van’T Klooster and Anton C. Beyneri Dietary Casein Phosphopeptides Prevént Bone Loss in Aged Ovariectomized Rats. Hiroshi Tsuchita, Toshiyuki Goto, Taki Shimizu, Yokc Yonehara and Tamotsu Kuwata Vitamin A Deficiency Diminishes the Salivary Immunoglobulin A Response and Enhances the Serum Immu- noglobulin G Response to Influenza A Virus Infection in BALB/c Mice. Charles B. Stephensen, Zina Moldoveanu and Nupur N. Gangopadhyay Community and International Nutrition Low Birth Weight Reduces the Likelihood of Breast-Feeding among Filipino Infants. Linda S. Adair and ge Re eee PEE eS PE SES 2 Re Eeeee e e eee Ske Validity of Single-Weight Measurements to Predict Current Malnutrition and Mortality in Children. Jan Van den Broeck, Roger Eeckels and Guy Massa Plasma Ascorbic Acid Concentrations ‘Are Related to Cardiovascular Risk Factors in African-Americans. Lynn Toohey, Mary A. Harris, Kenneth G. D. Allen and Christopher L. Melby ili iv Human and Clinical Nutrition Human Serum Carotenoid Concentrations Are Related to Physiologic and Lifestyle Factors. William E. Brady, Julie A. Mares-Perlman, Phyllis Bowen and Maria Stacewicz-Sapuntzakis Selenoprotein P Concentration in Plasma Is an Index of Selenium Status in Selenium-Deficient and Sele- nium-Supplemented Chinese Subjects. Kristina E. Hill, Yiming Xia, Bjérn Akesson, Martha E. Boeglin and Raymond F. Burk Maternal Underweight Status and Inadequate Rate of Weight Gain During the Third Trimester of Pregnancy Increase the Risk of Preterm Delivery. Anna Maria Siega-Riz, Linda S. Adair and Calvin J. Hobel .... Purified Ferritin and Soybean Meal Can be Sources of Iron for Treating Iron Deficiency in Rats. John L. Beard, Joseph W. Burton and Elizabeth C. Theil Dietary Soybean Protein Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Bahram H. Arjmandi, Lee Alekel, Bruce W. Hollis, Daxa Amin, Maria Stacewicz-Sapuntzakis, Peilin Guo and Subhash C. Kukreja Growth Failure and Altered Body Composition Are Established by One Month of Age in Infants with Bronchopulmonary Dysplasia. Raye-Ann O. deRegnier, Theresa W. Guilbert, Marla M. Mills and Michael K. Georgieff Nutrient Metabolism Absorption and Excretion of the Soy Isoflavone Genistein Rats. Roger A. King, Jessica L. Broadbent and Richard J]. Head Iron and Copper Interact during Their Uptake and Deposition in the Brain and Other Organs of Developing Rats Exposed to Dietary Excess of the Two Metals. Andrew Crowe and Evan H. Morgan Maillard Reaction Products in Purified Diets Induce Taurine Depletion in Cats Which Is Reversed by Antibiotics. Seungwook W. Kim, Quinton R. Rogers and James G. Morris Dietary 6-Carotene Elevates Plasma Steady-State and Tissue Concentrations of G-Carotene and Enhances Vitamin A Balance in Preruminant Calves. Peter P. Hoppe, Boon P. Chew, Anton Safer, Ingrid Stegemann and Hans K. Biesalski Interactions between Ruminal Degradable Nitrogen Intake and In Vitro Addition of Substrates on Patterns of Amino Acid Metabolism in Isolated Ovine Hepatocytes. Timothy Mutsvangwa, Jock G. Buchanan- Smith and Brian W. McBride The Acrodermatitis Enteropathica Mutation Transiently Affects Zinc Metabolism in Human Fibroblasts. Arthur Grider and Elizabeth M. Young