Table Of Content

CONTENTS [voL. 154 CD80 (B7) and CD86 (B70) Provide Similar Costimulatory Signals for T Cell Proliferation, Cytokine Production, and Generation of CTL Lewis L. Lanier, Shawn O’Fallon, Chamorro Somoza, Joseph H. Phillips, Peter S. Linsley, Ko Okumura, Daisuke Ito, and Miyuki Azuma IL-7 Drives Donor T Cell Proliferation and Can Costimulate Cytokine Secretion After MHC-Matched Allogeneic Bone Marrow Transplantation Robert B. Levy, Monica Jones, Brian L. Hamilton, John Paupe, Tamir Horowitz, and Richard Riley Human IL-12 p40 Homodimer Binds to the IL-12 Receptor but Does Not Mediate Biologic Activity Ping Ling, Maurice K. Gately, Ueli Gubler, Alvin S. Stern, Ping Lin, Kurt Hollfelder, Chang Su, Yu-Ching E. Pan, and John Hakimi Characterization of Fibroblasts with a Unique Defect in Processing Antigens with Disulfide Bonds Brian J. Merkel, Richard Mandel, Hugues J.-P. Ryser, and Kathleen L. McCoy Delivery of Nascent MHC Class II-Invariant Chain Complexes to Lysosomal Compartments and Proteolysis of Invariant Chain by Cysteine Proteases Precedes Peptide Binding in B-Lymphoblastoid Cells Phillip A. Morton, Michelle L. Zacheis, Karen S. Giacoletto, Julia A. Manning, and Benjamin D. Schwartz Human Vascular Smooth Muscle Cells Poorly Co-Stimulate and Actively Inhibit Allogeneic CD4* T Cell Proliferation In Vitro Allan G. Murray, Peter Libby, and Jordan S. Pober Prostaglandin E. Promotes B Lymphocyte Ig Isotype Switching to IgE Rachel L. Roper, Deborah M. Brown, and Richard P. Phipps Analysis of Antigen Receptor Signaling in B Cells from Mice with a Retrovirus-Induced Acquired Immunodeficiency Syndrome Linda A. Selvey, Herbert C. Morse III, Carl H. June, and Richard J. Hodes Multiple Defects in Innate and Adaptive Immunologic Function in NOD/LtSz-scid Mice Leonard D. Shultz, Peter A. Schweitzer, Sherri W. Christianson, Bruce Gott, Isabelle B. Schweitzer, Barbara Tennent, Sean McKenna, Larry Mobraaten, T. V. Rajan, Dale L. Greiner, and Edward H. Leiter 192 Cell Cycle Control of Apoptosis in Human Leukemic T Cells Liqing Zhu and Claudio Anasetti MOLECULAR AND STRUCTURAL IMMUNOLOGY 201 Rearrangement of a VH-Associated LINE-1 Element with the Expressed IgH Cluster in a Murine Myeloma Cell Line Jonathan A. Bard and Barbara K. Birshtein Characterization and Expression of Alternatively Spliced IgE Heavy Chain Transcripts Produced by Peripheral Blood Lymphocytes Facundo D. Batista, Dimitar G. Efremov, and Oscar R. Burrone CONTENTS [voL. 154 CD80 (B7) and CD86 (B70) Provide Similar Costimulatory Signals for T Cell Proliferation, Cytokine Production, and Generation of CTL Lewis L. Lanier, Shawn O’Fallon, Chamorro Somoza, Joseph H. Phillips, Peter S. Linsley, Ko Okumura, Daisuke Ito, and Miyuki Azuma IL-7 Drives Donor T Cell Proliferation and Can Costimulate Cytokine Secretion After MHC-Matched Allogeneic Bone Marrow Transplantation Robert B. Levy, Monica Jones, Brian L. Hamilton, John Paupe, Tamir Horowitz, and Richard Riley Human IL-12 p40 Homodimer Binds to the IL-12 Receptor but Does Not Mediate Biologic Activity Ping Ling, Maurice K. Gately, Ueli Gubler, Alvin S. Stern, Ping Lin, Kurt Hollfelder, Chang Su, Yu-Ching E. Pan, and John Hakimi Characterization of Fibroblasts with a Unique Defect in Processing Antigens with Disulfide Bonds Brian J. Merkel, Richard Mandel, Hugues J.