The Journal of Immunology 2002: Vol 169 Table of Contents

39 Pages·2002·11.4 MB·English

VOLUME 169 /N° 1 / JULY 1, 2002
CUTTING Crue
Cutting Edge: Chemical Dominance Does Not Relate to Immunodominance: Studies of the CD4* T Cell Response to a
Model Antigen
Richard J. DiPaolo and Emii R. Unanue
Cutting Edge: Molecular Portrait of Human Autoimmune Disease
Kevin Maas, Sanny Chan, Joel Parker, Angela Slater, Jason Moore. Nancy Olsen. and Thomas M. Auné
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
Osamu Takeuchi, Shintaro Sato, Takao Horiuchi, Katsuaki Hoshino, Kiyoshi Takeda, Zhongyun Dong, Robert L. Modlin.
and Shizuo Akira
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
2 Extracellular Adenine Nucleotides Inhibit the Activation of Human CD4* T Lymphocytes
15 Xavier Duhant, Liliane Schandené, Catherine Bruyns, Nathalie Suarez Gonzalez, Michel Goldman, Jean-Marie Boeynaems
and Didier Communi
Ly-49s3 Is a Promiscuous Activating Rat NK Cell Receptor for Nonclassical MHC Class I-Encoded Target Ligands
Christian Naper, Shigenari Hayashi, Lise Kveberg, Eréne C. Niemi, Lewis L. Lanier, John 7 Vaage, and James C. Ryan
NKT Cell-Derived RANTES Recruits APCs and CD8* T Cells to the Spleen During the Generation of Regulatory T Cells
in Tolerance
Douglas E. Faunce and Joan Stein-Streilein
Memory Functions and Death Proneness in Three CD4* CD45RO~ Human T Cell Subsets
Takaaki Ohara, Kazuaki Koyama, Yoichiro Kusunoki, Tomonori Hayashi, Naohiro Tsuyama, Yoshiko Kub
and Seishi Kyoizumi
Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-1
Joanne A. Fox, Karen Ung, Sonia G. Tanlimco, and Frank R. Jirik
2B4 Is Constitutively Associated with Linker for the Activation of T Cells in Glycolipid-Enriched Microdomains: Properties
Required for 2B4 Lytic Function
Jennifer Klem, Pamela C. Verrett, Vinay Kumar, and John D. Schatzle
IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1
Restricted CTL Response in Transgenic Mice
Katrin Peter, Michael J. Brunda, and Giampietro Corradin
Sre-Dependent Syk Activation Controls CD69-Mediated Signaling and Function on Human NK Cells
Simona Pisegna, Alessandra Zingoni, Gianluca Pirozzi, Benedetta Cinque, Maria Grazia Cifone, Stefania Morr
Mario Piccoli, Luigi Frati, Gabriella Palmieri, and Angela Santoni
C.D) 123s°o"t "™ ght Plasmacytoid Predendritic Ce. lls: Progenitors Undergoing Cell Fa) te Conversion )
Michael R. Comeau, Anne-Renee Van der Vuurstd e Vries, CharlesR . Maliszewski, and Laurent Galibert
Using Tolerance Induced Via the Anterior Chamber of the Eye to Inhibit Th2-Dependent Pulmonary Pathology
Kazumoto Katagiri, Jie Zhang-Hoover, Jun Song Mo, Joan Stein-Streilein, and J. Wayne Streileir
Dynamics of Memory T Cell Proliferation Under Conditions of Heterologous Immunity and Bystander Stimulation
Sung-Kwon Kim, Michael A. Brehm, Raymond M. Welsh, and Liisa K. Selin
Exogenous Peptides Delivered by Ricin Require Processing by Signal Peptidase for Transporter Associated with Antigen
Processing-Independent MHC Class I-Restricted Presentation
Daniel C. Smith, Awen Gallimore, Emma Jones, Brenda Roberts, J. Michael Lord, Emma Deeks, Vincenz erundok
and Lynne M. Roberts
Antigen Presentation Capacity and Cytokine Production by Murine Splenic Dendritic Cell Subsets upon Salmonella Encounter
Ulf Yrlid and MaryJ o Wick
Pertussis Toxin Modulates the Immune Response to Neuroantigens Injected in Incomplete Freund's Adjuvant: Induction of Th!
Cells and Experimental Autoimmune Encephalomyelitis in the Presence of High Frequencies of Th2 Cells
Harald H. Hofstetter, Carey L. Shive, and Thomas G. Forsthuber
A Ligand for the Murine NK Activation Receptor Ly-49D: Activation of Tolerized NK Cells from B.-Microglobulin-Deficient Mice
Hiroshi Furukawa, Koho lizuka, Jennifer Poursine-Laurent, Nilabh Shastri, and Wayne M. Yokoyama
Synergistic Antitumor Effect of Bispecific CD19 x CD3 and CD19 x CD16 Diabodies in a Preclinical Model of
Non-Hodgkin's Lymphoma
Sergey M. Kipriyanov, Bjérn Cochlovius, Holger J. Schafer, Gerhard Moldenhauer, Alexandra Bahre, Fabrice Le Gall,
Stefan Knackmuss, and Melvyn Little
Antigen-Dependent Release of IFN-y by Cytotoxic T Cells Up-Regulates Fas on Target Cells and Facilitates Exocytosis
Independent Specific Target Cell Lysis
Arno Miillbacher, Mario Lobigs, Ron Tha Hla, Thao Tran, Thomas Stehle, and Markus M. Simon
Absence of the CD1 Molecule Up-Regulates Antitumor Activity Induced by CpG Oligodeoxynucleotides in Mice
Lucia Sfondrini, Dario Besusso, Maria Teresa Zoia, Monica Rodolfo, Anna Maria Invernizzi, Masaru Taniguchi,
Toshinori Nakayama, Mario Paolo Colombo, Sylvie Ménard, and Andrea Balsari
Blebs and Apoptotic Bodies Are B Cell Autoantigens
Brian A. Cocca, Amy M. Cline, and Marko Z. Radic
Human Cytomegalovirus Disrupts Constitutive MHC Class II Expression
Colleen M. Cebulla, Daniel M. Miller, Yingrue Zhang, Brian M. Rahill, Peter Zimmerman, John M. Robinson
and Daniel D. Sedmak
CONTENTS
Expression and Function of the Eph A Receptors and Their Ligands Ephrins A in the Rat Thymus
Juan J. Mutioz, Luis M. Alonso-C., Rosa Sacedén, Tessa Crompton, Angeles Vicente , Eva Jiménez, Alberto Varas,
and Agustin G. Zapata
A Defective NF-«B/RelB Pathway in Autoimmune-Prone New Zealand Black Mice Is Associated with Inefficient Expansion of
Thymocyte and Dendritic Cells
René Valéro, Marie-Laurence Baron, Sandrine Guérin, Sophie Béliard, Hugues Lelouard, Brigitte Kahn-Perles, Bernard Vialettes,
Cathy Nguyen, Jean Imbert, and Philippe Naquet
Spatial Raft Coalescence Represents an Initial Step in FeyR Signaling
Hajime Kono, Takeshi Suzuki, Kazuhiko Yamamoto, Masato Okada, Tadashi Yamamoto, and Zen-ichiro Honda
Functional Human T Lymphocyte Development from Cord Blood CD34* Cells in Nonobese Diabetic/Shi-scid, IL-2 Receptor y
Null Mice
Takashi Yahata, Kiyoshi Ando, Yoshihiko Nakamura, Yoshito Ueyama, Kazuo Shimamura, Norikazu Tamaoki, Shunichi Kato,
and Tomomitsu Hotta
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Characterization of the Peptide-Binding Specificity of Mamu-B17 and Identification of Mamu-B17-Restricted Epitopes Derived from
210 Simian Immunodeficiency Virus Proteins
Bianca R. Mothé, John Sidney, John L. Dzuris, Max E. Liebil, Sarah Fuenger, David I. Watkins, and Alessandro Sette
NK Cell Receptors of the Orangutan (Pongo pygmaeus): A Pivotal Species for Tracking the Coevolution of Killer Cell Ig-Like
Receptors with MHC-C
Lisbeth A. Guethlein, Laura R. Flodin, Erin J. Adams, and Peter Parham
A Therapeutic CD4 Monoclonal Antibody Inhibits TCR-g Chain Phosphorylation ‘-Associated Protein of 70-kDa Tyr’*”
Phosphorylation, and TCR Internalization in Primary Human T Cells
Susanne Harding, Peter Lipp, and Denis R. Alexander
Genetic Control of Human NK Cell Repertoire
Heather G. Shilling, Neil Young, Lisbeth A. Guethlein, Nathalie W. Cheng, Clair M. Gardiner, Dolly Tyan, and Peter Parham