Absorption and Metabolism of Lipids in Rats Depend on Fatty Acid Isomeric Position. Toshiaki Aoyama, Kensuke Fukui, Kaori Taniguchi, Syuuji Nagaoka, Takashi Yamamoto and Yukio Hashimoto Methionine-Containing Peptides Can Be Used As Methionine Sources for Protein Accretion in Cultured C,C,. and MAC-T Cells. Yuanlong Pan, Patrick K. Bender, R. Michael Akers and Kenneth E. Webb, Jr. Folate Transport Pathways Regulate Urinary Excretion of 5-Methyltetrahydrofolate in Isolated Perfused Rat Kidney. Robert T. Muldoon, Donna M. Ross and Kenneth E. McMartin The Caco-2 Cell Culture System Can be Used as a Model to Study Food Iron Availability. Maria N. Garcia, Carol Flowers and James D. Cook Diet-Induced Nephrocalcinosis in Female Rats Is Irreversible and Is Induced Primarily before ~ Completion of Adolescence. Catherine A. Peterson, David H. Baker and John W. Erdman, Jr. A High Protein Diet Does Not Improve Protein Synthesis in the Nonweight-Bearing Rat Tibialis Anterior Muscle. Daniel Taillandier, Charles-Yannick Guezennec, Philippe Patureau-Mirand, Xavier Bigard, Maurice Arnal and Didier Attaix L-Glutamine Supplementation of a High Fat Diet Reduces Body Weight and Attenuates Hyperglycemia and Hyperinsulinemia in C57BL/6J Mice. Emmanuel C. Opara, Ann Petro, Allyson Tevrizian, Mark N. Feinglos and Richard S. Surwit Lactitol Enhances Short-Chain Fatty Acid and Gas Production by Swine Cecal Microflora to a Greater Extent When Fermenting Low Rather Than High Fiber Diets. Andrea Piva, Andrea Panciroli, Elena Meola and Andrea Formigoni Nutrient Requirements and Interactions Severe Protein Deficiency and Repletion Alter Body and Brain Composition and Organ Weights in Infant Pigs. Wilson G. Pond, Kenneth J. Ellis, Harry ]. Mersmann, Julian P. Heath, Lennart P. Krook, Douglas G. Burrin, Mary A. Dudley and Hwai-Ping Sheng Wheat Bran Abolishes the Inverse Relationship between Calcium Load Size and Absorption Fraction in Women. Connie M. Weaver, Robert P. Heaney, Dorothy Teegarden and Sharilyn M. Hinders Hemicellulose Does Not Affect Iron Bioavailability in Chicks. Alyce D. Fly, Gail L. Czarnecki-Maulden, George C. Fahey, Jr. and Evan C. Titgemeyer Weight Loss Alters Organ Concentrations and Contents of Lead and Some Essential Divalent Metals in Rats Previously Exposed to Lead. Shenggao Han, Xianwen Qiao, Scott Simpson, Pegah Ameri, Francis W. Kemp and John D. Bogden Response of Rainbow Trout teeiensiinghadion mykiss) Growing from 50 to 200 g to Supplements of Dibasic Sodium Phosphate in a Semipurified Diet. Markus Rodehutscord Caco-2 Cell Iron Uptake from Meat and Casein Digests Parallels In Vivo Studies: Use of a Novel In Vitro Method for Rapid Estimation of Iron Bioavailability. Raymond P. Glahn, Elizabeth M. Wien, Darrell R. van Campen and Dennis D. Miller Announcements SUPPLEMENT Stable Isotopic Tracers in Nutrition and Metabolism. Satish C. Kalhan and Sooja K. Kim, editors ....... 