Table Of Content

CONTENTS OF VOLUME 101 JULY 1993 VOLUME 101 NUMBER 1 IN THIS ISSUE Inhibition of Ornithine Decarboxylase Activity and Cell Proliferation by Ultraviolet B Radiation in EGF- Janet Rettig Emanuel Stimulated Cultured Human Epidermal Keratinocytes Janet H. Prystowsky, Charles V. Clevenger, and Zai-Sheng Zheng REVIEW Free Radical Production During Metabolism of Organic Homeobox Genes and Skin Development: A Review Hydroperoxides by Normal Human Keratinocytes Glynis A. Scott and Lowell A. Goldsmith Anna Iannone, Alessandra Marconi, Giovanna Zambruno, Alberto Giannetti, Vanio Vannini, and Aldo Tomasi REPORTS Wound Fluid from Chronic Leg Ulcers Contains Elevated Rabbits Immunized with a Peptide Encoded for by the Levels of Metalloproteinases MMP-2 and MMP-9 230-kD Bullous Pemphigoid Antigen cDNA Develop an Annette B. Wysocki, Lisa Staiano-Coico, and Frederick Grinnell Enhanced Inflammatory Response to UVB Irradiation: A Potential Animal Model for Bullous Pemphigoid Russell P. Hall III, John C. Murray, Melinda M. McCord, Absence of DNA Repair Deficiency in the Confirmed M. Joyce Rico, and Robert D. Streilein Heterozygotes of Xeroderma Pigmentosum Group A Shin-ichi Moriwaki, Chikako Nishigori, Tatsuyuki Teramoto, Toshihiro Tanaka, Satoshi Kore-eda, Hiraku Takebe, Lesion-Specific Activation of Cloned Human Tumor- and Sadao Imamura Infiltrating Lymphocytes by Autologous Tumor Cells: Induction of Proliferation and Cytokine Production Jiirgen C. Becker, Andreas Schwinn, Reinhard Dummer, Ginter Characterization of Endothelin-Binding Sites in Human Burg, and Eva-Bettina Brécker Skin and Their Regulation in Primary Raynaud’s Phenomenon and Systemic Sclerosis Gregory A. Knock, Giorgio Terenghi, Christopher B. Bunker, Helen A. Bull, Pauline M. Dowd, and Julia M. Polak Novel Mutations of the KIT (Mast/Stem Cell Growth Factor Receptor) Proto-Oncogene in Human Piebaldism Richard A. Spritz, Stuart A. Holmes, Peter Itin, Tumor Necrosis Factor-@ Induces Interleukin-1a@ and and Wolfgang Kister Interleukin-1 Receptor Antagonist Production by Cultured Human Keratinocytes Charlotte L. Kutsch, David A. Norris, and William P. Arend Oral Induction of Tolerance to Nickel Sensitization in Mice Ingrid M.W. Van Hoogstraten, Colin Boos, Dagmar Boden, Mary E. Von Blomberg, Rik J. Scheper, Modulation of Comedonal Levels of Interleukin-1 in Acne and Georg Kraal Patients Treated with Tetracyclines E. Anne Eady, Eileen Ingham, Christina E. Walters, Jonathan H. Cove, and William J. Cunliffe Human Keratinocytes Synthesize, Secrete, and Degrade Acetylcholine Sergei A. Grando, David A. Kist, Mei Qi, and Mark V. Dahl Expression of Type XIV Collagen During the Differentiation of Fetal Bovine Skin: Immunolabeling with Monoclonal Antibody Is Prominent in Morphogenetic Effects of Monomethylfumarate on Human Granulocytes Areas Claire Lethias, Yvette Descollonges, Robert Garrone, and Michel van der Rest Peter H. Nibbering, Bing Thio, Timo P.L. Zomerdijk, Anja C. Bezemer, Roderick L. Beijersbergen, and Ralph van Furth Human Keratinocytes Adhere to and Spread on Synthetic BRIEF REPORTS Peptide FN-C/H-V Derived from Fibronectin Mutation of the Tumor Suppressor Gene TP53 Is Not Mark S. Wilke, Jeff Vespa, Amy P. N. Skubitz, Leo T. Furcht, Detected in Psoriatic Skin Jean-Pierre Molés, Charles Theillet, and James B. McCarthy Nicole Basset-Séguin, and Jean-Jacques Guilhou Keratinocyte Growth Factor (FGF-7) Stimulates Migration Desmosome Differentiation During Epidermal and Plasminogen Activator Activity of Normal Human Cornification: New Observations Obtained from Keratinocytes Ryoji Tsuboi, Chiyo Sato, Yoriyuki Kurita, Intermediate Voltage Electron Microscopy Dina Ron, Jeffrey S. Rubin, and Hideoki Ogawa Carolyn A. Larabell, Kimie Fukuyama, and William L. Epstein 0022-202X/93/$06.00 Copyright © 1993 by The Society for Investigative Dermatology, Inc. 926 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY JULY 1993 VOLUME 101 NUMBER 1, SUPPLEMENT Preface David A. Norris, Kirk D. Wuepper, PIGMENTATION OF HAIR and Andrew Messenger Hair Melanins and Hair Color: Ultrastructural and Biochemical Aspects Jean-Paul Ortonne and Giuseppe Prota TRIBUTE Melanogenesis