-P. Ryser, and Kathleen L. McCoy Delivery of Nascent MHC Class II-Invariant Chain Complexes to Lysosomal Compartments and Proteolysis of Invariant Chain by Cysteine Proteases Precedes Peptide Binding in B-Lymphoblastoid Cells Phillip A. Morton, Michelle L. Zacheis, Karen S. Giacoletto, Julia A. Manning, and Benjamin D. Schwartz Human Vascular Smooth Muscle Cells Poorly Co-Stimulate and Actively Inhibit Allogeneic CD4* T Cell Proliferation In Vitro Allan G. Murray, Peter Libby, and Jordan S. Pober Prostaglandin E. Promotes B Lymphocyte Ig Isotype Switching to IgE Rachel L. Roper, Deborah M. Brown, and Richard P. Phipps Analysis of Antigen Receptor Signaling in B Cells from Mice with a Retrovirus-Induced Acquired Immunodeficiency Syndrome Linda A. Selvey, Herbert C. Morse III, Carl H. June, and Richard J. Hodes Multiple Defects in Innate and Adaptive Immunologic Function in NOD/LtSz-scid Mice Leonard D. Shultz, Peter A. Schweitzer, Sherri W. Christianson, Bruce Gott, Isabelle B. Schweitzer, Barbara Tennent, Sean McKenna, Larry Mobraaten, T. V. Rajan, Dale L. Greiner, and Edward H. Leiter 192 Cell Cycle Control of Apoptosis in Human Leukemic T Cells Liqing Zhu and Claudio Anasetti MOLECULAR AND STRUCTURAL IMMUNOLOGY 201 Rearrangement of a VH-Associated LINE-1 Element with the Expressed IgH Cluster in a Murine Myeloma Cell Line Jonathan A. Bard and Barbara K. Birshtein Characterization and Expression of Alternatively Spliced IgE Heavy Chain Transcripts Produced by Peripheral Blood Lymphocytes Facundo D. Batista, Dimitar G. Efremov, and Oscar R. Burrone CONTENTS A Simple Mathematical Model for the Functional Peptide/MHC/TCR Interactions Gérard Eberl, Mario A. Roggero, and Giampietro Corradin A Human Anti-Insulin IgG Autoantibody Apparently Arises Through Clonal Selection from an Insulin-Specific “Germ-Line” Natural Antibody Template: Analysis by V Gene Segment Reassortment and Site-Directed Mutagenesis Yuji Ichiyoshi, Min Zhou, and Paolo Casali Characterization of the Mouse Lymphotoxin-8 Gene Pornsri Lawton, Janice Nelson, Richard Tizard, and Jeffrey L. Browning Several HLA Alleles Share Overlapping Peptide Specificities John Sidney, Marie-France del Guercio, Scott Southwood, Victor H. Engelhard, Ettore Appella, Hans-George Rammensee, Kirsten Falk, Olaf Rétzschke, Masafumi Takiguchi, Ralph T. Kubo, Howard M. Grey, and Alessandro Sette HOST DEFENSE 260 Characterization of Regions of Herpes Simplex Virus Type 1 Glycoprotein E Involved in Binding the Fc Domain of Monomeric IgG and in Forming a Complex with Glycoprotein I Saswata Basu, Gary Dubin, Mitali Basu, Van Nguyen, and Harvey M. Friedman Alteration of Pulmonary Macrophage Function by Respiratory Syncytial Virus Infection In Vitro G. Franke-Ullmann, C. Pfértner, P. Walter, C. Steinmiiller, M.