Table Of Content

CONTENTS OF VOLUME 100 JANUARY 1993 VOLUME 100 NUMBER 1 IN THIS ISSUE Skin Organ Culture Model for Examining Epidermal Melanization Genji Imokawa and Itsuro Motegi Janet Rettig Emanuel REPORTS Subcellular Distribution of Tyrosinase and Tyrosinase- Evidence that Involucrin Is a Covalently Linked Related Protein-1: Implications for Melanosomal Constituent of Highly Purified Cultured Keratinocyte Biogenesis Seth J. Orlow, Raymond E. Boissy, Denis J. Moran, and Sharon Pifko-Hirst Cornified Envelopes Michael B. Yaffe, Shubha Murthy, and Richard L. Eckert Human Trichohyalin Gene Is Clustered with the Genes for Analysis of the 5'-Upstream Promoter Region of Human Other Epidermal Structural Proteins and Calcium-Binding Involucrin Gene: Activation by 12-O- Proteins at Chromosomal Locus 1q21 Seung-Chul Lee, Tetradecanoylphorbol-13-Acetate Hidetoshi Takahashi and Mary Wang, O. Wesley McBride, Edward J. O’Keefe, Hajime lizuka In-Gyu Kim, and Peter M. Steinert Major Histocompatibility Class II Antigen Expression on Special Program of Differentiation Expressed in the Surface of Epidermal Cells from Normal and Keratinocytes of Human Haarscheiben: An Analysis of Ultraviolet B Irradiated Subjects Mary-Jane Spencer, Individual Cytokeratin Polypeptides Ingrid Moll, Sergey M. Troyanovsky, and Roland Moll James P. Vestey, Michael J. Tidman, Eva McVittie, and John A.A. Hunter Rapid Effect of Treatment of Psoriatic Erythrocytes with Cultured Human Keratinocytes Synthesize and Secrete the Synthetic Retinoid Acitretin to Increase 8-Azido Endothelin-1 Joseph J. Yohn, Joseph G. Morelli, Cyclic AMP Binding to the RI Regulatory Subunit Sandra J. Walchak, Kristen B. Rundell, David A. Norris, Francoise Raynaud, Pascale Gerbaud, Anne Bouloc, and Martin R. Zamora Isabelle Gorin, Wayne B. Anderson, and Daniéle Evain-Brion A New 180-kDa Dermal Endothelial Cell Activation High-Affinity Fatty Acid- Binding Activity in Epidermis Antigen: In Vitro and In Situ Characteristics and Cultured Keratinocytes Is Attributable to High- Johan R. Westphal, Henrica W. Willems, Molecular-Weight and Not Low-Molecular-Weight Fatty Cornelia J.M. Schalkwijk, Dirk J. Ruiter, and Acid- Binding Proteins Nanna Y. Schurer, Nathan M. Bass, Robert M.W. de Waal Shan Jin, Joan A. Manning, Sreekumar Pillai, and Mary L. Williams Culturing Keratinocytes and Fibroblasts in a Three- RAPID COMMUNICATIONS Dimensional Mesh Results in Epidermal Differentiation Antibodies to Mycobacterial 65-kDa Heat Shock Protein and Formation of a Basal Lamina- Anchoring Zone and Other Immunodominant Antigens in Patients with Paul Contard, Ronnda L. Bartel, Lloydstone Jacobs II, Psoriasis Anura Rambukkana, Pranab K. Das, Leonard Witkamp, Jerome S. Perlish, E. Douglas MacDonald II, Lionel Handler, Diana Cone, and Raul Fleischmajer Sila Yong, Marcus M.H.M. Meinardi, and Jan D. Bos Characterization, Barrier Function, and Drug Metabolism Normal Molecular Weight of Type VII Collagen Produced of an In Vitro Skin Model Sandra R. Slivka, by Recessive Dystrophic Epidermolysis Bullosa Lee K. Landeen, Frank Zeigler, Michael P. Zimber, Keratinocytes Mark Jenison, Jo-David Fine, and Ronnda L. Bartel W. Ray Gammon, and Edward J. O’Keefe JANUARY 1993 VOLUME 100 NUMBER 1, SUPPLEMENT DEDICATION Anti-Ro(SS-A) HLA-D- PRosi3tiv e Women: The David A. Norris, Paul R. Bergstresser, and Interrelationship Between Some ANA Negative, SS, SCLE, Richard D. Sontheimer and NLE Mothers and SS/LE Overlap Female Patients Thomas T. Provost and Rosemarie Watson WHAT’S NEW IN CUTANEOUS LUPUS SYNDROMES Antiphospholipid Syndrome _ Ronald A. Asherson and Ricard Cervera Subacute Cutaneous Lupus Erythematosus Kathleen M. David-Bajar Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder 9S Neonatal Lupus Erythematosus Lela A. Lee W. Ray Gammon and Robert A. Briggaman 0022-202X/93/$06.00 Copyright © 1993 by The Society for Investigative Dermatology, Inc. 870 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY PHOTOSENSITIVITY AND LUPUS ERYTHEMATOSUS Accumulation of yd T Cells in Chronic Cutaneous Lupus Erythematosus Beatrix Volc-Platzer, Barbara Anegg, Mechanisms of UV-Induced Inflammation Stefan Milota, Winfried Pickl, and Gottfried Fischer Luciann Lisi Hruza and Alice P. Pentland IMMUNOLOGIC FIBROTIC DISEASES Epidermal Cytokines in Murine Lupus Daniel N. Sauder, Control of Fibrosis in Systemic Scleroderma David Wong, and Carl Laskin Cornelia Mauch, Beate Eckes, Nicolas Hunzelmann, Takashi Oono, Ewa Kozlowska, and Thomas Krieg Sunlight and Skin-Associated Lymphoid Tissues (SALT): If UVB Is the Trigger and TNFa Is its Mediator, What Is the L-Tryptophan and the Eosinophilia-Myalgia Syndrome: Message? J. Wayne Streilein Current Understanding of the Etiology and Pathogenesis John Varga, Sergio A. Jimenez, and Jouni Uitto Phototesting in Lupus Erythematosus Peter Kind, Percy Lehmann, and Gerd Plewig VASCULITIS PATHOGENESIS OF CUTANEOUS LUPUS Classification of Vasculitis Joseph L. Jorizzo Pathomechanisms of Photosensitive Lupus Erythematosus David A. Norris Role of Microvascular Endothelial Cells in Inflammation Robert A. Swerlick and Thomas J. Lawley T- and B-Cell Abnormalities in Systemic Lupus DERMATOMYOSITIS Philip L. Cohen Humoral Immunity in Polymyositis/Dermatomyositis Ira N. Targoff Molecular Characterization of the Ro/SS-A Autoantigens Daniel P. McCauliffe and Richard D. Sontheimer Amyopathic Dermatomyositis: A Review Rebecca L. Euwer and Richard D. Sontheimer Dendritic Epidermal T Cells: Lessons from Mice for Humans Paul R. Bergstresser, Ponciano D. Cruz, Jr., and Dermatomyositis and Malignancy Philippe Bernard and Akira Takashima Jean-Marie Bonnetblanc FEBRUARY 1993 VOLUME 100 NUMBER 2 IN THIS ISSUE Neuropeptides Modulate Leukotriene B, Mitogenicity Toward Cultured Human Keratinocytes Mireille J. Rabier, Janet Rettig Emanuel Eugene M. Farber, and David I. Wilkinson REPORTS Eosinophil Migration in Atopic Dermatitis I: Increased Clonal Origin of Dermatofibrosarcoma Protuberans Migratory Responses to N-Formyl]-Methiony]l-Leucy]l- Phenylalanine, Neutrophil-Activating Factor, Platelet- Anne E. Allan, Hui C. Tsou, Allan Harrington, Thomas Stasko, Xinhua Lee, Seong Pan Si, DonaldJ .G rande, and Monica Peacocke Activating Factor, and Platelet Factor 4 Piet L.B. Bruijnzeel, Philip H.M. Kuijper, Silvia Rihs, Effects of Adequate Versus Inadequate Treatment of Suzanne Betz, Ruud A.J. Warringa, and Leo Koenderman Cutaneous Manifestations of Lyme Borreliosis on the Up-Regulation of a4 Integrin on Activated Langerhans Incidence of Late Complications and Late Serologic Status Cells: Analysis of Adhesion Molecules on Langerhans Cells Angelika Plérer, Norbert Sepp, Erich Schmutzhard, Relating to Their Migration from Skin to Draining Lymph Sieghard Krabichler, Stefan Trobos, Gabriele Schauer, Caroline Pahl, Georg Stéffler, and Peter Fritsch Nodes Setsuya Aiba, Satoshi Nakagawa, Hiroaki Ozawa, Kensuke Miyake, Hideo Yagita, and Hachiro Tagami Lysosome-Associated Membrane Protein-1 (LAMP-1) Is the Retinoids and State of Differentiation Modulate CRABP II Melanocyte Vesicular Membrane Glycoprotein Band II Gene Expression in a Skin Equivalent Sylvia Sanquer, Bao-Kang Zhou, Raymond E. Boissy, Sharon Pifko-Hirst, Mark S. Eller, and Barbara A. Gilchrest Denis J. Moran, and Seth J. Orlow Immunoelectron Microscopical Localization of Human Papillomavirus Type 16 L1 and E4 Proteins in Cervical Migration of Human Melanoma Cells on Hyaluronate Is Keratinocytes Cultured In Vivo Jane C. Sterling, Related to CD44 Expression Luc Thomas, Takafumi Etoh, Jeremy N. Skepper, and Margaret A. Stanley Ivan Stamenkovic, Martin C. Mihm, Jr., and H. Randolph Byers Localization of 92-kDa Type IV Collagenase in Human Cytochemical Localization of Hyaluronan in Rat and Skin Tumors: Comparison with Normal Human Fetal and Human Skin Mast Cell Granules Peter S. Eggli and Adult Skin Tatiana V. Karelina, George J. Hruza, Werner Graber Gregory I. Goldberg, and Arthur Z. Eisen