Is Coupled to Murine Anagen: Toward New F.J.G Ebling, B.Sc., M.Sc., Ph.D., D.Sc., 1918-1992 Concepts for the Role of Melanocytes and the Regulation John S. Strauss of Melanogenesis in Hair Growth Andrzej Slominski and Ralf Paus OVERVIEW OF HAIR FOLLICLE GROWTH AND DEVELOPMENT HORMONAL EFFECTS ON HAIR GROWTH The Control of Hair Growth: An Overview Andrew G. Messenger Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles DEVELOPMENT OF THE HAIR FOLLICLE Franklin Kiesewetter, Akira Arai, and Hermann Schell Adhesion Molecules and Homeoproteins in the Phenotypic Determination of Skin Appendages Cheng-Ming Chuong, Fibroblast Growth Factor and Epidermal Growth Factor in Randall B. Widelitz, and Ting-Xin Jiang Hair Development Diana Lee du Cros Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation Hormones and Hair Growth: Variations in Androgen Robert M. Lavker, Stanley Miller, Caroline Wilson, Receptor Content of Dermal Papilla Cells Cultured from George Cotsarelis, Zhi-Gang Wei, Jing-Shan Yang, Human and Red Deer (Cervus Elaphus) Hair Follicles and Tung-Tien Sun Valerie Anne Randall, Margaret Julie Thornton, Andrew Guy Messenger, Nigel Andrew Hibberts, Regulation of Hair Follicle Development: An In Vitro Andrew Stewart Irving Loudon, and Barry Robert Brinklow Model for Hair Follicle Invasion of Dermis and Associated Connective Tissue Remodeling Stuart H. Yuspa, Qizhi Wang, Wendy C. Weinberg, Linda Goodman, REGULATION AND MODIFICATION Steven Ledbetter, Tom Dooley, and Ulrike Lichti OF GROWTH 19-Aldehydo-4-Androstene-3,17-Dione: An Estrogen Dermal-Epidermal Interactions — Follicle-Derived Cell Precursor that Inhibits Sebaceous Secretion in a Rat Populations in the Study of Hair-Growth Mechanisms Model FF. John G. Ebling and Vladimir Petrow Colin A.B. Jahoda and Amanda J. Reynolds Expression of Morphogens During Human Follicle In Vivo Regulation of Murine Hair Growth: Insights from Development In Vivo and a Model for Studying Follicle Grafting Defined Cell Populations onto Nude Mice Morphogenesis In Vitro Karen A. Holbrook, Lynne T. Smith, Ulrike Lichti, Wendy C. Weinberg, Linda Goodman, Steve Ledbetter, Tom Dooley, Dave Morgan, and Stuart H. Yuspa Elizabeth D. Kaplan, Sharon A. Minami, Gregory P. Hebert, and Robert A. Underwood Culture of Hair Matrix and Follicular Keratinocytes STRUCTURAL ASPECTS OF THE HAIR FOLLICLE Michael Detmar, Frank-Matthias Schaart, Ulrike Blume, and Constantin E. Orfanos Organization and Expression of Hair Follicle Genes George E. Rogers and Barry C. Powell Prostaglandins Protect Against Murine Hair Injury Produced by Ionizing Radiation or Doxorubicin Human Hair Keratins Jialin Yu, Da-wen Yu, Frederick D. Malkinson, Ling Geng, and Wayne R. Hanson Daniel M. Checkla, Irwin M. Freedberg, and Arthur P. Bertolino Effect of Retinoids on Follicular Cells Gail Bazzano, Hair Follicle Proteoglycans John R. Couchman Nia Terezakis, Hala Attia, Alicia Bazzano, Robin Dover, David Fenton, Nikki Mandir, Leonardo Celleno, Maria Tamburro, and Stefano Jaconi Trichohyalin: A Structural Protein of Hair, Tongue, Nail, and Epidermis Edward J. O’Keefe, Elizabeth H. Hamilton, Seung-Chul Lee, and Peter Steinert Chemical Agents and Peptides Affect Hair Growth Hideo Uno and Sotaro Kurata Epithelial Cornified Envelope Precursors Are in the Hair Follicle and Nail Howard P. Baden and Joseph C. Kvedar Potassium Channel Conductance as a Control Mechanism Sensory Innervation of the Hairy Skin (Light- and in Hair Follicles Allen E. Buhl, Steven J. Conrad, Electronmicroscopic Study) Zdenek Halata Daniel J. Waldon, and Marshall N. Brunden VOL. 101, NO. 6 DECEMBER 1993 VOLUME CONTENTS 927 AUGUST 1993 VOLUME 101 NUMBER 2 IN THIS ISSUE Inhibition of Cholesterol and Sphingolipid Synthesis Causes Paradoxical Effects on Permeability Barrier Janet Rettig Emanuel Homeostasis Man Mao-Qiang, Kenneth R. Feingold, REVIEW and Peter M. Elias Cell Death by Apoptosis in Epidermal Biology Relationship Between Heat Shock Protein Induction and Anne R. Haake and Renata R. Polakowska the Binding of Antibodies to the Extractable Nuclear Antigens on Cultured Human Keratinocytes REPORTS Fukumi Furukawa, Kouichi Ikai, Norihisa Matsuyoshi, Hemopoietic