Transcriptional Regulation of GATA-3 by an Intronic Regulatory Region and Fetal Liver Zinc Finger Protein |
Eun Sook Hwang, Andrew Choi, and I-Cheng Ho
Recruitment of Phosphatidylinositol 3-Kinase to CD28 Inhibits HIV Transcription by a Tat-Dependent Mechanism
Julie A. Cook, Avery August, and Andrew J. Henderson
Cloning and Characterization of a Promoter Flanking the Early B Cell Factor (EBF) Gene » Indicates roles for E-Proteins and
Autoregulation in the Control of EBF Expression
Emma M. K. Smith, Ramiro Gisler, and Mikael Sigvardsson
Unraveling of the Polymorphic CA2-CA3 Amplification and the Ke*Oz~ Polymorphism in the Human IgA Locus
Mirjam van der Burg, Barbara H. Barendregt, Ellen J. van Gastel-Mol, Talip Tiimkaya, Anton W. Langerak
and Jacques J. M. van Dongen
Key Residues of a Major Cytochrome P4502D6 Epitope Are Located on the Surface of the Molecule
Yun Ma, Mark G. Thomas, Manabu Okamoto, Dimitrios P. Bogdanos, Sylvia Nagl, Nanda Kerkar, Agnel R. Lopes,
Luigi Muratori, Marco Lenzi, Francesco B. Bianchi, Giorgina Mieli-Vergani, and Diego Vergani
Negative Feedback Regulation of the Tumor Suppressor PTEN by Phosphoinositide-Induced Serine Phosphorylation
Diana Birle, Nunzio Bottini, Scott Williams, Huong Huynh, lan deBelle, Eileen Adamson, and Tomas Mustelin
TCR Engagement Induces Proline-Rich Tyrosine Kinase-2 (Pyk2) Translocation to the T Cell-AP¢ Interface Independently of Pyk2
Activity and in an Immunoreceptor Tyrosine-Based Activation Motif-Mediated Fashion
David Sancho, Maria C. Montoya, Alicia Monjas, Ménica Gordén-Alonso, Takuya Katagiri, Diana Gil, Reyes Tejedor,
Balbino Alarcon, and Francisco Sanchez-Madrid
HOsT DEFENSE
Essential Role of Extrathymic T Cells in Protection Against Malaria
301 M. Kaiissar Mannoor, Ramesh C. Halder, Sufi Reza M. Morshed, Anoja Ariyasinghe, Hanaa Y. Bakir, Hiroki Kawamura,
Hisami Watanabe, Hiroho Sekikawa, and Toru Abo
Altered Neutrophil Trafficking During Sepsis
Ren-Feng Guo, Niels C. Riedemann, Ines J. Laude: s, Vidya J. Sarma, Robin G. Kunkel, Kari A. Dilley, Joseph D. Paulauskis,
and Peter A. Ward
Phenotype and Regulation of Persistent Intracerebral T Cells in Murine Toxoplasma Encephalitis
Dirk Schliiter, Timothy Meyer, Lai-Yu Kwok, Manuel Montesinos-Rongen, Sonja Liitjen, Andreas Strack, M. Lienhard Schmitz,
and Martina Deckert
Contribution of IL-18 to Thl Response and Host Defense Against Infection by Mycobacterium tuberculosis: A Comparative Study
with IL-12p40
Yuki Kinjo, Kazuyoshi Kawakami, Kaori Uezu, Satomi Yara, Kazuya Miyagi, Yoshinobu Koguchi, Tomoaki Hoshino,
Masaki Okamoto, Yusuke Kawase, Koichi Yokota, Kohichiro Yoshino, Kiyoshi Takeda, Shizuo Akira, and Atsushi Saito
Induction of CD1-Restricted Immune Responses in Guinea Pigs by Immunization with Mycobacterial Lipid Antigens
Kenji Hiromatsu, Christopher C. Dascher, Kenneth P. LeClair, Masahiko Sugita, Stephen T. Furlong, Michael B. Brenner,
and Steven A. Porcelli
The Role of Proinflammatory Cytokines in Wasting Disease During Lymphocytic Choriomeningitis Virus Infection
Cris Kamperschroer and Daniel G. Quinn
Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long
Peptides
Sander Zwaveling, Sandra C. Ferreira Mota, Jan Nouta, Mark Johnson, Grayson B. Lipford, Rienk Offringa,
Sjoerd H. van der Burg, and Cornelis J. M. Melief
The Murine Cytomegalovirus Immunomodulatory Gene m152 Prevents Recognition of Infected Cells by M45-Specific CTL But
Does Not Alter the Immunodominance of the M45-Specific CD8 T Cell Response In Vivo
Marielle C. Gold, Michael W. Munks, Markus Wagner, Ulrich H. Koszinowski, Ann B. Hill, and Steven P. Fling
2002] CONTENTS
Selective Expression of Type I IFN Genes in Human Dendritic Cells Infected with Mycobacterium tubercuiosis
Maria Elena Remoli, Elena Giacomini, Georges Lutfalla, Elisabetta Dondi, Graziella Orefici, Angela Battistini, Gilles Uz
Sandra Pellegrini, and Eliana M. Coccia
Type I IFN as a Natural Adjuvant for a Protective immune Response: Lessons from the Influenza Vaccine Model
Enrico Proietti, Laura Bracci, Simona Puzelli, Tiziana Di Pucchio, Paola Sestili. Enrico De Vincenzi. Massimo Venditti
Imerio Capone, Isabelle Seif, Edward De Maeyer, David Tough, Isabella Donatelli,j and Filippo Belardelli
INFLAMMATION
Anti-IL-10 Therapeutic Strategy Using the Immunomodulator AS101 in Protecting Mice from Sepsis-Induced Death: Dependenc¢
on Timing of Immunomodulating Intervention
Yona Kalechman, Uzi Gafter, Rivka Gal, Galit Rushkin, Donghong Yan, Michael Albeck, and Benjamin
The Epistatic Interrelationships of IL-1, IL-1 Receptor Antagonist, and the Type I IL-1 Receptor
Vera M. Irikura, Mouna Lagraoui, and David Hirsh
Differential Glucocorticoid Enhancement of the Cytokine-Driven Transcriptional Activation of the Human Acute Phase Serun
Amyloid A Genes, SAA] and SAA2
Caroline F. Thorn and Alexander S. Whitehead
Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells
James L. Lordan, Fabio Bucchieri, Audrey Richter, Athanassias Konstantinidis, John W Holloway, Matthew Thornber
Sarah M. Puddicombe, Diana Buchanan, Susan J. Wilson, Ratko Diukanovié. Stephen T. He lgate, and Donna FE. Davies
Modulation of Mac-1 (CD11b/CD18)-Mediated Adhesion by the Leukocyte-Specific Protein 1 Is Key to Its Role in Neutrophil
Polarization and Chemotaxis
Chunjie Wang, Hisayoshi Hayashi, Rene Harrison, Basil Chiu, Jason R. Chan, Hanne L. Ostergaard, Robert D. J
Jan Jongstra, Myron I. Cybulsky, and Jenny Jonastra-Bilen
Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and
Lymphoid Neogenesis
Sanjiv A. Luther, Afshin Bidgol, Diana C. Hargreaves, Andrea Schmidt, Yina Xu. Jyothi Paniyadi. Mehrda tloubian
and Jason G. Cyster
Impaired IFN-y-Dependent Inflammatory Responses in Human Keratinocytes Overexpressing the Suppressor of Cytokine
Signaling 1
Monica Federici, Maria Laura Giustizieri, Claudia Scarponi, Giampiero Girolomoni, and C
New IL-17 Family Members Promote Thl or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-2
Stephen D. Hurst, Tony Muchamuel, Daniel M. Gorman, Jonathan M. Gilbert, Theresa ¢ lifford, Sylvia Kwa Satish Menor
Brian Seymour, Craig Jackson, Ted T. Kung, Joan K. Brieland, Sandra M. Zurawski, Richard W. Chapman. Gerard Zuraws}
and Robert L. Coffman
Complement Deficiency Ameliorates Collagen-Induced Arthritis in Mice
Max Albert Hietala, Ing-Marie Jonsson, Andrej Tarkowski, Sandra Kleinau, and Marcela Pekna
IL-15-Dependent Activation-Induced Cell Death-Resistant Thl Type CD8aB* NK1.1° T Cells for the Development of Small
Intestinal Inflammation
Noriyuki Ohta, Takachika Hiroi, Mi-Na Kweon, Naotoshi Kinoshita, Myoung Ho Jang, Tadashi Mashi Jun-Ichi Miyazak
and Hiroshi Kiyono
Proinflammatory Cytokine IL-18 Promotes Tumor Growth of Lewis Lung Carcinoma by Induction of Angiog Factors: In Vive
Analysis of Tumor-Stromal Interaction
Yasuo Saijo, Masashi Tanaka, Makoto Miki, Kazuhiro Usui, Takuji Suzuki, Makoto Maemondo, X
