Table Of Content

THE JOURNAL OF IMMUNOLOGY VOLUME 149 NuMBERS I To 12 BALTIMORE, MD. 21202 1992 CopyricHT © 1992 By THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS CONTENTS NUMBER 1, JuLy 1, 1992 CELLULAR IMMUNOLOGY E. K. Bikoff Formation of Complexes between Self-Peptides and MHC Class II Molecules in Cells Defective for Presentation of Exogenous Protein Antigens O. Kanagawa, B. A. Nussrallah, Murine AIDS Superantigen Reactivity of the T Cells Bearing V5 T Cell M. E. Wiebenga, K. M. Mur- Antigen Receptor phy, H. C. Morse III, and F. R. Carbone Y. H. Kim, J. J. Proust, M. J. Expression of the Murine Homologue of the Cell Cycle Control Protein p34 Buchholz, F. J. Chrest, and in T Lymphocytes A. A. Nordin Y. Lu, A. Grannelli-Piperno, J. CD28-Induced T Cell Activation: Evidence for a Protein-Tyrosine Kinase M. Bjorndahl, C. A. Phillips, Signal Transduction Pathway and J. M. Trevillyan S. Nakamura, J. Imanishi, and R1-20, a Novel Monoclonal Antibody Reacting with a Molecule Distinct from J. Minowada Integrin Family Induces Homotypic Cell Aggregation N. J. Poindexter, C. Landon, P. Comparison of the T Cell Receptors on Insulin-Specific Hybridomas from J. Whiteley, and J. A. Kapp Insulin Transgenic and Nontransgenic Mice: Loss of a Subpopulation of Self-Reactive Clones L. L. Pritchard, R. Huchet, M. Induction and Suppression of Delayed-Type Hypersensitivity to Non-MHC Bruley-Rosset, N. Riché, Z. Antigens during Lethal Graft-versus-Host Reaction Mishal, and 0. Halle-Pan- nenko R. Schafer, D. A. Portnoy, S. A. Induction of a Cellular Immune Response to a Foreign Antigen by a Recom- Brassell, and Y. Paterson binant Listeria monocytogenes Vaccine C. L. Schultz, P. Rothman, R. T Helper Cell Membranes Promote IL-4-Independent Expression of Germ- Kuhn, M. Kehry, W. Miller, Line Cy1 Transcripts in B Cells K. Rajewsky, F. Alt, and R. L. Coffman F. Spertini, T. Chatila, and R. Signals Delivered via MHC Class II Molecules Synergize with Signals Deliv- S. Geha ered via TCR/CD3 to Cause Proliferation and Cytokine Gene Expression in T Cells T. Suda and A. Zlotnik In Vitro Induction of CD8 Expression on Thymic Pre-T Cells. II. Character- ization of CD3°CD4-CD8at Cells Generated in Vitro by Culturing CD25*CD3°CDCD48 Thymocytes with T Cell Growth Factor-6 and Tu- mor Necrosis Factor-a D. Wegmann, M. Norbury- High Efficiency Presentation of TNP-Conjugated Islet Antigen to Islet-Spe- Glaser, B. Bergman, and K. cific T Cells by a Hybrid B Cell Line Expressing TNP-Specific Surface Ig Haskins CYTOKINES « MEDIATORS ¢ REGULATORY MOLECULES N. Arima, W. A. Kuziel, T. A. IL-2-Induced Signal Transduction Involves the Activation of Nuclear NF-«B Grdina, and W. C. Greene Expression A. H. Enk and S. I. Katz Identification and Induction of Keratinocyte-Derived IL-10 K. Fan, Q. Ruan, L. Sensen- Up-Regulation of Granulocyte-Macrophage Colony-Stimulating Factor (GM- brenner, and B. D.-M. Chen CSF) Receptors in Murine Peritoneal Exudate Macrophages by Both GM- CSF and IL-3 S. H. Phan, M. Gharaee-Ker- Regulation of Rat Pulmonary Artery Endothelial Cell Transforming Growth mani, B. McGarry, S. L. Kun- Factor-@ Production by IL-18 and Tumor Necrosis Factor-a kel, and F. W. Wolber A. M. Zubiaga, E. Munoz, and IL-4 and IL-2 Selectively Rescue T Helper Cell Subsets from Glucocorticoid- B. T. Huber Induced Apoptosis IMMUNOCHEMISTRY M. P. Colombo, L. Lombardi, A. Granulocyte Colony-Stimulating Factor (G-CSF) Gene Transduction in Mu- Stoppacciaro, C. Melani, M. rine Adenocarcinoma Drives Neutrophil-Mediated Tumor Inhibition in iv CONTENTS VOL. 149 Parenza, B. Bottazzi, and G. Vivo: Neutrophils Discriminate between G-CSF-Producing and G-CSF- Parmiani Nonproducing Tumor Cells A. J. Cumber, E. S. Ward, G. Comparative Stabilities in Vitro and in Vivo of a Recombinant Mouse Winter, G. D. Parnell, and E. Antibody FvCys Fragment and a bisF vCys Conjugate J. Wawrzynczak C. Horgan, K. Brown, and S. H. Effect of H Chain V Region on Complement Activation by Immobilized Pincus Immune Complexes M. H. Newberg, J. P. Ridge, D. Species Specificity in the Interaction of CD8 with the a3 Domain of MHC R. Vining, R. D. Salter, and Class I Molecules V. H. Engelhard T. D. Rao, A. A. Maghazachi, A. A Novel IgA Receptor Expressed on a Murine B Cell Lymphoma V. Gonzalez, and J. M. Phil- lips-Quagliata IMMUNOPHARMACOLOGY S. C. Erzurum, G. P. Downey, Mechanisms of Lipopolysaccharide-Induced Neutrophil Retention: Relative D. E. Doherty, B. Schwarb III, Contributions of Adhesive and Cellular Mechanical Properties E. L. Elson, and G. S. Wor- then C.-M. Kam, T. J. Oglesby, M. K. Substituted Isocoumarins as Inhibitors of Complement Serine Proteases Pangburn, J. E. Volanakis, and J. C. Powers I. Melamed, G. Wang, and C. M. Antigen Receptor-Mediated Protein Tyrosine Kinase Activity Is Regulated Roifman by a Pertussis Toxin-Sensitive G Protein MICROBIAL IMMUNOLOGY R. Gazzinelli, Y. Xu, S. Hieny, Simultaneous Depletion of CD4* and CD8* T Lymphocytes Is Required to A. Cheever, and A. Sher Reactivate Chronic Infection with Toxoplasma gondii J. Gosselin, L. Flamand, M. Modulatory Effects of Epstein-Barr, Herpes Simplex, and Human Herpes-6 D’ Addario, J. Hiscott, I. Ste- Viral Infections and Coinfections on Cytokine Synthesis: A Comparative fanescu, D. V. Ablashi, R. C. Study Gallo, and J. Menezes S. H. Gregory, E. J. Wing, D. J. Primary Listerial Infections Are Exacerbated in Mice Administered Neu- Tweardy, R. K. Shadduck, tralizing Antibody to Macrophage Colony-Stimulating Factor and H.-S. Lin L. M. Kumaratilake and A. Fer- IL-4 Inhibits Macrophage-Mediated Killing of Plasmodium falciparum in rante Vitro: A Possible Parasite-Immune Evasion Mechanism J. C. Mathison, P. S. Tobias, E. Plasma Lipopolysaccharide (LPS)-Binding Protein: A Key Component in Wolfson, and R. J. Ulevitch Macrophage Recognition of Gram-Negative LPS Y. Suzuki, K. Ohsugi, and Y. EBV Increases Phosphoinositide Kinase Activities in Human B Cells Ono U. Utz, S. Koenig, J. E. Coligan, Presentation of Three Different Viral Peptides, HTLV-1 TAX, HCMV gB, and W. E. Biddison and Influenza Virus M1, Is Determined by Common Structural Features of the HLA-A2.1 Molecule MOLECULAR BIOLOGY e MOLECULAR GENETICS A. J. Feeney Predominance of Vy-D-Jy Junctions Occurring at Sites of Short Sequence Homology Results in Limited Junctional Diversity in Neonatal Antibodies R. Gonalez-Quintial and A. N. V@ Gene Repertoires in Aging Mice Theofilopoulos J. G. Haas, M. Strébel, A. Constitutive Monocyte-Restricted Activity of NF-M, a Nuclear Factor that Leutz, P. Wendelgaf, C. Binds to a C/EBP Motif Muller, E. Sterneck, G. Rieth- muller, and H. W. L. Ziegler- Heitbrock P. Sideras, L. Nilsson, K. B. Is- Transcription of Unrearranged Ig H Chain Genes in Human B Cell Malig- lam, I. Z. Quintana, L. nancies: Biased Expression of Genes Encoded within the First