Stem Cell Inhibitor (SCI/MIP-1a@) Also Kyoko Shimizu, and Sadao Imamura Inhibits Clonogenic Epidermal Keratinocyte Proliferation E. Kenneth Parkinson, Gerard J. Graham, Pierre Daubersies, Cold Shock Induces the Synthesis of Stress Proteins in Julie E. Burns, Christine Heufler, Mark Plumb, Gerold Schuler, Human Keratinocytes Diana B. Holland, Susan G. Roberts, and Jan B. Pragnell Edward J. Wood, and William J. Cunliffe Antisense Profilaggrin RNA Delays and Decreases Purification and Preliminary Characterization of Stratum Profilaggrin Expression and Alters In Vitro Differentiation Corneum Chymotryptic Enzyme: A Proteinase That May of Rat Epidermal Keratinocytes Paul V. Haydock, Be Involved in Desquamation Torbjorn Egelrud Chery! Blomquist, Steve Brumbaugh, Beverly A. Dale, Karen A. Holbrook, and Philip Fleckman Demonstration of 72-kDa and 92-kDa Forms of Type IV Collagenase in Human Skin: Variable Expression in MCP-1 mRNA Expression in Basal Keratinocytes of Various Blistering Diseases, Induction During Re- Psoriatic Lesions Reinhard Gillitzer, Klaus Wolff, Dan Tong, Epithelialization, and Decrease by Topical Glucocorticoids Christoph Miiller, Teizo Yoshimura, Albert A. Hartmann, Aarne Oikarinen, Meeri Kylmaniemi, Helena Autio-Harmainen, Georg Stingl, and Rudolf Berger Pekka Autio, and Tuula Salo Studies of Contact Hypersensitivity Induction in Mice with Microcirculatory Functions in Systemic Sclerosis: Optimal Sensitizing Doses of Hapten Iwao Kurimoto and Additional Parameters for Therapeutic Concepts? J. Wayne Streilein Hans-Peter Albrecht, Dorothea Hiller, Otto Paul Hornstein, Susanne Bithler-Singer, Michael Miick, and Matthias Gruschwitz Pathogenesis of the Platinum (c?) Mutation, a Model for Impaired Regulation of Collagen Pro-a@1(I) mRNA and Oculocutaneous Albinism Seth J. Orlow, Change in Pattern of Collagen-Binding Integrins on M. Lynn Lamoreux, Sharon Pifko-Hirst, and Bao-Kang Zhou Scleroderma Fibroblasts Mikael Ivarsson, Alan McWhirter, Identification of a Mammalian Melanosomal Matrix Carol M. Black, and Kristofer Rubin Glycoprotein Seth J. Orlow, Bao-Kang Zhou, Skin-Selective Lymphocyte Homing Mechanisms in the Raymond E. Boissy, and Sharon Pifko-Hirst Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma Combination of 4-Hydroxyanisole and All-Trans Retinoic Peter W. Heald, Shu-Ling Yan, Richard L. Edelson, Acid Produces Synergistic Skin Depigmentation in Swine Robert Tigelaar, and Louis J. Picker Xina Nair, Prakash Parab, Leigh Suhr, and Kenneth M. Tramposch Skin Test to Assess Immunity Against Cottontail Rabbit Mast Cell Degranulation Upregulates a6 Integrins on Papillomavirus Antigens in Rabbits with Progressing Epidermal Langerhans Cells Michael D. Ioffreda, Papillomas or After Papilloma Regression Diana Whitaker, and George F. Murphy Reinhard M. Hépfl, Neil D. Christensen, Michael G. Angell, and John W. Kreider Neutrophils, Differentiated Macrophages, and Monocyte/ Macrophage Antigen Presenting Cells Infiltrate Murine Intracytoplasmic Retention of Type VII Collagen and Epidermis After UV Injury Kevin D. Cooper, Dominant Dystrophic Epidermolysis Bullosa: Reversal of Defect Following Cessation of or Marked Improvement in Nandini Duraiswamy, Craig Hammerberg, Ed Allen, Candance Kimbrough-Green, William Dillon, Disease Activity Jo-David Fine, Lorraine B. Johnson, and David Thomas Donna Cronce, J. Timothy Wright, Irerne M. Leigh, Martha McCollough, and Robert A. Briggaman UVA-Induced Autocrine Stimulation of Fibroblast- Derived-Collagenase by IL-6: A Possible Mechanism in BRIEF COMMUNICATION Dermal Photodamage? Meinhard Wlaschek, Klaus Bolsen, Effects of All-Trans Retinoic Acid on Glycosaminoglycan Gernot Herrmann, Agatha Schwarz, Frank Wilmroth, Synthesis in Photodamaged Hairless Mouse Skin Peter C. Heinrich, Giinter Goerz, and Karin Scharffetter-Kochanek Simon Chen, Blake Beehler, Gary Sugimoto, and Kenneth M. Tramposch Effect of Phototherapy and Urocanic Acid Isomers on Natural Killer Cell Function Jill W. Gilmour, RAPID COMMUNICATIONS James P. Vestey, Sheru George, and Mary Norval A Keratin 14 Mutational Hot Spot for Epidermolysis Sialyl Lewis* Expression on Human Langerhans Cells Bullosa