-L. Lohmann-Matthes, L. Kobzik, and J. Freihorst Antitumor Activities of Subsets of Human IL-2-Activated Natural Killer Cells in Solid Tissues Nikola L. Vujanovic, Satoshi Yasumura, Hideki Hirabayashi, Wen-chang Lin, Simon Watkins, Ronald B. Herberman, and Theresa L. Whiteside Enhanced Cytotoxicity of IFN-y-Producing CD4* Cytotoxic T Lymphocytes Specific for T. gondii-Infected Human Melanoma Cells Tian-Hui Yang, Fumie Aosai, Kazumi Norose, Masakatsu Ueda, and Akihiko Yano INFLAMMATION 299 Ligation of Platelet/Endothelial Cell Adhesion Molecule 1 (PECAM-1/CD31) on Monocytes and Neutrophils Increases Binding Capacity of Leukocyte CR3 (CD11b/CD18) Miriam E. Berman and William A. Muller Inhibition of Chemotactic Peptide-Induced Neutrophil Adhesion to Vascular Endothelium by cAMP Modulators Claudia K. Derian, Rosemary J. Santulli, Patricia E. Rao, Howard F. Solomon, and John A. Barrett IgG Immune Complexes Inhibit IFN-y-Induced Transcription of the FcyRI Gene in Human Monocytes by Preventing the Tyrosine Phosphorylation of the p91 (Statl) Transcription Factor Gerald M. Feldman, Eric J. Chuang, and David S. Finbloom CONTENTS [vot. 154 Inhibition of Neutrophil Adhesion by Adenosine and an Adenosine Kinase Inhibitor: The Role of Selectins Gary S. Firestein, David A. Bullough, Mark D. Erion, Roland Jimenez, Michele Ramirez-Weinhouse, Jerzy Barankiewicz, C. Wayne Smith, Harry E. Gruber, and Kevin M. Mullane Functional Characterization of the Rat Chemokine KC and Its Importance in Neutrophil Recruitment in a Rat Model of Pulmonary Inflammation Charles W. Frevert, Songlih Huang, Hadi Danaee, Joseph D. Paulauskis, and Lester Kobzik Potential Requirement of a Functional Double-Stranded RNA-Dependent Protein Kinase (PKR) for the Tumoricidal Activation of Macrophages by Lipopolysaccharide or IFN-af, but not IFN-y G. Luca Gusella, Tiziana Musso, Sandra E. Rottschafer, Kari Pulkki, and Luigi Varesio Murine KIT* Lineage” Bone Marrow Progenitors Express Fcy-RII But Do Not Express Fce-RI Until Mast Cell Granule Formation Chris S. Lantz and Thomas F. Huff Constitutive Expression of Human hsp27, Drosophila hsp27, or Human aB-Crystallin Confers Resistance to TNF- and Oxidative Stress-Induced Cytotoxicity in Stably Transfected Murine L929 Fibroblasts Patrick Mehlen, Xavier Preville, Pierre Chareyron, Jérome Briolay, Roman Klemenz, and André-Patrick Arrigo Ig-Binding Surface Proteins of Streptococcus pyogenes also Bind Human C4b-Binding Protein (C4BP), a Regulatory Component of the Complement System Anette Thern, Lars Stenberg, Bj6rn Dahlbdck, and Gunnar Lindahl CLINICAL IMMUNOLOGY 388 Experimental Autoimmune Encephalomyelitis-Resistant Mice Have Highly Encephalitogenic Myelin Basic Protein (MBP)-Specific T Cell Clones That Recognize a MBP Peptide with High Affinity for MHC Class II Sara Abromson-Leeman, Jeff Alexander, Roderick Bronson, John Carroll, Scott Southwood, and Martin Dorf A Peptide-Based Human T Cell Leukemia Virus Type I Vaccine Containing T and B Cell Epitopes That Induces High Titers of Neutralizing Antibodies Eishi Baba, Minoru Nakamura, Kazu Ohkuma, Jun-ichi Kira, Yuetsu Tanaka, Shuji Nakano, and Yoshiyuki Niho Monoclonal IgM Rheumatoid Factor Secreted by CD5-Negative B Cells During Mixed Cryoglobulinemia: Evidence for Somatic Mutations and Intraclonal Diversity of the Expressed V,, Region Gene Rachel Crouzier, Thierry Martin, and Jean-Louis Pasquali HIV-1 Infection Alters Monocyte Interactions with Human Microvascular Endothelial Cells Subhash Dhawan, Benjamin S. Weeks, Carl Soderland, H. William Schnaper, Luis A. Toro, Sumita P. Asthana, Indira K. Hewlett, William