Pigment Production in Murine Melanoma Cell Is Vitronectin in Mouse Skin: Immunohistochemical Regulated by Tyrosinase, Tyrosinase-Related Protein 1 Demonstration of its Association with Cutaneous Amyloid (TRP1), DOPAchrome Tautomerase (TRP2), and a Karin Dahlback, Hans-Christian Wulf, and Bjorn Dahlback Melanogenic Inhibitor Koichiro Kameyama, Toshiyuki Takemura, Yuko Hamada, Chie Sakai, Coexpression of Keratins Characteristic of Skin and Hair Shigeo Kondoh, Shigeo Nishiyama, Kazunori Urabe, Differentiation in Nail Cells Takashi Kitahara and and Vincent J. Hearing Hideoki Ogawa VOL. 100, NO. 6 JUNE 1993 VOLUME CONTENTS 871 176 Detection of the 170-kDa Bullous Pemphigoid Antigen by UVA-Induced Ultrastructural Changes in Hairless Mouse Immunoprecipitation Tamotsu Ebihara, Takashi Hashimoto, Skin: A Comparison to UVB-Induced Damage Jun Kudoh, Shinobu Gamou, Nobuyoshi Shimizu, and Peishu Zheng and Lorraine H. Kligman Takeji Nishikawa Effect of Age and Diet on Stratum Corneum Barrier Function in the Fischer 344 Female Rat Paul A. Lehman Adherens Junctions: Demonstration in Human and Thomas J. Franz Epidermis Hans W. Kaiser, Winfried Ness, Isabel Jungblut, Robert A. Briggaman, Hans W. Kreysel, and Edward J. O’Keefe ABSTRACTS 10th Symposium on Advances in Skin Pharmacology— Effects of Systemic Indomethacin, Meclizine, and BW755C CIRD GALDERMA, “From Molecular Biology to on Chronic Ultraviolet B-Induced Effects in Hairless Therapeutics” Sophia Antipolis, October 1st to 3rd, 1992 Mouse Skin Irene E. Kochevar, Michael Moran, Nancy Lyon, Thomas Flotte, Elizabeth Siebert, and R. William Gange Index FEBRUARY 1993 VOLUME 100 NUMBER 2, SUPPLEMENT Preface Influence of Inflammatory Mediators and Cytokines on Yutaka Mishima and David A. Norris Human Melanocyte Function Joseph G. Morelli and David A. Norris MOLECULAR BIOLOGY OF THE TYROSINASE GENE Pigmentation Genes: the Tyrosinase Gene Family and the CONTROL OF CELL FUNCTION AND pmel 17 Gene Family Byoung S. Kwon MELANOGENESIS IN MALIGNANT MELANOMA Role of Growth Factors and Their Receptors in the Development and Progression of Melanoma _Ie-Ming Shih Expression of Tyrosinase Gene in Transgenic Mice: and Meenhard Herlyn Programmed Versus Non-Programmed Expression Takuji Takeuchi, Satoshi Tanaka, and Mika Tanaka Selective Increase of the a Subspecies of Protein Kinase C and Inhibition of Melanogenesis Induced by Retinoic Acid Functional Analysis of the Tyrosinase Gene and Brown- in Melanoma Cells Masahiro Oka, Kouji Ogita, Naoaki Saito, Locus Protein Gene Promoters Shigeki Shibahara and Yutaka Mishima Tyrosinase Gene Transcription and Its Control by Hydrogen Peroxide as an Inducer of Elevated Tyrosinase Melanogenic Inhibitors Shunsaku Ando, Level in Melanoma Cells Eszter Karg, Gerd Odh, Osamu Ando, Yasuo Suemoto, and Yutaka Mishima Anna Wittbjer, Evald Rosengren, and Hans Rorsman Appearance of Tumorous Phenotypes in Goldfish COMPLEX BIOCHEMISTRY OF MELANOGENESIS Erythrophores Transfected with ras, src, and myc Oncogenes Regulatory Mechanisms of Melanogenesis: Beyond the and Spontaneous Differentiation of the Transformants In Tyrosinase Concept Giuseppe Prota Vitro Jiro Matsumoto, Toyoko Akiyama, Nobuo Nemoto, Prince Masahito, and Takatoshi Ishikawa Dynamics of Melanogenesis Intermediates Stanislav Pavel Differences in Subcellular Distribution of Catechol-O- Methyltransferase and Tyrosinase in Malignant Melanoma High-Performance Liquid Chromatography (HPLC) Takakazu Shibata, Stan Pavel, Nico P.M. Smit, and Yutaka Mishima Analysis of Eu- and Pheomelanin in Melanogenesis Control Shosuke Ito Abnormalities in HLA Class I Antigen Expression by Melanoma Cells: Structural Characterization and Detection of Eumelanogenic and Pheomelanogenic Functional Implications Sebastiano Gattoni-Celli, Melanosomes in the Same Normal Human Melanocyte Lidio Calorini, Hugh Randolph Byers, Takafumi Etoh, Mizuho Inazu and Yutaka Mishima Zhigang Wang, and Soldano Ferrone SELECTED MECHANISMS OF ALTERED