Simplex, Dowling-Meara: Implications for Nobuko Tabata, Setsuya Aiba, Satoshi Nakagawa, Haruo Ohtani, Diagnosis Karen Stephens, Virginia P. Sybert, and Hachiro Tagami Ellen W. Wijsman, Pamela Ehrlich, and Anne Spencer Lipid Supplemented Medium Induces Lamellar Bodies and Cloning of the 5’ mRNA for the 230-kD Bullous Precursors of Barrier Lipids in Cultured Analogues of Pemphigoid Antigen by Rapid Amplification of cDNA Human Skin Steven T. Boyce and Mary L. Williams Ends George W. Elgart and John R. Stanley 928 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY SEPTEMBER 1993 VOLUME 101 NUMBER 3 IN THIS ISSUE Modulation of IL-6 Production and IL-1 Activity by Keratinocyte-Fibroblast Interaction Ingeborg Boxman, Janet Rettig Emanuel Clemens Loéwik, Lucien Aarden, and Maria Ponec EDITORIALS Comparison of CD271 (Adapalene) and All-Trans Retinoic Transformation in Cutaneous T-Cell Lymphoma Acid in Human Skin: Dissociation of Epidermal Effects and Irwin M. Braverman, and Christopher P.F. Redfern CRABP-II mRNA Expression Christopher E.M. Griffiths, James T. Elder, Bruno A. Bernard, Patricia Rossio, REVIEW Matthew A. Cromie, Lawrence J. Finkel, Braham Shroot, Type VII Collagen, Anchoring Fibrils, and Epidermolysis and John J. Voorhees Bullosa Robert E. Burgeson REPORTS Phototoxicity of Lumidoxycycline Christopher R. Shea, Gerard A. Olack, Harry Morrison, Norah Chen, and Tayyaba Hasan CD68 Positive Epidermal Dendritic Cells Peter Petzelbauer, Dagmar Foédinger, Klemens Rappersberger, Human Keratinocytes In Vivo and In Vitro Constitutively Beatrix Volc-Platzer, and Klaus Wolff Express The 72-kD Heat Shock Protein F. Trautinger, I. Trautinger, I. Kindas-Migge, D. Metze, and T. A. Luger Identification and Partial Characterization of a Novel 105- kDalton Lower Lamina Lucida Autoantigen Associated Immunofluorescence and Immunoelectron Microscopy with a Novel Immune-Mediated Subepidermal Blistering Analyses of a Human Monoclonal Anti-Epithelial Cell Disease Lawrence S. Chan, Jo-David Fine, Surface Antibody that Recognizes a 185-kD Polypeptide: Robert A. Briggaman, David T. Woodley, Craig Hammerberg, A Component of the Paraneoplastic Pemphigus Antigen Rhett J. Drugge, and Kevin D. Cooper Complex? Pascal Joly, Daniéle Gilbert, Elisabeth Thomine, Annie Delpech, Sylvie Verdier, Philippe Lauret, Expression of Cornifin in Squamous Differentiating and Francois Tron Epithelial Tissues, Including Psoriatic and Retinoic Acid- Treated Skin Wataru Fujimoto, Keith W. Marvin, Skin Proteasomes (High - Molecular-Weight Protease): Margaret D. George, Giulia Celli, Nadine Darwiche, Purification, Enzymologic Properties, Gross Structure, and Luigi M. De Luca, and Anton M. Jetten Tissue Distribution Yasushi Suga, Kenji Takamori and Hideoki Ogawa Prolactin Stimulates Proliferation of Cultured Human Keratinocytes Giampiero Girolomoni, J. Theodore Phillips, Expression and Topography of Integrins and Basement and Paul R. Bergstresser Membrane Proteins in Epidermal Carcinomas: Basal but not Squamous Cell Carcinomas Display Loss of «684 and Human Relaxin Decreases Collagen Accumulation In Vivo BM-600/Nicein Paola Savoia, Livio Trusolino, in Two Rodent Models of Fibrosis Elaine N. Unemori, Eugenio Pepino, Ottavio Cremona, and Pier Carlo Marchisio L. Steven Beck, Wyne Pun Lee, Yvette Xu, Mark Siegel, Gilbert Keller, H. Denny Liggitt, Eugene A. Bauer, Inhibition of Human Skin Phospholipase A, by and Edward P. Amento “Lipocortins” Is an Indirect Effect of Substrate/Lipocortin Interaction Boris Christoph Bastian, Corinna Sellert, Detection of Mucosal Human Papillomavirus Types 6/11 Axel Seekamp, Jiirgen Romisch, Eric-Paul Paques, in Cutaneous Lesions from Transplant Recipients and Eva-Bettina Brécker Chantal Soler, Yvette Chardonnet, Patrice Allibert, Sylvie Euvrard Daniel Schmitt, and Bernard Mandrand Differential Patterns of Epidermal Leukocyte Infiltration in Patch Test Reactions to Structurally Unrelated In Vitro HPV-11 Infection of Human Foreskin Chemical Irritants Carolyn M. Willis, Lloyd H. Smith, Chris Foster, Margaret E. Hitchcock, Catherine J.M. Stephens, and John D. Wilkinson and Rivkah Isseroff Mouse Dendritic Epidermal T Cells Exhibit Chemotactic