Toshiaki Kikuchi, Kouji Matsushima, and Toshihiro Nukiwa
Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events a
Permeability Independent of Transjunctional Migration
Heather A. Edens, Boaz P. Levi, David L. Jaye, Shaun Waish, Titus A. Reaves, Jerrold R. Turner
and Charles A. Parkos
A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophags
Clearance of Cells Undergoing Fas-Mediated Apoptosis
Valerian E. Kagan, Bettina Gleiss, Yulia Y. Tyurina, Vladimir A. Tyurin, Carina Elenstré6m-Magnusson, Shang-Xi Liu
F. Behice Serinkan, Antonio Arroyo, Joya Chandra, Sten Orrenius, and Bengt Fadeel
CLINICAL IMMUNOLOGY
Skin Graft Rejection Elicited by B.-Microglobulin as a Minor Transplantation Antigen Involves Multiple Effector Pathways: Role of
Fas-Fas Ligand Interactions and Th2-Dependent Graft Eosinophil Infiltrates
Murielle Surquin, Alain Le Moine, Véronique Flamand, Nathalie Nagy, Katia Rombaut, Francois-Xavier Den
Patrick Stordeur, Isabelle Salmon, Jean-Charles Guéry, Michel Goldman, and Daniel Abramowicz
Inhibition of Endogenous TGF-8 During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair
Alwin Scharstuhl, Harrie L. Glansbeek, Henk M. van Beuningen, Elly L. Vitters, Peter M. van der Kraay
and Wim B. van den Berg
An Autoreactive y6 TCR Derived from a Polymyositis Lesion
Heinz Wiendl, Joachim Malotka, Brigitte Holzwarth, Hans-Ulrich Weltzien, Hartmut Wekerle, Reinhard Hohlfeld
and Klaus Dornmaii
Analysis of the Innate and Adaptive Phases of Allograft Rejection by Cluster Analysis of Transcriptional Profiles
Kenneth ¢ hristopher, Thomas F. Mueller, Chunyan Ma, Yurong Liang, and David L. Perkins
Antimelanoma Activity of CTL Generated from Peripheral Blood Mononuclear Cells After Stimulation with Autologous Dendritic
Cells Pulsed with Melanoma gp100 Peptide G209-2M Is Correlated to TCR Avidity
Sixun Yang, GeraldP . Linette, Simonne Longerich, and Frank G. Haluska
Identification of HLA-A0201-Restricted T Cell Epitopes Derived from the Novel Overexpressed Tumor Antigen Calcium-Activated
Chloride Channel 2
Renate Konopitzky, Ulrich Kénig, Ralf G. Meyer, Wolfgang Sommergruber, Thomas Wolfel, and Tamas Schweighoffer
High Immunogenicity of Intracellular Myelin Oligodendrocyte Glycoprotein Epitopes
Robert Weissert, Jens Kuhle, Katrien L. de Graaf, Wolfgang Wienhold, Martin M. Herrmann, Claudia Miiller,
Thomas G. Forsthuber, Karl-Heinz Wiesmiiller, and Arthur Melms
CONTENTS [voL. 169
Identification of Naturally Processed CD4 T Cell Epitopes from the Prostate-Specific Antigen Kallikrein 4 Using Peptide-Based In
Vitro Stimulation
John A. Hural, Rachel S. Friedman, Andria McNabb, Sean S. Steen, Robert A. Henderson, and Michael Kalos
Differential Induction of Mucosal and Systemic Antibody Responses in Women After Nasal, Rectal, or Vaginal Immunization
Influence of the Menstrual Cycle
Pamela A. Kozlowski, Selvi B. Williams, Rebecca M. Lynch, Timothy P. Flanigan, Rosalyn R. Patterson, Susan Cu-Uvin,
and Marian R. Neutra
Generation of CTL Recognizing an HLA-A0201-Restricted Epitope Shared by MAGE-AI1, -A2, -A3, -A4, -A6, -A10, and -Al2 Tumor
Antigens: Implication in a Broad-Spectrum Tumor Immunotherapy
Stéphanie Graff-Dubois, Olivier Faure, David-Alexandre Gross, Pedro Alves, Antonio Scardino, Salem Chouaib
Francois A. Lemonnier, and Kostas Kosmatopoulos
Aberrant Production of IL-12 by Macrophages from Several Autoimmune-Prone Mouse Strains Is Characterized by Intrinsic and
Unique Patterns of NF-«B Expression and Binding to the IL-12 p40 Promoter
Jiajian Liu and David Beller
Induction of Autoantibody Production Is Limited in Nonautoimmune Mice
Ram Raj Singh, Fanny M. Ebling, D. Alves Albuquerque, Vijay Saxena, Vipin Kumar, Edward H. Giannini, Tony N. Marion,
Fred D. Finkelman, and Bevra H. Hahn
Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice
Expressing Human Ig Loci
Yuvxian He, William J. Honnen, Chavdar P. Krachmarov, Michael Burkhart, Samuel C. Kayman, Jose Corvalan,
and Abraham Pinter
Corrections
Author Index
Information for Authors
Editorial Policies and Practices
Submission Form: Full Length Articles
Submission Form: Cutting Edge
AAI Membership Application
AAI Trainee Membership Application
VOLUME 169 / NOS 2/ suLy 15, 2002
(UTTIDG Cue
Cutting Edge: Targeted Ligation of CTLA-4 In Vivo by Membrane-Bound Anti-CTLA-4 Antibody Prevents Rejection of
Allogeneic Cells
Kwang Woo Hwang, William B. Sweatt, lan E. Brown, Christian Blank, Thomas F. Gajewski, Jeffrey A. Bluestone,
and Maria-Luisa Alegre
Cutting Edge: CCR7" and CCR7 Memory T Cells Do Not Differ in Immediate Effector Cell Function
Heike Unsoeld, Stefan Krautwald, David Voehringer, Ulrich Kunzendorf, and Hanspeter Pircher
Cutting Edge: IL-17D, a Novel Member of the IL-17 Family, Stimulates Cytokine Production and Inhibits Hemopoiesis
642 Trevor Starnes, Hal E. Broameyer, Michael J. Robertson, and Robert Hromas
Cutting Edge: Changes in Histone Acetylation at the /L-4 and IFN-y Loci Accompany Th1/Th2 Differentiation
647 Patrick E. Fields, Sean T. Kim, and RichardA . Flavell
Cutting Edge: Th2 Cell Trafficking into the Allergic Lung Is Dependent on Chemoattractant Receptor Signaling
651 Anuja Mathew, Benjamin D. Medoff, Andrew D. Carafone, and Andrew D. Luster
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Endothelial Cell Apoptosis Induced by Antibodies Against Dengue Virus Nonstructural Protein 1 Via Production of Nitric Oxide
657 Chiou-Feng Lin, Huan-Yao Lei, Ai-Li Shiau, Hsiao-Sheng Liu Trai-Ming Yeh, Shun-Hua Chen, Ching-Chuan Liu,
Shu-Chen Chiu, and Yee-Shin Lin
Suppressive Effect of Glutamic Acid Decarboxylase 65-Specific Autoimmune B Lymphocytes on Processing of T Cell Determinants
Located Within the Antibody Epitope
Juan Carlos Jaume, Sarah Louise Parry, Anne-Marie Madec, Grete Sonderstrup, and Steinunn Baekkeskor
4 Soluble Isoform of the Rhesus Monkey Nonclassical MHC Class I Molecule Mamu-AG Is Expressed in the Placenta and
the Testis
Andy F. Ryan, Richard L. Grendell, Daniel E. Geraghty, and Thaddeus G. Golos
Thymic and Extrathymic T Cell Development Pathways Follow Different Rules
Rafik Terra, Nathalie Labrecque, and Claude Perreault
CD94/NKG2 Expression Does Not Inhibit Cytotoxic Function of Lymphocytic Choriomeningitis Virus-Specific CD8* T Cells
Joseph D. Miller, Michael Peters, Alp E. Oran, Guy W. Beresford, Laurie Harrington, Jeremy M. Boss, and John D. Altman
Phagocytosis of Apoptotic Cells by Macrophages Induces Novel Signaling Events Leading to Cytokine-Independent Survival and
Inhibition of Proliferation: Activation of Akt and Inhibition of Extracellular Signal-Regulated Kinases 1 and 2
Suman M. Reddy, K.-H. Kevin Hsiao, Vivian Elizabeth Abernethy, Hanli Fan, Angelika Longacre, Wilfred Lieberthal,
Joyce Rauch, Jason S. Koh, and Jerrold S. Levine
2002] CONTENTS
= The Homeostasis But Not the Differentiation of T Cells Is Regulated by p27
‘14 Randy Shen and Mark H. Kaplan
Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis
Michael H. Yen, Nancy Lepak, and Susan L. Swain
Regulation of Retinoid X Receptor Responsive Element-Dependent Transcription in T Lymphocytes by Ser/Thr Phosphatases
Functional Divergence of Protein Kinase C (PKC)@ and PKCa in Mediating Calcineurin-Induced Transactivation
Mohammad Ishaq, Ming Fan, Kip Wigmore, Arunasri Gaddam, and Ven Natarajan
The Majority of Immunogenic Epitopes Generate CD4* T Cells That Are Dependent on MHC Class II-Bound Peptide-Flanking
Residues
Paula Y. Arnold, Nicole L. La Gruta, Tim Miller, Kate M. Viqnali, P. Scott Adams, David L. Woodland, and Dario A. A. Viqnali
Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of (D4 Regulatory
Cells and Effector T Cells
Alice Banz, Christiane Pontoux, and Martine Papiernik
The B Cell Antigen Receptor Regulates the Transcriptional Activator B-Catenin Via Protein Kinase C-Mediated Inhibition of
Glycogen Synthase Kinase-3
Sherri L. Christian, Peter V. Sims, and Michael R. Gold
Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells
Jens Fleischer, Evelin Grage-Griebenow, Brigitte Kaspe r, Holaer Heine, Martin Ernst. Ernst Brandt. Hans-Dieter Flad
and Frank Petersen
Sre Homology Region 2 Domain-Containing Phosphatase 1 Positively Regulates B Cell Receptor-Induced Apoptosis by Modulating
Association of B Cell Linker Protein with Nck and Activation of c-Jun NH.-Terminal Kinase
Kazuya Mizuno, Yuko Tagawa, Katsuyuki Mitomo, Noriyuki Waianabe, Tatsuo Katagiri, Mami Ogimot« ind Hidetaka Yakure
3 Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Thl Cells by Elaborating [L-12
Hidekazu Shirota, Kunio Sano, Noriyasu Hirasawa, Tadashi Terui, Kazuo Ohuchi, Toshio Hattori, and Ger Tamura
Rapid Chromatin Remodeling of Toll-Like Receptor 2 Promoter During Infection of Macrophages with Mycobacterium aviun
Tianyi Wang, William P. Lafuse, Kiyoshi Takeda, Shizuo Akira, and Bruce S. Zwilling
Inhibition of Antigen-Specific T Cell Proliferation and Cytokine Production by Protein Kinase A Type |
Einar Martin Aandaihl, Walter J. Moretto, Patrick A. Haslett, Torkel Vang, Tone Bryn, Kjetil Tasken, and Douglas F. Nixon
Tumor-Infiltrating CD4° T Lymphocytes Express APO2 Ligand (APO2L)/TRAIL upon Specific Stimulation with Autologous Lung
Carcinoma Cells: Role of IFN-a on APO2L/TRAIL Expression and -Mediated Cytotoxicity
Guillaume Dorothée, Isabelle Vergnon, Jeanne Menez, Hamid Echchakir, Dominique Grunenwald, Marek Kubin, Salem Chouaib
and Fathia Mami-Chouaib
Effect of Environmental Antigens on the Ig Diversification and the Selection of Productive V-J Joints in the Bursa
818 Hiroshi Arakawa, Kei-ichi Kuma, Masahiro Yasuda, Shigeo Ekino, Akira Shimizu, and Hideo Yamagishi
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A Putative Silencer Element in the /L-5 Gene Recognized by Bcl6
Masafumi Arima, Hirochika Toyama, Hirohito Ichii, Satoko Kojima, Seiji Okada, Masahiko Hatano, Gang Cheng, Masato Kub
Takeshi Fukuda, and Takeshi Tokuhisa
Immunogenically Fit Subunit Vaccine Components Via Epitope Discovery from Natural Peptide Libraries
Leslie J. Matthews, Robert Davis, and George P. Smith
IFN-8 Pretreatment Sensitizes Human Melanoma Cells to TRAIL/Apo2 Ligand-Induced Apoptosis
Vamta Chawla-Sarkar, Douglas W. Leaman, Barbara S. Jacobs, and Ernest C. Borden
Bivalent Ligands with Rigid Double-Stranded DNA Spacers Reveal Structural Constraints on Signaling by FceRI
Jodi M. Paar, Nancie T. Harris, David Holowka, and Barbara Baird
B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-a and Ig-6
Roberta Pelanda, Uschi Braun, Elias Hobeika, Michel C. Nussenzweig, and Michael Reth
Characterization of Chromatin Structure and Enhancer Elements for Murine Recombination Activating Gene
Xing-Cheng Wei, Hiroyuki Kishi, Zhe-Xiong Jin, Wen-Pu Zhao, Sachiko Kondo, Tadashi Matsuda, Shigeru Sait
and Atsushi Muraguchi
Protein Structure Plays a Critical Role in Peanut Allergen Stability and May Determine Immunodominant IgE-Binding Epitopes
Moon Sen, Randall Koppe r, Laurent Pons, Edathara C. Abraham, A. Wesley Burks, and Gary A. Bannon
The Primary Antibody Repertoire Represents a Linked Network of Degenerate Antigen Specificities
Venkatasamy Manivel, Fahri Bayiroglu, Zaved Siddiqui, Dinakar M. Salunke, and Kanury V. S. Rac
HOST DEFENSE
Inhibition of the Spontaneous Apoptosis of Neutrophil Granulocytes by the Intracellular Parasite Leishmania major
Eresso Aga, Dérthe M. Katschinski, Ger van Zandbergen, Helmut Laufs, Birgit Hansen, Kerstin Miiller, Werner Solbach,
and Tamas Laskay
Antigen Presentation by CD1d Contributes to the Amplification of Th2 Responses to Schistosoma mansoni Glycoconjugates
in Mice
Christelle Faveeuw, Véronique Angeli, Josette Fontaine, Charles Maliszewski, André Capron, Luc Van Kaer, Muriel Moser,
Monique Capron, and Francois Trottein
Production of Granulocyte Colony-Stimulating Factor in the Nonspecific Acute Phase Response Enhances Host Resistance to
Bacterial Infection
Mahdad Noursadeghi, Maria C. M. Bickerstaff, Jeff Herbert, David Moyes, Jonathan Cohen, and Mark B. Pepys
Human Neutrophil-Expressed CD28 Interacts with Macrophage B7 to Induce Phosphatidylinositol 3-Kinase-Dependent IFN-y
Secretion and Restriction of Leishmania Growth
K. Venuprasad, Pinaki P. Banerjee, Subhasis Chattopadhyay, Satyan Sharma, Subrata Pal, P. B. Parab, Debashis Mitra,
and Bhaskar Saha
CONTENTS [voL. 169
Cytokine Regulation of Periportal Fibrosis in Humans Infected with Schistosoma mansoni: IFN-y Is Associated with Protection
Against Fibrosis and TNF-a with Aggravation of Disease
Sandrine Henri, Christophe Chevillard, Adil Mergani, Patricia Paris, Jean Gaudart, Christophe Camilla, Hélia Dessein,
Felix Montero, Nasr-Eldin M. A. Elwali, Osman K. Saeed, Mubarak Magzoub, and Alain J. Dessein
A Role for Inducible Costimulator Protein in the CD28-Independent Mechanism of Resistance to Toxoplasma gondii
Eric N. Villegas, Linda A. Lieberman, Nicola Mason, Sarah L. Blass, Valerie P. Zediak, Robert Peach, Tom Horan,
Steve Yoshinaga, and Christopher A. Hunter
Identification of T Cell Epitopes on the 33-kDa Fragment of Plasmodium yoelii Merozoite Surface Protein | and Their Antibody
Independent Protective Role in Immunity to Blood Stage Malaria
Jiraprapa Wipasa, Chakrit Hirunpetcharat, Yuvadee Mahakunkijcharoen, Huji Xu, Salenna Elliott, and Michael F. Good
Segregation of B and T Cell Epitopes of Treponema pallidum Repeat Protein K to Variable and Conserved Regions During
Experimental Syphilis Infection
Cecilia A. Morgan, Barbara J. Molini, Sheila A. Lukehart, and Wesley C. Van Voorhis
Heat Shock Protein 70 Is a Potential Virulence Factor in Murine Tovoplasma Infection Via Immunomodulation of Host NF-«B and
Nitric Oxide
Caroline A. Dobbin, Nicholas C. Smith, and Alan M. Johnson
In Vitro Correlates of L“-Restricted Resistance to Toxoplasmic Encephalitis and Their Critical Dependence on Parasite Strain