Exploitation of Pigment Biosynthesis Pathway as a PIGMENTATION IN DISEASE Selective Chemotherapeutic Approach for Malignant White Mutants in Mice Shedding Light on Humans Melanoma _ Kowichi Jimbow, Takashi Iwashina, Frank Alena, Koji Yamada, Jim Pankovich, and Tadahiro Umemura Ruth Halaban and Gisela Moellmann Tyrosinase Gene Mutations Causing Oculocutanoeu s Effects of Interferons and Cytokines on Melanoma Albinisms Yasushi Tomita Cells Claus Garbe and Konstantin Krasagakis 872 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY MARCH 1993 VOLUME 100 NUMBER 3 IN THIS ISSUE Epidermal Langerhans Cells Are Resistant to the Permeabilizing Effects of Extracellular ATP: In Vitro Janet Rettig Emanuel Evidence Supporting a Protective Role of Membrane ATPase Giampiero Girolomoni, Maria Lucia Santantonio, Saveria Pastore, HYPOTHESIS Paul R. Bergstresser, Alberto Giannetti, and Ponciano D. Cruz, Jr. A Potential Role for Superantigens in the Pathogenesis of Psoriasis Donald Y.M. Leung, Patrick Walsh, Ralph Giorno, Interferon Gamma Regulation of De Novo Protein and David A. Norris Synthesis in Human Dermal Fibroblasts in Culture Is Anatomic Site Dependent Terry J. Smith and Paul J. Higgins REPORTS Leukotriene B, Formation During Human Neutrophil Reconstitution of Hair Follicle Development In Vivo: Keratinocyte Interactions: Evidence for Transformation of Determination of Follicle Formation, Hair Growth, and Hair Quality by Dermal Cells Wendy C. Weinberg, Leukotriene A, by Putative Keratinocyte Leukotriene A, Hydrolase Lars Iversen, Karsten Fogh, Vincent A. Ziboh, Linda V. Goodman, Carmen George, David L. Morgan Peter Kristensen, Anne Schmedes, and Knud Kragballe Steve Ledbetter, Stuart H. Yuspa, and Ulrike Lichti Increased Interleukin 6 Production by T Cells Derived Cyclosporin A Prolongs Human Hair Growth In Vitro from Patients with Atopic Dermatitis Akito Toshitani, Michael Taylor, Anthony T.T. Ashcroft, and Andrew G. Messenger John C. Ansel, Sai C. Chan, Shi-Hua Li, and Jon M. Hanifin Effects of the Selective Protein Kinase C Inhibitor, Ro 31- Basophil Mediator Release in Atopic Dermatitis 7549, on the Proliferation of Cultured Mouse Epidermal Helen A. Bull, Paul F. Courtney, Christopher B. Bunker, Keratinocytes Wendy B. Bollag, Janet Ducote, and Malcolm H.A. Rustin, Fred L. Pearce, and Charles S. Harmon Pauline M. Dowd Thy 1+ Dendritic Epidermal Cells but not Langerhans Further Analyses of Epitopes for Human Monoclonal Cells Express Ly 48 Anthony A. Gaspari, Barbara Ferbel, and Anti- Basement Membrane Zone Antibodies Produced by John G. Frelinger Stable Human Hybridoma Cell Lines Constructed with Epstein-Barr Virus Transformants Takashi Hashimoto, Analysis of the Protective Effect of Different Sunscreens Masayuki Amagai, Tamotsu Ebihara, Shinobu Gamou, on Ultraviolet Radiation-Induced Local and Systemic Nobuyoshi Shimizu, Takuichi Tsubata, Akira Hasegawa, Suppression of Contact Hypersensitivity and Inflammatory Keizaburo Miki, and Takeji Nishikawa Responses in Mice Peter Wolf, Cherrie K. Donawho, and Margaret L. Kripke Penetration of Autoantibodies into Living Epithelial Cells Theo D. Golan, Azzudin E. Gharavi, and Keith B. Elkon Antioxidant Defense Mechanisms in Murine Epidermis and Expression of Functional a,8, Integrin by Human Dermal Dermis and Their Responses to Ultraviolet Light Yasuko Shindo, Eric Witt, and Lester Packer Fibroblasts James Gailit, Michael Pierschbacher, and Richard A.F. Clark Pyridoxine Toxicity to Cultured Fibroblasts Caused by Expression of Type VI Collagen mRNA During Wound Near-Ultraviolet Light Kenji Sato, Hiroyasu Taguchi, Healing Takashi Oono, Ulrich Specks, Beate Eckes, Tomoko Maeda, and Kunihiko Yoshikawa Slawomir Majewski, Nicolas Hunzelmann, Rupert Timpl, and Thomas Krieg HLA-DR, -DQ and -DP Alleles in Nickel, Chromium, and/or Cobalt-Sensitive Individuals: Genomic Analysis Expression of Interstitial Collagenase, 92-kDa Gelatinase, Based on Restriction Fragment Length Polymorphisms