Duplication Freihof, A. Rosén, G. Julius- Unit of the Ig H Chain Locus son, L. Hammarstrom, and C. 1. E. Smith 1992 CONTENTS B. Tjoa and D. M. Kranz Diversity of T Cell Receptor-a Chain Transcripts from Hyperimmune Allo- reactive T Cells TUMOR IMMUNOLOGY J. Jaaskelainen, A. Maenpaa, Migration of Recombinant IL-2-Activated T and Natural Killer Cells in the M. Patarroyo, C. G. Gahmb- Intercellular Space of Human H-2 Glioma Spheroids in Vitro: A Study on erg, K. Somersalo, J. Tark- Adhesion Molecules Involved kanen, M. Kallio, and T. Ti- monen J. Rogers and M. F. Mescher Augmentation of in Vivo Cytotoxic T Lymphocyte Activity and Reduction of Tumor Growth by Large Multivalent Immunogen M. Sensi, M. Bergomi, P. Pan- Involvement of Somatically Acquired Ecotropic Viruses in the Immunoge- ceri, C. Castelli, R. Lupetti, nicity of Nude-Transplanted NIH/3t3 Transformed Cell Lines C. Traversari, G. Carbone, and G. Parmiani CLINICAL IMMUNOLOGY ¢ IMMUNOPATHOLOGY D. Cefai, M. Ferrer, N. Ser- Internalization of HIV Glycoprotein gp120 Is Associated with Down-Modu- pente, T. Idziorek, A. Dautry- lation of Membrane CD4 and p56 Together with Impairment of T Cell Varsat, P. Debre, and G. Bis- Activation muth P. J. Doherty, S. X. Yang, R. M. Evidence for Clonal Expansion of T Cell Receptor VyII* T Cells in the Laxer, E. D. Silverman, R. In- Synovial Fluid of Patients with Arthritis man, and S. Pan J. Golay, G. Cusmano, and M. Independent Regulation of c-myc, B-myb, and c-myb Gene Expression by Introna Inducers and Inhibitors of Proliferation in Human B Lymphocytes M. M. Griffiths, M. A. Cremer, Immunogenetics of Collagen-Induced Arthritis in Rats: Both MHC and Non- D. S. Harper, S. McCall, and MHC Gene Products Determine the Epitope Specificity of Immune Re- G. W. Cannon sponse to Bovine and Chick Type II Collagens F. Koning and C. Rust Staphylococcal Enterotoxin-Mediated Human T-T Cell Interactions F. Mollinedo, C. Burgaleta, G. Enhancement of Human Neutrophil Functions by a Monoclonal Antibody Velasco, A. G. Arroyo, A. Ac- Directed against a 19-kDa Antigen evedo, and I. Barasoain M. S. Mulligan and P. A. Ward Immune Complex-Induced Lung and Dermal Vascular Injury: Differing Re- quirements for Tumor Necrosis Factor-a and IL-1 H. Rabinowich, D. Vitolo, S. Al- Role of Cytokines in the Adoptive Immunotherapy of an Experimental Model tarac, R. B. Herberman, and of Human Head and Neck Cancer by Human IL-2-Activated Natural Killer T. L. Whiteside Cells Failed Self-Tolerance and Autoimmunity in IgG Anti-DNA Transgenic Mice B. P. Tsao, K. Ohnishi, H. Cher- outre, B. Mitchell, M. Teitell, P. Mixter, M. Kronenberg, and B. H. Hahn A. L. Van Dervort, M. E. Doer- Antagonism of Lipopolysaccharide-Induced Priming of Human Neutrophils fler, P. Stuetz, and R. L. Dan- by Lipid A Analogs ner Author Index NUMBER 2, JULY 15, 1992 CELLULAR IMMUNOLOGY L. A. Bristol, K. Sakaguchi, E. 367 Thymocyte Costimulating Antigen Is CD26 (Dipeptidyl-Peptidase IV): Costi- Appella, D. Doyle, and L. mulation of Granulocyte, Macrophage, and T Lineage Cell Proliferation Takacs Via CD26 vi CONTENTS VOL. 149 C. Cerdan, D. Razanajaona, Y. Contributions of the CD2 and CD28 T Lymphocyte Activation Pathways to Martin, M. Courcoul, C. Pa- the Regulation of the Expression of the Colony-Stimulating Factor (CSF- von, C. Mawas, D. Olive, and 1) Gene F. Birg J. A. Gross, E. Callas, and J. P. Identification and Distribution of the