G. Stetler-Stevenson, Susan S. Yamada, Kenneth M. Yamada, and Monte S. Meltzer CONTENTS HIV-1-Specific Cytotoxic T Lymphocyte Responses in the First Year of Life Katherine Luzuriaga, Deborah Holmes, Amy Hereema, Johnson Wong, Dennis L. Panicali, and John L. Sullivan In Vivo Depletion of Thy-1-Positive Cells Originating from Normal Bone Marrow Abrogates the Suppression of gid Disease in Normal-gld Mixed Bone Marrow Chimeras Glen C. MacDonald, Vellalore N. Kakkanaiah, Eric S. Sobel, Philip L. Cohen, and Robert A. Eisenberg Retinoid Treatment of Experimental Allergic Encephalomyelitis: IL-4 Production Correlates with Improved Disease Course Michael K. Racke, Dionne Burnett, Seong-Hee Pak, Paul S. Albert, Barbara Cannella, Cedric S. Raine, Dale E. McFarlin, and Dorothy E. Scott Co-Infusion of Normal Bone Marrow Partially Corrects the gid T-Cell Defect: Evidence for an Intrinsic and Extrinsic Role for Fas Ligand Eric S. Sobel, Vellalore N. Kakkanaiah, Manickasundari Kakkanaiah, Philip L. Cohen, and Robert A. Eisenberg Enhanced Production of TGF-B by Blood Monocytes from Patients with Active Tuberculosis and Presence of TGF-B in Tuberculous Granulomatous Lung Lesions Zahra Toossi, Prema Gogate, Hiroe Shiratsuchi, Tzuguang Young, andJerrold J. Eliner Author Index Information for Authors Submission Form Membership Application VOLUME 154 /N°2 / JANUARY 15, 1995 CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 483 IL-15 Has Stimulatory Activity for the Induction of B Cell Proliferation and Differentiation Richard J. Armitage, Brian M. Macduff, June Eisenman, Raymond Paxton, and Kenneth H. Grabstein Ligand Binding to FcyR Induces c-myc-Dependent Apoptosis in IL-2- Stimulated NK Cells Livio Azzoni, Ignacio Anegon, Bruno Calabretta, and Bice Perussia a8, and a,8, Integrins Mediate Laminin/Merosin Binding and Function as Costimulatory Molecules for Human Thymocyte Proliferation Andrew C. Chang, Daniel R. Salomon, Scott Wadsworth, Myung-Joo P. Hong, Christopher F. Mojcik, Stephanie Otto, Ethan M. Shevach, and John E. Coligan CONTENTS [voL. 154 Presentation of Endogenous and Exogenous Antigens Is Not Affected by Inactivation of E, Ubiquitin-Activating Enzyme in Temperature-Sensitive Cell Lines Josephine H. Cox, Paul Galardy, Jack R. Bennink, and Jonathan W. Yewdell Nonresponders to Hepatitis B Vaccine Can Present Envelope Particles to T Lymphocytes Isabelle Desombere, Pierre Hauser, Rudi Rossau, Joseph Paradijs, and Geert Leroux-Roels Selective Processing of Exogenous Antigens by Antigen-Presenting Cells with Deleted MHC Genes Stephanie Diment and Sanjay Shinde Dendritic Cells Are the Most Efficient in Presenting Endogenous Naturally Processed Self-Epitopes to Class II-Restricted T Cells Jean-Charles Guéry and Luciano Adorini Constitutive Presentation of Dominant Epitopes from Endogenous Naturally Processed Self-82-Microglobulin to Class II-Restricted T Cells Leads to Self-Tolerance Jean-Charles Guéry, Alessandro Sette, Ettore Appella, and Luciano Adorini Limited Restriction in the TCR-aB V Region Usage of Antigen-Specific Clones: Recognition of Myelin Basic Protein (Amino Acids 84-102) and Mycobacterium bovis 65-kDa Heat Shock Protein (Amino Acids 3-13) by T Cell Clones Established from Peripheral