343S i i No. 2 FEBRUARY 1996 ! ARTICLES Biochemical and Molecular Roles of Nutrients Fermentable Carbohydrates Elevate Plasnia Enteroglucagon but High Viscosity Is Also Necessary to Stimulate Small Bowel Mucosal Cell Proliferation in Rats. ]. M. Gee, W. Lee-Finglas, G. W. Wortley and I. T. Johnson Soybean Protein Suppresses Hepatic Lipogenic Enzyme Gene Expression in Wistar Fatty Rats. Nobuko Iritani, Hiroko Hosomi, Hitomi Fukuda, Kayoko Tada and Hitoshi Ikeda Dietary a-Tocopherol Attenuates the Impact of y-Tocotrienol on Hepatic 3-Hydroxy-3-Methylglutaryl Coen- zyme A Reductase Activity in Chickens. Asaf A. Qureshi, Bradley C. Pearce, Rosnah M. Nor, A. Gapor, David M. Peterson and Charles E. Elson Nutritional State and the a d Inhibition of Proteolysis in Perfused Rat Liver. Stephan vom Dahl and Dieter Haussinger Hepatic Cytochrome P450 and UDP- Ciakneasae Transferase Are Affected by Five Sources of Dietary Fiber in Germ-Free Rats. Lionelle Nugon-Baudon, Nathalie Roland, Jean-Pierre Flinois and Phillipe Beaune . . Amylopectin Starch Induces Nonreversille Insulin Resistance in Rats. C. Elke Wiseman, Janine A. Higgins, Gareth S. Denyer and Janette C. Brand Miller Dietary Energy Restriction in Mice Negatively Regulates Hepatic Glucose-Regulated Protein 78 (GRP78) Expression at the Posttranscriptional Level. John B. Tillman, Patricia L. Mote, Joseph M. Dhahbi, Roy L. Walford and Stephen R. Spindler Exogenous Nucleotides Alter the Prolif eration, Differentiation and Apoptosis of Human Small Intestinal Epithelium. Mayumi Tanaka, Kaechoong Lee, Olga Martinez-Augustin, Youping He, Ian R. Sanderson and W. Allan Walker Community and International Nutrition Vitamin A Supplementation Fails to Reduce Incidence of Acute Respiratory Illness and Diarrhea in Preschool- Age Indonesian Children. Michael J. Dibley, Tonny Sadjimin, Chris L. Kjolhede and Lawrence H. Moulton Zinc Supplementation Reduces the Incidence of Persistent Diarrhea and Dysentery among Low Socioeco- nomic Children in India. Sunil Sazawal, Robert E. Black, Maharaj K. Bhan, Sanju Jalla, Nita Bhandari, Anju Sinha, and Sharmila Majumdar vi Vitamin A Status of Indonesian Children Infected with Ascaris lumbricoides after Dosing with Vitamin A Supplements and Albendazole. Sherry A. Tanumihardjo, Dewi Permaesih, Muherdiyantiningsih, Effendi Rustan, Kusnandi Rusmil, Alex C. Fatah, Steve Wilbur, Muhilal, Darwin Karyadi and James A. Olson Human and Clinical Nutrition Products Based on a High Fiber Barley Genotype, but Not on Common Barley or Oats, Lower Postprandial Glucose and Insulin Responses in Healthy Humans. Helena G. M. Liljeberg, Yvonne E. Granfeldt and Inger M. E. Bjérck Dietary Iron Supplementation Does Not Aggravate Experimental Malaria in Young Rats. Marly A. Cardoso, Marcelo U. Ferreira, Georgina S. Ribeiro, Marilene D. V. C. Penteado and Heitor F. Andrade, Jr. Dietary Aspergillus niger Phytase Increases Iron Absorption in Humans. Ann-Sofie Sandberg, Lena Rossander Hulthén and Maria Tiirk Digestibilities of Energy, Protein, Fat and Nonstarch Polysaccharides in a Low Fiber Diet and Diets Containing Coarse or Fine Whole Meal Rye Are Comparable in Rats and Humans. Elisabeth Wisker, Knud Erik Bach Knudsen, Martina Daniel, Walter Feldheim and Bjérn O. Eggum Nutrient Metabolism Biliary Manganese Excretion in Conscious Rats Is Affected by Acute and Chronic Manganese Intake but Not by Dietary Fat. Elise A. Malecki, Gwendolyn M. Radzanowski, Thaddeus ]. Radzanowski, Daniel D. Gallaher and J. L. Greger B-Carotene