and Tissue Inhibitor of Metalloproteinases-1 in Granuloma Lennart Emtestam, Henrik Zetterquist, and Olle Olerup Annulare and Necrobiosis Lipoidica Diabeticorum Ulpu K. Saarialho-Kere, Elise S. Chang, Howard G. Welgus, and Phorbol-12-Myristate-13-Acetate- Treated Human William C. Parks Keratinocytes Express B7-Like Molecules That Serve a Costimulatory Role in T-Cell Activation Direct Interaction of Antifungal Azole-Derivatives with Matthias Augustin, Andrea Dietrich, Roland Niedner, Calmodulin: A Possible Mechanism for Their Therapeutic Alexander Kapp, Erwin Schépf, Jeffrey A. Ledbetter, Activity Lutz Hegemann, Susan M. Toso, Khosrow I. Lahijani, William Brady, Peter S. Linsley, and Jan C. Simon Guy F. Webster, and Jouni Uitto MARCH 1993 VOLUME 100 NUMBER 3, SUPPLEMENT 245S Introduction Gerald S. Lazarus 251S Is Carcinogenesis Fundamentally Adversarial- Confrontational or Physiologic - Adaptive? Emmanuel Farber 246S Wallace H. Clark, Jr., M.D.: A Biography and Annotated 254S Cytogenetics of Melanocytic Tumors Annette H. Parmiter Bibliography and Peter C. Nowell . 100, NO. 6 JUNE 1993 VOLUME CONTENTS 873 Melanin Pigments and Melanosomal Proteins as Histopathologic Recognition and Grading of Dysplastic Differentiation Markers Unique to Normal and Neoplastic Melanocytic Nevi: An Interobserver Agreement Study Melanocytes Kowichi Jimbow, Simon K. Lee, Lyn M. Duncan, Marianne Berwick, Jan A. Bruijn, Michael G. King, Hiroyuki Hara, Hua Chen, Jamal Dakour, H. Randolph Byers, Martin C. Mihm, and Raymond L. Barnhill and Halyna Marusyk Melanocytic Nevi in Histologic Association with Primary Cutaneous Melanoma of Superficial Spreading and Variations in the Distribution, Frequency, and Phenotype Nodular Types: Effect of Tumor Thickness of Langerhans Cells During the Evolution of Malignant Richard W. Sagebiel Melanoma of the Skin Kan Toriyama, Duan-Ren Wen, Eberhard Paul, and Alistair J. Cochran Tumor Progression in Ocular Melanomas Robert Folberg Early Detection of Malignant Melanoma: Observation on Non-Melanosomal Regulatory Factors in Melanogenesis Results of Educational Strategies Rona M. MacKie Takakazu Shibata, Giuseppe Prota, and Yutaka Mishima Autologous Melanoma Vaccine Induces Inflammatory Growth Regulation of Cultured Human Nevus Cells Responses in Melanoma Metastases: Relevance to Maria-Laura Mancianti, Tibor Gyérfi, le-Ming Shih, Immunologic Regression and Immunotherapy Istvan Valyi-Nagy, Gwendolin Levengood, Hans D. Menssen, George F. Murphy, Antoaneta Radu, Michael Kaminer, Allan C. Halpern, David E. Elder, and Meenhard Herlyn and David Berd Lessons from Tumor Progression: The Invasive Radial Hair Follicles, Stem Cells, and Skin Cancer Growth Phase of Melanoma Is Common, Incapable of Stanley J. Miller, Tung-Tien Sun, and Robert M. Lavker Metastasis, and Indolent DuPont Guerry IV, Marie Synnestvedt, David E. Elder, and Delray Schultz Eccrine Differentiation in Basal Cell Carcinoma A Cohort Study of Melanoma in Patients with Dysplastic Peter J. Heenan and Matthew S. Bogle Nevi Allan C. Halpern, DuPont Guerry IV, David E. Elder, Bruce Trock, and Marie Synnestvedt Giant Congenital Nevi: A Conceptualization of Patterns Richard J. Reed Risk of Melanoma and Other Cancers in Melanoma-Prone Families Margaret A. Tucker, Mary C. Fraser, Alisa M. Goldstein, David E. Elder, DuPont Guerry IV, and Immunophenotyping of Compound and Spitz Nevi and Sara M. Organic Vertical Growth-Phase Melanomas Using a Panel of Monoclonal Antibodies Reactive in Paraffin Sections In Vivo Epiluminescence Microscopy: Improvement of Bette Lazzaro, David E. Elder, Ahlke Rebers, Laurie Power, Early Diagnosis of Melanoma Hubert Pehamberger, Meenhard Herlyn, Andreas Menrad, and Bernett Johnson Michael Binder, Andreas Steiner, and Klaus Wolff APRIL 1993 VOLUME 100 NUMBER 4 IN THIS ISSUE Expression of Distinct Desmocollin Isoforms in Human Epidermis Ian A. King, Anne Tabiowo, Patricia Purkis, Janet Rettig Emanuel Irene Leigh, and Anthony I. Magee REPORTS