Blood Mononuclear Cells of Monozygotic Twins and HLA-Identical Individuals Gail E. Hawes, Linda Struyk, Barbara C. Godthelp, and Peter J. van den Elsen Variations in the Number of Peptide-MHC Class I Complexes Required to Activate Cytotoxic T Cell Responses Shigeki Kageyama, Theodore J. Tsomides, Yuri Sykulev, and Herman N. Eisen Murine T and B Cell Responses to Natural and Recombinant Hornet Venom Allergen Dol m 5.02 and Its Recombinant Fragments Te Piao King, Loucia Kochoumian, and Gang Lu The Role of MHC Class I Molecules in the Generation of Endogenous Peptide/MHC Complexes Subramaniam Malarkannan, Samuel Goth, Daniel R. Buchholz, and Nilabh Shastri Fas Antigen-Mediated DNA Fragmentation and Apoptotic Morphologic Changes Are Regulated by Elevated Cytosolic Ca“* Level Yoko Oshimi and Shunichi Miyazaki TGF-B Suppression of IFN-y-Induced Class II MHC Gene Expression Does Not Involve Inhibition of Phosphorylation of JAK1, JAK2, or Signal Transducers and Activators of Transcription, or Modification of IFN-y Enhanced Factor X Expression R. Brian Panek, Yi-Ju Lee, and Etty N. Benveniste CONTENTS In Vivo State of Antiviral CTL Precursors: Characterization of a Cycling Cell Population Containing CTL Precursors in Immune Mice Enal S. Razvi, Raymond M. Welsh, and Hugh I. McFarland Characterization of Donor Chimerism, Alloreactive Host T Cells And Memory Cell Development in Thymi from Mice Resistant To Neonatal Transplantation Tolerance Phillip Ruiz, Mehdi Nassiri, Ana L. Viciana, Jayanthi Padmanabhan, and J. Wayne Streilein CD45-Cross-Linking Stimulates IFN-y Production in NK Cells F. Shen, X-L. Xu, L. H. Graf, and A. S.-F. Chong Oligomeric IgD Augments and Monomeric IgD Inhibits the Generation of IgG Memory Antibody Responses in Normal, but Not in IgD-Deficient, Mice Christina D. Swenson, Elana Rizinashvili, Ashok R. Amin, and G. Jeanette Thorbecke Definition of a Lamina Propria T Cell Responsive State: Enhanced Cytokine Responsiveness of T Cells Stimulated Through the CD2 Pathway Stephan R. Targan, Richard L. Deem, Min Liu, Schwale Wang, and André Nel MOLECULAR AND STRUCTURAL IMMUNOLOGY 676 Diversity of Vy Gene Segments Rearranged to the J y4 Gene in Mice Naoki Atsuta, Hitoshi Nishimura, Nobuhisa Nakamura, Masashi Emoto, Takako Iwatsuki, and Yasunobu Yoshikai Binding of a Peptide Antigen to Multiple HLA Alleles Allows Definition of an A2-Like Supertype Marie-France del Guercio, John Sidney, Gary Hermanson, Carl Perez, Howard M. Grey, Ralph T. Kubo, and Alessandro Sette cis-Acting DNA Elements of Mouse Granulocyte-Macrophage Colony- Stimulating Factor Gene Responsive to Fce Receptor Cross-Linking Stimulation in the Mouse Mast Cell Line MC/9 Ryuta Nishikomori, Masahiko Kawai, Eun-Young Jung, Guixiang Tai, Atsushi Miyajima, Naoko Arai, Mitsufumi Mayumi, and Toshio Heike HLA-A0201 Complexes with Two 10-Mer Peptides Differing at the P2 Anchor Residue Have Distinct Refolding Kinetics Penelope A. Robbins, David N. Garboczi, and Jack L. Strominger A cDNA Clone Coding for a Novel Allergen, Cla h Ill, of Cladosporium herbarum Identified as a Ribosomal P, Protein Lei Zhang, Gauri Muradia, Ivan H. A. Curran, Harold Rode, and Hari M. Vijay HoOsT DEFENSE 718 Lymphokine mRNA Expression by Transplantable