Costimulatory Receptor CD28 in the Allison Mouse D. M. Haverstick and L. S. Gray Lymphocyte Adhesion Mediated by Lymphocyte Function-Associated Anti- gen-1.1. Long Term Augmentation by Transient Increases in Intracellular AMP D. M. Haverstick and L. S. Gray Lymphocyte Adhesion Mediated by Lymphocyte Function-Associated Anti- gen-1. II. Interaction between Phorbol Ester- and cAMP-Sensitive Path- ways K. Kikly and G. Dennert Evidence for Extrathymic Development of Tyx Cells: NK1* CD3* Cells Re- sponsible for Acute Marrow Graft Rejection are Present in Thymus- Deficient Mice E. Payer, R. Strohal, R. Kutil, Demonstration of a CD3* Lymphocyte Subset in the Epidermis of Athymic A. Elbe, and G. Sting] Nude Mice: Evidence for T Cell Receptor Diversity S. Wadsworth, M. J. Halvorson, Developmentally Regulated Expression of the 6, Integrin on Immature and J. E. Coligan Mouse Thymocytes MOLECULAR AND STRUCTURAL IMMUNOLOGY J. M. Drezen, P. Nouvel, C. Ba- 429 Different Regulation of Class | Gene Expression in the Adult Mouse and binet, and D. Morello during Development G. A. Hollander, B. D. Luskey, 438 Functional Expression of Human CD8 in Fully Reconstituted Mice after D. A. Williams, and S. J. Bur- Retroviral-Mediated Gene Transfer of Hemopoietic Stem Cells akoff E. Kottgen, B. Hell, A. Kage, Lectin Specificity and Binding Characteristics of Human C-Reactive Protein and R. Tauber M. Moser, R. Crameri, G. Menz, Cloning and Expression of Recombinant Aspergillus fumigatus Allergen T. Schneider, T. Dudiler, C. V. 1/a (rAspf I/a) with IgE Binding and Type I Skin Test Activity Sen, M. Gmachl, K. Blaser, and M. Suter N. Otting, M. Kenter, P. van Mhc-DQB Repertoire Variation in Hominoid and Old World Primate Species Weeren, M. Jonker, and R. E. Bontrop L. S. Reidl, C. M. Kinoshita, Wild Mice Express an Ig V2 Gene that Differs from Any VX in BALB/c but and L. A. Steiner Resembles a Human VA Subgroup T. Tanaka, D. Camerini, B. Cloning and Functional Expression of the T Cell Activation Antigen CD26 Seed, Y. Torimoto, N. H. Dang, J. Kameoka, H. N. Dahlberg, S. F. Schlossman, and C. Morimoto B. J. Underdown, I. Switzer, Rat Secretory Component Binds Poorly to Rodent IgM and G. D. F. Jackson J. H. van Es, M. Heutink, H. Sequence Analysis of Members of the Human Ig V;,4 Gene Family Derived Aanstoot, and T. Logtenberg from a Single Vy Locus: Identification of Novel Germ-Line Members L. Vidard, K. L. Rock, and B. Diversity in MHC Class II Ovalbumin T Cell Epitopes Generated by Distinct Benacerraf Proteases J. A. Villadangos, B. Galocha, Role of Binding Pockets for Amino-Terminal Peptide Residues in HLA-B27 D. Lopez, V. Calvo, and J. A. Allorecognition Lopez de Castro R. Wasserman, Y. Ito, N. Galili, The Pattern of Joining (J1) Gene Usage in the Human IgH Chain is Estab- M. Yamada, B. A. Reichard, lished Predominantly at the B Precursor Cell Stage S. Shane, B. Lange, and G. Rovera IMMUNE MODULATION N. D. Griggs, M. A. Jarpe, J. L. Sif N-Terminus and C-Terminus of IFN-y Are Binding Domains for Cloned Pace, S. W. Russell, and H. M. Soluble IFN-y Receptor Johnson R. Meade, P. W. Askenase, G. 521 Transforming Growth Factor-8 Inhibits Murine Immediate and Delayed P. Geba, K. Neddermann, R. Type Hypersensitivity QO. Jacoby, and R. D. Paster- nak 1992 CONTENTS Vii S. Narumi, J. M. Tebo, J. H. IFN-y and IL-2 Cooperatively Activate NF, in Murine Peritoneal Macrophages Finke, and T. A. Hamilton