Transformation of Mycosis Fungoides: T-Cell Receptor 8 Migration Toward PAM 212 Keratinocyte Culture Gene Analysis Demonstrates a Common Clonal Origin for Supernatants Byoung Soo Chung, Paul R. Bergstresser, Plaque-Type Mycosis Fungoides and CD30* Large-Cell and Akira Takashima Lymphoma Gary S. Wood, David W. Bahler, Richard T. Hoppe, Roger A. Warnke, Jeffrey L. Sklar, Monoclonal Antibody Modulates Human Neutrophil and Ronald Levy Chemotaxis to N-formyl-Methionyl-Leucyl-Phenylalanine (f{MLP) M. Carol McNeely, Thomas J. Lawley, Autoradiographic Detection of Substance P Receptors in and Liana Harvath Normal and Psoriatic Skin Carlo Pincelli, Fabrizio Fantini, Luciana Giardino, Massimo Zanni, Laura Calza, Cinzia Sevignani, Cultured Human Melanocytes Express the Intermediate and Alberto Giannetti Filament Vimentin Seong Pan Si, Hui C. Tsou, Xinhua Lee, and Monica Peacocke Antileukoprotease in Psoriatic Scales Oliver Wiedow, ABSTRACTS Janice A. Young, Matthew D. Davison, and Enno Christophers The Second Tricontinental Meeting of the JSID, SID, and Surfactant-Induced Stratum Corneum Hydration In Vivo: ESDR_ The Kyoto International Conference Hall, Kyoto, Prediction of the Irritation Potential of Anionic Japan, October 28-31, 1993 Surfactants Klaus-P. Wilhelm, Anastasia B. Cua, Helmut H. Wolff, and Howard I. Maibach Index VOL. 101, NO. 6 DECEMBER 1993 VOLUME CONTENTS 929 OCTOBER 1993 VOLUME 101 NUMBER 4 IN THIS ISSUE Phorbol Ester TPA- and Bradykinin-Induced Arachidonic Acid Release from Keratinocytes Is Catalyzed by a EDITORIAL Cytosolic Phospholipase A, (cPLA,) Raimund Kast, Gerhard Firstenberger, and Friedrich Marks Superantigens and Their Role in Immune-Mediated Disease Conrad Hauser and Hans Acha Orbea Time- and Stimulus-Dependent Secretion of NAP-1/IL-8 by Human Fibroblasts and Endothelial Cells REPORTS Michael Sticherling, Frank Hetzel, Jens-M. Schroder, and Enno Christophers Identification of a Calcium-Inducible, Epidermal-Specific Regulatory Element in the 3’-Flanking Region of the A Quantitative Study of the Differential Expression of Human Keratin 1 Gene Joseph A. Rothnagel, Alpha-Smooth Muscle Actin in Cell Populations of David A. Greenhalgh, Todd A. Gagne, Mary A. Longley, Follicular and Non-Follicular Origin Amanda J. Reynolds, and Dennis R. Roop Christine Chaponnier, Colin A.B. Jahoda, and Giulio Gabbiani Conformational Polymorphisms of cRNA of T-Cell- Induction of Hair Growth in Ear Wounds by Cultured Receptor Genes as a Clone-Specific Molecular Marker for Dermal Papilla Cells Colin A.B. Jahoda, Amanda J. Reynolds, and Roy F. Oliver Cutaneous Lymphoma Matthias Volkenandt, Ralf Wienecke, Olaf M. Koch, Jan Buer, Michael Probst, Jens Atzpodien, Mouse Skin Is Particularly Susceptible to Tumor Initiation Tetsuro Horikoshi, Kathleen Danenberg, Peter Danenberg, During Early Anagen of the Hair Cycle: Possible and Joseph R. Bertino Involvement of Hair Follicle Stem Cells Stanley J. Miller, Zhi-Gang Wei, Caroline Wilson, Leonard Dzubow, Expression of Class IH omeobox Genes in Fetal and Adult Tung-Tien Sun, and Robert M. Lavker Murine Skin Kristina Detmer, H. Jeffrey Lawrence, and Corey Largman 7,12-Dimethylbenz[a]janthracene-Induced Mouse Keratinocyte Malignant Transformation Independent of Effects of Sunscreens and a DNA Excision Repair Enzyme Harvey ras Activation Brandt L. Schneider, G. Tim Bowden, on Ultraviolet Radiation -Induced Inflammation, Immune Christian Sutter, Jurgen Schweizer, Kyung-An Han, Suppression, and Cyclobutane Pyrimidine Dimer and Molly F. Kulesz-Martin Formation in Mice Peter Wolf, Daniel B. Yarosh, and Margaret L. Kripke Distinctive Integrin Expression in the Newly Forming Epidermis During Wound Healing in Humans Analysis of the Mechanism of Ultraviolet (UV) B Andrea Cavani, Giovanna Zambruno, Alessandra Marconi, Radiation -Induced Prostaglandin E, Synthesis by Human Vania Manca, Maurizio Marchetti, and Alberto Giannetti Epidermoid Carcinoma Cells Markus Grewe, Uwe Trefzer, Annette Ballhorn, Karin Gyufko, Hanspeter Henninger, Melanocyte Movement In Vitro: Role of Matrix Proteins and Jean Krutmann and Integrin Receptors Joseph G. Morelli, Joseph J. Yohn, Tamara Zekman, and David A. Norris Activation