966 Jennifer J. Johnson, Craig W. Roberts, Constance Pope, Fiona Roberts, Michael J. Kirisits. Randee Estes, Ernest Mui.
Tim Krieger, Charles R. Brown, Jim Forman, and Rima McLeod
INFLAMMATION
Differential Effects of Ebselen on Neutrophil Recruitment, Chemokine, and Inflammatory Mediator Expression in a Rat Model of
974 Lipopo!ysaccharide-Induced Pulmonary Inflammation
El-Bdaoui Haddad, Kerryn McCluskie, Mark A. Birrell, Dominika Dabrowski, Michela Pecoraro, Steve Underwood, Bei Chen,
George T. De Sanctis, Steve E. Webber, Martyn L. Foster, and Maria G. Belvisi
Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells
Patricia F. Lalor, Sarah Edwards, Gillian McNab, Marko Salmi, Sirpa Jalkanen, and David H. Adams
Immobilized Lactoferrin Is a Stimulus for Eosinophil Activation
Larry L. Thomas, Wei Xu, and Tamir T. Ardon
Overlapping Roles of P-Selectin and a, Integrin to Recruit Leukocytes to the Central Nervous System in Experimental
1000 Autoimmune Encephalomyelitis
Steven M. Kerfoot and Paul Kubes
Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in
Endothelial Cells
Paul W. Thompson, Anna M. Randi, and Anne J. Ridley
Mast Cell Chymase Modifies Cell-Matrix Interactions and Inhibits Mitogen-Induced Proliferation of Human Airway Smooth
Muscle Cells
Aili L. Lazaar, Michael I. Plotnick, Umberto Kucich, Irene Crichton, Shidan Lotfi, Susan K. P. Das. Sibyl Kane, Joel Rosenbloom
Reynold A. Panettieri, Jr.. Norman M. Schechter, and Ellen Pure
Eosinophils Express Functional IL-13 in Eosinophilic Inflammatory Diseases
Peter Schmid-Grendelmeier, Frank Altznauer, Barbra Fischer, Christian Bizer, Alex Straumann, Giinter Menz. Kurt Blaser.
Brunello Wiithrich, and Hans-Uwe Simon
Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase
Grant R. Stenton, Marina Ulanova, René E. Déry, Shaheed Merani, Moo-Kyung Kim, Mark Gilchrist, Lakshmi Puttagqunta,
Sorin Musat-Marcu, Deborah James, Alan D. Schreiber, and A. Dean Befus
Critical Role for CXCR3 Chemokine Biology in the Pathogenesis of Bronchiolitis Obliterans Syndrome
John A. Belperio, Michael P. Keane, Marie D. Burdick, Joseph P. Lynch III, Ying Ying Xue, Kewang Li, David J. Ross
and Robert M. Strieter
CLINICAL IMMUNOLOGY
Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine
1050 Sjégren’s Syndrome
Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Kenji Mishima, Rieko Arakaki, Takashi Suda, Ichiro Saito
and Yoshio Hayashi
Autocrine Production of IFN-y by Macrophages Controls Their Recruitment to Kidney and the Development of Glomerulonephritis
in MRL/Ipr Mice
Carla E. Carvalho-Pinto, Maria I. Garcia, Mario Mellado, J. Miquel Rodriquez-Frade, Juan Martin-Caballero, Juana Flores.
Carlos Martinez-A, and Dimitrios Balomenos
Characterization of Autoreactive T Cells to the Autoantigens Heterogeneous Nuclear Ribonucleoprotein A2 (RA33) and Filaggrin
in Patients with Rheumatoid Arthritis
Ruth Fritsch, Daniela Eselbéck, Kari Skriner, Beatrice Jahn-Schmid, Clemens Scheinecker. Barbara Bohle.
Makiyeh Tohidast-Akrad, Silvia Hayer, Josef Neumiiller, Serafin Pinol-Roma, Josef S. Smolen, and Giinter Steiner
Resistance to Experimental Autoimmune Myasthenia Gravis in IL-6-Deficient Mice Is Associated with Reduced Germinal Center
Formation and C3 Production
Caishu Deng, Elzbieta Goluszko, Erdem Tiiziin, Huan Yang, and Premkumar Christadoss
Late Pregnancy Suppresses Relapses in Experimental Autoimmune Encephalomyelitis: Evidence for a Suppressive Pregancy
Related Serum Factor
Annette Langer-Gould, Hideki Garren, Amy Slansky, Pedro J.R uiz, and Lawrence Steinman
Persistent Mitochondrial Hyperpolarization, Increased Reactive Oxygen Intermediate Production, and Cytoplasmic Alkalinization
1092 Characterize Altered IL-10 Signaling in Patients with Systemic Lupus Erythematosus
Peter Gergely, Jr., Brian Niland, Nick Gonchoroff, Rudolf Pullmann, Jr., Paul E. Phillips, and Andras Perl
Large Scale Identification of Human Hepatocellular Carcinoma-Associated Antigens by Autoantibodies
Yu Wang, Ke-Jun Han, Xue-Wen Pang, Hilary A. Vaughan, Wei Qu, Xue-Yuan Dong, Ji-Run Peng, Hai-Tao Zhao, Jing-An Rui,
Xi-Sheng Leng, Jonathan Cebon, Antony W. Burgess, and Wei-Feng Chen
2002] CONTENTS
TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity
Patrick Chames, Ralph A. Willemsen, Gertrudis Rojas, Detlef Dieckmann, Louise Rem, Gerold Schuler, Reinder L. Bothuis,
and Hennie R. Hoogenboom
“Superhumanized” Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human
Germline Sequences: Application to an Anti-CD28
Philip Tan, David A. Mitchell, Timothy N. Buss, Margaret A. Holmes, Claudio Anasetti, and Jefferson Foote
Histone Peptide-Induced Nasal Tolerance: Suppression of Murine Lupus
Henry Yim Wu, Frank J. Ward, and Norman A. Staines
Letter of Retraction
Correction
Author Index
AAI Membership Application
AAI Trainee Membership Application
VOLUME 169 / N° 3/ AUGUST 1, 2002
CUTTING Cue
Cutting Edge: Molecular Mechanisms of Synergy Between CD40 and the B Cell Antigen Receptor: Role for TNF Receptor
Associated Factor 2 in Receptor Interaction
Sokol A. Haxhinasto, Bruce S. Hostager, and Gail A. Bishop
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Essential Role of NF-«B-Inducing Kinase in T Cell Activation Through the TCR/CD3 Pathway
1151 Mitsuru Matsumoto, Takuji Yamada, Steven K. Yoshinaga, Tom Boone, Tom Horan, Shigeru Fujita, Yi Li, and Tasuku Mitani
Generation of CD4*° CD45RA* Effector T Cells by Stimulation in the Presence of Cyclic Adenosine
1159 5'-Monophosphate-Elevating Agents
{na Suarez, Lourdes Mozo, and Carmen Gutiérrez
Modulation of Tissue-Specific Immune Response to Cardiac Myosin Can Prolong Survival of Allogeneic Heart Transplants
Eugenia V. Fedoseyeva, Koji Kishimoto, Hillary K. Rolls, Ben M.-W. Illigens, Victor M. Dong, Anna Valujskikh, Peter S. Heeger
Mohamed H. Sayegh, and Gilles Benichou
Requirement for the Lymphocyte Semaphorin, CD100, in the Induction of Antigen-Specific T Cells and the Maturation of
Dendritic Cells
Atsushi Kumanogoh, Kazuhiro Suzuki, EweSeng Ch'ng, Chie Watanabe, Satoko Marukawa, Noriko Takegahara, Isao Ishida,