G. Rodriguez-Tarduchy, M. K. Insulin-Like Growth Factor-] Inhibits Apoptosis in IL-3-Dependent Hemo- L. Collins, I. Garcia, and A. poietic Cells Lopez-Rivas HOST DEFENSE P. F. Barnes, D. Chatterjee, J. Cytokine Production Induced by Mycobacterium tuberculosis Lipoarabi- S. Abrams, S. Lu, E. Wang, nomannan: Relationship to Chemical Structures M. Yamamura, P. J. Brenna, and R. L. Modlin S. P. Chang, H. L. Gibson, C. T. A Carboxyl-Terminal Fragment of Plasmodium falciparum gp195 Ex- Lee-Ng, P. J. Barr, and G. S. pressed by a Recombinant Baculovirus Induces Antibodies that Com- N. Hui pletely Inhibit Parasite Growth R. F. Graziano and P. M. Allen Enhancing the Immunogenicity of a Permissive Binding T Cell Epitope Derived from the Simian Immunodeficiency Virus-Encoded Negative Reg- ulatory Factor V. T. Heussler, M. Eichhorn, R. Constitutive IL-2 mRNA Expression in Lymphocytes Infected with the In- Reeves, N. S. Magnuson, R. tracellular Parasite Theileria parva O. Williams, and D. A. E. Dob- belaere K. Hiromatsu, G. Matsuzaki, Y. Sequential Analysis of T Cells in the Liver during Murine Listerial Infection Tauchi, Y. Yoshikai, and K. Nomoto S. L. Newman, L. Gootee, R. Digestion of Histoplasma capsulatum Yeasts by Human Macrophages Morris, and W. E. Bullock A. A. Scalzo, N. A. Fitzgerald, The Effect of the Cmv-I Resistance Gene, Which Is Linked to the Natural C. R. Wallace, A. E. Gibbons, Killer Cell Gene Complex, Is Mediated by Natural Killer Cells Y. C. Smart, R. C. Burton, and G. R. Shellam K. Somersalo, J. Tarkkanen, Involvement of £2-Integrins in the Migration of Human Natural Killer Cells M. Patarroyo, and E. Saksela INFLAMMATION Human Recombinant c-kit Receptor Ligand, rhSCF, Induces Mediator Re- M. Columbo, E. M. Horowitz, L. M. Botana, D. W. Mac- lease from Human Cutaneous Mast Cells and Enhances IgE, Dependent Glashan, Jr., B. S. Bochner, Mediator Release from Both Skin Mast Cells and Peripheral Blood Baso- S. Gillis, K. M. Zsebo, S. J. phils Galli, and L. M. Lichtenstein G. J. Dobos, J. Norgauer, M. C5a Reduces Formyl! Peptide-Induced Actin Polymerization and Phosphati- Eberle, P. J. Schollmeyer, dylinositol(3,4,5)trisphosphate Formation, but not Phosphatidylinosi- and A. E. Traynor-Kaplan tol(4,5)bisphosphate Hydrolysis and Superoxide Production, in Human Neutrophils M. M. Hamawy, C. Oliver, S. E. Adherence of Rat Basophilic Leukemia (RBL-2H3) Cells to Fibronectin- Mergenhagen, and R. P. Sir- Coated Surfaces Enhances Secretion aganian Y. Kanaho, A. Nishida, and Y. Calcium Rather Than Protein Kinase C Is the Major Factor to Activate Nozawa Phospholipase D in FMLP-Stimuiated Rabbit Peritoneal Neutrophils: Pos- sible Involvement of Calmodulin/Myosin L Chain Kinase Pathway H. Kita, D. A. Weiler, R. Release of Granule Proteins from Eosinophils Cultured with IL-5 Abu-Ghazaleh, C. J. Sander- son, and G. J. Gleich P. Kuna, S. R. Reddigari, T. J. “RANTES,” a Monocyte and T Lymphocyte Chemotactic Cytokine, Releases Schall, D. Rucinski, M. Y. Histamine from Human Basophils Viksman, and A. P. Kaplan J. M. Weiler, R. E. Edens, and Eosinophil Granule Cationic Proteins Regulate Complement. |. Activity on G. J. Gleich the Alternative Pathway CONTENTS CLINICAL IMMUNOLOGY S. Chamat, P. Nara, L. Berqu- Two Major Groups of Neutralizing Anti-gp120 Antibodies Exist in HIV- ist, A. Whalley, W. J. W. Mor- Infected Individuals: Evidence for Epitope Diversity around the CD4 At- row, H. Kohler, and C.