Desmocollins I and II Are Recognized by Certain Sera from Inhibition of Neutrophil Adherence to Antibody by Patients with Various Types of Pemphigus, Particularly Dapsone: A Possible Therapeutic Mechanism of Dapsone in Brazilian Pemphigus Foliaceus Marian Dmochowski, Takashi Hashimoto, David R. Garrod, and Takeji Nishikawa the Treatment of IgA Dermatoses Vu Thuong-Nguyen, Donald P. Kadunce, John D. Hendrix, W. Ray Gammon, and John J. Zone Comparative Study of Bullous Pemphigoid Antigens Among Japanese, British, and U.S. Patients Indicates Similar Antigen Profiles with the 170-kD Antigen Present both in Stimulus-Selective Induction of CRABP-II mRNA: A the Basement Membrane and on the Keratinocyte Cell Marker for Retinoic Acid Action in Human Skin Membrane Takashi Hashimoto, Tamotsu Ebihara, Akira Ishiko, James T. Elder, Matthew A. Cromie, Christopher E. M. Griffiths, Hiroshi Shimizu, Balbir S. Bhogal, Martin M. Black, John R. Stanley, Pierre Chambon, and John J. Voorhees and Takeji Nishikawa Immunohistochemical Localization of SKALP/Elafin in Pigmentation and Inhibition of Wound Contraction by Psoriatic Epidermis J. Schalkwijk, I.M.J.J. van Vlijmen, Cultured Skin Substitutes with Adult Melanocytes After J.A.C. Alkemade, and G.J. de Jongh Transplantation to Athymic Mice Steven T. Boyce, Estela E. Medrano, Zalfa Abdel-Malek, Andrew P. Supp, Purification and Immunohistochemical Localization of JoAnn M. Dodick, James J. Nordlund, and Glenn D. Warden Aspartic Proteinases in Rat Epidermis Kenji Hara, Kimie Fukuyama, Hideaki Sakai, Kenji Yamamoto, and Structural Variations in Anchoring Fibrils in Dystrophic William L. Epstein Epidermolysis Bullosa: Correlation with Type VII Collagen Expression John A. McGrath, Akemi Ishida-Yamamoto, Rate of Stratum Corneum Formation in the Perinatal Rat Anthony O’Grady, Irene M. Leigh, and Robin A.J. Eady Steven B. Hoath, Reiko Tanaka, and Steven T. Boyce 874 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY Ontogeny of Water Sorption-Desorption in the Perinatal Physical Interaction Between Langerhans Cells and Rat Randall R. Wickett, Julie L. Mutschelknaus, and T-Lymphocytes During Antigen Presentation In Vitro Steven B. Hoath Miguel Concha, Alejandra Vidal, Gladys Garcés, Carlos D. Figueroa, and Italo Caorsi Presence of Anti-La(SS-B) Is Associated with Binding to the 13-kD Carboxyl Terminus of 60-kD Ro(SS-A) in Systemic ESDR ABSTRACTS Lupus Erythematosus W. Darryl Dickey, Juliet E. van Egmond, Kathy L. Hardgrave, John B. Harley, Abstracts for the Annual Scientific Meeting RAI Congress R. Hal Scofield Centre, Amsterdam, The Netherlands, April 3-6, 1993 Induction of Intercellular Adhesion Molecule 1 (ICAM-1) Expression in Normal Human Eosinophils by Inflammatory Index Cytokines Wolfgang Czech, Jean Krutmann, Anne Budnik, Erwin Schépf, and Alexander Kapp SID ABSTRACTS CD44 Antibody Stimulates Adhesion of Peripheral Blood T Abstracts for the 1993 Annual Meeting Sheraton Washington Cells to Keratinocytes Through the Leukocyte Function- Hotel, Washington, D.C., April 28- May 1, 1993 Associated Antigen-1/Intercellular Adhesion Molecule-1 Pathway Ineke Bruynzeel, Gerrit Koopman, Liesbeth M.H. van der Raaij, Steven T. Pals, and Rein Willemze Index MAY 1993 VOLUME 100 NUMBER 5 IN THIS ISSUE Spironolactone Directly Inhibits Proliferation of Cultured Human Facial Sebocytes and Acts Antagonistically to Janet Rettig Emanuel Testosterone and 5-a-Dihydrotestosterone In Vitro REVIEW Hirohiko Akamatsu, Christos C. Zouboulis, and Constantin E. Orfanos Involu—c Strruictnur e and Role in Envelope Assembly Richard L. Eckert, Michael B. Yaffe, James F. Crish, Shubha Murthy, Ellen A. Rorke, and Jean F. Welter Immunocytochemical Localization of Androgen Receptors in Human Skin Using Monoclonal Antibodies Against the REPORTS Androgen Receptor Tehming Liang, Sheryl Hoyer, Riley Yu, Autoantibodies to Type VII Collagen Recognize Epitopes in Keyoumars Soltani, Allan L. Lorincz, Richard A. Hiipakka, and