Takehito Sato, Sonoko Habu, Kanji Yoshida, Wei Shi, and Hitoshi Kikutani
CD40 Ligand and CTLA-4 Are Reciprocally Regulated in the Thl Cell Proliferative Response Sustained by CD8* Dendritic Cells
Francesca Fallarino, Ursula Grohmann, Carmine Vacca, Roberta Bianchi, Maria C. Fioretti, and Paolo Puccetti
Immune Surveillance and Effector Functions of CCR10*~ Skin Homing T Cells
Susan Hudak, Michael Hagen, Ying Liu, Daniel Catron, Elizabeth Oldham, Leslie M. McEvoy, and Edward P. Bowman
Cross-Reactive Antigen Is Required to Prevent Erosion of Established T Cell Memory and Tumor Immunity: A Heterologous
Bacterial Model of Attrition
Dean K. Smith, Renu Dudani, Joao A. Pedras-Vasconcelos, Yvan Chapdelaine, Henk van Faassen, and Subash Sad
Direct Ex Vivo Analysis of Human CD4~ Memory T Cell Activation Requirements at the Single Clonotype Le‘
Arlene D. Bitmansour, Daniel C. Douek, Vernon C. Maino, and LouisJ . Picker
Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates
its Signal Transduction
Michael Hértner, Ulrich Nielsch, Lorenz M. Mayr, James A. Johnston, Peter C. Heinrich, and Serge Haan
Dendritic Cell Immunogenicity Is Regulated by Peroxisome Proliferator-Activated Receptor
Alessio Nencioni, Frank Griinebach, Anke Zobywlaski, Claudio Denzlinger, Wolfram Brugger, and Peter Bi
T Cell Antigen Receptor Engagement and Specificity in the Recognition of Stress-Inducible MHC Class I-Related Chains by Human
Epithelial yé T Cells
Jennifer Wu, Veronika Groh, and Thomas Spies
T Cell Proliferation Induced by Autologous Non-T Cells Is a Response to Apoptotic Cells Processed by Dendritic Cells
4nna D. Chernysheva, Kyriakos A. Kirou, and Mary K. Crou
Priming Biologically Active Antibody Responses Against an Isolated, Conformational Viral Epitope by DNA Vaccination
Petra Riedl, Shereen El Kholy, Jérg Reimann, and Reinhold Schirmbeck
IFN Consensus Sequence Binding Proteir/IFN Regulatory Factor-8 Guides Bone Marrow Progenitor Cells Toward the
Macrophage Lineage
Hideki Tsujimura, Tokiko Nagamura-Inoue, Tomohiko Tamura, and Keiko Ozato
The CD154-CD40 T Cell Costimulation Pathway Is Required for Host Sensitization of CD8* T Cells by Skin Grafts Via Direct
Antigen Presentation
Yuan Zhai, Xiu-Da Shen, Feng Gao, Ana J. Coito, Barbara A. Wasowska, Alan Salama, Isabela Schmitt, Ronald W. Busuttil,
Mohamed H. Sayegh, and Jerzy W. Kupiec-Weglinski
Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a
Memory Immune Response
Anja E. Hauser, Gudrun F. Debes, Sergio Arce, Giuliana Cassese, Alf Hamann, Andreas Radbruch, and Rudolf A. Manz
CONTENTS [voL. 169
Level of B Cell Antigen Receptor Surface Expression Influences Both Positive and Negative Selection of B Cells During Primary
Development
Lynn M. Heltemes and Tim Manser
Infection of APC by Human Cytomegalovirus Controlled Through Recognition of Endogenous Nuclear Immediate Early Protein 1
by Specific CD4* T Lymphocytes
Emmanuelle Le Roy, Michel Baron, Wolfgang Faigle, Daniéle Clément, David M. Lewinsohn, Daniel N. Streblow, Jay A. Nelson,
Sebastian Amigorena, and Jean-Luc Davignon
302 Two Distinct Doma; ins ‘ Within the N-Terminal Region of Janus Kinase 1 Interact with Cytokine Receptors
302 Anna Usacheva, Sergei Kotenko, Michael M. Witte, and Oscar R. Colamonici
Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice Reveal Dynamic Receptor Modulation During Thymocyte
1309 Development
Judson A. Brewer, Barry P. Sleckman, Wojciech Swat, and Louis J. Muglia
MOLECULAR AND STRUCTURAL IMMUNOLOGY
ae A Role for NF-«B Activation in Perforin Expression of NK Cells Upon IL-2 Receptor Signaling
1319 Jun Zhou, Jin Zhang, Mathias G. Lichtenheld, and Gary G. Meadows
208 Regulation of Class II MHC Expression in APCs: Roles of Types I, III, and IV Class II Transactivator
1326 Rish K. Pai, David Askew, W. Henry Boom, and Clifford V. Harding
Clq Regulatory Region Polymorphism Down-Regulating Murine Clq Protein Levels with Linkage to Lupus Nephritis
1334 Yuko Miura-Shimura, Kazuhiro Nakamura, Mareki Ohtsuji, Hideaki Tomita, Yi Jiang, Masaaki Abe, Danqging Zhana,
Yoshitomo Hamano, Hiroshi Tsuda, Hiroshi Hashimoto, Hiroyuki Nishimura, Shinsuke Taki, Toshikazu Shirai,
and Sachiko Hirose
The Val4 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex
Stéphane Sidobre, Olga V. Naidenko, Bee-Cheng Sim, Nicholas R. J. Gascoigne, K. Christopher Garcia, and Mitchell Kronenberg
Diversification of Ig Heavy Chain Genes in Human Preterm Neonates Prematurely Exposed to Environmental Antigens
Karl Bauer, Michael Zemlin, Michael Hummel, Sabine Pfeiffer, Julia Karstaedt, Gudrun Steinhauser, Xin Xiao, Hans Versmold,
and Ciaudia Berek
Isolation and Detection of Human IgA Using a Streptococcal IgA-Binding Peptide
Charlotta Sandin, Sara Linse, Thomas Areschoug, Jenny M. Woof, Jesper Reinholdt, and Gunnar Lindahl
The Rap GTPases Regulate B Cell Migration Toward the Chemokine Stromal Cell-Derived Factor-1 (CXCL12): Potential Role for
Rap2 in Promoting B Cell Migration
Sarah J. McLeod, Anson H. Y. Li, Rosaline L. Lee, Anita E. Burgess, and Michael R. Gold
The Avian Chb6 Alloantigen Triggers Apoptosis in a Mammalian Cell Line
Jeannette Pifer, Donald Robison, and Phillip E. Funk
Isotype Can Affect the Fine Specificity of an Antibody for a Polysaccharide Antigen
Gary R. McLean, Marcela Torres, Natalia Elguezabal, Antonio Nakouzi, and Arturo Casadevall
The Chemokine ESkine/CCL27 Displays Novel Modes of Intracrine and Paracrine Function
Andreas Gortz, Robert J. B. Nibbs, Pauline McLean, David Jarmin, Wendy Lambie, Janet W. Baird, and Gerard J. Graham
Structural Studies of Allelic Diversity of the MHC Class I Homolog MIC-B, a Stress-Inducible Ligand for the Activating
Immunoreceptor NKG2D
Margaret A. Holmes, Pingwei Li, Effie W. Petersdorf, and Roland K. Strong
HOST DEFENSE
Mitogen-Activated Protein Kinases and NF-«B Are Involved in TNF-a Responses to Group B Streptococci
1401 Giuseppe Mancuso, Angelina Midiri, Concetta Beninati, Giovanna Piraino, Andrea Valenti, Giacomo Nicocia, Diana Teti.