-Y. tachment Site Kang W. C. Fanslow, D. M. Anderson, Soluble Forms of CD40 Inhibit Biologic Responses of Human B Cells K. H. Grabstein, E. A. Clark, D. Cosman, and R. J. Armi- tage N. Goebels, D. Michaelis, H. Human Myoblasts as Antigen-Presenting Cells Wekerle, and R. Hohlfeld J. M. Houlihan, P. A. Biro, A. Evidence for the Expression of Non-HLA-A, -B, -C Class I Genes in the Fergar-Payne, K. L. Simpson, Human Fetal Liver and C. H. Holmes P. K. Peterson, G. Gekker, C. C. Cocaine Amplifies HIV-1 Replication in Cytomegalovirus-Stimulated Periph- Chao, R. Schut, J. Verhoef, eral Blood Mononucledar Cell Cocultures C. K. Edelman, A. Erice, and H. H. Balfour, Jr. S. Ratner, P. Patrick, and G. Lymphocyte Development of Adherence and Motility in Extracellular Matrix Bora during IL-2 Stimulation S. K. Stanley, S. W. Kessler, J. CD34* Bone Marrow Cells Are Infected with HIV in a Subset of Seropositive S. Justement, S. M. Schnitt- Individuals man, J. J. Greenhouse, C. C. Brown, L. Musongela, K. Mu- sey, B. Kapita, and A. S. Fauci R. A. Swerlick, K. H. Lee, L.-J. Regulation of Vascular Cell Adhesion Molecule 1 on Human Dermal Micro- Li, N. T. Sepp, S. W. Caugh- vascular Endothelial Cells man, and T. J. Lawley H. Tsutsui, Y. Terano, C. Sak- Drug-Specific T Cells Derived from Patients with Drug-Induced Allergic agami, I. Hasegawa, Y. Mizo- Hepatitis guchi, and S. Morisawa D. Valmori, A. Pessi, E. Bian- Use of Human Universally Antigenic Tetanus Toxin T Cell Epitopes as chi, and G. Corradin Carriers for Human Vaccination P. M. Villiger, R. Terkeltaub, Production of Monocyte Chemoattractant Protein-1 by Inflamed Synovial and M. Lotz Tissue and Cultured Synoviocytes H. Yamamoto, D. J. Ringler, M. Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes Are D. Miller, Y. Yasutomi, T. Ha- Present in the AIDS-Associated Skin Rash In Rhesus Monkeys sunuma, and N. L. Letvin L.-J. Zhou, R. Schwarting, H. A Novel Cell-Surface Molecule Expressed by Human Interdigitating Reticu- M. Smith, and T. F. Tedder lum Cells, Langerhans Cells, and Activated Lymphocytes Is a New Member of the Ig Superfamily Letter to the Editor Errata Announcements Author Index NUMBER 3, AUGUST 1, 1992 CELLULAR IMMUNOLOGY V. Bazil and V. Horejsi Shedding of the CD44 Adhesion Molecule from Leukocytes Induced by Anti- CD44 Monoclonal Antibody Simulating the Effect of a Natural Receptor Ligand S. Ceman, R. Rudersdorf, E. O. MH Class II Deletion Mutant Expresses Normal Levels of Transgene En- Long, and R. Demars coded Class II Molecules that Have Abnormal Conformation and Impaired Antigen Presentation Ability S.-S. A. Chen, Q. Li, E. Pearl- Dual Mechanisms of Potentiation of Murine Antigen-Specific IgE Production man, and W.-H. Chen by Cyclosporin A in Vitro C.-C. Delibrias, E. Fischer, G. Expression, Molecular Association, and Functions of C3 Complement Re- Bismuth, and M. D. Kazatch- ceptors CR1 (CD35) and CR2 (CD21) on the Human T Cell Line HPB-ALL kine 1992 CONTENTS ix A. H. M. Galy and H. Spits CD40 Is Functionally Expressed on Human Thymic Epithelial Cells J. M. Greer, V. K. Kuchroo, R. Identification and Characterization of a Second Encephalitogenic Determi- A. Sobel, and M. B. Lees nant of Myelin Proteolipid Protein (Residues 178-191) for SUL Mice M. J. Mamula, R.