Murine B Lymphocytic Malignancies: Tumor-Derived IL-10 as a Possible Mechanism for Modulating the Anti-Tumor Response Kenneth L. Bost, Samuel C. Bieligk, and Bernard M. Jaffe CONTENTS [vo.. 154 Melanoma Patients Immunized with Melanoma Cell Vaccine Induce Antibody Responses to Recombinant MAGE-1 Antigen Dave S. B. Hoon, Dale Yuzuki, Mike Hayashida, and Donald L. Morton Fibrosarcoma Cells Expressing Allogeneic MHC Class II Antigens Induce Protective Antitumor Immunity Dana R. Leach and Gerald N. Callahan Activation-Induced CD4* T Cell Death by Apoptosis in Experimental Chagas’ Disease Marcela F. Lopes, Venicio F. da Veiga, Adalberto R. Santos, Maria Evangelina F. Fonseca, and George A. DosReis The WI-1 Antigen of Blastomyces dermatitidis Yeasts Mediates Binding to Human Macrophage CD11b/CD18 (CR3) and CD14 Simon L. Newman, Sudha Chaturvedi, and Bruce S. Klein Generation of Tumor-Specific CTLs from Melanoma Patients by Using Peripheral Blood Stimulated with Allogeneic Melanoma Tumor Cell Lines: Fine Specificity and MART-1 Melanoma Antigen Recognition Emily J. Stevens, Laura Jacknin, Paul F. Robbins, Yutaka Kawakami, Mona El Gamil, Steven A. Rosenberg, and John R. Yannelli Reactivity of Autologous CD4* T Lymphocytes Against Human Melanoma: Evidence for a Shared Melanoma Antigen Presented by HLA-DR15 Tohru Takahashi, Paul B. Chapman, Soo Young Yang, Isao Hara, Setaluri Vijayasaradhi, and Alan N. Houghton 780 NK Cell Response to Viral Infections in B.,-Microglobulin-Deficient Mice Chin-Hun Tay, Raymond M. Welsh, and Randy R. Brutkiewicz INFLAMMATION 790 Conformation and Ion Channel Activity of Lymphotoxin at Neutral and Low pH Rae Lynn Baldwin, Tajib Mirzabekov, Bruce L. Kagan, and Bernadine J. Wisnieski IL-13 Selectively Induces Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells Bruce S. Bochner, David A. Klunk, Sherry A. Sterbinsky, Robert L. Coffman, and Robert P. Schleimer Mechanisms Underlying Acute Mast Cell-Induced Leukocyte Rolling and Adhesion In Vivo Jeffrey P. Gaboury, Brent Johnston, Xiao-Fei Niu, and Paul Kubes Synthetic Hexa- and Heptapeptides That Inhibit IL-8 from Binding to and Activating Human Blood Neutrophils Shinichiro Hayashi, Anna Kurdowska, Edmund J. Miller, Michael E. Albright, Beverly E. Girten, and Allen B. Cohen CONTENTS Induction of Human Serum Amyloid A in Hep 3B Cells by IL-6 and IL-18 Involves Both Transcriptional and Post-Transcriptional Mechanisms Shun-Lin Jiang, Gerard Lozanski, David Samols, and Irving Kushner Antitumoral Properties of Aged Human Monocytes Julie A. McLachlan, Carla D. Serkin, Kathleen M. Morrey, and Ouahid Bakouche Complement Component C7 Is a Plasminogen-Binding Protein Jeannette Reinartz, G. Maria Hdnsch, and Michael D. Kramer Activation of Human Monocytes by Streptococcal Rhamnose Glucose Polymers Is Mediated by CD14 Antigen, and Mannan Binding Protein Inhibits TNF-a Release Martine Soell, Elisabeth Lett, Fabienne Holveck, Marie Schiller, Dominique Wachsmann, and Jean-Paul Klein Chlorpromazine Amplifies Macrophage-Dependent IL-10 Production In Vivo Raquel Tarazona, Ana Gonzdlez-Garcia, Naoufal Zamzami, Philippe Marchetti, Nancy Frechin, José Angel Gonzalo, Mariano Ruiz-Gayo, Nico van Rooijen, Carlos Martinez-A., and Guido Kroemer Heparan