James Cook, and Giuseppe Teti
Cross-Presentation of Listeria monocytogenes-Derived CD4 T Cell Epitopes
Mojca Skoberne, Simone Schenk, Herbert Hof, and Gernot Geginat
Antibodies Highly Effective in SCID Mice During Infection by the Intracellular Bacterium Ehrlichia chaffeensis Are of Picomolar
Affinity and Exhibit Preferential Epitope and Isotype Utilization
Julia Shu-yi Li, Frederick Chu, Andrew Reilly, and Gary M. Winslou
Critical Role of NK Cells Rather Than Val4* NKT Cells in Lipopolysaccharide-Induced Lethal Shock in Mice
Masashi Emoto, Mamiko Miyamoto, Izumi Yoshizawa, Yoshiko Emoto, Ulrich E. Schaible, Eiji Kita, and Stefan H. E Kaufmann
The CXC Chemokine Murine Monokine Induced by IFN-y (CXC Chemokine Ligand 9) Is Made by APCs, Targets Lymphocytes
Including Activated B Cells, and Supports Antibody Responses to a Bacterial Pathogen In Vivo
Matthew K. Park, Doron Amichay, Paul Love, Elizabeth Wick, Fang Liao, Alex Grinberg, Ronald L. Rabin, Hongwei H. Zhang,
Senkuta Gebeyehu, Timothy M. Wright, Akiko Iwasaki, Youmin Weng, Julie A. DeMartino, Karen L. Elkins.
and Joshua M. Farber
Viral and Bacterial Infections Induce Expression of Multiple NK Cell Receptors in Responding CD8* T Cells
Christopher W. McMahon, Allan J. Zajac, Amanda M. Jamieson, Laura Corral, Gianna E. Hammer, Rafi Ahmed,
and David H. Raulet
Marginal Zone Macrophages and Immune Responses Against Viruses
1453 Stephan Oehen, Bernhard Odermatt, Urs Karrer, Hans Hengartner, Rolf Zinkernagel, and Constantino Lépez-Macias
INFLAMMATION
The Importance of IL-1 and TNF-a, and the Noninvolvement of IL-6, in the Development of Monoclonal
1459 Antibody-Induced Arthritis
Takashi Kagari, Hiromi Doi, and Takaichi Shimozato
Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-
Activated Receptor4
Nathalie Vergnolle, Claudia K. Derian, Michael R. D'Andrea, Martin Steinhoff, and Patricia Andrade-Gordon
2002] CONTENTS
Apical, But Not Basolateral, Endotoxin Preincubation Protects Alveolar Epithelial Cells Against Hydrogen Peroxide-Induced Loss
1474 of Barrier Function: The Roie of Nitric Oxide Synthesis
Frank Rose, Bernd Guthmann, Tobias Tenenbaum, Ludger Fink, Ardeschir Ghofrani, Norbert Weissmann, Peter Kénig
Leander Ermert, Gabriele Dahlem, Joerg Haenze, Wolfgang Kummer, Werner Seeger, and Friedrich Grimminger
Effects of Rhinovirus Infection on Histamine and Cytokine Production by Cell Lines from Human Mast Cells and Basophils
Masayoshi Hosoda, Mutsuo Yamaya, Tomoko Suzuki, Norihiro Yamada, Masato Kamanaka, Kiyohisa Sekizawa
Joseph H. Butterfield, Takehiko Watanabe, Hidekazu Nishimura, and Hidetada Sasaki
Long-Term Protective and Antigen-Specific Effect of Heat-Killed Mycobacterium vaccae in a Murine Model of Allergic
Pulmonary Inflammation
Claudia Zuany-Amorim, Corinne Manlius, Alexandre Trifilieff, Laura R. Brunet, Graham Rook, Gareth Bowen, Graham Pay
and Christoph Walker
Functional Activation of the Formyl Peptide Receptor by a New Endogenous Ligand in Human Lung A5 49 Cells
Ursula Rescher, Antje Danielczyk, Arseni Markoff, and Volker Gerke
Leukocyte Infiltration, But Not Neurodegeneration, in the CNS of Transgenic Mice with Astrocyte Production of the CX¢
Chemokine Ligand 10
Kaan Boztug, Monica J. Carson, Naan Pham-Mitchell, Valérie C. Asensio, Julie DeMartino, and lain L. Campbell
Stimulation by Toll-Like Receptors Inhibits Osteoclast Differentiation
1516 Masamichi Takami, Nacksung Kim, Jaerang Rho, and Yongwon Choi
CLINICAL IMMUNOLOGY
ait Monocyte-Derived Dendritic Cells Induce a House Dust Mite-Specific Th2 Aliergic Inflammation in the Lung of Humanized SCID
1524 Mice: Involvement of CCR7
Hamida Hammad, Bart N. Lambrecht, Pierre Pochard, Philippe Gosset, Philippe Marquillies, André-Bernard Tonnel
and Joél Pestel
Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses
Jenny Kim, Maria-Teresa Ochoa, Stephan R. Krutzik, Osamu Takeuchi, Satoshi Uematsu, Annaliza J. Legaspi
Hans D. Brightbill, Diana Holland, William J. Cunliffe, Shizuo Akira, Peter A. Sieling, Paul J. Godowski, and Robert L. Modlin
Evidence for Immune Responses to a Self-Antigen in Lung Transplantation: Role of Type V Collagen-Specific T Cells in the
Pathogenesis of Lung Allograft Rejection
M. Azizul Haque, Teruaki Mizobuchi, Kazuhiro Yasufuku, Takehiko Fujisawa, Randy R. Brutkiewicz, Yan Zheng, Kena Woods
Gerald N. Smith, Oscar W. Cummings, Kathleen M. Heidler, Janice S. Blum, and David S. Wilkes
Bystander CD8 T Cell-Mediated Demyelination After Viral Infection of the Central Nervous System
Jodie S. Haring, Lecia L. Pewe, and Stanley Perlman
Differential Expression of the IFN-y-Inducible CXCR3-Binding Chemokines, IFN-Inducible Protein 10, Monokine Induced by IFN
and IFN-Inducible T Cell a Chemoattractant in Human Cardiac Allografts: Association with Cardiac Allograft Vasculopathy and
Acute Rejection
David Xiao-Ming Zhao, Yenya Hu, Geraldine G. Miller, Andrew D. Luster, Richard N. Mitchell, and Peter Libby
Intrathecal Fas Ligand Infusion Strengthens Immunoprivilege of Central Nervous System and Suppresses Experimental
Autoimmune Encephalomyelitis
Bing Zhu, Liqing Luo, Yongliang Chen, Donald W. Paty, and Max S. Cynader
The Molecular Basis of Complete Complement C4A and C4B Deficiencies in a Systemic Lupus Erythematosus Patient with
Homozygous C4A and C4B Mutant Genes
Kristi L. Rupert, Joann M. Moulds, Yan Yang, Frank C. Arnett, Robert W. Warren, John D. Reveille, Barry L. Myones
Carol A. Blanchong, and C. Yung Yu
Muscle Responds to an Antibody Reactive with the Acetylcholine Receptor by Up-Regulating Monocyte Chemoattractant Protein
1: A Chemokine with the Potential to Influence the Severity and Course of Experimental Myasthenia Gravis
Sara Reyes-Reyna, Timothy Stegall, and Keith A. Krolick
A Role for the Cr2 Gene in Modifying Autoantibody Production in Systemic Lupus Erythematosus
Xiaobo Wu, Ning Jiang, Christine Deppong, Jasvinder Singh, Gregory Dolecki, Dailing Mao, Laurence More
and Hector D. Molina
Epstein-Barr Nuclear Antigen 1-Specific CD4~ Th1 Cells Kill Burkitt’s Lymphoma Cells
Casper Paludan, Kara Bickham, Sarah Nikiforow, Ming L. Tsang, Kiera Goodman, Willem A. Hanekon
Jean-Francois Fonteneau, Stefan Stevanovic, and Christian Miinz
: V75R576 IL4 Receptor a Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function
1604 Kimberly A. Risma, Ning Wang, Ryan P. Andrews, Christie M. Cunningham, Mark B. Ericksen, Jonathan A. Be