-H. Lin, C. A. Breaking T Cell Tolerance with Foreign and Self Co-lmmunogens: A Study Janeway, Jr., and J. A. Har- of Autoimmune B and T Cell Epitopes of Cytochrome c din F. Manca Selective Functional Depletion of HIV gp120 Peptides Complexed with MHC from Antigen-Presenting Cells Engaged with Specific T Lymphocytes N. Miki, M. Hatano, K. Wakita, Role of I-A Molecules in Early Stages of B Cell Maturation S. Imoto, S. Nishikawa, S.-I. Nishikawa, and T. Tokuhisa V. Palathumpat, S. Dejbakhsh- Different Subsets of T Cells in the Adult Mouse Bone Marrow and Spleen Jones, B. Holm, and S. Induce or Suppress Acute Graft-versus-Host Disease Strober R. Rajasekar and A. Augustin Selective Proliferation of ~é6 T Lymphocytes Exposed to High Doses of lonomycin MOLECULAR AND STRUCTURAL IMMUNOLOGY T. C. Chiles and T. L. Rothstein Surface Ig Receptor-Induced Nuclear AP-1-Dependent Gene Expression in B Lymphocytes L. E. Daitch, M. W. Moore, D. M. Transcription and Recombination of the Murine RS Element Persiani, J. M. Durdik, and E. Selsing F. Hirsch, S. Germana, K. Gus- Structure and Expression of Class Il « Genes in Miniature Swine tafsson, K. Pratt, D. H. Sachs, and C. LeGuern W. Kasinrerk, E. Fiebiger, I. Human Leukocyte Activation Antigen M6, a Member of the Ig Superfamily, Stefanova, T. Baumruker, W. Is the Species Homologue of Rat OX-47, Mouse Basigin, and Chicken HT7 Knapp, and H. Stockinger Molecule Chicken IgA H Chains: Implications Concerning the Evolution of H Chain A. Mansikka Genes H. Nishikata, C. Oliver, S. E. The Rat Mast Cell Antigen AD1 (Homologue to Human CD63 or Melanoma Mergenhagen, and R. P. Sir- Antigen ME 491) Is Expressed in Other Cells in Culture aganian T. Nobunaga, G. D. Brown, D. A Novel DNA Binding Activity Is Elevated in Thymocytes Expressing High R. Morris, and D. Meruelo Levels of H-2D‘ after Radiation Leukemia Virus Infection W. H. Robinson, H. Ying, M. C. Extensive Polymorphism in the Extracellular Domain of the Mouse B Cell Miceli, and J. R. Parnes Differentiation Antigen Lyb-2/CD72 H. P. Smith, P. Nguyen, D. L. T Cell Receptor a-Chain Influences Reactivity to Mis-1 in V88.1 Transgenic Woodland, and M. A. Black- Mice man Z.-S. Ye, J.-P. Kinet, and W. E. Structure of the Gene for the a-Chain of the Mouse High Affinity Receptor Paul for IgE (FceRI) IMMUNE MODULATION L. Chiodetti and R. H. Schwartz Induction of Competence to Respond to IL-4 by CD4* T Helper Type 1 Cells Requires Costimulation G. Gehr, R. Gentz, M. Brock- Both Tumor Necrosis Factor Receptor Types Mediate Proliferative Signals haus, H. Loetscher, and W. in Human Mononuclear Cell Activation Lesslauer I. Gorgen, T. Hartung, M. Leist, Granulocyte Colony-Stimulating Factor Treatment Protects Rodents against M. Niehorster, G. Tiegs, S. Lipopolysaccharide-Induced Toxicity via Suppression of Systemic Tumor Uhlig, F. Weitzel, and A. Necrosis Factor-a Wendel E. Orino, S. Sone, A. Nii, and T. IL-4 Up-Regulates IL-1 Receptor Antagonist Gene Expression and Its Pro- Ogura duction in Human Blood Monocytes HOST DEFENSE A Kinetic Study of Immune Mediators in the Lungs of Mice Infected with T. Hennet, H. J. Ziltener, D. K. Frei, and E. Peterhans Influenza A Virus x CONTENTS VOL. 149 M. Kuroki, M. Nakamura, Y. Identification of New Epitopes Recognized by Human Monoclonal Antibodies Itoyama, Y. Tanaka, H. Shi- with Neutralizing and Antibody-Dependent Cellular Cytotoxicity Activities raki, E. Baba, T. Esaki, T. Specific for Human T Cell Leukemia Virus Type 1 Tatsumoto, S. Nagafuchi, S. Nakano, and Y. Niho C. M. Loeffler, M. J. Smyth, D. Immunoregulation