of Neutrophil Membrane-Associated Oxidative Metabolism by Ultraviolet Radiation Joanne E. Savage, Effect of Organic Solvents on In Vitro Human Skin Water Annette J. Theron, and Ronald Anderson Barrier Function Kenneth Abrams, Jeff D. Harvell, David Shriner, Philip Wertz, Hilda Maibach, Profiles of Cytokine mRNA Expressed by Dendritic Howard I. Maibach, and S.J. Rehfeld Epidermal T Cells in Mice Hiroyuki Matsue, Influence of Schedule and Mode of Administration on Ponciano D. Cruz, Jr., Paul R. Bergstresser, Effectiveness of Podofilox Treatment of Papillomas and Akira Takashima John W. Kreider and Martin D. Pickel Reciprocal Cytokine-Mediated Cellular Interactions in Identification of a Basement Membrane Zone Antigen Mouse Epidermis: Promotion of yd T-Cell Growth by IL-7 Reactive with Circulating IgA Antibody in Ocular and TNFa and Inhibition of Keratinocyte Growth by Cicatricial Pemphigoid Eileen Pazderka Smith, yIFN Hiroyuki Matsue, Paul R. Bergstresser, Ted B. Taylor, Laurence J. Meyer, and John J. Zone and Akira Takashima Skin Explant Culture: A Reliable Method for Detecting Pentoxifylline Suppresses Irritant and Contact Pemphigoid Antibodies in Pemphigoid Sera that Are Hypersensitivity Reactions Agatha Schwarz, Negative by Standard Immunofluorescence and Christine Krone, Franz Trautinger, Yoshinori Aragane, Immunoblotting Diya F. Mutasim, Amy Vaughan, Peter Neuner, Thomas A. Luger, and Thomas Schwarz Nantapat Supapannachart, and Jamal Farooqui Differential Expression of Protein Kinase C Isoenzymes in Altered Proliferation, Synthetic Activity, and Normal and Psoriatic Adult Human Skin: Reduced Differentiation of Cultured Human Sebocytes in the Expression of Protein Kinase C-fII in Psoriasis Absence of Vitamin A and Their Modulation by Synthetic Gary J. Fisher, Amir Tavakkol, Kathy Leach, David Burns, Retinoids Christos C. Zouboulis, Bernhard P. Korge, Patricia Basta, Carson Loomis, Christopher E. M. Griffiths, Dietmar Mischke, and Constantin E. Orfanos Kevin D. Cooper, Nicholas J. Reynolds, James T. Elder, Etta Livneh, and John J. Voorhees RAPID COMMUNICATION Evidence for an Altered Protein Kinase C (PKC) Signaling Human Hair Follicle Germinative Epidermal Cell Culture Pathway in Psoriasis Hanne H. Rasmussen and Julio E. Celis Amanda J. Reynolds, Clifford M. Lawrence, and Colin A.B. Jahoda 930 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY NOVEMBER 1993 VOLUME 101 NUMBER 5 ACKNOWLEDGMENTS T-Lymphocyte Clones Initiated from Lesional Psoriatic Skin Release Growth Factors that Induce Keratinocyte Proliferation Poul Strange, Kevin D. Cooper, Erik R. Hansen, Gary Fisher, Jorgen K. Larsen, David Fox, Christen Krag, IN THIS ISSUE John J. Voorhees, and Ole Baadsgaard The Cytokine Network in Lesional and Lesion-Free REPORTS Psoriatic Skin Is Characterized by a T-Helper Type 1 Cell- Human Herpesvirus 6 Is Present in Lesions of Langerhans Mediated Response Koichi Uyemura, Masahiro Yamamura, Cell Histiocytosis Maureen A. Leahy, Sonja M. Krejci, David F. Fivenson, Robert L. Modlin, and Brian J. Nickoloff Marti Friednash, Stephen S. Stockert, Harry Wilson, J. Clark Huff, William L. Weston, and Sylvia L. Brice Vitamin D, and Calcipotriol Decrease Extracellular Plasminogen Activator Activity in Cultured Keratinocytes Direct Effects of Cutaneous Neuropeptides on Adenylyl Katri Koli and Jorma Keski-Oja Cyclase Activity and Proliferation in a Keratinocyte Cell Line: Stimulation of Cyclic AMP Formation by CGRP and VIP /PHM, and Inhibition by NPY Through G Protein- Regulation of Keratinocyte Growth, Differentiation, and Coupled Receptors Kenzo Takahashi, Shigetada Nakanishi, Vitamin D Metabolism by Analogs of 1,25- and Sadao Imamura Dihydroxyvitamin D Daniel D. Bikle, Elaine Gee, and Sreekumar Pillai Upper Human Hair Follicle Contains a Subpopulation of Keratinocytes with Superior In Vitro Proliferative Keratinocyte Differentiation Is Associated with Changes in Potential Jing-Shan Yang, Robert M. Lavker, the Expression and Regulation of Phospholipase C and Tung-Tien Sun Isoenzymes Kari Punnonen, Mitchell Denning, Edmund Lee, Luowei Li, Sue Goo Rhee, and Stuart H. Yuspa Identification and Characterization of Two Isozymic Forms