Ranajit Chakraborty, and Gurjit K. Khurana Hershey
Detection and Induction of CTLs Specific for SYT-SSX-Derived Peptides in HLA-A24~ Patients with Synovial Sarcoma
Yuriko Sato, Yuki Nabeta, Tomohide Tsukahara, Yoshihiko Hirohashi, Rong Syunsui, Akiko Maeda, Hiroeki Sahara,
Hideyuki Ikeda, Toshihiko Torigoe, Shingo Ichimiya, Takuro Wada, Toshihiko Yamashita, Hiroaki Hiraga, Akira Kawai
Takeshi Ishii, Nobuhito Araki, Akira Myoui, Seiichi Matsumoto, Tohru Umeda, Seiichi Ishii, Satoshi Kawaguchi
and Noriyuki Sato
T Cell Subset Patterns That Predict Resistance to Spontaneous Lymphoma, Mammary Adenocarcinoma, and Fibrosarcoma in Mice
RichardA . Miller and Clarence Chrisp
Role of the Passive Apoptotic Pathway in Graft-Versus-Host Disease
William R. Drobyski, Richard Komorowski, Brent Logan, and Maria Gendelman
Transfection of Macrophage Inflammatory Protein la into B16 F10 Melanoma Cells Inhibits Growth of Pulmonary Metastases But
Not Subcutaneous Tumors
Hendrik W. van Deventer, Jonathon S. Serody, Karen P. McKinnon, Casey Clements, W. June Brickey, and Jenny P.-Y. Ting
Interacting Quantitative Trait Loci Control Loss of Peripheral Tolerance and Susceptibility to Autoimmune Ovarian Dysgenesis
After Day 3 Thymectomy in Mice
Randall J. Roper, Runlin Z. Ma, Julia E. Biggins, Russell J. Butterfield, Sandra D. Michael, Kenneth S. K. Tung,
Rebecca W. Doerge, and Cory Teuscher
Correction
Author Index
CONTENTS [voL. 169
1651 AAI Membership Application
1652 AAI Trainee Membership Application
VOLUME 169 / N° 4/ AuGuUST 15, 2002
CUTTING Cue
Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-y Induction by Gram-Negative Bacteria Based on STAT4 Activation by
1665 Type I IFN and IL-18 Signaling
Marina A. Freudenberg, Thomas Merlin, Christoph Kalis, Yolande Chvatchko, Hella Stiibig, and Chris Galanos
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Messenger RNA Electroporation of Human Monocytes, Followed by Rapid In Vitro Differentiation, Leads to Highly Stimulatory
1669 Antigen-Loaded Mature Dendritic Cells
Peter Ponsaerts, Glenn Van den Bosch, Nathalie Cools, Ann Van Driessche, Griet Nijs, Marc Lenjou, Filip Lardon,
Christine Van Broeckhoven, Dirk R. Van Bockstaele, Zwi N. Berneman, and Viggo F. I. Van Tendeloo
Cytokine Control of Memory B Cell Homing Machinery
1676 Meenakshi P. Roy, Chang H. Kim, and Eugene C. Butcher
IL-17 Selectively Down-Regulates TNF-a-Induced RANTES Gene Expression in Human Colonic Subepithelial Myofibroblasts
1683 Akira Andoh, Sanae Fujino, Shigeki Bamba, Yoshio Araki, Takafumi Okuno, Tadao Bamba, and Yoshihide Fujiyama
Mature Dendritic Cell Generation Promoted by Lysophosphatidylcholine
1688 Frédéric Coutant, Laure Perrin-Cocon, Sophie Agaugué, Thierry Delair, Patrice André, and Vincent Lotteau
IL-4 Promotes Stat6-Dependent Survival of Autoreactive B Cells In Vivo Without Inducing Autoantibody Production
1696 Suzanne C. Morris, Nanette L. Dragula, and Fred D. Finkelman
TCR/CD3 Down-Modulation and ¢ Degradation Are Regulated by ZAP-70
1705 Céline Dumont, Nicolas Blanchard, Vincenzo Di Bartolo, Nathalie Lezot, Evelyne Dufour, Sébastien Jauliac, and Claire Hivroz
Thymocyte Development in Early Growth Response Gene 1-Deficient Mice
1713 Matthew Bettini, Hongkang Xi, Jeffrey Milbrandt, and Gilbert J. Kersh
Aberrant DAP 12 Signaling in the 129 Strain of Mice: Implications for the Analysis of Gene-Targeted Mice
1721 Daniel W. McVicar, Robin Winkler-Pickett, Lynn S. Taylor, Andrew Makrigiannis, Michael Bennett, Stephen K. Anderson,
and John R. Ortaldo
Editing Autoreactive TCR Enables Efficient Positive Selection
Fabio R. Santori, Ivica Arsov, Mirjana Lili, and Stanislav Vukmanovic
The Unique Antigen Receptor Signaling Phenotype of B-1 Cells Is Influenced by Locale but Induced by Antigen
Michael J. Chumley, Joseph M. Dal Porto, and John C. Cambie
Role of B7 Costimulatory Molecules in the Adjuvant Activity of the Heat-Labile Enterotoxin of Escherichia coli
Michael Martin, Arlene Sharpe, John D. Clements, and Suzanne M. Michalek
Opposing Effects of IL-2 in Tumor Immunotherapy: Promoting CD8 T Cell Growth and Inducing Apoptosis
Protul Shrikant and Matthew F. Mescher
Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients Express Functional IL-15 Receptor Complex: Endogenous IL-15
in Autocrine Fashion Enhances Cell Proliferation and Expression of Bel-x, and Bcl-2
Mariola Kurowska, Weronika Rudnicka, Ewa Kontny, Iwona Janicka, Magdalena Chorazy, Jacek Kowalczewski
Maria Zidlkowska, Sylvie Ferrari-Lacraz, Terry B. Strom, and Wlodzimierz Maslivski
L-Selectin Serves as an E-Selectin Ligand on Cultured Human T Lymphoblasts
Mark A. Jutila, Sandy Kurk, Larrisa Jackiw, Randall N. Knibbs, and Lloyd M. Stoolman
Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain
Govindarajan Rajagopalan, Michele K. Smart, Christopher J. Krco, and Chella S. David
CD30 Expression Identifies the Predominant Proliferating T Lymphocyte Population in Human Alloimmune Responses
Keith W. Chan, Corwyn D. Hopke, Sheri M. Krams, and Olivia M. Martinez
1-1 BB-Specific Monoclonal Antibody Promotes the Generation of Tumor-Specific Immune Responses by Direct Activation of CD8
T Cells in a CD40-Dependent Manner
Robert E. Miller, Jon Jones, Tiep Le, James Whitmore, Norman Boiani, Brian Gliniak, and David H. Lynch
The Thi-Specific Costimulatory Molecule, M150, Is a Posttranslational Isoform of Lysosome-Associated Membrane Protein-1
1801 Durbaka V. R. Prasad, Vrajesh V. Parekh, Bimba N. Joshi, Pinaki P. Banerjee, Pradeep B. Parab, Samit Chattopadhyay,
Anil Kumar, and Gyan C. Mishra
FceRI Induces the Tryptophan Degradation Pathway Involved in Regulating T Ce!l Responses
1810 Dagmar von Bubnoff, Heike Matz, Christine Frahnert, Marie Luise Rao, Daniel Hanau, Henri de la Salle, and Thomas Bieber
A Reassessment of the Effect of Activated Notchl on CD4 and CD8 T Cell Development
B. J. Fowlkes and Ellen A. Robey
The Poststimulation Program of CD4 Versus CD8 T Cells (Death Versus Activation-Induced Nonresponsiveness)
Ee Loon Tham and Matthew F. Mescher
Antigen-Driven Oligoclonal Expansion of Tumor-Infiltrating B Cells in Infiltrating Ductal Carcinoma of the Breast
Julia A. Coronella, Catherine Spier, Matthew Welch, Katrina T. Trevor, Alison T. Stopeck, Hugo Villar, and Evan M. Hersh
Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo
Judson A. Brewer, Osami Kanagawa, Barry P. Sleckman, and Louis J. Muglia