Absorption and Cleavage in Rats Is Affected by the Vitamin A Concentration of the Diet. Trinette van Vliet, Martje Fentener van Vlissingen, Frank van Schaik and Henk van den Berg Dietary Antibiotics Decrease Taurine Loss in Cats Fed a Canned Heat-Processed Diet. Seungwook W. Kim, Quinton R. Rogers and James G. Morris Muscle and Liver Protein Synthesis Adapt Efficiently to Food Deprivation and Refeeding in 12-Month-Old Rats. Laurent Mosoni, Thierry Malmezat, Marie-Claude Valluy, Marie-Louise Houlier and Philippe Patureau Mirand Riboflavin-Binding Protein Induces Early Death of Chicken Embryos. Christine M. Lee and Harold B. White, III Methionine and 2-Hydroxy-4-Methylthiobutanoic Acid Are Transported by Distinct Na*-Dependent Systems in the Brush Border Membrane of the Chick Intestinal Epithelium. David D. Maenz and Carmen M. Engele-Schaan Phylloquinone and Menaquinone-4 Distribution in Rats: Synthesis rather than Uptake Determines Menaqui- none-4 Organ Concentrations. H. H. W. Thijssen, M. J. Drittij-Reijnders and M. A. J. G. Fischer Moderate Food Restriction Abolishes the Pregnancy-Associated Rise in Serum Growth Hormone and De- creases Serum Insulin-Like Growth Factor-I (IGF-I) Concentrations without Altering IGF-I mRNA Expres- sion in Rats. Marcia H. Monaco and Sharon M. Donovan Nutrient Requirements and Interactions Fermentation of Carbohydrate in Rat Ileal Excreta Is Enhanced with Cecal Inocula Compared with Fecal Inocula. David J. Monsma and Judith A. Marlett 554 Obese Pigs Fed a High Cholesterol Diet from Birth to 2 Months Are Less Susceptible than Lean Pigs to Atherosclerosis. Anne M. Hackman, Wilson G. Pond, Harry ]. Mersmann, William W. Wong, Lennart P. Krook and Shide Zhang 564 The Protein Efficiency Ratios of 30:70 Mixtures of Animal:Vegetable Protein Are Similar or Higher than Those of the Animal Foods Alone. Miguel Hernandez, Irene Montalvo, Virginia Sousa and Angela Sotelo 574 LETTERS TO THE EDITOR Soybean Protease Inhibitors and Pancreatic Carcinogenesis. Irvin E. Liener Soybean Protease Inhibitors and Pancreatic Carcinogenesis: A Reply to Liener. Ann R. Kennedy Announcements No. 3 MARCH 1996 | i { ARTICLES i | ! | Biochemical and Molecular Roles of Nutrients A Total Parenteral Nutrition Solution Supplemented with a Nucleoside and Nucleotide Mixture Sustains Intestinal Integrity, but Does Not Stimulate Intestinal Function after Massive Bowel Resection in Rats. Shohei lijima, Toshimasa Tsujinaka,; Masanori Kishibuchi, Yoshihiro Kido, Chikara Ebisui, Kazuomi Kan, Masahiko Yano and Takesada Mori Development of Insulin Resistance in the Rat Is Dependent on the Rate of Glucose Absorption from the Diet. Janine A. Higgins, Janette C. Brand Miller and Gareth S. Denyer (n-3) Polyunsaturated Fatty Acids Modulate the Expression of Functionally Associated Molecules on Human Monocytes In Vitro. David A. Hughes, Susan Southon and Andrew C. Pinder High Carbohydrate Diet and Starvation Regulate Lipogenic mRNA in Rats in a Tissue-Specific Manner. Tae-Suk Kim and Hedley C. Freake |; Auditory Startle Response Is Diminished in Rats after Recovery from Perinatal Copper Deficiency. Joseph R. Prohaska and Richard G. Hoffman i i} f Community and International