of Arylamine N-Acetyltransferase in Syrian Characteristics of Oligonucleotide Uptake in Human Hamster Skin Stephen J. Gaudet, Andrzej Slominski, Keratinocyte Cultures Sarah B. Noonberg, Mohammad Etminan, Daniel Pruski, Ralf Paus, Marvin R. Garovoy, and C. Anthony Hunt and M.A.A. Namboodiri Annexin-1 Localization in Human Skin: Possible Treatment of Human Melanocytes and S91 Melanoma Association with Cytoskeletal Elements in Keratinocytes of Cells with the DNA Repair Enzyme T4 Endonuclease V the Stratum Spinosum Roy A. Fava, Lillian B. Nanney, Enhances Melanogenesis After Ultraviolet Irradiation David Wilson, and Lloyd E. King, Jr. Barbara A. Gilchrest, Sen Zhai, Mark S. Eller, Daniel B. Yarosh, and Mina Yaar Nicein (BM-600) in Junctional Epidermolysis Bullosa: Polyclonal Antibodies Provide New Clues for Pathogenic Inhibitory Effect of Melanin Pigment on Sensitization and Elicitation of Murine Contact Photosensitivity: Mechanism Role Patrick Verrando, Olivia Schofield, of Low Responsiveness in C57BL/10 Background Mice Akemi Ishida- Yamamoto, Daniel Aberdam, Odile Partouche, Robin A. J. Eady, and Jean-Paul Ortonne Yoshiki Tokura, Hiroaki Yagi, Takahiro Satoh, and Masahiro Takigawa Ultraviolet Hypermutability of a Shuttle Vector Novel and Known Protein Tyrosine Kinases and Their Propagated in Xeroderma Pigmentosum Variant Cells Abnormal Expression in Human Melanoma David J. Easty, Haywood L. Waters, Saraswathy Seetharam, Sue E. Ganz, Christine J. Farr, Cary Lai, Meenhard Herlyn, Michael M. Seidman, and Kenneth H. Kraemer and Dorothy C. Bennett Transepidermal Induction of Contact Hypersensitivity in Melanin Reduces Ultraviolet-Induced DNA Damage Mice with a Water-Soluble Hapten Tadamichi Shimizu, Formation and Killing Rate in Cultured Human Melanoma C. Gwyneth Munn, and J. Wayne Streilein Cells }Nobuhiko Kobayashi, Tsutomu Muramatsu, Yukio Yamashina, Toshihiko Shirai, Takeo Ohnishi, and Toshio Mori RAPID COMMUNICATION In Situ Expression of a B7-Like Adhesion Molecule on IL-8 Gene Expression and Production in Human Keratinocytes from Human Epidermis Thomas E. Fleming, Keratinocytes and Their Modulation by UVB Seiji Kondo, William S. Mirando, Uwe Trefzer, Karen A. Tubesing, Takeshi Kono, Daniel N. Sauder, and Roderick C. McKenzie and Craig A. Elmets VOL. 101, NO. 6 DECEMBER 1993 VOLUME CONTENTS 931 DECEMBER 1993 VOLUME 101 NUMBER 6 759 IN THIS ISSUE Expression of an Epitope as Detected by the Novel Monoclonal Antibody 4F7 on Dermal and Epidermal Dendritic Cells. I. Identification and Characterization of REPORTS the 4F7*+ Dendritic Cell In Situ Mansour Mohamadzadeh, Cyclosporin A Rapidly Inhibits Epidermal Cytokine Thilo Lipkow, Gerhard Kolde, and Jiirgen Knop Expression in Psoriasis Lesions, But Not in Cytokine- Stimulated Cultured Keratinocytes James T. Elder, Retinoid Toxicity for Fibroblasts and Epithelial Cells Is Craig Hammerberg, Kevin D. Cooper, Takayuki Kojima, Separable From Growth Promoting Activity James Varani, Rajan P. Nair, Charles N. Ellis, and JohnJ . Voorhees Dennis R. Inman, Patricia Perone, Suzanne E. G. Fligiel, and John J. Voorhees GRO-a mRNA Is Selectively Overexpressed in Psoriatic Epidermis and Is Reduced by Cyclosporin A In Vivo, But Cytopathic Effect in Human Papillomavirus Type 1- Not in Cultured Keratinocytes Takayuki Kojima, Induced Inclusion Warts: In Vitro Analysis of the Contribution of Two Forms of the Viral E4 Protein Matthew A. Cromie, Gary J. Fisher, John J. Voorhees, and James T. Elder Claire Rogel-Gaillard, Gérard Pehau-Arnaudet, Francoise Breitburd, and Gérard Orth Expression of Gap Junction Proteins Connexin 26 and 43 Is Podofilox-Induced Regression of Shope Papillomas May Modulated During Differentiation of Keratinocytes in Be Independent of Host Immunity Masafumi Okabayashi, Newborn Mouse Epidermis Yoshihito Kamibayashi, Martin D. Pickel, Lynn R. Budgeon, Nancy M. Cladel, Masahito Oyamada, Yumiko Oyamada, and Michio Mori and John W. Kreider IgG Antibodies from Patients with Bullous Pemphigoid Differentiation-Associated Localization of nPKCn, a Ca**- Bind to Fusion Proteins Encoded by BPAgi cDNA Independent Protein Kinase C, in Normal Human Skin and Jeanne E. Miller, M. Joyce