Sulfate Initiates Signals in Murine Macrophages Leading to Divergent Biologic Outcomes Lucile E. Wrenshall, Frank B. Cerra, Ravinder K. Singh, and Jeffrey L. Platt CLINICAL IMMUNOLOGY 882 Balance Between IL-18, TNF-a, and Their Specific Inhibitors in Chronic Renal Failure and Maintenance Dialysis: Relationships with Activation Markers of T Cells, B Cells, and Monocytes Béatrice Descamps-Latscha, André Herbelin, Anh Thu Nguyen, Pascale Roux-Lombard, Johanna Zingraff, Anne Moynot, Christian Verger, Djamal Dahmane, Donat de Groote, Paul Jungers, and Jean-Michel Dayer Neutralizing Recombinant Human Antibodies to a Conformational V2- and CD4-Binding Site-Sensitive Epitope of HIV-1 gp120 Isolated by Using an Epitope-Masking Procedure Henrik J. Ditzel, James M. Binley, John P. Moore, Joseph Sodroski, Nancy Sullivan, Lynette S. W. Sawyer, R. Michael Hendry, Wei-Ping Yang, Carlos F. Barbas III, and Dennis R. Burton Divergent Effects of Chronic HIV-1 Infection on Human Thymocyte Maturation in SCID-hu Mice Tobias R. Kollmann, Ana Kim, Massimo Pettoello-Mantovani, Moshe Hachamovitch, Arye Rubinstein, Marsha M. Goldstein, and Harris Goldstein Synergistic Effect of Rapamycin and Cyclosporin A in the Treatment of Experimental Autoimmune Uveoretinitis Daniel F. Martin, L. Raymond DeBarge, Robert B. Nussenblatt, Chi-Chao Chan, and Francois G. Roberge CONTENTS [voL. 154 Increased Severity of Experimental Autoimmune Encephalomyelitis in Rats Tolerized as Adults but Not Neonatally to a Protective TCR VB8 CDR2 Idiotope Halina Offner, Michele K. H. Malotky, Louise Pope, Margarita Vainiene, Bozena Celnik, Stephen D. Miller, and Arthur A. Vandenbark Apoptosis Abnormalities of Splenic Lymphocytes in Autoimmune lpr and gld Mice Elizabeth A. Reap, David Leslie, Mark Abrahams, Robert A. Eisenberg, and Philip L. Cohen TNF-a Expression by Resident Microglia and Infiltrating Leukocytes in the Central Nervous System of Mice with Experimental Allergic Encephalomyelitis: Regulation by Thl Cytokines Toufic Renno, Michelle Krakowski, Ciriaco Piccirillo, Jia-you Lin, and Trevor Owens “Anticardiolipin” Autoantibodies Recognize B,-Glycoprotein I in the Absence of Phospholipid: Importance of Ag Density and Bivalent Binding Robert A. S. Roubey, Robert A. Eisenberg, Mark F. Harper, and John B. Winfield Analysis of the Autoantibody Response to Fibrillarin in Human Disease and Murine Models of Autoimmunity Ken Takeuchi, Shannon J. Turley, Eng M. Tan, and K. Michael Pollard Letters to the Editor Author Index Information for Authors Submission Form Membership Application VOLUME 154 /N°3 / FEBRUARY 1, 1995 Distinct Signal Transduction in Mouse CD4* and CD8* Splenic T Cells After CD28 Receptor Ligation Ryo Abe, Peter Vandenberghe, Nancy Craighead, Douglas S. Smoot, Kelvin P. Lee, and Carl H. June Vy2V82 TCR-Dependent Recognition of Non-Peptide Antigens and Daudi Cells Analyzed by TCR Gene Transfer Jack F. Bukowski, Craig T. Morita, Yoshimasa Tanaka, Barry R. Bloom, Michael B. Brenner, and Hamid Band CD28 Costimulation Up-Regulates Long-Term IL-2R6 Expression in Human T Cells Through Combined Transcriptional and Post-Transcriptional Regulation Chantal Cerdan, Yves Martin, Marianne Courcoul, Claude Mawas, Francoise Birg, and Daniel Olive