Nutrition Acute Respiratory Infections Prevent Inprovement of Vitamin A Status in Young Infants Supplemented with Vitamin A. M. Mujibur Rahman, D. Mahalanabis, J. O. Alvarez, M. A. Wahed, M. A. Islam, D. Habte, and M. A. Khaled Human and Clinical Nutrition Proteinase inhibitors Induce Selective Stimulation of Human Trypsin and Chymotrypsin Secretion. Janne E. Reseland, Halvor Holm, Morten B. Jacobsen, Trond G. Jenssen and Lars E. Hanssen a-Tocopherol Influences In Vivo Indices of Lipid Peroxidation in Postmenopausal Women Given Fish Oil. Rosemary C. Wander, Shi-Hua Du and Sharon O. Ketchum ! Nutrient Metabolism Dietary Fatty Acid Profile Influences the Composition of Skeletal Muscle Phospholipids in Rats. Kerry J. Ayre and Anthony J. Hulbert Parenteral Glycyl-L-Tyrosine Maintains Tyrosine Pools and Supports Growth and Nitrogen Balance in Phe- nylalanine-Deficient Rats. Peter Stelle, Sabine Weber and Peter Fiirst Carbon Flow through the Hepatic Folate-Dependent One-Carbon Pool Is Not Altered in Vitamin A-Deficient Rats. Kevin L. Schalinske and Robeit D. Steele Hypoxia Inhibits Gastric Emptying and Gastric Acid Secretion in Conscious Rats. Ryoichi Yamaji, Miki Sakamoto, Kazutaka Miyatake and Yoshihisa Nakano | '{ | Nutrient Requirements and Inte ractions Dietary Butter Protects against Ultraviolet Radiation-Induced Suppression of Contact Hypersensitivity in Skh:HR-1 Hairless Mice. Ranald 3. Cope, Meira Bosnic, Christa Boehm-Wilcox, Detlef Mohr and Vivienne E. Reeve Brain Iron and Behavior of Rats are Not Normalized by Treatment of Iron Deficiency Anemia during Early Development. Barbara T. Felt and Betsy Lozoff SPECIAL REPORT Genetically Modified Crops The Composition of Glyphosate-Tolerant Soybean Seeds Is Equivalent to That of Conventional Soybeans. Stephen R. Padgette, Nancy Biest Taylor, Debbie L. Nida, Michele R. Bailey, John MacDonald, Larry R. Holden and Roy L. Fuchs The Feeding Value of Soybeans Fed to Rats, Chickens, Catfish and Dairy Cattle Is Not Altered by Genetic Incorporation of Glyphosate Tolerance. Bruce G. Hammond, John L. Vicini, Gary F. Hartnell, Mark W. Naylor, Christopher D. Knight, Edwin H. Robinson, Roy L. Fuchs and Stephen R. Padgette The Expressed Protein in Glyphosate-Tolerant Soybean, 5-Enolypyruvylshikimate-3-Phosphate Synthase from Agrobacterium sp. Strain CP4, Is Rapidly Digested In Vitro and Is Not Toxic to Acutely Gavaged Mice. Leslie A. Harrison, Michele R. Bailey, Mark W. Naylor, Joel E. Ream, Bruce G. Hammond, Debbie L. Nida, Barry L. Burnette, Thomas E. Nickson, Timothy A. Mitsky, Mary L. Taylor, Roy L. Fuchs and Stephen R. Padgette BOOK REVIEW Bioavailability of Nutrients for Animals. Reviewed by Duane E. Ullrey Announcements SUPPLEMENT Fortifying Policy with Science—The Case of Folate. Gerald E. Gaull, editor No. 4 APRIL 1996 ARTICLES Biographical Article Remembering Hamish Munro (1915-1994). Robert M. Russell History of Nutrition Emil Abderhalden: His Contribution to the Nutritional Biochemistry of Protein. George Wolf Biochemical and Molecular Roles of Nutrients Oxidized Ethyl Linoleate Induces Mucosal Hypertrophy of the Large Intestine and Affects Cecal Fermenta- tion of Dietary Fiber in Rats. Hiroshi Hara, Kazuo