Rico, and Russell P. Hall III Skin Diseases Hiroko Koizumi, Yohko Kohno, Shin-ichi Osada, Shigeo Ohno, Akira Ohkawara, Localization of Adducin in Epidermis Hans W. Kaiser, and Toshio Kuroki Winfried Ness, Edward O’Keefe, Andrea Balcerkiewicz, and Hans W. Kreysel Analyses of Mixed Melanogenesis in Tyrosinase cDNA- Transfected Human Amelanotic Melanoma Cells Osamu Ando, Yutaka Mishima, Seigo Hanada, Yasuo Suemoto, Talin: Adherens Junction Protein Is Localized at the Jun Atobe, and Masashi Kurimoto Epidermal-Dermal Interface in Skin Hans W. Kaiser, Winfried Ness, Michael Offers, Edward J. O’Keefe, Glutathione Depletion Increases Tyrosinase Activity in and Hans W. Kreysel Human Melanoma Cells Véronique del Marmol, Predominance of Epidermal CD8+ T Lymphocytes in Francisco Solano, André Sels, Georges Huez, Anita Libert, Bullous Cutaneous Reactions Caused by f-Lactam Ferdinand Lejeune, and Ghanem Ghanem Antibiotics Michael Hertl, Heribert Bohlen, Frank Jugert, Phenotypic Differences in Cytokine Responsiveness of Claudia Boecker, Renate Knaup, and Hans F. Merk Hypertrophic Scar Versus Normal Dermal Fibroblasts Warren L. Garner, Soverin Karmiol, Jorge L. Rodriguez, Expression of Diazepam-Binding Inhibitor Peptide in David J. Smith, Jr., and Sem H. Phan Human Skin: An Immunohistochemical and Ultrastructural Study Hannu Alho, Annikki Vaalasti, Irina Podkletnova, and Leena Rechardt BRIEF COMMUNICATIONS Enhanced Low-Density Lipoprotein Degradation and Agarose Gel Keratinocyte Outgrowth System as a Model of Cholesterol Synthesis in Monocyte-Derived Macrophages Skin Re-epithelization: Requirement of Endogenous of Patients with Adult Xanthogranulomatosis Acetylcholine for Outgrowth Initiation Sergei A. Grando, Reuven Bergman, Michael Aviram, Avner Shemer, Annika M. Crosby, Brian D. Zelickson, and Mark V. Dahl Yehudit Oiknine, Daniel A. Vardi, and Rachel Friedman-Birnbaum Direct Comparison of a Cultured Composite Skin Regulation of Expression of B7 by Murine Langerhans Substitute Containing Human Keratinocytes and Cells: A Direct Relationship Between B7 mRNA Levels Fibroblasts to an Epidermal Sheet Graft Containing and the Level of Surface Expression of B7 by Langerhans Human Keratinocytes on Athymic Mice Cells Min Geol Lee, Teresa A. Borkowski, and Mark C. Udey Matthew L. Cooper, Christoph Andree, John F. Hansbrough, Ramon L. Zapata-Sirvent, and Richard L. Spielvogel Hematogenous Spread of Malignant Melanoma Cells in Different Stages of Disease Peter Brossart, Ulrich Keilholz, Hyaluronan Is Inversely Correlated with the Expression of Martina Willhauck, Carmen Scheibenbogen, Thomas Mohler, CD44 in the Dermal Condensation of the Embryonic Hair and Werner Hunstein Follicle Charles B. Underhill RAPID COMMUNICATION C3d,g Deposits in Inflammatory Skin Diseases: Use of Psoriatic Skin as a Model of Cutaneous Inflammation Evidence Against Keratin Gene Mutations in a Family with Nicole Basset-Séguin, Marc Porneuf, Olivier Dereure, Ichthyosis Hystrix Curth-Macklin Jeannette M. Bonifas, Valérie Mils, A. Tesniéres, Kim B. Yancey, John W. Bare, Marisa A. Chen, Annamari Ranki, and Jean-Jacques Guilhou Kirsti-Maria Neimi, and Ervin H. Epstein, Jr. VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY BOOK REVIEW EUROPEAN SOCIETY FOR DERMATOLOGICAL RESEARCH Wound Coverage with Biologic Dressings and Cultured Skin Substitutes. By John F. Hansbrough Jeffrey M. Davidson Minutes of the European Society for Dermatological Research Annual General Meeting Amsterdam (RAI SOCIETY FOR INVESTIGATIVE DERMATOLOGY Congress Centre), Sunday April 4, 1993, 6:15 PM Acknowledgments Minutes of the Meeting of the Board of Directors JOURNAL REPORTS San Francisco, California, December 4, 1992 Editor’s Report Edward J. O’Keefe Minutes of the Meeting of the Board of Directors Reviewers Used in 1991 and 1992 Washington, D.C., April 28, 1993 Minutes of the Annual Meeting, First Executive Session Washington, D.C., April 29, 1993 INDEXES FOR VOLUME 101 Author Index Minutes of the Annual Meeting, Second Executive Session Washington, D.C., April 30, 1993 Subject and Title Index Minutes of the Final Meeting of the Board of Directors Washington, D.C., May 1, 1993 Volume Contents