a Fibronectin-Like Region of the Noncollagenous (NC1) Shutsung Liao Domain W. Ray Gammon, Dédée F. Murrell, Mark W. Jenison, Karen M. Padilla, Phillip S. Prisayanh, Drew A. Jones, Robert A. Briggaman, and Stephen W. Hunt III Leukemic T Cells from Patients with Cutaneous T-Cell Lymphoma Demonstrate Enhanced Activation Through CDw60, CD2, and CD28 Relative to Activation Through the Conversion of Acitretin to Etretinate in Psoriatic Patients Is T-Cell Antigen Receptor Complex Erik R. Hansen, Influenced by Ethanol Frederik Gronhgj Larsen, Gunhild L. Vejlsgaard, Kevin D. Cooper, Michael Heidenheim, Preben Jakobsen, Jens Knudsen, Kaare Weismann, Knud Kragballe, Jorgen K. Larsen, Vincent C. Ho, Charles W. Ross, David A. Fox, and Folmer Nielsen-Kudsk Kristian Thomsen, and Ole Baadsgaard TGFa Enhances Locomotion of Cultured Human Keratinocytes William D. Ju, John T. Schiller, In Vivo Cytokine Expression in Normal and Perturbed M.K. Kazempour, and Douglas R. Lowy Murine Skin— Analysis by Competitive Quantitative Polymerase Chain Reaction Oliver Kilgus, Elisabeth Payer, Epidermal Growth Factor and Insulin-Like Growth Factor I Susanne Schreiber, Adelheid Elbe, Robert Strohal, and Georg Sting] Enhance Keratinocyte Migration Yoshihiro Ando and Pamela J. Jensen Increased Interleukin-4 Production by Atopic Mononuclear Role of Integrin a, 8, (VLA-2) in the Migration of Human Leukocytes Correlates with Increased Cyclic Adenosine Melanoma Cells on Laminin and Type IV Collagen Monopho- sPhopsphhodaiestteeras e Activity and Is Takafumi Etoh, Luc Thomas, Cecile Pastel-Levy, Reversible by Phosphodiesterase Inhibition Sai C. Chan, Robert B. Colvin, Martin C. Mihm Jr., and H. Randolph Byers Shi-Hua Li, and Jon M. Hanifin Migration of Langerhans Cells into Human Epidermis of “Reconstructed” Skin, Normal Skin, or Healing Skin, After Subclass Reactivity of Pemphigus Foliaceus Autoantibodies Grafting onto the Nude Mouse Michel Démarchez, with Recombinant Human Desmoglein Elizabeth M. Allen, Daniel Asselineau, and Janusz Czernielewski George J. Giudice, and Luis A. Diaz 12-O-Tetradecanoylphorbol-13-Acetate Not Only Modulates Proliferation Rates, But Also Alters Antigen Expression and Ultraviolet A-Induced Lipid Peroxidation and Antioxidant LAK-Cell Susceptibility of Normal Human Melanocytes In Defense Systems in Cultured Human Skin Fibroblasts Vitro Konstantin Krasagakis, Claus Garbe, Annie Moysan, Isabelle Marquis, Francois Gaboriau, René Santus, Sabine Kriiger-Krasagakes, and Constantin E. Orfanos Louis Dubertret, and Patrice Morliére VOL. 100, NO. 6 JUNE 1993 VOLUME CONTENTS 875 699 Apoptotic Index: Discriminant Feature for the 717 Further Evidence for Borrelia burgdorferi Infection in Differentiation of Cutaneous Diffuse Malignant Follicular Morphea and Lichen Sclerosus et Atrophicus Confirmed by Center Cell Lymphomas from Lymphoid Hyperplasia DNA Amplification Christoph Schempp, Hubertus Bocklage, Clelia Miracco, Donatella Spina, Rosa Santopietro, Robert Lange, Hans W. Kélmel, Constantin E. Orfanos, and Vincenzo Sforza, Lorenzo Leoncini, Lorenzo Pacenti, Harald Gollnick Maria M. de Santi, Roberto Lio, Pietro Luzi, Piero Tosi, Rainer Kraft, and Hans Cottier Characterization of the Skin In Vivo by High Resolution PROGRESS IN DERMATOLOGY Magnetic Resonance Imaging: Water Behavior and Age- Chronic Wounds: Pathophysiologic and Experimental Related Effects Stéphanie Richard, Bernard Querleux, Considerations Vincent Falanga Jacques Bittoun, Odile Jolivet, Ilana Idy-Peretti, Olivier de Lacharriere, and Jean-Luc Leveque Scattering of Light from Histologic Sections: A New TRIBUTE Method for the Analysis of Connective Tissue Ariel G. Ferdman and Ioannis V. Yannas 726 Tribute to Samuel M. Peck, M.D. David Bickers JUNE 1993 VOLUME 100 NUMBER 6 IN THIS ISSUE Decreased Type VI Collagen Gene Expression in Cultured Werner’s Syndrome Fibroblasts Atsushi Hatamochi, Janet Rettig Emanuel Kenichi Mori, Koji Takeda, Masami Arakawa, Hiroaki Ueki, and Hidekatsu