Miyashita, Satoshi Ito and Takanori Kasai Aspects of Cardiomyopathy Are Exacerbated by Elevated Dietary Fat in Copper-Restricted Rats. Thunder Jalili, Denis M. Medeiros and Robert E. C. Wildman Dietary Components Modify the Ability of Garlic to Suppress 7,12-Dimethylbenz(aJanthracene-Induced Mammary DNA Adducts. Harunobu Amagase, Eric M. Schaffer and John A. Milner { i ii| ' Transgenic Mice That Overexpress Metallothionein-I Resist Dietary Zinc Deficiency. Tim Dalton, Kai Fu, Richard D. Palmiter and Glen K. Andrews 1,25-Dihydroxycholecalciferol Regulates; Rat Intestinal Calbindin D,, Posttranscriptionally. Catherine Duflos, Claire Bellaton, Nathalie Baghdassarian, Myléne Gadoux, Danielle Pansu and Felix Bronner Dietary Zinc Deficiency Alters 5a- Redu¢ tion and Aromatization of Testosterone and Androgen and Estro- gen Receptors in Rat Liver. Ae-Son Om and Kyung-Won Chung The CD4/CD8 Ratio in the Blood Does’ Not Reflect the Response of This Index in Secondary Lymphoid Organs of Weanling Mice in Models of Protein-Energy Malnutrition Known to Depress Thymus- Dependent Immunity. Wen-Hui Lee «nd Bill D. Woodward Apolipoprotein B mRNA Editing Is Preserved in the Intestine and Liver of Zinc-Deficient Rats. Fatiha Nassir, Raymond K. Blanchard, Andizej Mazur, Robert J. Cousins and Nicholas O. Davidson | Human and Clinical Nutrition Insulin Increases Lipogenic Enzyme Activity in Human Adipocytes in Primary Culture. Naima Moustaid, Brynn H. Jones and James W. Taylor; A Diet High in Wheat Fiber Decreases the Bioavailability of Soybean Isoflavones in a Single Meal Fed to Women. Bee-Yen Tew, Xia Xu, Huei-Ju Wang, Patricia A. Murphy and Suzanne Hendrich | Nutrient Metabolism | Proline Is Synthesized from Glutamate: during Intragastric Infusion but Not during Intravenous Infusion in Neonatal Piglets. Janice M. Murphy, Susan J. Murch and Ronaid O. Ball Dietary Long-Chain Polyunsaturated Fatty Acids Influence Tissue Fatty Acid Composition in Rats at Weaning. Antonio Sudrez, Maria deli\Carmen Ramirez, Maria José Faus and Angel Gil .... Bone Growth Rather than Myofibrillar| Protein Turnover Is Strongly Affected by Nutritional Restriction at Early Weaning of Calves. Masayuki Funaba, Shigemitsu Saito, Kensuke Kagiyama, Tsunenori Iriki and Matanobu Abe Protein and Lipid Refeeding Changes Protein Metabolism and Colonic but Not Small Intestinal Morphology in Protein-Depleted Rats. Zhensherjg Qu, Pei Ra Ling, Steven R. Tahan, Pilar Sierra, Andrew B. earner hese asst bat. tesecin stesso EEE Ee OLE LT CORE CEE TEEEEETLE: Cee Short-Term Metabolic Responses Do Not Differ Between Neonatal Piglets Fed Formulas Containing Hy- drolyzed or Intact Soy Proteins. Ruurd T. Zijlstra, Anna M. Mies, Barbara’A. McCracken, Jack Odle, H. Rex Gaskins, Eric L. Lien and Sharon M. Donovan Changes in Gut and Liver Glucose, Lactate, Insulin, and Oxygen Flux in Mature Ewes during Mesenteric or Abdominal Vena Cava Glucose Infusion. H. C. Freetly and J]. Klindt Dietary Restriction Induces Biochemical and Morphometric Changes in the Small Intestine of Nursing Piglets. Maria C. Nufiez, Juan D. Bueno, Maria V. Ayudarte, Antonio Almendros, Antonio Rios, Maria D. Sudrez and Angel Gil Somatotropin Treatment Does Not Affect