in Cancer-Bearing Hosts: Down-Regulation of Gene L. Longo, W. C. Kopp, L. K. Expression and Cytotoxic Function in CD8* T Cells Harvey, H. R. Tribble, J. E. Tase, W. J. Urba, A. S. Leon- ard, H. A. Young, and A. C. Ochoa L. Pond, D. L. Wassom, and C. Influence of Resistant and Susceptible Genotype, IL-1, and Lymphoid Organ E. Hayes on Trichinella spiralis-Induced Cytokine Secretion M. Sedegah, B. K. L. Sim, C. Naturally Acquired CD8* Cytotoxic T Lymphocytes against the Plasmodium Mason, T. Nutman, A. Malik, falciparum Circumsporozoite Protein C. Roberts, A. Johnson, J. Ochola, D. Koech, B. Were, and S. L. Hoffman D. E. Speiser, D. Kyburz, U. Discrepancy between in Vitro Measurable and in Vivo Virus Neutralizing Stubi, H. Hengartner, and R. Cytotoxic T Cell Reactivities: Low T Cell Receptor Specificity and Avidity M. Zinkernagel Sufficient for in Vitro Proliferation or Cytotoxicity to Peptide-Coated Tar- get Cells but not for in Vivo Protection S.-I. Tamura, Y. Ito, H. Asan- Cross-Protection against Influenza Virus Infection Afforded by Trivalent uma, Y. Hirabayashi, Y. Su- Inactivated Vaccines Inoculated Intranasally with Cholera Toxin B Sub- zuki, T. Nagamine, C. Ai- unit zawa, and T. Kurata INFLAMMATION R. R. Kew, C. M. Grimaldi, M. Human Neutrophil FcyRIIIB and Formy] Peptide Receptors Are Functionally B. Furie, and H. B. Fleit Linked during Formyl-Methionyl-Leucyl-Phenylalanine-Induced Chemo- taxis T. W. Kuijpers, M. Hoogerwert, Cross-Linking of Sialophorin (CD43) Induces Neutrophil Aggregation in a K. C. Kuijpers, B. R. CD18-Dependent and a CD18-Independent Way Schwartz, and J. M. Harlan R. Maze, B. Sherry, B. S. Kwon, Myelosuppressive Effects in Vivo of Purified Recombinant Murine Macro- A. Cerami, and H. E. Brox- phage Inflammatory Protein-la meyer R. A. J. Oostendorp, E. F. Knol, An Immunosuppressive Retrovirus-Derived Hexapeptide Interferes with In- A. J. Verhoeven, and R. J. tracellular Signaling in Monocytes and Granulocytes through N-Formyl- Scheper peptide Receptors W. A. Phillips, M. Croatto, and Priming of the Respiratory Burst of Bone Marrow-Derived Macrophages Is J. A. Hamilton Associated with an Increase in Protein Kinase C Content M. A. Tufano, C. Tetta, L. Bian- Salmonella typhimurium Porins Stimulate Platelet-Activating Factor Syn- cone, E. L. Iorio, A. Baroni, thesis by Human Polymorphonuclear Neutrophils A. Giovane, and G. Camussi K. Yamada, C. L. Jelsema, and Certain Inhibitors of Protein Serine/Threonine Kinases also Inhibit Tyro- M. A. Beaven sine-Phosphorylation of Phospholipase Cy1 and Other Proteins and Re- veal Distinct Roles for Tyrosine Kinase(s) and Protein Kinase C in Stim- ulated Rat Basophilic RBL-2H3 Cells CLINICAL IMMUNOLOGY E. Chronopoulou and G. Car- Identification of a Thyroidotigenic Sequence within the Thyroglobulin Mol- ayanniotis ecule M. A. Cremer, K. Terato, W. C. Collagen-Induced Arthritis in Rats: Examination of the Epitope Specificities Watson, M. M. Griffiths, A. S. of Circulating and Cartilage-Bound Antibodies Produced by Outbred and Townes, and A. H. Kang Inbred Rats Using Cyanogen Bromide-Derived Peptides Purified from Heterologous and Homologous Type II Collagens G. S. Firestein, A. E. Berger, D. IL-1 Receptor Antagonist Protein Production and Gene Expression in Rheu- E. Tracey, J. G. Chosay, D. L. matoid Arthritis and Osteoarthritis Synovium Chapman, M. M. Paine, C. Yu, and N. J. Zvaifler