Yoshioka REVIEW Structure, Function, and Dynamics of Keratin Intermediate Gamma Interferon Potently Induces Tryptophanyl-tRNA Filaments Peter M. Steinert Synthetase Expression in Human Keratinocytes Alain Reano, Marie-Helene Richard, Luc Denoroy, Jacqueline Viac, REPORTS Jean-Pierre Benedetto, and Daniel Schmitt Allelic Variations of Human Keratins K4 and K5 Provide Polymorphic Markers Within the Type II Keratin Gene Biphasic Effects of Interleukin-1a@ on Dermal Fibroblasts: Cluster on Chromosome 12. Reinhard Wanner, Enhancement of Chemotactic Responsiveness at Low Hans-Heinrich Forster, Irmgard Tilmans, and Dietmar Mischke Concentrations and of mRNA Expression for Collagenase at High Concentrations M. Heckmann, B.C. Adelmann-Grill, R. Hein, and T. Krieg Cloned Spindle and Epithelioid Cells from Murine Kaposi’s Sarcoma-Like Tumors Are of Endothelial Origin Kathryn A. O’Connell and A. Andrew Rudmann Changes in the Distribution of Actin-Associated Proteins During Epidermal Wound Healing M. Dominique Kubler and Fiona M. Watt p53 Mutations Are Common and Early Events that Precede Tumor Invasion in Squamous Cell Neoplasia of the Skin Christine Campbell, Anthony G. Quinn, Young-Suck Ro, Cyclobutane Pyrimidine Dimers in UV-DNA Induce Brian Angus, and Jonathan L. Rees Release of Soluble Mediators that Activate the Human Immunodeficiency Virus Promoter Daniel B. Yarosh, Oligonucleotide Typing Reveals Association of Type I Lori Alas, Jeannie Kibitel, Adrienne O’Connor, France Carrier and Albert J. Fornace, Jr. Psoriasis with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 Extended Haplotype Marcus Schmitt-Egenolf, Wolf-Henning Boehncke, Markward Stander, Detection of Thymine Dimers in Suprabasal and Basal Cells Thomas H. Eiermann, and Wolfram Sterry of Chronically UV-B Exposed Hairless Mice Arie A. Vink, Rob J.W. Berg, Frank R. de Gruijl, Paul H.M. Lohman, Len Roza, A 5’ Portion of the ICAM-1 Gene Confers Tissue-Specific and Robert A. Baan Differential Expression Levels and Cytokine Responsiveness Lynn A. Cornelius, Jane T. Taylor, Klaus Degitz, Lian-Jie Li, Differential Regulation of Tyrosinase Activity in Skin of Thomas J. Lawley, and S. Wright Caughman White and Black Individuals In Vivo by Topical Retinoic Acid Harvinder S. Talwar, Christopher E.M. Griffiths, Nickel Chloride and Cobalt Chloride, Two Common GaryJ . Fisher, Andrew Russman, Kent Krach, Soheila Benrazavi, and Contact Sensitizers, Directly Induce Expression of John J. Voorhees Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Endothelial Leukocyte Adhesion Molecule (ELAM-1) by Endothelial Cells Role of Tyrosinase as the Determinant of Pigmentation in Matthias Goebeler, Georg Meinardus-Hager, Johannes Roth, Cultured Human Melanocytes Ken Iozumi, Sergij Goerdt, and Clemens Sorg George E. Hoganson, Raffaele Pennella, Mark A. Everett, and Bryan B. Fuller Expression of Cross-Reactive Idiotypes at the Basement Membrane Zone in Patients with Bullous Pemphigoid Cytolytic Antibodies to Melanocytes in Vitiligo Jian Cui, M. Joyce Rico, LaDonna S. White, and Russell P. Hall III Yuko Arita, and Jean-Claude Bystryn 876 VOLUME CONTENTS THE JOURNAL OF INVESTIGATIVE DERMATOLOGY 816 Presence or Absence of Melanocytes in Vitiligo Lesions: An 829 Inactivation of Enzymes of the Glutathione Antioxidant Immunohistochemical Investigation 1. Caroline Le Poole, System by Treatment of Cultured Human Keratinocytes René M.J.G.J. van den Wijngaard, Wiete Westerhof, with Peroxides Donald A. Vessey and Kyung-Hee Lee Richard P. Dutrieux, and Pranab K. Das Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue Rebecca Williams, Michael P. Philpott, and Terence Kealey Coexistence and Relationship of Antikeratinocyte and Antimelanocyte Antibodies in Patients with Ganglioside G,,, Inhibits the Proliferation of Cultured Non-Segmental-Type Vitiligo Hsin-Su Yu, Chao-Hsing Kao, Keratinocytes Amy S. Paller, Sheryl L. Arnsmeier, and Chia-Li Yu Maira Alvarez-Franco, and Eric G. Bremer