Nonesterified Fatty Acid Response to Adrenergic Injections in Underfed or Overfed Nonlactating Cows. Anne Ferlay, Yves Chilliard, Anne-Marie Sala, Christine Durier and Frangois Bocquier Gut Endogenous Nitrogen and Amino eid Excretions in Adult Domestic Cats Fed a Protein-free Diet or an Enzymatically Hydrolyzed Casein- Based Diet. Wouter H. Hendriks, Paul J. Moughan and Michael F. Tarttelin Kinetic Model of Molybdenum Metaboljsm Developed from Dual Stable Isotope Excretion in Men Consum- ing a Low Molybdenum Diet. Katherine H. Thompson and Judith R. Turnlund | } | Nutrient Requirements and Interactions Long-Term Administration of High Dose Vitamin A to Rats Does Not Cause Fetal Malformations: Macro- scopic, Skeletal and Physicochemicai Findings. Hans K. Biesalski, Christian Hemmes, Magdy El Hanafy, Harald Weiser, Horst Zschaebitz and Eckart Stofft The Riboflavin Requirement of Adult| Dogs at Maintenance Is Greater than Previous Estimates. Jill L. Cline, Jack Odle and Robert A..Easier || | | x Nutrition, Pharmacology, and Toxicology Feeding of Potato, Tomato and Eggplant Alkaloids Affects Food Consumption and Body and Liver Weights in Mice. Mendel Friedman, P. R. Henika and B. E. Mackey LETTERS TO THE EDITOR Dietary Saturated Fatty Acids and LDL Receptor Activity. K. C. Hayes and Pramod Khosla Dietary Saturated Fatty Acids and LDL Receptor Activity: A Response to Hayes and Khosla. Arthur F. Stucchi and Robert J. Nicolosi Announcements No. 4S APRIL 1996 AIN 1995 SYMPOSIGM PROCEEDINGS SYMPOSIA Symposium: Consumer Issues in Biotechnology: Genetically Engineered Foods Industry’s Responsibility to the Consumer. James W. Lauderdale A Government Agency’s Responsibility to the Consumer. Alvin L. Young and Marti R. Asner The Administration’s Responsibility to the Consumer. Catherine E. Woteki and George Vermont Biotechnology and Society: We Scientists Have Responsibilities Too. Gerald E. Gaull and Robin W. Yeaton Woo Symposium: Dietary Guidelines for Children: A Focus on Fat Introduction. Gregory D. Miller A Review of the Canadian “Nutrition Recommendations Update: Dietary Fat and Children. "Stanley H. Zlotkin Dietary Guidelines for Children: U.S. Recommendations. Ronald E. Kleinman, Laurence F. Finberg, William J]. Klish and Ronald N. Lauer Considerations about Dietary Fat Restrictions for Children. Dietary Guidelines in Perspective. Alfred E. Harper Symposium: Formation, Metabolism and Physiologic Effects of Oxidatively Modified Low Density Lipoprotein Overview. Rachel Shireman The Role of Oxidized Low Density Lipoprotein in Atherogenesis. Ishwarlal Jialal and Sridevi Devaraj 1053S Dietary Fatty Acids, Low Density Lipoprotein Composition and Oxidation and Primate Atherosclerosis. Michael J. Thomas and Lawrence L. Rudel Mechanisms of Metal Ion-Dependent Oxidation of Human Low Density Lipoprotein. Sean M. Lynch and Balz Frei Prevention of Atherosclerosis with Dietary Antioxidants: Fact or Fiction? P. Barton Duell Oxidized Low Density Lipoproteins Alter Macrophage Lipid Uptake, Apoptosis, Viability and Nitric Oxide Synthesis. Xiaochun Yang, Narmer F. Galeano, Matthias Szabolcs, Robert R. Sciacca and Paul]. Cannon 1072S

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